Cd55b (CD55 molecule, decay accelerating factor for complement B) - Rat Genome Database

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Gene: Cd55b (CD55 molecule, decay accelerating factor for complement B) Mus musculus
Analyze
No known orthologs.
Symbol: Cd55b
Name: CD55 molecule, decay accelerating factor for complement B
RGD ID: 1623314
MGI Page MGI
Description: Predicted to enable enzyme inhibitor activity; lipid binding activity; and virus receptor activity. Predicted to be involved in several processes, including positive regulation of CD4-positive, alpha-beta T cell proliferation; positive regulation of T cell cytokine production; and regulation of lipopolysaccharide-mediated signaling pathway. Predicted to act upstream of or within complement activation, classical pathway and innate immune response. Predicted to be located in apical plasma membrane; cell surface; and membrane raft. Is expressed in several structures, including alimentary system; metanephros; olfactory epithelium; respiratory system; and trigeminal ganglion. Human ortholog(s) of this gene implicated in prostate cancer and protein-losing enteropathy. Orthologous to human CD55 (CD55 molecule (Cromer blood group)).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AI323748; complement decay-accelerating factor transmembrane isoform; complement-transmembrane; Daf; Daf-T; Daf-TM; Daf2; decay accelerating factor 2; MGC156369; TM-DA; TM-DAF
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391130,316,263 - 130,350,831 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1130,316,274 - 130,350,746 (-)EnsemblGRCm39 Ensembl
GRCm381130,388,526 - 130,423,097 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1130,388,537 - 130,423,009 (-)EnsemblGRCm38mm10GRCm38
MGSCv371132,285,105 - 132,319,576 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361132,216,072 - 132,250,555 (-)NCBIMGSCv36mm8
Celera1133,017,026 - 133,051,496 (-)NCBICelera
Cytogenetic Map1E4NCBI
cM Map156.89NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
2. Mouse MP Annotation Import Pipeline RGD automated import pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7545711   PMID:9435343   PMID:9892684   PMID:10349636   PMID:10417349   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:16141072   PMID:16141073  
PMID:16517735   PMID:17287827   PMID:21267068   PMID:21677750   PMID:21873635   PMID:30973865   PMID:38355793  


Genomics

Variants

.
Variants in Cd55b
48 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:214
Count of miRNA genes:118
Interacting mature miRNAs:119
Transcripts:ENSMUST00000112488, ENSMUST00000119432, ENSMUST00000136497
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134760138150193871Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134760138150193871Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134760138150193871Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163920002153557562Mouse
1300989Lrdg1_mlight induced retinal degeneration 1 (mouse)Not determined173755175147125370Mouse
4141914Gcsfis_mG-CSF induced splenomegaly (mouse)Not determined74516235148715579Mouse
1357847Jckm2_mjuvenile cystic kidney modifier 2 (mouse)Not determined174991977133290937Mouse
27095928Pglq6_mpelvic girdle length QTL 6, 10 week (mouse)175976637148775742Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)175976637181327565Mouse
1301350Nidd4k_mNidd4 on KK-A (mouse)Not determined782291982147125370Mouse
1357439Popoa_mpremature ovulation and primary oocyte arrest (mouse)Not determined182643189135615379Mouse
27095913Scvln2_msacral vertebrae length 2, 5 week (mouse)194127725148775742Mouse
27095901Scvln8_msacral vertebrae length 2, 10 week (mouse)194127725172027567Mouse
27226779Tibl1_mtibia length 1, 5 week (mouse)195527725162027569Mouse
1301123Cd8mts2_mCD8 memory T cell subset 2 (mouse)Not determined196618386130618557Mouse
1301753Tir3a_mtrypansomiasis infection response 3a (mouse)Not determined197053986131054190Mouse
1301536Pbbcp1_mperipheral blood B cell percentage 1 (mouse)Not determined199507660133507845Mouse
1301193Lxw3_mlupus BXSB x NZW 3 (mouse)Not determined1102968534136968667Mouse
10412162Nobq3_mNew Zealand obese QTL 3 (mouse)Not determined1103933405191225397Mouse
12790994Aaaq1_maortic arch angle QTL 1 (mouse)1109495943143495943Mouse
1301979Melm1_mmelanoma modifier 1 (mouse)Not determined1109638262143638479Mouse
1357600Obq17_mobesity QTL 17 (mouse)Not determined1110553179144553298Mouse
10401248Bglu12_mblood glucose level 12 (mouse)Not determined1110553179144553298Mouse
1301149Lrnx12_mlearning-contextual 12 (mouse)Not determined1112008822168186402Mouse
1302098Eila1_methanol induced locomotor activity 1 (mouse)Not determined1112008822175468938Mouse
1301249Sbw1_msplenomegaly-NZB x NZW 1 (mouse)Not determined1112131005146131085Mouse
10045640Jckm4_mjuvenile cystic kidney modifier 4 (mouse)Not determined1116290836150290937Mouse
27095915Scvln13_msacral vertebrae length 2, 16 week (mouse)1117527730179827565Mouse
1302161Exq2_mexploratory and excitability QTL 2 (mouse)Not determined1118099720152099816Mouse
27226714Metcl1_mmetatarsal-calcaneal length 1, 5 week (mouse)1121727729139727738Mouse
27226740Metcl13_mmetatarsal-calcaneal length 13, 16 week (mouse)1121727729153775746Mouse
27226743Metcl7_mmetatarsal-calcaneal length 7, 10 week (mouse)1121727729153875746Mouse
27226767Tibl10_mtibia length 10, 10 week (mouse)1121727729164827569Mouse
27226799Feml5_mfemur length 5, 5 week (mouse)1122027729164827569Mouse
12880408V125Dq3_mvitamin D active form serum level QTL 3 (mouse)1122927738156927738Mouse
27095935Ulnl5_mulna length 5, 10 week (mouse)1128727737181327565Mouse
1301608Emo3_memotionality 3 (mouse)Not determined1129130858163130993Mouse

Markers in Region
AI323748  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381130,461,850 - 130,461,933UniSTSGRCm38
GRCm381130,422,143 - 130,422,226UniSTSGRCm38
MGSCv371132,318,720 - 132,318,803UniSTSGRCm37
MGSCv371132,358,427 - 132,358,510UniSTSGRCm37
Celera1133,050,640 - 133,050,723UniSTS
Celera1133,090,318 - 133,090,401UniSTS
Cytogenetic Map1E4UniSTS
cM Map167.6UniSTS
cM Map167.6UniSTS
Whitehead/MRC_RH11722.0UniSTS
AW552990  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381130,389,768 - 130,389,898UniSTSGRCm38
MGSCv371132,286,345 - 132,286,475UniSTSGRCm37
Celera1133,018,266 - 133,018,396UniSTS
Cytogenetic Map1E4UniSTS
cM Map167.6UniSTS
Whitehead/MRC_RH10974.86UniSTS
BB285655  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381130,437,672 - 130,437,817UniSTSGRCm38
MGSCv371132,334,249 - 132,334,394UniSTSGRCm37
Celera1133,066,166 - 133,066,311UniSTS
Cytogenetic Map1E4UniSTS
cM Map167.6UniSTS
Whitehead/MRC_RH11722.77UniSTS
C87253  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381130,439,126 - 130,439,341UniSTSGRCm38
GRCm381130,390,162 - 130,390,376UniSTSGRCm38
MGSCv371132,286,739 - 132,286,953UniSTSGRCm37
MGSCv371132,335,703 - 132,335,918UniSTSGRCm37
Celera1133,018,660 - 133,018,874UniSTS
Celera1133,067,620 - 133,067,835UniSTS
Cytogenetic Map1E4UniSTS
cM Map167.6UniSTS
cM Map167.6UniSTS
Whitehead/MRC_RH11719.05UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001317361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001404948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_007827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_175893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_175894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017314396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB003321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC111067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC116692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF143540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI326546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC115954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC127150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ046619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ236680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU222534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L41365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L41500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000112488   ⟹   ENSMUSP00000108107
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1130,316,274 - 130,350,746 (-)Ensembl
GRCm38.p6 Ensembl1130,388,537 - 130,423,009 (-)Ensembl
RefSeq Acc Id: ENSMUST00000119432   ⟹   ENSMUSP00000113352
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1130,316,274 - 130,350,746 (-)Ensembl
GRCm38.p6 Ensembl1130,388,537 - 130,423,009 (-)Ensembl
RefSeq Acc Id: ENSMUST00000136497
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1130,347,338 - 130,350,477 (-)Ensembl
GRCm38.p6 Ensembl1130,419,601 - 130,422,740 (-)Ensembl
RefSeq Acc Id: NM_001317361   ⟹   NP_001304290
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391130,316,265 - 130,350,780 (-)NCBI
GRCm381130,388,528 - 130,423,043 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001404948   ⟹   NP_001391877
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391130,319,124 - 130,350,780 (-)NCBI
RefSeq Acc Id: NM_007827   ⟹   NP_031853
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391130,316,265 - 130,350,780 (-)NCBI
GRCm381130,388,528 - 130,423,043 (-)NCBI
MGSCv371132,285,105 - 132,319,576 (-)RGD
Celera1133,017,026 - 133,051,496 (-)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_175893
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391130,316,263 - 130,350,516 (-)NCBI
RefSeq Acc Id: NR_175894
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391130,319,124 - 130,350,516 (-)NCBI
RefSeq Acc Id: XM_017314396   ⟹   XP_017169885
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391130,316,263 - 130,350,831 (-)NCBI
GRCm381130,388,526 - 130,423,097 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_031853   ⟸   NM_007827
- Peptide Label: isoform 1 precursor
- UniProtKB: E9QLT3 (UniProtKB/Swiss-Prot),   Q61476 (UniProtKB/Swiss-Prot),   E9QAP4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017169885   ⟸   XM_017314396
- Peptide Label: isoform X4
- UniProtKB: Q61476 (UniProtKB/Swiss-Prot),   E9QLT3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001304290   ⟸   NM_001317361
- Peptide Label: isoform 2 precursor
- UniProtKB: E9Q731 (UniProtKB/TrEMBL),   A0JP41 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000113352   ⟸   ENSMUST00000119432
RefSeq Acc Id: ENSMUSP00000108107   ⟸   ENSMUST00000112488
RefSeq Acc Id: NP_001391877   ⟸   NM_001404948
- Peptide Label: isoform 3 precursor
Protein Domains
Sushi

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q61476-F1-model_v2 AlphaFold Q61476 1-407 view protein structure

Promoters
RGD ID:6874812
Promoter ID:EPDNEW_M857
Type:initiation region
Name:Cd55b_1
Description:Mus musculus CD55 molecule, decay accelerating factor for complementB , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381130,423,043 - 130,423,103EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:104849 AgrOrtholog
Ensembl Genes ENSMUSG00000026401 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000112488 ENTREZGENE
  ENSMUST00000112488.9 UniProtKB/TrEMBL
  ENSMUST00000119432 ENTREZGENE
  ENSMUST00000119432.2 UniProtKB/TrEMBL
Gene3D-CATH Complement Module, domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Sushi/SCR/CCP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi_SCR_CCP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13137 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:104849 ENTREZGENE
NCBI Gene 13137 ENTREZGENE
PANTHER COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  COMPLEMENT DECAY-ACCELERATING FACTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Sushi UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cd55b PhenoGen
PROSITE SUSHI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CCP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57535 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0JP41 ENTREZGENE, UniProtKB/TrEMBL
  DAF2_MOUSE UniProtKB/Swiss-Prot
  E9Q731 ENTREZGENE, UniProtKB/TrEMBL
  E9QAP4 ENTREZGENE, UniProtKB/TrEMBL
  E9QLT3 ENTREZGENE
  Q61476 ENTREZGENE
  Q9R1C2_MOUSE UniProtKB/TrEMBL
UniProt Secondary E9QLT3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-06-30 Cd55b  CD55 molecule, decay accelerating factor for complement B  Daf2  decay accelerating factor 2  Symbol and/or name change 5135510 APPROVED