Fam170b (family with sequence similarity 170, member B) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Fam170b (family with sequence similarity 170, member B) Mus musculus
Analyze
Symbol: Fam170b
Name: family with sequence similarity 170, member B
RGD ID: 1622167
MGI Page MGI
Description: Involved in positive regulation of acrosome reaction and regulation of fertilization. Located in outer acrosomal membrane. Orthologous to human FAM170B (family with sequence similarity 170 member B).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 4922501K12Rik; AI449756; hypothetical protein LOC105511; putative protein FAM170B; uncharacterized protein LOC105511
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391432,555,938 - 32,558,746 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1432,555,919 - 32,558,746 (+)EnsemblGRCm39 Ensembl
GRCm381432,833,962 - 32,836,789 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1432,833,962 - 32,836,789 (+)EnsemblGRCm38mm10GRCm38
MGSCv371433,647,148 - 33,649,975 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361431,663,413 - 31,665,881 (+)NCBIMGSCv36mm8
Celera1429,091,197 - 29,094,024 (+)NCBICelera
Cytogenetic Map14BNCBI
cM Map1419.4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fam170bMouseCockayne syndrome B  ISOFAM170B (Homo sapiens)8554872ClinVar Annotator: match by term: Cockayne Syndrome and Type IIClinVarPMID:25741868 and PMID:38177409
Fam170bMousemegacolon  ISOFAM170B (Homo sapiens)8554872ClinVar Annotator: match by term: MegacolonClinVarPMID:21681106
Fam170bMouseschizophrenia  ISOFAM170B (Homo sapiens)8554872ClinVar Annotator: match by term: SchizophreniaClinVarPMID:21681106 and PMID:30208311

1 to 12 of 12 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fam170bMouse3-chloropropane-1,2-diol decreases expressionISOFam170b (Rattus norvegicus)6480464alpha-Chlorohydrin results in decreased expression of FAM170B mRNACTDPMID:28522335
Fam170bMouseaflatoxin B1 increases methylationISOFAM170B (Homo sapiens)6480464Aflatoxin B1 results in increased methylation of FAM170B geneCTDPMID:27153756
Fam170bMousebenzo[a]pyrene affects methylationISOFAM170B (Homo sapiens)6480464Benzo(a)pyrene affects the methylation of FAM170B 3' UTRCTDPMID:27901495
Fam170bMousebenzo[a]pyrene increases methylationISOFAM170B (Homo sapiens)6480464Benzo(a)pyrene results in increased methylation of FAM170B exonCTDPMID:27901495
Fam170bMousebisphenol A decreases methylationISOFAM170B (Homo sapiens)6480464bisphenol A results in decreased methylation of FAM170B geneCTDPMID:31601247
Fam170bMousecarbon nanotube decreases expressionEXP 6480464Nanotubes and Carbon results in decreased expression of FAM170B mRNACTDPMID:25554681
Fam170bMouseformaldehyde decreases expressionISOFAM170B (Homo sapiens)6480464Formaldehyde results in decreased expression of FAM170B mRNACTDPMID:27905399
Fam170bMouseresveratrol multiple interactionsISOFAM170B (Homo sapiens)6480464[Plant Extracts co-treated with Resveratrol] results in decreased expression of FAM170B mRNACTDPMID:23557933
Fam170bMousesodium fluoride increases expressionEXP 6480464Sodium Fluoride results in increased expression of FAM170B proteinCTDPMID:28918527
Fam170bMousetitanium dioxide decreases expressionEXP 6480464titanium dioxide results in decreased expression of FAM170B mRNACTDPMID:29264374
Fam170bMousetrichloroethene increases expressionISOFam170b (Rattus norvegicus)6480464Trichloroethylene results in increased expression of FAM170B mRNACTDPMID:33387578
Fam170bMousevalproic acid increases methylationISOFAM170B (Homo sapiens)6480464Valproic Acid results in increased methylation of FAM170B geneCTDPMID:29154799

1 to 12 of 12 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fam170bMousefertilization involved_inIBAPANTHER:PTN002128019 and MGI:19241752290270 GO_CentralGO_REF:0000033
Fam170bMousepositive regulation of acrosome reaction involved_inIMP 2290270 PMID:26179146UniProtPMID:26179146
Fam170bMouseregulation of fertilization involved_inIMP 2290270 PMID:26179146UniProtPMID:26179146

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fam170bMouseacrosomal vesicle is_active_inIBAPANTHER:PTN002128051 more ...2290270 GO_CentralGO_REF:0000033
Fam170bMouseacrosomal vesicle located_inIDA 2290270 PMID:26179146UniProtPMID:26179146
Fam170bMouseacrosomal vesicle located_inISOUniProtKB:A6NMN32290270 GO_CentralGO_REF:0000119
Fam170bMouseouter acrosomal membrane located_inIDA 2290270 PMID:26179146CACAOPMID:26179146

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fam170bMousemolecular_function enablesND 2290270 MGIGO_REF:0000015
Fam170bMouseprotein binding enablesISOUniProtKB:Q9HD269068941 PMID:26179146UniProtPMID:26179146

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fam170bMousedecreased litter size  IAGP 5509061 MGIPMID:32588889
Fam170bMousereduced male fertility  IAGP 5509061 MGIPMID:32588889
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15613475   PMID:16141072   PMID:16141073   PMID:21267068   PMID:21873635   PMID:26179146  
PMID:32588889   PMID:38250762  



Fam170b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391432,555,938 - 32,558,746 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1432,555,919 - 32,558,746 (+)EnsemblGRCm39 Ensembl
GRCm381432,833,962 - 32,836,789 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1432,833,962 - 32,836,789 (+)EnsemblGRCm38mm10GRCm38
MGSCv371433,647,148 - 33,649,975 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361431,663,413 - 31,665,881 (+)NCBIMGSCv36mm8
Celera1429,091,197 - 29,094,024 (+)NCBICelera
Cytogenetic Map14BNCBI
cM Map1419.4NCBI
FAM170B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381049,131,154 - 49,134,021 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1049,131,154 - 49,134,021 (-)EnsemblGRCh38hg38GRCh38
GRCh371050,339,199 - 50,342,066 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361050,009,205 - 50,012,083 (-)NCBINCBI36Build 36hg18NCBI36
Celera1043,924,786 - 43,927,652 (-)NCBICelera
Cytogenetic Map10q11.23NCBI
HuRef1044,603,939 - 44,606,805 (-)NCBIHuRef
CHM1_11050,621,005 - 50,623,871 (-)NCBICHM1_1
T2T-CHM13v2.01049,980,036 - 49,982,902 (-)NCBIT2T-CHM13v2.0
Fam170b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8168,108,210 - 8,111,020 (+)NCBIGRCr8
mRatBN7.2168,101,914 - 8,104,724 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl168,101,914 - 8,104,705 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx168,120,706 - 8,123,516 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0169,265,605 - 9,268,415 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0168,113,290 - 8,116,100 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0169,074,044 - 9,076,885 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl169,074,033 - 9,076,865 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01611,038,456 - 11,041,249 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4168,359,344 - 8,361,599 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera167,100,834 - 7,103,682 (-)NCBICelera
Cytogenetic Map16p16NCBI
Fam170b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555561,072,692 - 1,077,761 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555561,072,826 - 1,075,332 (+)NCBIChiLan1.0ChiLan1.0
FAM170B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2861,398,023 - 61,400,890 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11061,403,342 - 61,406,209 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01045,110,158 - 45,113,019 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
FAM170B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1281,046,362 - 1,059,992 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha281,275,335 - 1,288,740 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0281,222,515 - 1,235,927 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1281,020,871 - 1,034,297 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0281,064,692 - 1,078,076 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0281,187,756 - 1,201,172 (-)NCBIUU_Cfam_GSD_1.0
Fam170b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721379,930,591 - 79,933,421 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367281,133,569 - 1,135,787 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367281,133,569 - 1,135,742 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FAM170B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1489,752,705 - 89,755,121 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11489,752,340 - 89,754,922 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21497,546,814 - 97,549,782 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FAM170B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1942,667,503 - 42,671,443 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl942,668,682 - 42,670,983 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660482,429,382 - 2,432,251 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fam170b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624928821,167 - 823,610 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Fam170b
75 total Variants

Predicted Target Of
Summary Value
Count of predictions:194
Count of miRNA genes:168
Interacting mature miRNAs:182
Transcripts:ENSMUST00000104926
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 19 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
27226748Femd8_mfemur midshaft diameter 8, 10 week (mouse)141376927346737457Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142106245071885801Mouse
27226744Metcl6_mmetatarsal-calcaneal length 6, 5 week (mouse)143032195752937457Mouse
27226775Tibl7_mtibia length 7, 5 week (mouse)143032195748837457Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143032195787937436Mouse
4142485Modor2_mmodifier of ocular retardation 2 (mouse)Not determined142492624858179769Mouse
1301372Sluc13_msusceptibility to lung cancer 13 (mouse)Not determined141882760452827726Mouse
4141550Dbm3_mdiabetes modifier 3 (mouse)Not determined514347339143596Mouse
1300544Hypn_mhyperinsulinemia (mouse)Not determined141516061649160765Mouse

1 to 10 of 19 rows
AI449756  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381432,836,544 - 32,836,651UniSTSGRCm38
MGSCv371433,649,730 - 33,649,837UniSTSGRCm37
Celera1429,093,779 - 29,093,886UniSTS
Cytogenetic Map14A3UniSTS
Whitehead/MRC_RH14251.35UniSTS
UniSTS:487617  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381432,835,206 - 32,836,501UniSTSGRCm38
MGSCv371433,648,392 - 33,649,687UniSTSGRCm37
Celera1429,092,441 - 29,093,736UniSTS
Cytogenetic Map14A3UniSTS







Ensembl Acc Id: ENSMUST00000104926   ⟹   ENSMUSP00000100529
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1432,555,919 - 32,558,746 (+)Ensembl
GRCm38.p6 Ensembl1432,833,962 - 32,836,789 (+)Ensembl
Ensembl Acc Id: ENSMUST00000227787
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1432,556,278 - 32,558,743 (+)Ensembl
GRCm38.p6 Ensembl1432,834,321 - 32,836,786 (+)Ensembl
RefSeq Acc Id: NM_001164485   ⟹   NP_001157957
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391432,555,938 - 32,558,746 (+)NCBI
GRCm381432,833,962 - 32,836,789 (+)ENTREZGENE
MGSCv371433,647,148 - 33,649,975 (+)RGD
Celera1429,091,197 - 29,094,024 (+)RGD
cM Map14 ENTREZGENE
Sequence:
Protein RefSeqs NP_001157957 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI17715 (Get FASTA)   NCBI Sequence Viewer  
  AAI28504 (Get FASTA)   NCBI Sequence Viewer  
  AAI28505 (Get FASTA)   NCBI Sequence Viewer  
  E9PXT9 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000100529
  ENSMUSP00000100529.3
RefSeq Acc Id: NP_001157957   ⟸   NM_001164485
- UniProtKB: E9PXT9 (UniProtKB/TrEMBL),   Q08ED8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000100529   ⟸   ENSMUST00000104926

Name Modeler Protein Id AA Range Protein Structure
AF-E9PXT9-F1-model_v2 AlphaFold E9PXT9 1-378 view protein structure

RGD ID:8681884
Promoter ID:EPDNEW_M18973
Type:initiation region
Name:Fam170b_1
Description:Mus musculus family with sequence similarity 170, member B ,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381432,833,981 - 32,834,041EPDNEW


1 to 13 of 13 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000078127 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000104926 ENTREZGENE
  ENSMUST00000104926.3 UniProtKB/Swiss-Prot
InterPro Spt46-like UniProtKB/Swiss-Prot
KEGG Report mmu:105511 UniProtKB/Swiss-Prot
MGD MGI:2145650 ENTREZGENE
NCBI Gene 105511 ENTREZGENE
PANTHER PTHR33517 UniProtKB/Swiss-Prot
  PTHR33517:SF2 UniProtKB/Swiss-Prot
Pfam Spt46 UniProtKB/Swiss-Prot
PhenoGen Fam170b PhenoGen
UniProt E9PXT9 ENTREZGENE, UniProtKB/Swiss-Prot
  Q08ED8 ENTREZGENE, UniProtKB/TrEMBL
1 to 13 of 13 rows