Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Styxl2 | Mouse | 1,4-dichlorobenzene | increases expression | EXP | | 6480464 | 4-dichlorobenzene results in increased expression of STYXL2 mRNA | CTD | PMID:26975756 | Styxl2 | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Styxl2 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of STYXL2 mRNA | CTD | PMID:33387578 | Styxl2 | Mouse | 3,3',5,5'-tetrabromobisphenol A | decreases expression | EXP | | 6480464 | tetrabromobisphenol A results in decreased expression of STYXL2 mRNA | CTD | PMID:25172293 | Styxl2 | Mouse | 4,4'-sulfonyldiphenol | increases expression | EXP | | 6480464 | bisphenol S results in increased expression of STYXL2 mRNA | CTD | PMID:30951980 | Styxl2 | Mouse | acetamide | increases expression | ISO | Styxl2 (Rattus norvegicus) | 6480464 | acetamide results in increased expression of STYXL2 mRNA | CTD | PMID:31881176 | Styxl2 | Mouse | all-trans-retinoic acid | increases expression | ISO | Styxl2 (Rattus norvegicus) | 6480464 | Tretinoin results in increased expression of STYXL2 mRNA | CTD | PMID:20488242 | Styxl2 | Mouse | benzo[a]pyrene | affects methylation | ISO | STYXL2 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of STYXL2 intron | CTD | PMID:30157460 | Styxl2 | Mouse | benzo[a]pyrene | decreases methylation | ISO | STYXL2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of STYXL2 3' UTR | CTD | PMID:27901495 | Styxl2 | Mouse | benzo[a]pyrene | increases methylation | ISO | STYXL2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of STYXL2 exon | CTD | PMID:27901495 | Styxl2 | Mouse | bisphenol A | increases expression | ISO | Styxl2 (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of STYXL2 mRNA | CTD | PMID:25181051 and PMID:30816183 | Styxl2 | Mouse | bisphenol A | decreases expression | ISO | Styxl2 (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of STYXL2 mRNA | CTD | PMID:34947998 | Styxl2 | Mouse | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of STYXL2 mRNA | CTD | PMID:30951980 | Styxl2 | Mouse | bisphenol F | increases expression | EXP | | 6480464 | bisphenol F results in increased expression of STYXL2 mRNA | CTD | PMID:30951980 | Styxl2 | Mouse | cyclosporin A | increases methylation | ISO | STYXL2 (Homo sapiens) | 6480464 | Cyclosporine results in increased methylation of STYXL2 promoter | CTD | PMID:27989131 | Styxl2 | Mouse | dibutyl phthalate | increases expression | ISO | Styxl2 (Rattus norvegicus) | 6480464 | Dibutyl Phthalate results in increased expression of STYXL2 mRNA | CTD | PMID:21266533 | Styxl2 | Mouse | doxorubicin | decreases expression | ISO | STYXL2 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of STYXL2 mRNA | CTD | PMID:29803840 | Styxl2 | Mouse | folic acid | decreases expression | ISO | STYXL2 (Homo sapiens) | 6480464 | Folic Acid results in decreased expression of STYXL2 mRNA | CTD | PMID:21867686 | Styxl2 | Mouse | gentamycin | increases expression | ISO | Styxl2 (Rattus norvegicus) | 6480464 | Gentamicins results in increased expression of STYXL2 mRNA | CTD | PMID:33387578 | Styxl2 | Mouse | lipopolysaccharide | decreases expression | ISO | STYXL2 (Homo sapiens) | 6480464 | Lipopolysaccharides results in decreased expression of STYXL2 mRNA | CTD | PMID:35811015 | Styxl2 | Mouse | lipopolysaccharide | multiple interactions | ISO | STYXL2 (Homo sapiens) | 6480464 | [S-(1 more ... | CTD | PMID:35811015 | Styxl2 | Mouse | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of STYXL2 mRNA | CTD | PMID:17562736 | Styxl2 | Mouse | phenobarbital | affects expression | EXP | | 6480464 | Phenobarbital affects the expression of STYXL2 mRNA | CTD | PMID:19136022 | Styxl2 | Mouse | pioglitazone | multiple interactions | EXP | | 6480464 | [N-nitroso-tris-chloroethylurea co-treated with Pioglitazone] results in decreased expression of STYXL2 mRNA | CTD | PMID:27935865 | Styxl2 | Mouse | pirinixic acid | affects expression | EXP | | 6480464 | pirinixic acid affects the expression of STYXL2 mRNA | CTD | PMID:19136022 | Styxl2 | Mouse | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | STYXL2 (Homo sapiens) | 6480464 | [S-(1 more ... | CTD | PMID:35811015 | Styxl2 | Mouse | sunitinib | decreases expression | ISO | STYXL2 (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of STYXL2 mRNA | CTD | PMID:31533062 | Styxl2 | Mouse | trichloroethene | increases expression | ISO | Styxl2 (Rattus norvegicus) | 6480464 | Trichloroethylene results in increased expression of STYXL2 mRNA | CTD | PMID:33387578 | Styxl2 | Mouse | triclosan | decreases expression | ISO | STYXL2 (Homo sapiens) | 6480464 | Triclosan results in decreased expression of STYXL2 mRNA | CTD | PMID:30510588 | Styxl2 | Mouse | triptonide | increases expression | EXP | | 6480464 | triptonide results in increased expression of STYXL2 mRNA | CTD | PMID:33045310 | Styxl2 | Mouse | valproic acid | decreases expression | ISO | STYXL2 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of STYXL2 mRNA | CTD | PMID:28001369 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Gene Ontology Annotations Click to see Annotation Detail View
Biological Process
Cellular Component
Molecular Function
Phenotype Annotations Click to see Annotation Detail View
Mammalian Phenotype
Gene-Chemical Interaction Annotations
Click to see Annotation Detail View
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Gene Ontology Annotations
Click to see Annotation Detail View
Molecular Function
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Phenotype Annotations
Click to see Annotation Detail View
References
References - curated
| # | Reference Title | Reference Citation |
| 1. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 2. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
Additional References at PubMed
| PMID:10349636 | PMID:11042159 | PMID:11076861 | PMID:11217851 | PMID:12466851 | PMID:12477932 | PMID:12520002 | PMID:12904583 | PMID:14610273 | PMID:15475267 | PMID:16141072 | PMID:16141073 |
| PMID:17976645 | PMID:21267068 | PMID:21873635 | PMID:32325033 | PMID:32554809 | PMID:37196079 | PMID:38355793 | PMID:38829202 |
Genomics
Comparative Map Data
| Styxl2 (Mus musculus - house mouse) |
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| STYXL2 (Homo sapiens - human) |
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| Styxl2 (Rattus norvegicus - Norway rat) |
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| Styxl2 (Chinchilla lanigera - long-tailed chinchilla) |
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| STYXL2 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| STYXL2 (Canis lupus familiaris - dog) |
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| Styxl2 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| STYXL2 (Sus scrofa - pig) |
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| STYXL2 (Chlorocebus sabaeus - green monkey) |
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| Styxl2 (Heterocephalus glaber - naked mole-rat) |
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miRNA Target Status
Predicted Target Of
| The detailed report is available here: |  | Full Report | | CSV | | TAB | | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
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QTLs in Region (GRCm39)
| The following QTLs overlap with this region. | | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Markers in Region
| UniSTS:234259 |
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Expression
RNA-SEQ Expression
Sequence
Nucleotide Sequences
| Ensembl Acc Id: | ENSMUST00000085992 ⟹ ENSMUSP00000083155 | ||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| Ensembl Acc Id: | ENSMUST00000192369 ⟹ ENSMUSP00000141564 | ||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| RefSeq Acc Id: | NM_001033344 ⟹ NP_001028516 | ||||||||||||||||||||||||
| RefSeq Status: | VALIDATED | ||||||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||||||
| Position: |
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| Sequence: |
| RefSeq Acc Id: | NM_001160049 ⟹ NP_001153521 | ||||||||||||||||||||||||
| RefSeq Status: | VALIDATED | ||||||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||||||
| Position: |
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| Sequence: |
Protein Sequences
| RefSeq Acc Id: | NP_001028516 ⟸ NM_001033344 |
| - UniProtKB: | Q6PCZ9 (UniProtKB/Swiss-Prot), Q3UQN8 (UniProtKB/Swiss-Prot), Q8BX87 (UniProtKB/Swiss-Prot), Q148W8 (UniProtKB/Swiss-Prot) |
| - Sequence: |
| RefSeq Acc Id: | NP_001153521 ⟸ NM_001160049 |
| - UniProtKB: | Q6PCZ9 (UniProtKB/Swiss-Prot), Q3UQN8 (UniProtKB/Swiss-Prot), Q8BX87 (UniProtKB/Swiss-Prot), Q148W8 (UniProtKB/Swiss-Prot) |
| - Sequence: |
| Ensembl Acc Id: | ENSMUSP00000083155 ⟸ ENSMUST00000085992 |
| Ensembl Acc Id: | ENSMUSP00000141564 ⟸ ENSMUST00000192369 |
Protein Structures
| Name | Modeler | Protein Id | AA Range | Protein Structure |
| AF-Q148W8-F1-model_v2 | AlphaFold | Q148W8 | 1-1138 | view protein structure |
Promoters
| RGD ID: | 6875560 | ||||||||
| Promoter ID: | EPDNEW_M1231 | ||||||||
| Type: | initiation region | ||||||||
| Name: | Dusp27_1 | ||||||||
| Description: | Mus musculus dual specificity phosphatase 27 , transcript variant2, mRNA. | ||||||||
| SO ACC ID: | SO:0000170 | ||||||||
| Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
| Experiment Methods: | Single-end sequencing. | ||||||||
| Position: |
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| RGD ID: | 6817628 | ||||||||
| Promoter ID: | MM_KWN:2728 | ||||||||
| Type: | Non-CpG | ||||||||
| SO ACC ID: | SO:0000170 | ||||||||
| Source: | MPROMDB | ||||||||
| Tissues & Cell Lines: | ES_Cell, MEF_B6 | ||||||||
| Transcripts: | NM_001033344, NM_001160049 | ||||||||
| Position: |
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Additional Information
External Database Links
| Database | Acc Id | Source(s) |
| AGR Gene | MGI:2685055 | AgrOrtholog |
| Ensembl Genes | ENSMUSG00000026564 | Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSMUST00000085992 | ENTREZGENE |
| ENSMUST00000085992.4 | UniProtKB/Swiss-Prot | |
| ENSMUST00000192369 | ENTREZGENE | |
| ENSMUST00000192369.6 | UniProtKB/Swiss-Prot | |
| Gene3D-CATH | 3.90.190.10 | UniProtKB/Swiss-Prot |
| InterPro | Atypical_DUSP_famA | UniProtKB/Swiss-Prot |
| Dual-sp_phosphatase_cat-dom | UniProtKB/Swiss-Prot | |
| Prot-tyrosine_phosphatase-like | UniProtKB/Swiss-Prot | |
| TYR_PHOSPHATASE_dom | UniProtKB/Swiss-Prot | |
| TYR_PHOSPHATASE_DUAL_dom | UniProtKB/Swiss-Prot | |
| KEGG Report | mmu:240892 | UniProtKB/Swiss-Prot |
| MGD | MGI:2685055 | ENTREZGENE |
| NCBI Gene | 240892 | ENTREZGENE |
| PANTHER | PTHR45682 | UniProtKB/Swiss-Prot |
| SERINE/THREONINE/TYROSINE-INTERACTING-LIKE PROTEIN 2 | UniProtKB/Swiss-Prot | |
| Pfam | DSPc | UniProtKB/Swiss-Prot |
| PhenoGen | Styxl2 | PhenoGen |
| PRINTS | ADSPHPHTASE | UniProtKB/Swiss-Prot |
| ADSPHPHTASEA | UniProtKB/Swiss-Prot | |
| PROSITE | TYR_PHOSPHATASE_2 | UniProtKB/Swiss-Prot |
| TYR_PHOSPHATASE_DUAL | UniProtKB/Swiss-Prot | |
| SMART | DSPc | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | SSF52799 | UniProtKB/Swiss-Prot |
| UniProt | DUS27_MOUSE | UniProtKB/Swiss-Prot, ENTREZGENE |
| Q3UQN8 | ENTREZGENE | |
| Q6PCZ9 | ENTREZGENE | |
| Q8BX87 | ENTREZGENE | |
| UniProt Secondary | Q3UQN8 | UniProtKB/Swiss-Prot |
| Q6PCZ9 | UniProtKB/Swiss-Prot | |
| Q8BX87 | UniProtKB/Swiss-Prot |
Nomenclature History
| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2023-01-16 | Styxl2 | serine/threonine/tyrosine interacting like 2 | Dusp27 | dual specificity phosphatase 27 (putative) | Symbol and/or name updated | 27372883 | PROVISIONAL |