Styxl2 (serine/threonine/tyrosine interacting like 2) - Rat Genome Database

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Gene: Styxl2 (serine/threonine/tyrosine interacting like 2) Ictidomys tridecemlineatus
Analyze
Symbol: Styxl2
Name: serine/threonine/tyrosine interacting like 2 (Ensembl:dual specificity phosphatase 27, atypical)
RGD ID: 12549736
Description: ENCODES a protein that exhibits MAP kinase phosphatase activity (inferred); protein tyrosine/serine/threonine phosphatase activity (inferred); INVOLVED IN negative regulation of MAPK cascade (inferred); ASSOCIATED WITH gastrointestinal stromal tumor (ortholog); genetic disease (ortholog); parathyroid carcinoma (ortholog); FOUND IN cytoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: dual specificity phosphatase 27 (putative); dual specificity phosphatase 27, atypical; Dusp27; inactive dual specificity phosphatase 27; putative dual specificity phosphatase 27 (putative); serine/threonine/tyrosine-interacting-like protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344100,976,146 - 101,003,394 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648118,823,316 - 18,849,342 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648118,822,927 - 18,850,130 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Styxl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344100,976,146 - 101,003,394 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648118,823,316 - 18,849,342 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648118,822,927 - 18,850,130 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STYXL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381167,094,075 - 167,129,165 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1167,094,075 - 167,129,165 (+)EnsemblGRCh38hg38GRCh38
GRCh371167,063,312 - 167,098,402 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361165,330,711 - 165,365,026 (+)NCBINCBI36Build 36hg18NCBI36
Celera1140,169,211 - 140,203,525 (+)NCBICelera
Cytogenetic Map1q24.1NCBI
HuRef1138,310,510 - 138,344,915 (+)NCBIHuRef
CHM1_11168,486,561 - 168,520,890 (+)NCBICHM1_1
T2T-CHM13v2.01166,441,246 - 166,476,239 (+)NCBIT2T-CHM13v2.0
Styxl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391165,925,717 - 165,955,467 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1165,925,717 - 165,955,491 (-)EnsemblGRCm39 Ensembl
GRCm381166,098,148 - 166,127,898 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1166,098,148 - 166,127,922 (-)EnsemblGRCm38mm10GRCm38
MGSCv371168,028,279 - 168,058,029 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361167,293,559 - 167,323,359 (-)NCBIMGSCv36mm8
MGSCv361167,934,828 - 167,964,573 (-)NCBIMGSCv36mm8
Celera1168,550,169 - 168,571,293 (-)NCBICelera
Cytogenetic Map1H2.3NCBI
cM Map173.45NCBI
Styxl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81380,882,341 - 80,911,458 (-)NCBIGRCr8
mRatBN7.21378,349,361 - 78,378,480 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1378,349,365 - 78,378,458 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1380,966,719 - 80,994,694 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01382,270,729 - 82,299,163 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01379,518,593 - 79,547,003 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01384,302,824 - 84,332,899 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1384,302,830 - 84,331,905 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01389,180,887 - 89,209,650 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41381,826,412 - 81,854,918 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1378,059,437 - 78,088,302 (-)NCBICelera
Cytogenetic Map13q23NCBI
Styxl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554629,791,747 - 9,836,987 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554629,792,135 - 9,836,927 (-)NCBIChiLan1.0ChiLan1.0
STYXL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2182,645,166 - 82,681,059 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1182,313,444 - 82,349,376 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01142,515,889 - 142,551,807 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11146,301,600 - 146,336,497 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1146,301,600 - 146,336,497 (+)Ensemblpanpan1.1panPan2
STYXL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1731,241,169 - 31,273,103 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl731,242,731 - 31,273,050 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha730,781,186 - 30,811,957 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0731,063,789 - 31,094,547 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl731,063,789 - 31,094,514 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1730,902,301 - 30,933,026 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0730,934,078 - 30,964,854 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0731,172,570 - 31,203,360 (-)NCBIUU_Cfam_GSD_1.0
STYXL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl483,871,436 - 83,902,292 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1483,871,434 - 83,902,313 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2491,545,602 - 91,576,474 (-)NCBISscrofa10.2Sscrofa10.2susScr3
STYXL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12561,901,351 - 61,940,812 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2561,901,350 - 61,940,308 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605563,636,900 - 63,677,235 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Styxl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248265,187,257 - 5,226,278 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248265,184,908 - 5,226,790 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000010480   ⟹   ENSSTOP00000009404
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493648118,823,316 - 18,849,342 (-)Ensembl
RefSeq Acc Id: XM_040277805   ⟹   XP_040133739
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024409344100,976,146 - 101,003,394 (-)NCBI
Protein Sequences
Protein RefSeqs XP_040133739 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000009404.3
GenBank Protein KAG3258826 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_040133739   ⟸   XM_040277805
- UniProtKB: I3MFK3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSSTOP00000009404   ⟸   ENSSTOT00000010480
Protein Domains
Tyrosine specific protein phosphatases   Tyrosine-protein phosphatase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000010472 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000010480.3 UniProtKB/TrEMBL
Gene3D-CATH 3.90.190.10 UniProtKB/TrEMBL
InterPro Atypical_DUSP_subfamA UniProtKB/TrEMBL
  Dual-sp_phosphatase_cat-dom UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/TrEMBL
  TYR_PHOSPHATASE_DUAL_dom UniProtKB/TrEMBL
NCBI Gene Dusp27 ENTREZGENE
PANTHER PTHR45682 UniProtKB/TrEMBL
  SERINE/THREONINE/TYROSINE-INTERACTING-LIKE PROTEIN 2 UniProtKB/TrEMBL
Pfam DSPc UniProtKB/TrEMBL
PRINTS ADSPHPHTASE UniProtKB/TrEMBL
  ADSPHPHTASEA UniProtKB/TrEMBL
PROSITE TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_DUAL UniProtKB/TrEMBL
SMART DSPc UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/TrEMBL
UniProt I3MFK3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-06-09 Styxl2  serine/threonine/tyrosine interacting like 2  Dusp27  dual specificity phosphatase 27, atypical  Symbol and/or name change 5135510 APPROVED
2017-08-15 Dusp27  dual specificity phosphatase 27, atypical    dual specificity phosphatase 27 (putative)  Symbol and/or name change 5135510 APPROVED