Tmem253 (transmembrane protein 253) - Rat Genome Database

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Gene: Tmem253 (transmembrane protein 253) Mus musculus
Analyze
Symbol: Tmem253
Name: transmembrane protein 253
RGD ID: 1619576
MGI Page MGI
Description: Predicted to be located in membrane. Orthologous to human TMEM253 (transmembrane protein 253).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: G630016D24Rik; tranmembrane protein 253; transmembrane protein C14orf176 homolog
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391452,252,309 - 52,257,244 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1452,253,115 - 52,257,251 (+)EnsemblGRCm39 Ensembl
GRCm381452,014,852 - 52,019,787 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1452,015,658 - 52,019,794 (+)EnsemblGRCm38mm10GRCm38
MGSCv371452,636,540 - 52,639,462 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361450,938,816 - 50,941,740 (+)NCBIMGSCv36mm8
Celera1448,996,770 - 48,999,666 (+)NCBICelera
Cytogenetic Map14C2NCBI
cM Map1426.77NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tmem253MouseBrain-Lung-Thyroid Syndrome  ISOTMEM253 (Homo sapiens)8554872ClinVar Annotator: match by term: Brain-lung-thyroid syndromeClinVarPMID:25741868
Tmem253Mousepurine nucleoside phosphorylase deficiency  ISOTMEM253 (Homo sapiens)8554872ClinVar Annotator: match by term: Purine-nucleoside phosphorylase deficiencyClinVarPMID:24767876 and PMID:28492532

1 to 20 of 20 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tmem253Mouse2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOTmem253 (Rattus norvegicus)6480464Tetrachlorodibenzodioxin results in decreased expression of TMEM253 mRNACTDPMID:33387578
Tmem253Mouseacrylamide increases expressionISOTmem253 (Rattus norvegicus)6480464Acrylamide results in increased expression of TMEM253 mRNACTDPMID:28959563
Tmem253Mouseaflatoxin B1 decreases methylationISOTMEM253 (Homo sapiens)6480464Aflatoxin B1 results in decreased methylation of TMEM253 geneCTDPMID:27153756
Tmem253Mousearistolochic acid A increases expressionISOTMEM253 (Homo sapiens)6480464aristolochic acid I results in increased expression of TMEM253 mRNACTDPMID:33212167
Tmem253Mousebenzo[b]fluoranthene increases expressionEXP 6480464benzo(b)fluoranthene results in increased expression of TMEM253 mRNACTDPMID:26377693
Tmem253Mousebisphenol A decreases expressionISOTmem253 (Rattus norvegicus)6480464bisphenol A results in decreased expression of TMEM253 mRNACTDPMID:25181051
Tmem253Mousebisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of TMEM253 mRNACTDPMID:32156529
Tmem253Mousecisplatin multiple interactionsISOTMEM253 (Homo sapiens)6480464[Cisplatin co-treated with jinfukang] results in increased expression of TMEM253 mRNACTDPMID:27392435
Tmem253Mousecisplatin increases expressionISOTMEM253 (Homo sapiens)6480464Cisplatin results in increased expression of TMEM253 mRNACTDPMID:27392435
Tmem253Mousediquat increases expressionEXP 6480464Diquat results in increased expression of TMEM253 mRNACTDPMID:36851058
Tmem253Mouseepoxiconazole increases expressionEXP 6480464epoxiconazole results in increased expression of TMEM253 mRNACTDPMID:35436446
Tmem253Mousegentamycin decreases expressionISOTmem253 (Rattus norvegicus)6480464Gentamicins results in decreased expression of TMEM253 mRNACTDPMID:33387578
Tmem253Mousehexamethylene diisocyanate increases methylationISOTMEM253 (Homo sapiens)64804641 and 6-hexamethylene diisocyanate results in increased methylation of TMEM253 promoterCTDPMID:25445006
Tmem253Mouseiron dichloride decreases expressionISOTMEM253 (Homo sapiens)6480464ferrous chloride results in decreased expression of TMEM253 mRNACTDPMID:35984750
Tmem253Mouselipopolysaccharide multiple interactionsISOTMEM253 (Homo sapiens)6480464[S-(1 more ...CTDPMID:35811015
Tmem253Mouseparacetamol increases expressionISOTmem253 (Rattus norvegicus)6480464Acetaminophen results in increased expression of TMEM253 mRNACTDPMID:33387578
Tmem253MouseS-(1,2-dichlorovinyl)-L-cysteine multiple interactionsISOTMEM253 (Homo sapiens)6480464[S-(1 more ...CTDPMID:35811015
Tmem253MouseS-(1,2-dichlorovinyl)-L-cysteine increases expressionISOTMEM253 (Homo sapiens)6480464S-(1 and 2-dichlorovinyl)cysteine results in increased expression of TMEM253 mRNACTDPMID:35811015
Tmem253Mousesodium arsenite decreases expressionEXP 6480464sodium arsenite results in decreased expression of TMEM253 mRNACTDPMID:37682722
Tmem253Mouseurethane decreases expressionISOTMEM253 (Homo sapiens)6480464Urethane results in decreased expression of TMEM253 mRNACTDPMID:28818685

1 to 20 of 20 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tmem253Mousebiological_process involved_inND 2290270 MGIGO_REF:0000015

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tmem253Mousecellular_component is_active_inND 2290270 MGIGO_REF:0000015
Tmem253Mousemembrane located_inIEAUniProtKB-SubCell:SL-01622290270 UniProtGO_REF:0000044

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tmem253Mousemolecular_function enablesND 2290270 MGIGO_REF:0000015


#
Reference Title
Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:16141072   PMID:16141073   PMID:21677750  



Tmem253
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391452,252,309 - 52,257,244 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1452,253,115 - 52,257,251 (+)EnsemblGRCm39 Ensembl
GRCm381452,014,852 - 52,019,787 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1452,015,658 - 52,019,794 (+)EnsemblGRCm38mm10GRCm38
MGSCv371452,636,540 - 52,639,462 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361450,938,816 - 50,941,740 (+)NCBIMGSCv36mm8
Celera1448,996,770 - 48,999,666 (+)NCBICelera
Cytogenetic Map14C2NCBI
cM Map1426.77NCBI
TMEM253
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381421,098,836 - 21,103,724 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1421,098,811 - 21,103,724 (+)EnsemblGRCh38hg38GRCh38
GRCh371421,566,995 - 21,571,883 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361420,639,343 - 20,641,723 (+)NCBINCBI36Build 36hg18NCBI36
Celera141,427,654 - 1,432,447 (+)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef141,687,284 - 1,692,081 (+)NCBIHuRef
CHM1_11421,568,829 - 21,573,619 (+)NCBICHM1_1
T2T-CHM13v2.01415,296,249 - 15,301,137 (+)NCBIT2T-CHM13v2.0
Tmem253
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81527,180,029 - 27,182,607 (+)NCBIGRCr8
mRatBN7.21524,706,517 - 24,709,107 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1524,706,529 - 24,708,625 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01528,413,414 - 28,416,039 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1528,413,461 - 28,415,554 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01532,221,865 - 32,226,503 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41527,445,186 - 27,447,282 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1525,011,020 - 25,013,645 (+)NCBICelera
Cytogenetic Map15p14NCBI
Tmem253
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555501,862,719 - 1,866,822 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555501,862,781 - 1,867,230 (+)NCBIChiLan1.0ChiLan1.0
TMEM253
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21522,550,226 - 22,554,472 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11421,766,747 - 21,770,959 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0141,913,655 - 1,917,874 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
TMEM253
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11518,187,622 - 18,194,700 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1518,187,616 - 18,193,427 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1518,671,660 - 18,685,505 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01518,447,013 - 18,460,567 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1518,450,237 - 18,452,076 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11518,128,293 - 18,142,133 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01518,184,255 - 18,198,096 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01518,312,210 - 18,326,061 (+)NCBIUU_Cfam_GSD_1.0
Tmem253
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864032,393,443 - 32,398,684 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936880304,740 - 306,616 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936880302,889 - 307,007 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM253
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl778,030,446 - 78,032,537 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1777,991,665 - 78,033,146 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TMEM253
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12921,573,831 - 21,577,932 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2921,574,780 - 21,576,691 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605924,858,547 - 24,860,919 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem253
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248257,095,542 - 7,097,636 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248257,093,627 - 7,098,746 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Tmem253
156 total Variants

Predicted Target Of
Summary Value
Count of predictions:301
Count of miRNA genes:212
Interacting mature miRNAs:228
Transcripts:ENSMUST00000100638
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 24 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
1300625Cosz2_mcocaine seizure 2 (mouse)Not determined143504579768785736Mouse
1301777Bglq15_mbody growth late QTL 15 (mouse)Not determined144296241676962593Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142106245071885801Mouse
1301424Skull21_mskull morphology 21 (mouse)Not determined144296241676962593Mouse
27226744Metcl6_mmetatarsal-calcaneal length 6, 5 week (mouse)143032195752937457Mouse
4141400Nilac8_mnicotine induced locomotor activity 8 (mouse)Not determined144306584777066045Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143032195787937436Mouse
4142485Modor2_mmodifier of ocular retardation 2 (mouse)Not determined142492624858179769Mouse
4142419Tgq26_mtriglyceride QTL 26 (mouse)Not determined4033731974337319Mouse

1 to 10 of 24 rows






Ensembl Acc Id: ENSMUST00000100638   ⟹   ENSMUSP00000098203
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1452,254,322 - 52,257,251 (+)Ensembl
GRCm38.p6 Ensembl1452,016,865 - 52,019,794 (+)Ensembl
Ensembl Acc Id: ENSMUST00000226268
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1452,253,115 - 52,254,398 (+)Ensembl
GRCm38.p6 Ensembl1452,015,658 - 52,016,941 (+)Ensembl
Ensembl Acc Id: ENSMUST00000227295   ⟹   ENSMUSP00000154460
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1452,254,376 - 52,256,807 (+)Ensembl
GRCm38.p6 Ensembl1452,016,919 - 52,019,350 (+)Ensembl
Ensembl Acc Id: ENSMUST00000228408   ⟹   ENSMUSP00000153729
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1452,254,351 - 52,254,879 (+)Ensembl
GRCm38.p6 Ensembl1452,016,894 - 52,017,422 (+)Ensembl
RefSeq Acc Id: NM_001033805   ⟹   NP_001028977
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391452,254,322 - 52,257,244 (+)NCBI
GRCm381452,016,865 - 52,019,787 (+)NCBI
MGSCv371452,636,540 - 52,639,462 (+)RGD
Celera1448,996,770 - 48,999,666 (+)RGD
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011245128   ⟹   XP_011243430
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391452,252,309 - 52,257,232 (+)NCBI
GRCm381452,014,852 - 52,019,775 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017316105   ⟹   XP_017171594
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391452,252,725 - 52,257,232 (+)NCBI
GRCm381452,015,048 - 52,019,775 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030247905   ⟹   XP_030103765
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391452,252,725 - 52,256,807 (+)NCBI
GRCm381452,016,556 - 52,019,773 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036158775   ⟹   XP_036014668
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391452,254,007 - 52,257,232 (+)NCBI
Sequence:
1 to 11 of 11 rows
Protein RefSeqs NP_001028977 (Get FASTA)   NCBI Sequence Viewer  
  XP_011243430 (Get FASTA)   NCBI Sequence Viewer  
  XP_017171594 (Get FASTA)   NCBI Sequence Viewer  
  XP_030103765 (Get FASTA)   NCBI Sequence Viewer  
  XP_036014668 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI47690 (Get FASTA)   NCBI Sequence Viewer  
  BAE25829 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000098203
  ENSMUSP00000098203.3
  ENSMUSP00000154460
GenBank Protein Q3UNB8 (Get FASTA)   NCBI Sequence Viewer  
1 to 11 of 11 rows
RefSeq Acc Id: NP_001028977   ⟸   NM_001033805
- UniProtKB: Q3UNB8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011243430   ⟸   XM_011245128
- Peptide Label: isoform X1
- UniProtKB: Q3UNB8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017171594   ⟸   XM_017316105
- Peptide Label: isoform X1
- UniProtKB: Q3UNB8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030103765   ⟸   XM_030247905
- Peptide Label: isoform X2
- UniProtKB: A0A2I3BR52 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000154460   ⟸   ENSMUST00000227295

Name Modeler Protein Id AA Range Protein Structure
AF-Q3UNB8-F1-model_v2 AlphaFold Q3UNB8 1-204 view protein structure

RGD ID:8682178
Promoter ID:EPDNEW_M19120
Type:initiation region
Name:Tmem253_1
Description:Mus musculus transmembrane protein 253 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381452,016,865 - 52,016,925EPDNEW
RGD ID:6824945
Promoter ID:MM_KWN:16619
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day4,   ES_Cell,   Kidney
Transcripts:ENSMUST00000100638
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361452,635,636 - 52,636,497 (+)MPROMDB


1 to 14 of 14 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000072571 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000100638 ENTREZGENE
  ENSMUST00000100638.4 UniProtKB/Swiss-Prot
  ENSMUST00000227295 ENTREZGENE
InterPro TMEM253 UniProtKB/Swiss-Prot
KEGG Report mmu:619301 UniProtKB/Swiss-Prot
MGD MGI:3588246 ENTREZGENE
NCBI Gene 619301 ENTREZGENE
PANTHER PTHR37359 UniProtKB/Swiss-Prot
  TRANSMEMBRANE PROTEIN 253 UniProtKB/Swiss-Prot
PhenoGen Tmem253 PhenoGen
UniProt A0A2I3BPD3_MOUSE UniProtKB/TrEMBL
  A0A2I3BR52 ENTREZGENE, UniProtKB/TrEMBL
  Q3UNB8 ENTREZGENE, UniProtKB/Swiss-Prot
1 to 14 of 14 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-01-08 Tmem253  transmembrane protein 253    tranmembrane protein 253  Symbol and/or name change 5135510 APPROVED
2012-11-27 Tmem253  tranmembrane protein 253  G630016D24Rik  RIKEN cDNA G630016D24 gene  Symbol and/or name change 5135510 APPROVED