A3galt2 (alpha 1,3-galactosyltransferase 2) - Rat Genome Database

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Gene: A3galt2 (alpha 1,3-galactosyltransferase 2) Mus musculus
Analyze
Symbol: A3galt2
Name: alpha 1,3-galactosyltransferase 2
RGD ID: 1616578
MGI Page MGI
Description: Enables alpha-1,3-galactosyltransferase activity. Acts upstream of or within glycosphingolipid biosynthetic process. Predicted to be located in Golgi cisterna membrane. Predicted to be active in Golgi apparatus and vesicle. Orthologous to human A3GALT2 (alpha 1,3-galactosyltransferase 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: alpha 1,3-galactosyltransferase 2 (isoglobotriaosylceramide synthase); alpha-1,3-galactosyltransferase 2; galactosyltransferase; Gm433; iGb; iGb3; iGb3 synthase; iGb3S; isoglobotriaosylceramide synthase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394128,653,051 - 128,663,091 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4128,649,157 - 128,663,091 (+)EnsemblGRCm39 Ensembl
GRCm384128,759,258 - 128,769,298 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4128,755,364 - 128,769,298 (+)EnsemblGRCm38mm10GRCm38
MGSCv374128,436,502 - 128,446,542 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364128,261,562 - 128,271,602 (+)NCBIMGSCv36mm8
Celera4127,097,903 - 127,107,951 (+)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map462.23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
A3galt2MouseCharcot-Marie-Tooth disease dominant intermediate C  ISOA3GALT2 (Homo sapiens)8554872ClinVar Annotator: match by term: Charcot-Marie-Tooth disease dominant intermediate CClinVarPMID:28492532

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
A3galt2Mouse1,2-dichloroethane decreases expressionEXP 6480464ethylene dichloride results in decreased expression of A3GALT2 mRNACTDPMID:28960355
A3galt2Mouse1-naphthyl isothiocyanate increases expressionISOA3galt2 (Rattus norvegicus)64804641-Naphthylisothiocyanate results in increased expression of A3GALT2 mRNACTDPMID:30723492
A3galt2Mouse2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of A3GALT2 mRNACTDPMID:21570461
A3galt2Mouse2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOA3galt2 (Rattus norvegicus)6480464Tetrachlorodibenzodioxin results in decreased expression of A3GALT2 mRNACTDPMID:33387578 and PMID:34747641
A3galt2Mouseacetamide increases expressionISOA3galt2 (Rattus norvegicus)6480464acetamide results in increased expression of A3GALT2 mRNACTDPMID:31881176
A3galt2Mouseatrazine decreases expressionISOA3galt2 (Rattus norvegicus)6480464Atrazine results in decreased expression of A3GALT2 mRNACTDPMID:36841081
A3galt2Mousebeta-naphthoflavone multiple interactionsISOA3galt2 (Rattus norvegicus)6480464[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of A3GALT2 mRNACTDPMID:18164116
A3galt2Mousebisphenol A decreases expressionISOA3galt2 (Rattus norvegicus)6480464bisphenol A results in decreased expression of A3GALT2 mRNACTDPMID:25181051 and PMID:34947998
A3galt2Mousebisphenol A decreases methylationEXP 6480464bisphenol A results in decreased methylation of A3GALT2 promoterCTDPMID:27312807
A3galt2Mousebisphenol A increases methylationISOA3galt2 (Rattus norvegicus)6480464bisphenol A results in increased methylation of A3GALT2 geneCTDPMID:28505145
A3galt2Mousecadmium dichloride increases expressionISOA3GALT2 (Homo sapiens)6480464Cadmium Chloride results in increased expression of A3GALT2 mRNACTDPMID:38568856
A3galt2Mousecobalt dichloride decreases expressionISOA3galt2 (Rattus norvegicus)6480464cobaltous chloride results in decreased expression of A3GALT2 mRNACTDPMID:24386269
A3galt2Mousecopper atom decreases expressionISOA3galt2 (Rattus norvegicus)6480464Copper results in decreased expression of A3GALT2 mRNACTDPMID:30556269
A3galt2Mousecopper(0) decreases expressionISOA3galt2 (Rattus norvegicus)6480464Copper results in decreased expression of A3GALT2 mRNACTDPMID:30556269
A3galt2Mousediuron decreases expressionISOA3galt2 (Rattus norvegicus)6480464Diuron results in decreased expression of A3GALT2 mRNACTDPMID:21551480
A3galt2Mousedopamine increases expressionISOA3galt2 (Rattus norvegicus)6480464Dopamine results in increased expression of A3GALT2 mRNACTDPMID:21983523
A3galt2Mouseendosulfan decreases expressionISOA3galt2 (Rattus norvegicus)6480464Endosulfan results in decreased expression of A3GALT2 mRNACTDPMID:29391264
A3galt2Mousefenoldopam increases expressionISOA3galt2 (Rattus norvegicus)6480464Fenoldopam results in increased expression of A3GALT2 mRNACTDPMID:21983523
A3galt2Mousefenvalerate increases expressionISOA3galt2 (Rattus norvegicus)6480464fenvalerate results in increased expression of A3GALT2 mRNACTDPMID:30307764
A3galt2Mouseflavonoids increases expressionISOA3galt2 (Rattus norvegicus)6480464Flavonoids results in increased expression of A3GALT2 mRNACTDPMID:18035473

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Biological Process
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1 to 11 of 11 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
A3galt2MouseGolgi apparatus located_inISSUniProtKB:A0A4Z32290270 UniProtGO_REF:0000024
A3galt2MouseGolgi apparatus located_inISOA3galt2 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
A3galt2MouseGolgi apparatus is_active_inIBAPANTHER:PTN000049004 more ...2290270 GO_CentralGO_REF:0000033
A3galt2MouseGolgi cisterna membrane located_inIEAUniProtKB-SubCell:SL-01362290270 UniProtGO_REF:0000044
A3galt2Mousevesicle located_inISOA3galt2 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
A3galt2Mousevesicle located_inISSUniProtKB:A0A4Z32290270 UniProtGO_REF:0000024
A3galt2Mousevesicle is_active_inIBAPANTHER:PTN000049004 and A3galt2 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000033

Molecular Function
1 to 9 of 9 rows

  
1 to 9 of 9 rows

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
A3galt2Mouseno abnormal phenotype detected  IAGP 5509061 MGIPMID:17372206

#
Reference Title
Reference Citation
1. Mouse MP Annotation Import Pipeline RGD automated import pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:15539565   PMID:16141072   PMID:16141073   PMID:16456004   PMID:16476743   PMID:17372206   PMID:18348765  
PMID:18810447   PMID:19033672   PMID:21677750   PMID:21873635   PMID:22875802  



A3galt2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394128,653,051 - 128,663,091 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4128,649,157 - 128,663,091 (+)EnsemblGRCm39 Ensembl
GRCm384128,759,258 - 128,769,298 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4128,755,364 - 128,769,298 (+)EnsemblGRCm38mm10GRCm38
MGSCv374128,436,502 - 128,446,542 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364128,261,562 - 128,271,602 (+)NCBIMGSCv36mm8
Celera4127,097,903 - 127,107,951 (+)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map462.23NCBI
A3GALT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38133,306,766 - 33,321,098 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl133,306,766 - 33,321,098 (-)EnsemblGRCh38hg38GRCh38
GRCh37133,772,367 - 33,786,699 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36133,544,954 - 33,559,286 (-)NCBINCBI36Build 36hg18NCBI36
Celera132,044,033 - 32,050,184 (-)NCBICelera
Cytogenetic Map1p35.1NCBI
HuRef131,888,724 - 31,902,934 (-)NCBIHuRef
CHM1_1133,887,824 - 33,902,079 (-)NCBICHM1_1
T2T-CHM13v2.0133,168,388 - 33,182,706 (-)NCBIT2T-CHM13v2.0
A3galt2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85146,385,725 - 146,398,156 (+)NCBIGRCr8
mRatBN7.25141,101,329 - 141,113,760 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5141,107,983 - 141,115,641 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5143,797,192 - 143,809,595 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05145,567,021 - 145,579,424 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05145,567,944 - 145,580,207 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05146,933,592 - 146,945,882 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5146,933,592 - 146,945,880 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05150,671,102 - 150,683,392 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45147,981,004 - 147,994,143 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15147,991,042 - 148,004,180 (+)NCBI
Celera5139,585,640 - 139,597,893 (+)NCBICelera
Cytogenetic Map5q36NCBI
A3galt2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545211,474,472 - 11,480,849 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545211,476,485 - 11,489,243 (-)NCBIChiLan1.0ChiLan1.0
A3GALT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21193,513,103 - 193,526,655 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11192,635,241 - 192,648,166 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0132,592,614 - 32,598,986 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1133,778,059 - 33,792,420 (-)NCBIpanpan1.1PanPan1.1panPan2
A3GALT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1268,117,648 - 68,138,610 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl268,118,413 - 68,138,095 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha264,695,829 - 64,716,770 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0268,679,761 - 68,700,702 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl268,679,595 - 68,700,717 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1265,492,524 - 65,513,408 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0266,515,072 - 66,535,968 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0267,507,076 - 67,528,016 (+)NCBIUU_Cfam_GSD_1.0
A3galt2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505850,310,334 - 50,322,761 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647416,135,644 - 16,145,518 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647416,135,076 - 16,138,930 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
A3GALT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl689,558,423 - 89,562,490 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1689,557,492 - 89,562,835 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2683,571,441 - 83,573,210 (-)NCBISscrofa10.2Sscrofa10.2susScr3
A3GALT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12099,564,275 - 99,573,839 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2099,561,311 - 99,573,752 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603317,119,668 - 17,129,303 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
A3galt2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476416,339,948 - 16,351,846 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476416,340,488 - 16,353,127 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in A3galt2
472 total Variants

Predicted Target Of
Summary Value
Count of predictions:898
Count of miRNA genes:370
Interacting mature miRNAs:419
Transcripts:ENSMUST00000030585, ENSMUST00000106077
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 69 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
4142139Adip12_madiposity 12 (mouse)Not determined4124621281156860686Mouse
10047132Albq19_malbuminuria QTL 19 (mouse)Not determined4112824389146824389Mouse
1301525Lmb1_mlupus in MRL and B6 F2 cross (mouse)Not determined4124264957150676858Mouse
14746982Manh56_mmandible shape 56 (mouse)4117815917151815917Mouse
4141623W6q13_mweight 6 weeks QTL 13 (mouse)Not determined88982069140468203Mouse
12910797Pwgrq4_mpre-weaning growth rate QTL 4 (mouse)4105835310141433838Mouse
25314312Syncl2_msynaptonemal complex length 2 (mouse)465718237146584457Mouse
12910794Pwbwq8_mpost-weaning body weight QTL 8 (mouse)4105835310141433838Mouse
1300743Skull6_mskull morphology 6 (mouse)Not determined4111009051145009280Mouse
1301382Arvm2_mautoimmune renal vasculitis 2 (mouse)Not determined4107791564141791756Mouse

1 to 10 of 69 rows






Ensembl Acc Id: ENSMUST00000030585   ⟹   ENSMUSP00000030585
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4128,653,051 - 128,663,091 (+)Ensembl
GRCm38.p6 Ensembl4128,759,258 - 128,769,298 (+)Ensembl
Ensembl Acc Id: ENSMUST00000106077   ⟹   ENSMUSP00000101687
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4128,649,157 - 128,662,381 (+)Ensembl
GRCm38.p6 Ensembl4128,755,364 - 128,768,588 (+)Ensembl
RefSeq Acc Id: NM_001009819   ⟹   NP_001009819
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394128,653,051 - 128,663,091 (+)NCBI
GRCm384128,759,258 - 128,769,298 (+)NCBI
MGSCv374128,436,502 - 128,446,542 (+)RGD
Celera4127,097,903 - 127,107,951 (+)RGD
cM Map4 ENTREZGENE
Sequence:
1 to 9 of 9 rows
Protein RefSeqs NP_001009819 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAS66769 (Get FASTA)   NCBI Sequence Viewer  
  BAE21111 (Get FASTA)   NCBI Sequence Viewer  
  CAQ52296 (Get FASTA)   NCBI Sequence Viewer  
  EDL30228 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000030585
  ENSMUSP00000030585.8
  ENSMUSP00000101687.2
GenBank Protein Q3V1N9 (Get FASTA)   NCBI Sequence Viewer  
1 to 9 of 9 rows
RefSeq Acc Id: NP_001009819   ⟸   NM_001009819
- UniProtKB: B2KGX6 (UniProtKB/Swiss-Prot),   B2KGX5 (UniProtKB/Swiss-Prot),   M9MMK2 (UniProtKB/Swiss-Prot),   Q3V1N9 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000101687   ⟸   ENSMUST00000106077
Ensembl Acc Id: ENSMUSP00000030585   ⟸   ENSMUST00000030585

Name Modeler Protein Id AA Range Protein Structure
AF-Q3V1N9-F1-model_v2 AlphaFold Q3V1N9 1-370 view protein structure

RGD ID:6834736
Promoter ID:MM_KWN:39740
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000106077
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364128,432,366 - 128,433,097 (+)MPROMDB
RGD ID:6834735
Promoter ID:MM_KWN:39741
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour,   Brain,   MEF_B6
Transcripts:ENSMUST00000030585
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364128,435,521 - 128,436,697 (+)MPROMDB


1 to 23 of 23 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000028794 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000030585 ENTREZGENE
  ENSMUST00000030585.8 UniProtKB/Swiss-Prot
  ENSMUST00000106077.8 UniProtKB/Swiss-Prot
Gene3D-CATH Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A UniProtKB/Swiss-Prot
InterPro Glyco_trans_6 UniProtKB/Swiss-Prot
  Nucleotide-diphossugar_trans UniProtKB/Swiss-Prot
KEGG Report mmu:215493 UniProtKB/Swiss-Prot
MGD MGI:2685279 ENTREZGENE
NCBI Gene 215493 ENTREZGENE
PANTHER ALPHA-1,3-GALACTOSYLTRANSFERASE 2 UniProtKB/Swiss-Prot
  PTHR10462 UniProtKB/Swiss-Prot
Pfam Glyco_transf_6 UniProtKB/Swiss-Prot
PhenoGen A3galt2 PhenoGen
Superfamily-SCOP SSF53448 UniProtKB/Swiss-Prot
UniProt A3LT2_MOUSE UniProtKB/Swiss-Prot
  B2KGX5 ENTREZGENE
  B2KGX6 ENTREZGENE
  M9MMK2 ENTREZGENE
  Q3V1N9 ENTREZGENE
UniProt Secondary B2KGX5 UniProtKB/Swiss-Prot
  B2KGX6 UniProtKB/Swiss-Prot
  M9MMK2 UniProtKB/Swiss-Prot
1 to 23 of 23 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-06-27 A3galt2  alpha 1,3-galactosyltransferase 2  A3galt2  alpha 1,3-galactosyltransferase 2 (isoglobotriaosylceramide synthase)  Symbol and/or name change 5135510 APPROVED