Gpr180 (G protein-coupled receptor 180) - Rat Genome Database

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Gene: Gpr180 (G protein-coupled receptor 180) Mus musculus
Analyze
Symbol: Gpr180
Name: G protein-coupled receptor 180
RGD ID: 1615910
MGI Page MGI
Description: Predicted to be involved in G protein-coupled receptor signaling pathway and response to pheromone. Predicted to be located in membrane. Is expressed in embryo. Orthologous to human GPR180 (G protein-coupled receptor 180).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AB041545; E130016I23Rik; I; integral membrane protein GPR180; intimal thickness-related receptor; Itr
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914118,374,513 - 118,401,644 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl14118,374,570 - 118,400,673 (+)EnsemblGRCm39 Ensembl
GRCm3814118,137,105 - 118,164,232 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14118,137,158 - 118,163,261 (+)EnsemblGRCm38mm10GRCm38
MGSCv3714118,536,349 - 118,563,454 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3614117,019,505 - 117,047,938 (+)NCBIMGSCv36mm8
Celera14116,691,545 - 116,719,686 (+)NCBICelera
Cytogenetic Map14E4NCBI
cM Map1461.78NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Mouse MP Annotation Import Pipeline RGD automated import pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12538434   PMID:15489334   PMID:15782199   PMID:16141072  
PMID:16141073   PMID:16919269   PMID:18973680   PMID:21267068   PMID:21677750   PMID:34880217   PMID:37111058  


Genomics

Comparative Map Data
Gpr180
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914118,374,513 - 118,401,644 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl14118,374,570 - 118,400,673 (+)EnsemblGRCm39 Ensembl
GRCm3814118,137,105 - 118,164,232 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14118,137,158 - 118,163,261 (+)EnsemblGRCm38mm10GRCm38
MGSCv3714118,536,349 - 118,563,454 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3614117,019,505 - 117,047,938 (+)NCBIMGSCv36mm8
Celera14116,691,545 - 116,719,686 (+)NCBICelera
Cytogenetic Map14E4NCBI
cM Map1461.78NCBI
GPR180
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381394,601,857 - 94,634,661 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1394,601,857 - 94,634,661 (+)EnsemblGRCh38hg38GRCh38
GRCh371395,254,111 - 95,286,915 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361394,052,105 - 94,079,947 (+)NCBINCBI36Build 36hg18NCBI36
Celera1376,102,074 - 76,129,910 (+)NCBICelera
Cytogenetic Map13q32.1NCBI
HuRef1375,851,373 - 75,884,161 (+)NCBIHuRef
CHM1_11395,223,550 - 95,256,344 (+)NCBICHM1_1
T2T-CHM13v2.01393,805,369 - 93,838,171 (+)NCBIT2T-CHM13v2.0
Gpr180
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr815101,602,870 - 101,635,556 (+)NCBIGRCr8
mRatBN7.21595,195,782 - 95,224,955 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1595,199,777 - 95,228,373 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1599,104,681 - 99,128,263 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.015100,236,642 - 100,260,224 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01597,165,331 - 97,188,913 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.015103,340,387 - 103,369,633 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15103,344,476 - 103,369,630 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.015106,779,454 - 106,808,159 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.415102,931,713 - 102,955,239 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.115102,947,492 - 102,971,018 (+)NCBI
Celera1594,051,859 - 94,075,480 (+)NCBICelera
Cytogenetic Map15q24NCBI
Gpr180
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540415,250,532 - 15,275,392 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540415,250,532 - 15,275,381 (-)NCBIChiLan1.0ChiLan1.0
GPR180
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21496,130,516 - 96,193,324 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11394,799,189 - 94,832,461 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01375,774,879 - 75,808,210 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11394,930,657 - 94,964,493 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1394,930,349 - 94,957,032 (+)Ensemblpanpan1.1panPan2
GPR180
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12245,402,127 - 45,434,693 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2245,401,443 - 45,431,483 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2245,188,938 - 45,221,073 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02245,833,299 - 45,865,441 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2245,831,339 - 45,865,430 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12245,486,445 - 45,518,575 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02245,527,326 - 45,559,461 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02245,536,897 - 45,569,057 (+)NCBIUU_Cfam_GSD_1.0
Gpr180
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945180,962,446 - 180,990,884 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647214,959,862 - 14,989,709 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647214,963,022 - 14,989,709 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPR180
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1163,720,095 - 63,751,684 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11163,720,048 - 63,764,720 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21169,826,935 - 69,859,762 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GPR180
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1373,429,949 - 73,460,134 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl373,430,165 - 73,458,011 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604629,819,561 - 29,854,657 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpr180
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248791,387,867 - 1,410,767 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248791,388,033 - 1,412,727 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gpr180
1270 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:435
Count of miRNA genes:314
Interacting mature miRNAs:353
Transcripts:ENSMUST00000022728
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
4142508Tgq25_mtriglyceride QTL 25 (mouse)Not determined85134068119134068Mouse
12903991Opfaq4_mopen field activity QTL 4 (mouse)14111211209118699845Mouse
12792981Fbmd5_mfemoral bone mineral density 5, females only (mouse)1499838217125033054Mouse
10755523Hgb2_mhemoglobin 2 (mouse)14105884654125139656Mouse


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_021434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006519335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030247903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003950877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_383197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB041545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC108833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK040165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK053422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK181071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK182770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC055726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC069981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX210992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000022728   ⟹   ENSMUSP00000022728
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl14118,374,570 - 118,400,673 (+)Ensembl
GRCm38.p6 Ensembl14118,137,158 - 118,163,261 (+)Ensembl
RefSeq Acc Id: NM_021434   ⟹   NP_067409
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3914118,374,539 - 118,401,644 (+)NCBI
GRCm3814118,137,127 - 118,164,232 (+)NCBI
MGSCv3714118,536,349 - 118,563,454 (+)RGD
Celera14116,691,545 - 116,719,686 (+)RGD
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006519335   ⟹   XP_006519398
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3914118,374,547 - 118,400,677 (+)NCBI
GRCm3814118,137,135 - 118,163,265 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030247903   ⟹   XP_030103763
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3914118,374,529 - 118,400,677 (+)NCBI
GRCm3814118,137,117 - 118,163,265 (+)NCBI
Sequence:
RefSeq Acc Id: XR_003950877
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3914118,374,513 - 118,400,677 (+)NCBI
GRCm3814118,137,111 - 118,163,265 (+)NCBI
Sequence:
RefSeq Acc Id: XR_383197
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3914118,374,513 - 118,400,677 (+)NCBI
GRCm3814118,137,105 - 118,163,265 (+)NCBI
Sequence:
RefSeq Acc Id: NP_067409   ⟸   NM_021434
- Peptide Label: precursor
- UniProtKB: Q9JJG1 (UniProtKB/Swiss-Prot),   Q8BPS4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006519398   ⟸   XM_006519335
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_030103763   ⟸   XM_030247903
- Peptide Label: isoform X2
Ensembl Acc Id: ENSMUSP00000022728   ⟸   ENSMUST00000022728
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BPS4-F1-model_v2 AlphaFold Q8BPS4 1-441 view protein structure

Promoters
RGD ID:8683190
Promoter ID:EPDNEW_M19626
Type:initiation region
Name:Gpr180_1
Description:Mus musculus G protein-coupled receptor 180 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M19627  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3814118,137,147 - 118,137,207EPDNEW
RGD ID:8683192
Promoter ID:EPDNEW_M19627
Type:single initiation site
Name:Gpr180_2
Description:Mus musculus G protein-coupled receptor 180 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M19626  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3814118,146,687 - 118,146,747EPDNEW
RGD ID:6825048
Promoter ID:MM_KWN:17781
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_021434,   UC007UYR.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3614118,535,966 - 118,536,466 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1930949 AgrOrtholog
Ensembl Genes ENSMUSG00000022131 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000022728 ENTREZGENE
  ENSMUST00000022728.4 UniProtKB/Swiss-Prot
InterPro GPR180-like_N UniProtKB/Swiss-Prot
  GPR180/TMEM145 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Intimal_thickness-rel_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:58245 UniProtKB/Swiss-Prot
MGD MGI:1930949 ENTREZGENE
NCBI Gene 58245 ENTREZGENE
PANTHER INTEGRAL MEMBRANE PROTEIN GPR180 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTIMAL THICKNESS RECEPTOR-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GP180_GOLD UniProtKB/Swiss-Prot
  GpcrRhopsn4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gpr180 PhenoGen
UniProt GP180_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q8C9Z2_MOUSE UniProtKB/TrEMBL
  Q9JJG1 ENTREZGENE
UniProt Secondary Q9JJG1 UniProtKB/Swiss-Prot