Unc93b1 (unc-93 homolog B1, TLR signaling regulator) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Unc93b1 (unc-93 homolog B1, TLR signaling regulator) Mus musculus
Analyze
Symbol: Unc93b1
Name: unc-93 homolog B1, TLR signaling regulator
RGD ID: 1615140
MGI Page MGI
Description: Enables Toll-like receptor binding activity. Involved in endolysosomal toll-like receptor signaling pathway and intracellular protein transport. Acts upstream of or within several processes, including T cell antigen processing and presentation; antigen processing and presentation of exogenous peptide antigen via MHC class II; and positive regulation of cytokine production. Located in cytoplasmic vesicle; endoplasmic reticulum; and lysosome. Is expressed in brain; cerebral cortex; liver; lung; and spleen. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human UNC93B1 (unc-93 homolog B1, TLR signaling regulator).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: protein unc-93 homolog B1; unc-93 homolog B; unc-93 homolog B1; unc-93 homolog B1 (C. elegans); Unc-93B1; Unc93b
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39193,985,222 - 3,999,340 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl193,985,186 - 3,999,340 (+)EnsemblGRCm39 Ensembl
GRCm38193,935,158 - 3,949,340 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl193,935,186 - 3,949,340 (+)EnsemblGRCm38mm10GRCm38
MGSCv37193,935,186 - 3,949,340 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36193,935,219 - 3,949,340 (+)NCBIMGSCv36mm8
Celera193,816,022 - 3,830,362 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map193.65NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal antigen presentation via MHC class I  (IAGP)
abnormal antigen presentation via MHC class II  (IAGP)
abnormal bone marrow morphology  (IAGP)
abnormal circulating interferon level  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal dendritic cell antigen presentation  (IAGP)
abnormal dendritic cell morphology  (IAGP)
abnormal dendritic cell physiology  (IAGP)
abnormal erythrocyte physiology  (IAGP)
abnormal liver morphology  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal T-helper 1 cell differentiation  (IAGP)
abnormal T-helper 17 cell differentiation  (IAGP)
abnormal tumor necrosis factor level  (IAGP)
abnormal tumor necrosis factor secretion  (IAGP)
anemia  (IAGP)
decreased B cell proliferation  (IAGP)
decreased circulating interleukin-12b level  (IAGP)
decreased circulating interleukin-6 level  (IAGP)
decreased interferon-alpha secretion  (IAGP)
decreased interleukin-12b secretion  (IAGP)
decreased interleukin-6 secretion  (IAGP)
decreased marginal zone B cell number  (IAGP)
decreased tumor necrosis factor secretion  (IAGP)
enlarged spleen  (IAGP)
glomerulonephritis  (IAGP)
increased anti-nuclear antigen antibody level  (IAGP)
increased autoantibody level  (IAGP)
increased B cell number  (IAGP)
increased B cell proliferation  (IAGP)
increased CD4-positive, alpha-beta memory T cell number  (IAGP)
increased circulating alanine transaminase level  (IAGP)
increased circulating aspartate transaminase level  (IAGP)
increased circulating bilirubin level  (IAGP)
increased circulating creatinine level  (IAGP)
increased circulating lactate dehydrogenase level  (IAGP)
increased circulating tumor necrosis factor level  (IAGP)
increased erythroblast number  (IAGP)
increased IgG2a level  (IAGP)
increased IgG2b level  (IAGP)
increased interferon-alpha secretion  (IAGP)
increased interleukin-12b secretion  (IAGP)
increased memory T cell number  (IAGP)
increased spleen weight  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased susceptibility to Herpesvirales infection  (IAGP)
increased T-helper 1 cell number  (IAGP)
increased T-helper 17 cell number  (IAGP)
increased tumor necrosis factor secretion  (IAGP)
liver failure  (IAGP)
liver inflammation  (IAGP)
multifocal hepatic necrosis  (IAGP)
premature death  (IAGP)
thrombocytopenia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Pathogen recognition by the innate immune system. Kumar H, etal., Int Rev Immunol. 2011 Feb;30(1):16-34.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9798653   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12935356   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16415873  
PMID:16782034   PMID:16889948   PMID:17452530   PMID:17658280   PMID:18305481   PMID:18931679   PMID:19451267   PMID:19574451   PMID:20007584   PMID:20457904   PMID:20592086   PMID:20668698  
PMID:20865117   PMID:21045126   PMID:21097503   PMID:21164516   PMID:21267068   PMID:21308776   PMID:21677750   PMID:21683627   PMID:21753151   PMID:21873635   PMID:21903422   PMID:21966468  
PMID:22078797   PMID:22114338   PMID:22447976   PMID:22466646   PMID:22541070   PMID:22634614   PMID:22723955   PMID:22745710   PMID:22777843   PMID:22896636   PMID:23008447   PMID:23110254  
PMID:23142781   PMID:23241879   PMID:23290966   PMID:23325805   PMID:23426999   PMID:23585677   PMID:23589617   PMID:23728775   PMID:23754400   PMID:23761632   PMID:23791646   PMID:23817982  
PMID:24042114   PMID:24130907   PMID:24145778   PMID:24145779   PMID:24534189   PMID:24778236   PMID:24848930   PMID:24889626   PMID:25008929   PMID:25210785   PMID:25648980   PMID:25675947  
PMID:26011644   PMID:26621862   PMID:26880763   PMID:27264176   PMID:27509078   PMID:27551155   PMID:27903802   PMID:28330900   PMID:28400473   PMID:28607148   PMID:29055005   PMID:29150239  
PMID:29158474   PMID:29212904   PMID:29521626   PMID:29768176   PMID:29805094   PMID:29997629   PMID:30111894   PMID:30170812   PMID:30199535   PMID:30429335   PMID:30550785   PMID:30683700  
PMID:31097594   PMID:31387916   PMID:31433296   PMID:31433298   PMID:31534009   PMID:31546246   PMID:31546247   PMID:31732532   PMID:31852751   PMID:31913271   PMID:32209688   PMID:32554809  
PMID:32632165   PMID:33432245   PMID:34362834   PMID:34589086   PMID:35245345   PMID:36222510   PMID:38029747   PMID:38169466   PMID:38207055   PMID:38780621  


Genomics

Comparative Map Data
Unc93b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39193,985,222 - 3,999,340 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl193,985,186 - 3,999,340 (+)EnsemblGRCm39 Ensembl
GRCm38193,935,158 - 3,949,340 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl193,935,186 - 3,949,340 (+)EnsemblGRCm38mm10GRCm38
MGSCv37193,935,186 - 3,949,340 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36193,935,219 - 3,949,340 (+)NCBIMGSCv36mm8
Celera193,816,022 - 3,830,362 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map193.65NCBI
UNC93B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381167,991,100 - 68,004,097 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1167,991,100 - 68,004,982 (-)EnsemblGRCh38hg38GRCh38
GRCh371167,758,571 - 67,771,567 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361167,515,151 - 67,528,169 (-)NCBINCBI36Build 36hg18NCBI36
Build 341167,515,150 - 67,528,169NCBI
Celera1165,092,238 - 65,105,264 (-)NCBICelera
Cytogenetic Map11q13.2NCBI
HuRef1164,093,625 - 64,106,650 (-)NCBIHuRef
CHM1_11167,642,323 - 67,655,340 (-)NCBICHM1_1
T2T-CHM13v2.01167,994,743 - 68,007,749 (-)NCBIT2T-CHM13v2.0
Unc93b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81210,596,639 - 210,607,579 (+)NCBIGRCr8
mRatBN7.21201,167,388 - 201,178,343 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1201,152,693 - 201,178,338 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1209,540,615 - 209,551,507 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01216,629,429 - 216,640,333 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01209,303,631 - 209,314,535 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01219,172,987 - 219,183,941 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1219,144,205 - 219,183,963 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01226,043,713 - 226,054,652 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41206,460,302 - 206,471,239 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11206,613,779 - 206,624,694 (+)NCBI
Celera1198,720,875 - 198,731,812 (+)NCBICelera
Cytogenetic Map1q43NCBI
Unc93b1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542217,814,079 - 17,824,190 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542217,814,174 - 17,823,945 (+)NCBIChiLan1.0ChiLan1.0
UNC93B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2968,941,767 - 68,954,774 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11169,985,008 - 69,998,010 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01163,073,076 - 63,086,078 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11166,382,059 - 66,394,485 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1166,382,059 - 66,394,541 (-)Ensemblpanpan1.1panPan2
UNC93B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11849,826,044 - 49,835,417 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1849,826,026 - 49,882,461 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1848,434,706 - 48,444,744 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01850,746,392 - 50,756,504 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1850,746,471 - 50,756,495 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11849,959,954 - 49,969,984 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01849,534,991 - 49,544,968 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01850,328,350 - 50,338,396 (+)NCBIUU_Cfam_GSD_1.0
Unc93b1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049475,666,943 - 5,675,436 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365992,109,292 - 2,117,143 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365992,109,292 - 2,146,006 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UNC93B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl24,898,409 - 4,909,856 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.124,898,414 - 4,909,833 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.223,539,633 - 3,550,646 (+)NCBISscrofa10.2Sscrofa10.2susScr3
UNC93B1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.116,537,198 - 6,549,457 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl16,537,273 - 6,549,450 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038103,814,836 - 103,827,116 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Unc93b1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476718,860,017 - 18,868,581 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476718,859,990 - 18,869,083 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Unc93b1
345 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:847
Count of miRNA genes:405
Interacting mature miRNAs:494
Transcripts:ENSMUST00000161415, ENSMUST00000162193, ENSMUST00000162708, ENSMUST00000165711
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142302Nstr1_mnerve sheath tumor resistance QTL 1 (mouse)Not determined19122371338Mouse
1301271Datd_mdopamine transporter density (mouse)Not determined19132340234Mouse
1300923Bits4_mbitterness sensitivity 4 (mouse)Not determined19332321637323348Mouse
4142406Pbctlp1_mperipheral blood cytotoxic T lymphocyte percentage 1 (mouse)Not determined132875174Mouse
1300776Lfp3_mlong free running period 3 (mouse)Not determined19120328703Mouse
1300904Chab5_mcholesterol absorption 5 (mouse)Not determined19165376435653927Mouse
26884385Skwq14_mskull length QTL 14, 16 week (mouse)19325000035877400Mouse
1301800Faq10_mfluctuating asymmetry QTL 10 (mouse)Not determined19332321637323348Mouse
1300591Pas3_mpulmonary adenoma susceptibility 3 (mouse)Not determined19332321637323348Mouse
1302126Skull26_mskull morphology 26 (mouse)Not determined19332321637323348Mouse
4142161Drinksac2_mdrink saccharin 2 (mouse)Not determined120695286Mouse
1357819Tgct2_mtesticular germ cell tumor 2 (mouse)Not determined19332855120539663Mouse


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001161428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001403609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001403610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_019449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC133523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI462917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ422144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK030488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK039526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK162535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC018388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC023731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC025587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY199008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U89424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000161415
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl193,992,440 - 3,999,340 (+)Ensembl
GRCm38.p6 Ensembl193,942,440 - 3,949,340 (+)Ensembl
Ensembl Acc Id: ENSMUST00000162193
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl193,985,226 - 3,986,746 (+)Ensembl
GRCm38.p6 Ensembl193,935,226 - 3,936,746 (+)Ensembl
Ensembl Acc Id: ENSMUST00000162708   ⟹   ENSMUSP00000124272
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl193,985,186 - 3,999,340 (+)Ensembl
GRCm38.p6 Ensembl193,935,186 - 3,949,340 (+)Ensembl
Ensembl Acc Id: ENSMUST00000165711   ⟹   ENSMUSP00000128751
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl193,985,186 - 3,999,339 (+)Ensembl
GRCm38.p6 Ensembl193,935,186 - 3,949,339 (+)Ensembl
Ensembl Acc Id: ENSMUST00000236920   ⟹   ENSMUSP00000157793
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl193,985,286 - 3,991,933 (+)Ensembl
GRCm38.p6 Ensembl193,935,286 - 3,941,933 (+)Ensembl
Ensembl Acc Id: ENSMUST00000237030   ⟹   ENSMUSP00000158499
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl193,991,537 - 3,997,112 (+)Ensembl
GRCm38.p6 Ensembl193,941,537 - 3,947,112 (+)Ensembl
Ensembl Acc Id: ENSMUST00000237112
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl193,986,079 - 3,991,558 (+)Ensembl
GRCm38.p6 Ensembl193,936,079 - 3,941,558 (+)Ensembl
RefSeq Acc Id: NM_001161428   ⟹   NP_001154900
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39193,985,222 - 3,999,340 (+)NCBI
GRCm38193,935,186 - 3,949,340 (+)ENTREZGENE
MGSCv37193,935,186 - 3,949,340 (+)RGD
Celera193,816,022 - 3,830,362 (+)RGD
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001403609   ⟹   NP_001390538
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39193,985,222 - 3,999,340 (+)NCBI
RefSeq Acc Id: NM_001403610   ⟹   NP_001390539
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39193,985,222 - 3,999,340 (+)NCBI
RefSeq Acc Id: NM_019449   ⟹   NP_062322
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39193,985,222 - 3,999,340 (+)NCBI
GRCm38193,935,186 - 3,949,340 (+)ENTREZGENE
MGSCv37193,935,186 - 3,949,340 (+)RGD
Celera193,816,022 - 3,830,362 (+)RGD
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_062322   ⟸   NM_019449
- Peptide Label: isoform a
- UniProtKB: Q8VCW4 (UniProtKB/Swiss-Prot),   Q8CIK1 (UniProtKB/Swiss-Prot),   Q710D2 (UniProtKB/Swiss-Prot),   Q3TNR9 (UniProtKB/Swiss-Prot),   O89077 (UniProtKB/Swiss-Prot),   Q8R3D0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001154900   ⟸   NM_001161428
- Peptide Label: isoform b
- UniProtKB: E9Q8P6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000158499   ⟸   ENSMUST00000237030
Ensembl Acc Id: ENSMUSP00000157793   ⟸   ENSMUST00000236920
Ensembl Acc Id: ENSMUSP00000128751   ⟸   ENSMUST00000165711
Ensembl Acc Id: ENSMUSP00000124272   ⟸   ENSMUST00000162708
RefSeq Acc Id: NP_001390539   ⟸   NM_001403610
- Peptide Label: isoform d
RefSeq Acc Id: NP_001390538   ⟸   NM_001403609
- Peptide Label: isoform c

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VCW4-F1-model_v2 AlphaFold Q8VCW4 1-598 view protein structure

Promoters
RGD ID:6830505
Promoter ID:MM_KWN:25952
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung,   Spleen
Transcripts:NM_001161428,   UC008FXR.1,   UC008FXS.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36193,935,051 - 3,935,551 (+)MPROMDB
RGD ID:13678358
Promoter ID:EPDNEW_M23328
Type:initiation region
Name:Unc93b1_1
Description:Mus musculus unc-93 homolog B1 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38193,935,222 - 3,935,282EPDNEW
RGD ID:6847611
Promoter ID:MM_ACW:25754
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Lung,   Spleen
Transcripts:UNC93B1.FSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36193,935,796 - 3,936,296 (+)MPROMDB
RGD ID:6830506
Promoter ID:MM_KWN:25953
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:UC008FXT.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36193,941,756 - 3,942,867 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1859307 AgrOrtholog
Ensembl Genes ENSMUSG00000036908 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000162708 ENTREZGENE
  ENSMUST00000162708.7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSMUST00000165711 ENTREZGENE
  ENSMUST00000165711.3 UniProtKB/TrEMBL
  ENSMUST00000236920.2 UniProtKB/TrEMBL
  ENSMUST00000237030.2 UniProtKB/TrEMBL
InterPro Ion_channel_UNC-93 UniProtKB/TrEMBL
  UNC93B1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:54445 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1859307 ENTREZGENE
NCBI Gene 54445 ENTREZGENE
PANTHER PROTEIN UNC-93 HOMOLOG B1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR46744 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam UNC-93 UniProtKB/TrEMBL
PhenoGen Unc93b1 PhenoGen
UniProt A0A494B9X0_MOUSE UniProtKB/TrEMBL
  A0A494BBK7_MOUSE UniProtKB/TrEMBL
  E9PYK0_MOUSE UniProtKB/TrEMBL
  E9Q8P6 ENTREZGENE, UniProtKB/TrEMBL
  O89077 ENTREZGENE
  Q3TNR9 ENTREZGENE
  Q710D2 ENTREZGENE
  Q8CIK1 ENTREZGENE
  Q8R3D0 ENTREZGENE
  Q8VCW4 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary O89077 UniProtKB/Swiss-Prot
  Q3TNR9 UniProtKB/Swiss-Prot
  Q710D2 UniProtKB/Swiss-Prot
  Q8CIK1 UniProtKB/Swiss-Prot
  Q8R3D0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-06-05 Unc93b1  unc-93 homolog B1, TLR signaling regulator    unc-93 homolog B1 (C. elegans)  Symbol and/or name change 5135510 APPROVED