TMEM109 (transmembrane protein 109) - Rat Genome Database

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Gene: TMEM109 (transmembrane protein 109) Homo sapiens
Analyze
Symbol: TMEM109
Name: transmembrane protein 109
RGD ID: 1601968
HGNC Page HGNC:28771
Description: Predicted to enable voltage-gated monoatomic cation channel activity. Acts upstream of or within cellular response to gamma radiation and negative regulation of programmed cell death. Located in extracellular exosome.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hSND3; mg23; MGC5508; mitsugumin-23; SND3; SRP-independent targeting 3 homolog; voltage-gated monoatomic cation channel TMEM109
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381160,914,158 - 60,923,443 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1160,913,907 - 60,923,443 (+)EnsemblGRCh38hg38GRCh38
GRCh371160,681,630 - 60,690,915 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361160,438,253 - 60,447,491 (+)NCBINCBI36Build 36hg18NCBI36
Celera1158,042,259 - 58,051,802 (+)NCBICelera
Cytogenetic Map11q12.2NCBI
HuRef1157,027,540 - 57,037,083 (+)NCBIHuRef
CHM1_11160,547,675 - 60,557,219 (+)NCBICHM1_1
T2T-CHM13v2.01160,865,308 - 60,874,594 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
TMEM109Humanintellectual disability  IAGPRGD:427234668554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 
TMEM109Humanleukocyte adhesion deficiency 3  IAGPRGD:1564430298554872ClinVar Annotator: match by term: Leukocyte adhesion deficiency 3ClinVarPMID:28492532

1 to 20 of 76 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
TMEM109Human1,2-dimethylhydrazine multiple interactionsISORGD:16167776480464[1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of TMEM109 mRNACTDPMID:22206623
TMEM109Human17alpha-ethynylestradiol affects expressionISORGD:16167776480464Ethinyl Estradiol affects the expression of TMEM109 mRNACTDPMID:17555576
TMEM109Human2,3,7,8-tetrachlorodibenzodioxine decreases expressionISORGD:16167776480464Tetrachlorodibenzodioxin results in decreased expression of TMEM109 mRNACTDPMID:19465110
TMEM109Human2,3,7,8-tetrachlorodibenzodioxine increases expressionISORGD:13595386480464Tetrachlorodibenzodioxin results in increased expression of TMEM109 mRNACTDPMID:32109520|PMID:33387578
TMEM109Human2,3,7,8-tetrachlorodibenzodioxine affects expressionISORGD:16167776480464Tetrachlorodibenzodioxin affects the expression of TMEM109 mRNACTDPMID:21570461|PMID:24680724
TMEM109Human2,3,7,8-tetrachlorodibenzodioxine affects expressionISORGD:13595386480464Tetrachlorodibenzodioxin affects the expression of TMEM109 mRNACTDPMID:22298810
TMEM109Human2,3,7,8-tetrachlorodibenzodioxine decreases expressionISORGD:13595386480464Tetrachlorodibenzodioxin results in decreased expression of TMEM109 mRNACTDPMID:21215274
TMEM109Human2,6-dinitrotoluene affects expressionISORGD:135953864804642,6-dinitrotoluene affects the expression of TMEM109 mRNACTDPMID:21346803
TMEM109Human2-methylcholine affects expressionEXP 6480464beta-methylcholine affects the expression of TMEM109 mRNACTDPMID:21179406
TMEM109Human3-isobutyl-1-methyl-7H-xanthine multiple interactionsEXP 6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] more ...CTDPMID:28628672
TMEM109Human4,4'-sulfonyldiphenol affects expressionEXP 6480464bisphenol S affects the expression of TMEM109 proteinCTDPMID:31945527
TMEM109Human4,4'-sulfonyldiphenol increases expressionEXP 6480464bisphenol S results in increased expression of TMEM109 proteinCTDPMID:34186270
TMEM109Humanaflatoxin B1 decreases methylationEXP 6480464Aflatoxin B1 results in decreased methylation of TMEM109 geneCTDPMID:27153756
TMEM109Humanaristolochic acid A increases expressionEXP 6480464aristolochic acid I results in increased expression of TMEM109 mRNACTDPMID:33212167
TMEM109Humanarsane multiple interactionsEXP 6480464[sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of TMEM109 more ...CTDPMID:32525701
TMEM109Humanarsenic atom multiple interactionsEXP 6480464[sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of TMEM109 more ...CTDPMID:32525701
TMEM109Humanarsenite(3-) increases expressionISORGD:16167776480464arsenite results in increased expression of TMEM109 proteinCTDPMID:37955338
TMEM109Humanbenzo[a]pyrene increases expressionISORGD:16167776480464Benzo(a)pyrene results in increased expression of TMEM109 mRNACTDPMID:22228805
TMEM109Humanbenzo[a]pyrene increases expressionEXP 6480464Benzo(a)pyrene results in increased expression of TMEM109 mRNACTDPMID:32234424
TMEM109Humanbenzo[a]pyrene affects methylationEXP 6480464Benzo(a)pyrene affects the methylation of TMEM109 promoterCTDPMID:27901495

1 to 20 of 76 rows

Biological Process
1 to 9 of 9 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
TMEM109Humancellular response to gamma radiation acts_upstream_of_or_withinIMP 150520179 PMID:23542032MGIPMID:23542032
TMEM109Humancellular response to gamma radiation involved_inIBAPANTHER:PTN002684508|UniProtKB:Q9BVC6150520179 GO_CentralGO_REF:0000033
TMEM109Humancellular response to gamma radiation involved_inIEAInterPro:IPR039492150520179 InterProGO_REF:0000002
TMEM109Humanintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator involved_inIBAMGI:1915789|PANTHER:PTN002684508150520179 GO_CentralGO_REF:0000033
TMEM109Humanintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator acts_upstream_of_or_withinIEAUniProtKB:Q3UBX0|ensembl:ENSMUSP00000039529150520179 EnsemblGO_REF:0000107
TMEM109Humanmonoatomic cation transmembrane transport involved_inIEAGO:0022843150520179 GOCGO_REF:0000108
TMEM109Humanmonoatomic ion transmembrane transport involved_inIEAUniProtKB-KW:KW-0407|UniProtKB-KW:KW-0851150520179 UniProtGO_REF:0000043
TMEM109Humanmonoatomic ion transport involved_inIEAUniProtKB-KW:KW-0406150520179 UniProtGO_REF:0000043
TMEM109Humannegative regulation of programmed cell death acts_upstream_of_or_withinIMP 150520179 PMID:23542032MGIPMID:23542032
1 to 9 of 9 rows

Cellular Component
1 to 10 of 10 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
TMEM109Humanendoplasmic reticulum located_inIEAUniProtKB-KW:KW-0256150520179 UniProtGO_REF:0000043
TMEM109Humanendoplasmic reticulum membrane located_inIEAUniProtKB-SubCell:SL-0097150520179 UniProtGO_REF:0000044
TMEM109Humanextracellular exosome located_inHDA 150520179 PMID:19199708, PMID:20458337UniProtPMID:19199708|PMID:20458337
TMEM109Humanmembrane located_inIEAUniProtKB-KW:KW-0472150520179 UniProtGO_REF:0000043
TMEM109Humanmonoatomic ion channel complex part_ofIEAUniProtKB-KW:KW-0851150520179 UniProtGO_REF:0000043
TMEM109Humannuclear outer membrane located_inIEAUniProtKB-SubCell:SL-0183150520179 UniProtGO_REF:0000044
TMEM109Humannucleus located_inIEAUniProtKB-KW:KW-0539150520179 UniProtGO_REF:0000043
TMEM109Humansarcoplasmic reticulum located_inIEAUniProtKB-KW:KW-0703150520179 UniProtGO_REF:0000043
TMEM109Humansarcoplasmic reticulum membrane located_inIEAUniProtKB-SubCell:SL-0241150520179 UniProtGO_REF:0000044
TMEM109Humansarcoplasmic reticulum membrane located_inISSUniProtKB:O77751150520179 UniProtGO_REF:0000024
1 to 10 of 10 rows

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
TMEM109Humanprotein binding enablesIPIUniProtKB:O14880|UniProtKB:O43278-2|UniProtKB:O43315|UniProtKB:P27105|UniProtKB:P41181|UniProtKB:Q05940|UniProtKB:Q13113|UniProtKB:Q4KMG9|UniProtKB:Q8NBJ4|UniProtKB:Q8TED1|UniProtKB:Q96HE8|UniProtKB:Q96K19-5|UniProtKB:Q9H2K0|UniProtKB:Q9NR31|UniProtKB:Q9Y282150520179 PMID:32296183IntActPMID:32296183
TMEM109Humanvoltage-gated monoatomic cation channel activity enablesISSUniProtKB:O77751150520179 UniProtGO_REF:0000024

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
TMEM109HumanIntellectual disability  IAGPRGD:427234668554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 

#
Reference Title
Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:8619474   PMID:9110174   PMID:12477932   PMID:15489334   PMID:18022941   PMID:18029348   PMID:19199708   PMID:20060811   PMID:20360068   PMID:20458337   PMID:21873635   PMID:22810586  
PMID:23269685   PMID:23376485   PMID:23542032   PMID:23686814   PMID:24623722   PMID:25959826   PMID:25963833   PMID:26186194   PMID:26209915   PMID:26496610   PMID:26638075   PMID:27025967  
PMID:28225217   PMID:29117863   PMID:29128334   PMID:29180619   PMID:29395067   PMID:29509190   PMID:29961565   PMID:30021884   PMID:30194290   PMID:30804502   PMID:30833792   PMID:31056421  
PMID:31073040   PMID:31091453   PMID:31501420   PMID:31536960   PMID:31617661   PMID:31871319   PMID:32129710   PMID:32296183   PMID:32344865   PMID:32687490   PMID:32707033   PMID:32788342  
PMID:32989298   PMID:33545068   PMID:33729478   PMID:33961781   PMID:34079125   PMID:34186245   PMID:34349018   PMID:34597346   PMID:34709727   PMID:34732716   PMID:34917906   PMID:35271311  
PMID:35696571   PMID:35850772   PMID:35906200   PMID:35941108   PMID:35993436   PMID:36139500   PMID:36180527   PMID:36215168   PMID:36517590   PMID:36597993   PMID:36610398   PMID:36774506  
PMID:37071682   PMID:37528093   PMID:37774976   PMID:37827155   PMID:39468006  



TMEM109
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381160,914,158 - 60,923,443 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1160,913,907 - 60,923,443 (+)EnsemblGRCh38hg38GRCh38
GRCh371160,681,630 - 60,690,915 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361160,438,253 - 60,447,491 (+)NCBINCBI36Build 36hg18NCBI36
Celera1158,042,259 - 58,051,802 (+)NCBICelera
Cytogenetic Map11q12.2NCBI
HuRef1157,027,540 - 57,037,083 (+)NCBIHuRef
CHM1_11160,547,675 - 60,557,219 (+)NCBICHM1_1
T2T-CHM13v2.01160,865,308 - 60,874,594 (+)NCBIT2T-CHM13v2.0
Tmem109
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391910,848,021 - 10,859,107 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1910,848,024 - 10,859,365 (-)EnsemblGRCm39 Ensembl
GRCm381910,870,657 - 10,881,743 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1910,870,660 - 10,882,001 (-)EnsemblGRCm38mm10GRCm38
MGSCv371910,945,150 - 10,956,233 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361910,937,705 - 10,948,788 (-)NCBIMGSCv36mm8
Celera1911,563,729 - 11,574,942 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map197.29NCBI
Tmem109
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81216,944,516 - 216,955,091 (-)NCBIGRCr8
mRatBN7.21207,519,628 - 207,530,245 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1207,519,624 - 207,530,215 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1215,894,466 - 215,905,041 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01222,955,182 - 222,965,747 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01215,648,854 - 215,659,431 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01226,925,114 - 226,935,710 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1226,925,117 - 226,935,689 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01233,990,663 - 234,001,279 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41213,368,573 - 213,379,148 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11213,527,004 - 213,537,578 (-)NCBI
Celera1205,012,212 - 205,022,789 (-)NCBICelera
Cytogenetic Map1q43NCBI
Tmem109
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555115,562,206 - 5,565,267 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555115,557,322 - 5,564,866 (+)NCBIChiLan1.0ChiLan1.0
TMEM109
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2962,083,184 - 62,092,709 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11163,127,455 - 63,136,746 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01156,177,335 - 56,186,645 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11159,617,802 - 59,627,349 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1159,617,802 - 59,627,349 (+)Ensemblpanpan1.1panPan2
TMEM109
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11855,377,331 - 55,389,810 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1855,363,698 - 55,385,587 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1853,950,499 - 53,963,229 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01856,425,747 - 56,438,173 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1856,425,747 - 56,434,036 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11855,483,265 - 55,495,701 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01855,104,766 - 55,117,373 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01855,985,877 - 55,998,618 (-)NCBIUU_Cfam_GSD_1.0
Tmem109
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494711,895,525 - 11,912,018 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365812,009,162 - 2,019,426 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365812,009,357 - 2,019,381 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM109
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl210,828,652 - 10,837,062 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1210,828,644 - 10,837,124 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2210,372,979 - 10,382,064 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM109
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1112,924,736 - 12,934,755 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl112,924,606 - 12,934,810 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038110,293,096 - 110,302,880 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem109
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624926278,541 - 285,934 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624926278,602 - 285,772 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in TMEM109
21 total Variants

1 to 10 of 36 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11q12.1-12.3(chr11:58935215-62177656)x3 copy number gain not provided [RCV000683362] Chr11:58935215..62177656 [GRCh37]
Chr11:11q12.1-12.3
likely pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11q12.2(chr11:60690580-60708611)x3 copy number gain not provided [RCV000737540] Chr11:60690580..60708611 [GRCh37]
Chr11:11q12.2
benign
GRCh37/hg19 11q12.2(chr11:60499486-61529578)x3 copy number gain not provided [RCV000848682] Chr11:60499486..61529578 [GRCh37]
Chr11:11q12.2
uncertain significance
NM_024092.3(TMEM109):c.307G>A (p.Ala103Thr) single nucleotide variant not specified [RCV004290804] Chr11:60920955 [GRCh38]
Chr11:60688427 [GRCh37]
Chr11:11q12.2
uncertain significance
GRCh37/hg19 11q12.2-12.3(chr11:60385382-62456278)x3 copy number gain not provided [RCV001006412] Chr11:60385382..62456278 [GRCh37]
Chr11:11q12.2-12.3
uncertain significance
1 to 10 of 36 rows

Predicted Target Of
Summary Value
Count of predictions:1825
Count of miRNA genes:657
Interacting mature miRNAs:770
Transcripts:ENST00000227525, ENST00000536171, ENST00000540280
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
407298948GWAS947924_Hblood protein measurement QTL GWAS947924 (human)5e-113blood protein amount (VT:0005416)blood protein measurement (CMO:0000028)116092197360921974Human
597301327GWAS1397401_Htransmembrane protein 132A measurement QTL GWAS1397401 (human)3e-92transmembrane protein 132A measurement116092197360921974Human
597123611GWAS1219685_Hblood protein measurement QTL GWAS1219685 (human)2e-199blood protein amount (VT:0005416)blood protein measurement (CMO:0000028)116092197360921974Human
597177814GWAS1273888_Htransmembrane protein 132A measurement QTL GWAS1273888 (human)2e-477transmembrane protein 132A measurement116092197360921974Human

WI-12296  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371160,690,710 - 60,690,859UniSTSGRCh37
Build 361160,447,286 - 60,447,435RGDNCBI36
Celera1158,051,597 - 58,051,746RGD
Cytogenetic Map11q12.2UniSTS
HuRef1157,036,878 - 57,037,027UniSTS
GeneMap99-GB4 RH Map11227.83UniSTS
Whitehead-RH Map11289.1UniSTS
NCBI RH Map11557.1UniSTS
RH11560  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371160,689,746 - 60,689,853UniSTSGRCh37
Build 361160,446,322 - 60,446,429RGDNCBI36
Celera1158,050,633 - 58,050,740RGD
Cytogenetic Map11q12.2UniSTS
HuRef1157,035,914 - 57,036,021UniSTS
GeneMap99-GB4 RH Map11227.42UniSTS
NCBI RH Map11496.8UniSTS
RH121096  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371160,687,212 - 60,687,536UniSTSGRCh37
Build 361160,443,788 - 60,444,112RGDNCBI36
Celera1158,048,099 - 58,048,423RGD
Cytogenetic Map11q12.2UniSTS
HuRef1157,033,380 - 57,033,704UniSTS
TNG Radiation Hybrid Map1126705.0UniSTS
D11S2290E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371160,690,637 - 60,690,755UniSTSGRCh37
Build 361160,447,213 - 60,447,331RGDNCBI36
Celera1158,051,524 - 58,051,642RGD
Cytogenetic Map11q12.2UniSTS
HuRef1157,036,805 - 57,036,923UniSTS
GeneMap99-GB4 RH Map11227.73UniSTS
G30169  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371160,689,660 - 60,689,785UniSTSGRCh37
Build 361160,446,236 - 60,446,361RGDNCBI36
Celera1158,050,547 - 58,050,672RGD
Cytogenetic Map11q12.2UniSTS
HuRef1157,035,828 - 57,035,953UniSTS
D11S2248E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371160,689,748 - 60,689,852UniSTSGRCh37
Build 361160,446,324 - 60,446,428RGDNCBI36
Celera1158,050,635 - 58,050,739RGD
Cytogenetic Map11q12.2UniSTS
HuRef1157,035,916 - 57,036,020UniSTS
GeneMap99-GB4 RH Map11227.83UniSTS
NCBI RH Map11557.1UniSTS




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2438 2788 2253 4965 1725 2351 5 624 1951 465 2268 7305 6471 53 3727 1 852 1744 1617 175 1



Ensembl Acc Id: ENST00000227525   ⟹   ENSP00000227525
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1160,914,158 - 60,923,443 (+)Ensembl
Ensembl Acc Id: ENST00000536171   ⟹   ENSP00000443990
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1160,919,678 - 60,923,376 (+)Ensembl
Ensembl Acc Id: ENST00000540280
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1160,922,618 - 60,923,443 (+)Ensembl
Ensembl Acc Id: ENST00000715796   ⟹   ENSP00000520520
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1160,913,907 - 60,923,443 (+)Ensembl
RefSeq Acc Id: NM_024092   ⟹   NP_076997
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381160,914,158 - 60,923,443 (+)NCBI
GRCh371160,681,351 - 60,690,915 (+)NCBI
Build 361160,438,253 - 60,447,491 (+)NCBI Archive
Celera1158,042,259 - 58,051,802 (+)RGD
HuRef1157,027,540 - 57,037,083 (+)RGD
CHM1_11160,547,675 - 60,557,219 (+)NCBI
T2T-CHM13v2.01160,865,308 - 60,874,594 (+)NCBI
Sequence:
1 to 11 of 11 rows
Protein RefSeqs NP_076997 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH01309 (Get FASTA)   NCBI Sequence Viewer  
  BAG36636 (Get FASTA)   NCBI Sequence Viewer  
  BAG64885 (Get FASTA)   NCBI Sequence Viewer  
  CAE11624 (Get FASTA)   NCBI Sequence Viewer  
  CAE11625 (Get FASTA)   NCBI Sequence Viewer  
  EAW73906 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000227525
  ENSP00000227525.3
  ENSP00000443990.1
GenBank Protein Q9BVC6 (Get FASTA)   NCBI Sequence Viewer  
1 to 11 of 11 rows
RefSeq Acc Id: NP_076997   ⟸   NM_024092
- Peptide Label: precursor
- UniProtKB: Q9BVC6 (UniProtKB/Swiss-Prot),   B2R9T9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000227525   ⟸   ENST00000227525
Ensembl Acc Id: ENSP00000443990   ⟸   ENST00000536171
Ensembl Acc Id: ENSP00000520520   ⟸   ENST00000715796

Name Modeler Protein Id AA Range Protein Structure
AF-Q9BVC6-F1-model_v2 AlphaFold Q9BVC6 1-243 view protein structure

RGD ID:6789435
Promoter ID:HG_KWN:13031
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:UC001NQG.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361160,437,854 - 60,438,354 (+)MPROMDB
RGD ID:6789436
Promoter ID:HG_KWN:13032
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell_12Hour
Transcripts:UC001NQH.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361160,443,576 - 60,444,076 (+)MPROMDB
RGD ID:7220499
Promoter ID:EPDNEW_H15995
Type:initiation region
Name:TMEM109_2
Description:transmembrane protein 109
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H15996  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381160,913,953 - 60,914,013EPDNEW
RGD ID:7220501
Promoter ID:EPDNEW_H15996
Type:initiation region
Name:TMEM109_1
Description:transmembrane protein 109
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H15995  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381160,914,176 - 60,914,236EPDNEW


1 to 18 of 18 rows
Database
Acc Id
Source(s)
COSMIC TMEM109 COSMIC
Ensembl Genes ENSG00000110108 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000227525 ENTREZGENE
  ENST00000227525.8 UniProtKB/Swiss-Prot
  ENST00000536171.1 UniProtKB/Swiss-Prot
GTEx ENSG00000110108 GTEx
HGNC ID HGNC:28771 ENTREZGENE
Human Proteome Map TMEM109 Human Proteome Map
InterPro TMEM109 UniProtKB/Swiss-Prot
KEGG Report hsa:79073 UniProtKB/Swiss-Prot
NCBI Gene 79073 ENTREZGENE
OMIM 619168 OMIM
PANTHER PTHR14550 UniProtKB/Swiss-Prot
  TRANSMEMBRANE PROTEIN 109 UniProtKB/Swiss-Prot
Pfam BRI3BP UniProtKB/Swiss-Prot
PharmGKB PA142670760 PharmGKB
UniProt B2R9T9 ENTREZGENE, UniProtKB/TrEMBL
  Q9BVC6 ENTREZGENE, UniProtKB/Swiss-Prot
1 to 18 of 18 rows