Celf5 (CUGBP, Elav-like family member 5) - Rat Genome Database

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Gene: Celf5 (CUGBP, Elav-like family member 5) Rattus norvegicus
Analyze
Symbol: Celf5
Name: CUGBP, Elav-like family member 5
RGD ID: 1565016
Description: Predicted to enable mRNA binding activity. Predicted to be involved in mRNA splice site selection and regulation of alternative mRNA splicing, via spliceosome. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human CELF5 (CUGBP Elav-like family member 5); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: bruno-like 5, RNA binding protein; bruno-like 5, RNA binding protein (Drosophila); Brunol5; CUG-BP- and ETR-3-like factor 5; CUGBP Elav-like family member 5; LOC314647; RGD1565016; similar to bruno-like 5, RNA binding protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.278,225,787 - 8,250,322 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,225,825 - 8,250,322 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx711,111,860 - 11,136,274 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0712,987,344 - 13,011,759 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0710,854,468 - 10,879,038 (+)NCBIRnor_WKY
Rnor_6.0711,095,449 - 11,119,941 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,095,468 - 11,119,941 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,262,391 - 11,287,130 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.479,709,875 - 9,735,811 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera76,416,360 - 6,439,598 (+)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11158314  


Genomics

Comparative Map Data
Celf5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.278,225,787 - 8,250,322 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,225,825 - 8,250,322 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx711,111,860 - 11,136,274 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0712,987,344 - 13,011,759 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0710,854,468 - 10,879,038 (+)NCBIRnor_WKY
Rnor_6.0711,095,449 - 11,119,941 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,095,468 - 11,119,941 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,262,391 - 11,287,130 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.479,709,875 - 9,735,811 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera76,416,360 - 6,439,598 (+)NCBICelera
Cytogenetic Map7q11NCBI
CELF5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38193,224,661 - 3,297,076 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl193,224,661 - 3,297,076 (+)EnsemblGRCh38hg38GRCh38
GRCh37193,224,659 - 3,297,074 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36193,175,701 - 3,248,074 (+)NCBINCBI36Build 36hg18NCBI36
Build 34193,175,700 - 3,248,071NCBI
Celera193,161,110 - 3,233,889 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef192,992,255 - 3,064,363 (+)NCBIHuRef
CHM1_1193,224,288 - 3,296,678 (+)NCBICHM1_1
T2T-CHM13v2.0193,199,540 - 3,272,447 (+)NCBIT2T-CHM13v2.0
Celf5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391081,295,061 - 81,318,564 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1081,295,061 - 81,318,543 (-)EnsemblGRCm39 Ensembl
GRCm381081,459,227 - 81,482,730 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1081,459,227 - 81,482,709 (-)EnsemblGRCm38mm10GRCm38
MGSCv371080,921,973 - 80,945,454 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361080,865,343 - 80,885,807 (-)NCBIMGSCv36mm8
Celera1082,482,165 - 82,506,092 (-)NCBICelera
Cytogenetic Map10C1NCBI
Celf5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554955,185,126 - 5,214,718 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554955,182,758 - 5,214,724 (-)NCBIChiLan1.0ChiLan1.0
CELF5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1193,230,999 - 3,274,900 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0192,250,694 - 2,278,961 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CELF5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12056,027,245 - 56,075,579 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2056,029,575 - 56,075,948 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2055,751,352 - 55,799,556 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02056,686,152 - 56,734,387 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2056,686,738 - 56,734,681 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12055,741,712 - 55,789,866 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02056,225,332 - 56,273,852 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02056,424,157 - 56,472,338 (-)NCBIUU_Cfam_GSD_1.0
Celf5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118215,947,705 - 215,982,648 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365881,852,126 - 1,887,240 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365881,864,793 - 1,887,082 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CELF5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl275,314,834 - 75,364,103 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1275,314,808 - 75,364,189 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2275,956,800 - 75,987,394 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CELF5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.162,988,764 - 3,065,099 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660815,518,308 - 5,594,527 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Celf5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248285,982,552 - 6,005,839 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248285,980,299 - 6,015,202 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Celf5
101 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:393
Count of miRNA genes:224
Interacting mature miRNAs:290
Transcripts:ENSRNOT00000061219
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 69 2
Low 3 2 20 14 12 14 5 18 34 3
Below cutoff 35 28 18 7 18 7 8 13 5 8 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000061219   ⟹   ENSRNOP00000057932
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl78,225,825 - 8,250,322 (+)Ensembl
Rnor_6.0 Ensembl711,095,468 - 11,119,941 (+)Ensembl
RefSeq Acc Id: NM_001135603   ⟹   NP_001129075
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,225,825 - 8,250,322 (+)NCBI
Rnor_6.0711,095,468 - 11,119,941 (+)NCBI
Rnor_5.0711,262,391 - 11,287,130 (+)NCBI
RGSC_v3.479,709,875 - 9,735,811 (+)RGD
Celera76,416,360 - 6,439,598 (+)RGD
Sequence:
RefSeq Acc Id: XM_006240942   ⟹   XP_006241004
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,225,787 - 8,250,322 (+)NCBI
Rnor_6.0711,095,449 - 11,119,941 (+)NCBI
Rnor_5.0711,262,391 - 11,287,130 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008765104   ⟹   XP_008763326
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,236,655 - 8,250,322 (+)NCBI
Rnor_6.0711,106,303 - 11,119,941 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008765105   ⟹   XP_008763327
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,226,391 - 8,250,322 (+)NCBI
Rnor_6.0711,096,080 - 11,119,941 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594819   ⟹   XP_017450308
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,225,787 - 8,250,322 (+)NCBI
Rnor_6.0711,095,449 - 11,119,941 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039079023   ⟹   XP_038934951
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,225,787 - 8,250,322 (+)NCBI
RefSeq Acc Id: XM_039079024   ⟹   XP_038934952
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,236,255 - 8,250,322 (+)NCBI
RefSeq Acc Id: XM_039079025   ⟹   XP_038934953
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,236,255 - 8,250,322 (+)NCBI
RefSeq Acc Id: XM_039079026   ⟹   XP_038934954
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,236,255 - 8,250,322 (+)NCBI
RefSeq Acc Id: XM_039079027   ⟹   XP_038934955
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,236,655 - 8,250,322 (+)NCBI
RefSeq Acc Id: XM_039079028   ⟹   XP_038934956
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,236,655 - 8,250,322 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001129075   ⟸   NM_001135603
- UniProtKB: D4A8V0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241004   ⟸   XM_006240942
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008763327   ⟸   XM_008765105
- Peptide Label: isoform X9
- Sequence:
RefSeq Acc Id: XP_008763326   ⟸   XM_008765104
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_017450308   ⟸   XM_017594819
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000057932   ⟸   ENSRNOT00000061219
RefSeq Acc Id: XP_038934951   ⟸   XM_039079023
- Peptide Label: isoform X1
- UniProtKB: D4A8V0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934952   ⟸   XM_039079024
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038934953   ⟸   XM_039079025
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038934954   ⟸   XM_039079026
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038934955   ⟸   XM_039079027
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038934956   ⟸   XM_039079028
- Peptide Label: isoform X10
Protein Domains
RRM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A8V0-F1-model_v2 AlphaFold D4A8V0 1-395 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565016 AgrOrtholog
BioCyc Gene G2FUF-35035 BioCyc
Ensembl Genes ENSRNOG00000004695 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000057932 ENTREZGENE
  ENSRNOP00000057932.3 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000061219 ENTREZGENE
  ENSRNOT00000061219.3 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.330 UniProtKB/TrEMBL
InterPro CELF3/4/5/6_RRM1 UniProtKB/TrEMBL
  Nucleotide-bd_a/b_plait_sf UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/TrEMBL
  RRM_RNP1 UniProtKB/TrEMBL
KEGG Report rno:314647 UniProtKB/TrEMBL
NCBI Gene 314647 ENTREZGENE
Pfam RRM_1 UniProtKB/TrEMBL
PhenoGen Celf5 PhenoGen
PROSITE RRM UniProtKB/TrEMBL
SMART RRM UniProtKB/TrEMBL
Superfamily-SCOP SSF54928 UniProtKB/TrEMBL
UniProt D4A8V0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-28 Celf5  CUGBP, Elav-like family member 5  Brunol5  bruno-like 5, RNA binding protein (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Brunol5  bruno-like 5, RNA binding protein (Drosophila)  RGD1565016_predicted  similar to bruno-like 5, RNA binding protein (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1565016_predicted  similar to bruno-like 5, RNA binding protein (predicted)  LOC314647  similar to bruno-like 5, RNA binding protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC314647  similar to bruno-like 5, RNA binding protein      Symbol and Name status set to provisional 70820 PROVISIONAL