Cep250 (centrosomal protein 250) - Rat Genome Database

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Gene: Cep250 (centrosomal protein 250) Rattus norvegicus
Analyze
Symbol: Cep250
Name: centrosomal protein 250
RGD ID: 1562262
Description: Predicted to enable protein domain specific binding activity. Predicted to be involved in several processes, including centrosome cycle; detection of light stimulus involved in visual perception; and non-motile cilium assembly. Predicted to be located in microtubule organizing center; photoreceptor inner segment; and photoreceptor outer segment. Predicted to be part of protein-containing complex. Predicted to be active in centriole and centrosome. Orthologous to human CEP250 (centrosomal protein 250); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: centrosomal protein 250kDa; centrosome-associated protein CEP250; LOC311573; RGD1562262; similar to centrosomal Nek2-associated protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83164,931,033 - 164,976,210 (+)NCBIGRCr8
mRatBN7.23144,470,946 - 144,516,125 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3144,471,214 - 144,516,125 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.03151,508,366 - 151,544,631 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3151,508,361 - 151,544,674 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03157,871,732 - 157,909,249 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43146,378,670 - 146,407,642 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3143,193,686 - 143,237,883 (+)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:9647649   PMID:10880350   PMID:11076968   PMID:12140259   PMID:15784680   PMID:18851962   PMID:19056867   PMID:19117032   PMID:21399614   PMID:23213374   PMID:23789104   PMID:24421332  
PMID:24554434   PMID:26337392   PMID:27623382   PMID:28005958   PMID:30998843  


Genomics

Comparative Map Data
Cep250
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83164,931,033 - 164,976,210 (+)NCBIGRCr8
mRatBN7.23144,470,946 - 144,516,125 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3144,471,214 - 144,516,125 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.03151,508,366 - 151,544,631 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3151,508,361 - 151,544,674 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03157,871,732 - 157,909,249 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43146,378,670 - 146,407,642 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3143,193,686 - 143,237,883 (+)NCBICelera
Cytogenetic Map3q42NCBI
CEP250
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382035,455,165 - 35,519,280 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2035,455,164 - 35,519,280 (+)EnsemblGRCh38hg38GRCh38
GRCh372034,043,419 - 34,107,108 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362033,506,564 - 33,563,217 (+)NCBINCBI36Build 36hg18NCBI36
Build 342033,506,563 - 33,563,216NCBI
Celera2030,791,817 - 30,848,393 (+)NCBICelera
Cytogenetic Map20q11.22NCBI
HuRef2030,820,686 - 30,877,262 (+)NCBIHuRef
CHM1_12033,944,595 - 34,001,171 (+)NCBICHM1_1
T2T-CHM13v2.02037,175,894 - 37,240,174 (+)NCBIT2T-CHM13v2.0
Cep250
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392155,798,197 - 155,840,820 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2155,798,378 - 155,840,820 (+)EnsemblGRCm39 Ensembl
GRCm382155,956,285 - 155,998,900 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2155,956,458 - 155,998,900 (+)EnsemblGRCm38mm10GRCm38
MGSCv372155,782,294 - 155,824,636 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362155,653,413 - 155,690,144 (+)NCBIMGSCv36mm8
Celera2161,890,406 - 161,932,764 (+)NCBICelera
Cytogenetic Map2H1NCBI
cM Map277.26NCBI
Cep250
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542225,932,377 - 25,978,524 (-)NCBIChiLan1.0ChiLan1.0
CEP250
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22141,187,779 - 41,244,882 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12041,180,882 - 41,245,326 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02031,782,894 - 31,847,152 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12032,903,441 - 32,959,715 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2032,903,536 - 32,959,714 (+)Ensemblpanpan1.1panPan2
CEP250
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12424,411,882 - 24,461,916 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2424,418,859 - 24,461,640 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2424,057,594 - 24,107,149 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02425,104,410 - 25,154,447 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2425,114,422 - 25,154,444 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12424,391,383 - 24,440,881 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02424,485,933 - 24,535,811 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02424,925,394 - 24,975,424 (+)NCBIUU_Cfam_GSD_1.0
Cep250
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640173,418,491 - 173,466,289 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365615,280,959 - 5,322,038 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365615,283,258 - 5,331,688 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CEP250
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1738,810,522 - 38,867,203 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11738,809,724 - 38,872,796 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21743,931,399 - 43,988,115 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CEP250
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1256,361,451 - 56,422,146 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl256,361,483 - 56,421,798 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660872,513,015 - 2,575,540 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cep250
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248423,901,172 - 3,939,526 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248423,900,685 - 3,947,241 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cep250
99 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:125
Count of miRNA genes:64
Interacting mature miRNAs:69
Transcripts:ENSRNOT00000026149, ENSRNOT00000055251, ENSRNOT00000070959
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3121056165145956249Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3140069424146976080Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141339013162184794Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141339236155617360Rat

Markers in Region
BF389198  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera3143,196,535 - 143,196,691UniSTS
RH 3.4 Map31307.3UniSTS
Cytogenetic Map3q42UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 14 17 10 14 10 57 24 34 3
Low 1 29 40 31 5 31 8 11 17 11 7 8 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000055251   ⟹   ENSRNOP00000052126
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3144,471,214 - 144,516,125 (+)Ensembl
Rnor_6.0 Ensembl3151,508,361 - 151,544,674 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000112796   ⟹   ENSRNOP00000087302
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3144,471,214 - 144,483,687 (+)Ensembl
RefSeq Acc Id: NM_001427194   ⟹   NP_001414123
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83164,931,299 - 164,976,210 (+)NCBI
RefSeq Acc Id: XM_039106869   ⟹   XP_038962797
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83164,931,033 - 164,976,210 (+)NCBI
mRatBN7.23144,470,946 - 144,516,125 (+)NCBI
RefSeq Acc Id: XM_039106870   ⟹   XP_038962798
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83164,931,306 - 164,976,210 (+)NCBI
mRatBN7.23144,471,196 - 144,516,125 (+)NCBI
RefSeq Acc Id: XM_039106871   ⟹   XP_038962799
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83164,931,247 - 164,976,210 (+)NCBI
mRatBN7.23144,471,161 - 144,516,125 (+)NCBI
RefSeq Acc Id: XM_039106872   ⟹   XP_038962800
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83164,958,543 - 164,976,210 (+)NCBI
mRatBN7.23144,498,462 - 144,516,125 (+)NCBI
RefSeq Acc Id: XM_063283848   ⟹   XP_063139918
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83164,931,033 - 164,976,210 (+)NCBI
RefSeq Acc Id: XM_063283849   ⟹   XP_063139919
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83164,931,294 - 164,976,210 (+)NCBI
RefSeq Acc Id: XR_005502972
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83164,931,247 - 164,972,036 (+)NCBI
mRatBN7.23144,471,161 - 144,511,951 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000052126   ⟸   ENSRNOT00000055251
RefSeq Acc Id: XP_038962797   ⟸   XM_039106869
- Peptide Label: isoform X1
- UniProtKB: F1M7J7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962799   ⟸   XM_039106871
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038962798   ⟸   XM_039106870
- Peptide Label: isoform X1
- UniProtKB: F1M7J7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962800   ⟸   XM_039106872
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000087302   ⟸   ENSRNOT00000112796
RefSeq Acc Id: XP_063139918   ⟸   XM_063283848
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063139919   ⟸   XM_063283849
- Peptide Label: isoform X2
RefSeq Acc Id: NP_001414123   ⟸   NM_001427194
- UniProtKB: F1M7J7 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M7J7-F1-model_v2 AlphaFold F1M7J7 1-2306 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562262 AgrOrtholog
BioCyc Gene G2FUF-47112 BioCyc
Ensembl Genes ENSRNOG00000019340 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000055251.6 UniProtKB/TrEMBL
  ENSRNOT00000112796.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.1490 UniProtKB/TrEMBL
NCBI Gene 311573 ENTREZGENE
PANTHER CENTROSOMAL PROTEIN 2 UniProtKB/TrEMBL
  CENTROSOME-ASSOCIATED PROTEIN CEP250 UniProtKB/TrEMBL
Pfam Rootletin UniProtKB/TrEMBL
PhenoGen Cep250 PhenoGen
RatGTEx ENSRNOG00000019340 RatGTEx
UniProt A0A8I6A436_RAT UniProtKB/TrEMBL
  F1M7J7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-04-27 Cep250  centrosomal protein 250  Cep250  centrosomal protein 250kDa  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-29 Cep250  centrosomal protein 250kDa  Cep250  centrosomal protein 250  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-29 Cep250  centrosomal protein 250  RGD1562262_predicted  similar to centrosomal Nek2-associated protein 1 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1562262_predicted  similar to centrosomal Nek2-associated protein 1 (predicted)  LOC311573  similar to centrosomal Nek2-associated protein 1  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC311573  similar to centrosomal Nek2-associated protein 1      Symbol and Name status set to provisional 70820 PROVISIONAL