Stard8 (StAR-related lipid transfer domain containing 8) - Rat Genome Database

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Gene: Stard8 (StAR-related lipid transfer domain containing 8) Rattus norvegicus
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Symbol: Stard8
Name: StAR-related lipid transfer domain containing 8
RGD ID: 1560770
Description: Predicted to enable GTPase activator activity. Predicted to be involved in actin cytoskeleton organization and regulation of Rho protein signal transduction. Orthologous to human STARD8 (StAR related lipid transfer domain containing 8); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC312113; RGD1560770; similar to START domain containing 8; StAR-related lipid transfer (START) domain containing 8; stAR-related lipid transfer protein 8; START domain containing 8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X68,119,276 - 68,236,247 (+)NCBIGRCr8
mRatBN7.2X64,079,079 - 64,196,052 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX64,124,574 - 64,196,052 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX65,665,621 - 65,679,569 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X69,165,962 - 69,179,914 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X66,726,912 - 66,740,854 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X68,713,157 - 68,785,046 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX68,713,123 - 68,785,052 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X69,587,772 - 69,659,522 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X87,088,565 - 87,102,511 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX64,551,816 - 64,565,762 (+)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15632090  


Genomics

Comparative Map Data
Stard8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X68,119,276 - 68,236,247 (+)NCBIGRCr8
mRatBN7.2X64,079,079 - 64,196,052 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX64,124,574 - 64,196,052 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX65,665,621 - 65,679,569 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X69,165,962 - 69,179,914 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X66,726,912 - 66,740,854 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X68,713,157 - 68,785,046 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX68,713,123 - 68,785,052 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X69,587,772 - 69,659,522 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X87,088,565 - 87,102,511 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX64,551,816 - 64,565,762 (+)NCBICelera
Cytogenetic MapXq22NCBI
STARD8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X68,647,666 - 68,725,836 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX68,647,666 - 68,725,842 (+)EnsemblGRCh38hg38GRCh38
GRCh37X67,867,508 - 67,945,678 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X67,784,236 - 67,862,403 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X67,650,531 - 67,728,698NCBI
CeleraX68,220,334 - 68,298,611 (+)NCBICelera
Cytogenetic MapXq13.1NCBI
HuRefX61,695,452 - 61,772,608 (+)NCBIHuRef
CHM1_1X67,760,683 - 67,838,871 (+)NCBICHM1_1
T2T-CHM13v2.0X67,081,162 - 67,159,288 (+)NCBIT2T-CHM13v2.0
Stard8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X98,046,539 - 98,118,334 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX98,046,854 - 98,118,334 (+)EnsemblGRCm39 Ensembl
GRCm38X99,002,933 - 99,074,728 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX99,003,248 - 99,074,728 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X96,237,920 - 96,270,067 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X95,245,384 - 95,277,447 (+)NCBIMGSCv36mm8
CeleraX85,983,748 - 86,015,610 (+)NCBICelera
Cytogenetic MapXC3NCBI
cM MapX43.19NCBI
Stard8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554758,245,754 - 8,278,319 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554758,203,624 - 8,278,319 (+)NCBIChiLan1.0ChiLan1.0
STARD8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X68,299,028 - 68,377,083 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X68,302,603 - 68,380,880 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X57,890,362 - 57,968,391 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X67,955,393 - 68,031,958 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX67,954,883 - 68,031,958 (+)Ensemblpanpan1.1panPan2
STARD8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X53,128,122 - 53,211,115 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX53,128,095 - 53,210,852 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX43,953,760 - 44,036,713 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X54,087,072 - 54,170,149 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX54,086,983 - 54,169,887 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X52,061,722 - 52,144,669 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X53,390,428 - 53,473,431 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X53,314,126 - 53,397,128 (+)NCBIUU_Cfam_GSD_1.0
Stard8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X48,876,064 - 48,953,571 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936777323,367 - 358,243 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936777316,332 - 358,241 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STARD8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX54,773,171 - 54,856,711 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X54,773,189 - 54,856,716 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X61,989,481 - 62,001,599 (+)NCBISscrofa10.2Sscrofa10.2susScr3
STARD8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X58,487,688 - 58,569,710 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX58,556,806 - 58,566,551 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666065342,579 - 420,535 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Stard8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248911,508,980 - 1,547,811 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248911,509,113 - 1,540,416 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Stard8
502 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:186
Count of miRNA genes:125
Interacting mature miRNAs:152
Transcripts:ENSRNOT00000043872
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
70221Bp56Blood pressure QTL 564.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X5704214165612192Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 93 10 6 6 3 3 20 93 3 45 3
Low 21 48 217 141 69 141 33 42 229 22 112 21
Below cutoff 30

Sequence


Ensembl Acc Id: ENSRNOT00000043872   ⟹   ENSRNOP00000042131
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX64,124,574 - 64,196,052 (+)Ensembl
Rnor_6.0 EnsemblX68,771,100 - 68,785,046 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000075995   ⟹   ENSRNOP00000067895
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX68,782,872 - 68,783,725 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076690   ⟹   ENSRNOP00000067952
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX68,713,123 - 68,776,156 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000077039   ⟹   ENSRNOP00000068015
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX68,752,597 - 68,783,944 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000081662   ⟹   ENSRNOP00000070263
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX68,774,699 - 68,785,052 (+)Ensembl
RefSeq Acc Id: NM_001107849   ⟹   NP_001101319
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X68,204,224 - 68,235,677 (+)NCBI
mRatBN7.2X64,164,037 - 64,195,484 (+)NCBI
Rnor_6.0X68,771,100 - 68,785,046 (+)NCBI
Rnor_5.0X69,587,772 - 69,659,522 (+)NCBI
RGSC_v3.4X87,088,565 - 87,102,511 (+)RGD
CeleraX64,551,816 - 64,565,762 (+)RGD
Sequence:
RefSeq Acc Id: XM_006257074   ⟹   XP_006257136
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X68,164,740 - 68,236,247 (+)NCBI
mRatBN7.2X64,124,555 - 64,195,530 (+)NCBI
Rnor_6.0X68,713,157 - 68,784,234 (+)NCBI
Rnor_5.0X69,587,772 - 69,659,522 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039099690   ⟹   XP_038955618
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X68,204,730 - 68,236,247 (+)NCBI
mRatBN7.2X64,164,545 - 64,196,052 (+)NCBI
RefSeq Acc Id: XM_039099691   ⟹   XP_038955619
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X68,119,276 - 68,236,247 (+)NCBI
mRatBN7.2X64,079,079 - 64,195,530 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001101319 (Get FASTA)   NCBI Sequence Viewer  
  XP_006257136 (Get FASTA)   NCBI Sequence Viewer  
  XP_038955618 (Get FASTA)   NCBI Sequence Viewer  
  XP_038955619 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL95951 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000042131.4
RefSeq Acc Id: NP_001101319   ⟸   NM_001107849
- UniProtKB: A6IQ62 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257136   ⟸   XM_006257074
- Peptide Label: isoform X2
- UniProtKB: D4A5B9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000042131   ⟸   ENSRNOT00000043872
Ensembl Acc Id: ENSRNOP00000068015   ⟸   ENSRNOT00000077039
Ensembl Acc Id: ENSRNOP00000067895   ⟸   ENSRNOT00000075995
Ensembl Acc Id: ENSRNOP00000070263   ⟸   ENSRNOT00000081662
Ensembl Acc Id: ENSRNOP00000067952   ⟸   ENSRNOT00000076690
RefSeq Acc Id: XP_038955619   ⟸   XM_039099691
- Peptide Label: isoform X3
- UniProtKB: A6IQ62 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955618   ⟸   XM_039099690
- Peptide Label: isoform X1
Protein Domains
Rho-GAP   START

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A5B9-F1-model_v2 AlphaFold D4A5B9 1-1014 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701861
Promoter ID:EPDNEW_R12381
Type:single initiation site
Name:Stard8_1
Description:StAR-related lipid transfer domain containing 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R12382  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X68,713,141 - 68,713,201EPDNEW
RGD ID:13701862
Promoter ID:EPDNEW_R12382
Type:initiation region
Name:Stard8_2
Description:StAR-related lipid transfer domain containing 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R12381  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X68,752,629 - 68,752,689EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560770 AgrOrtholog
BioCyc Gene G2FUF-2156 BioCyc
Ensembl Genes ENSRNOG00000033883 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000043872.5 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.2070 UniProtKB/TrEMBL
  1.10.555.10 UniProtKB/TrEMBL
  3.30.530.20 UniProtKB/TrEMBL
InterPro Rho_GTPase_activation_prot UniProtKB/TrEMBL
  RhoGAP UniProtKB/TrEMBL
  SAM/pointed_sf UniProtKB/TrEMBL
  START-like_dom UniProtKB/TrEMBL
  START_lipid-bd UniProtKB/TrEMBL
NCBI Gene 312113 ENTREZGENE
PANTHER RHO-TYPE GTPASE ACTIVATING PROTEIN UniProtKB/TrEMBL
  STAR-RELATED LIPID TRANSFER PROTEIN 8 UniProtKB/TrEMBL
Pfam RhoGAP UniProtKB/TrEMBL
  START UniProtKB/TrEMBL
PhenoGen Stard8 PhenoGen
PROSITE RHOGAP UniProtKB/TrEMBL
  START UniProtKB/TrEMBL
RatGTEx ENSRNOG00000033883 RatGTEx
SMART RhoGAP UniProtKB/TrEMBL
  START UniProtKB/TrEMBL
Superfamily-SCOP Bet v1-like UniProtKB/TrEMBL
  Rho_GAP UniProtKB/TrEMBL
  SSF47769 UniProtKB/TrEMBL
UniProt A6IQ62 ENTREZGENE, UniProtKB/TrEMBL
  D4A5B9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-12 Stard8  StAR-related lipid transfer domain containing 8  Stard8  StAR-related lipid transfer (START) domain containing 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-23 Stard8  StAR-related lipid transfer (START) domain containing 8  Stard8  START domain containing 8   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Stard8  START domain containing 8   Stard8_predicted  START domain containing 8 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Stard8_predicted  START domain containing 8 (predicted)  RGD1560770_predicted  similar to START domain containing 8 (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1560770_predicted  similar to START domain containing 8 (predicted)  LOC312113  similar to START domain containing 8  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC312113  similar to START domain containing 8      Symbol and Name status set to provisional 70820 PROVISIONAL