C4A (complement C4A (Chido/Rodgers blood group)) - Rat Genome Database

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Gene: C4A (complement C4A (Chido/Rodgers blood group)) Homo sapiens
Analyze
Symbol: C4A
Name: complement C4A (Chido/Rodgers blood group)
RGD ID: 1350864
HGNC Page HGNC:1323
Description: Enables complement component C1q complex binding activity. Involved in complement activation and positive regulation of apoptotic cell clearance. Located in several cellular components, including axon; dendrite; and neuronal cell body. Implicated in Graves' disease; complement component 4a deficiency; renal cell carcinoma; systemic lupus erythematosus; and vitiligo.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: acidic C4; acidic complement C4; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2; C4; C4A anaphylatoxin; C4A2; C4A3; C4A4; C4A6; C4AD; C4S; CO4; complement C4-A; complement C4A (Rodgers blood group); complement component 4a; complement component 4A (Rodgers blood group); CPAMD2; MGC164979; MHC class III region complement; RG; Rodgers form of C4
RGD Orthologs
Mouse
Rat
Bonobo
Squirrel
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38631,982,057 - 32,002,681 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl631,982,057 - 32,002,681 (+)EnsemblGRCh38hg38GRCh38
GRCh37631,949,834 - 31,970,458 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36632,090,549 - 32,111,173 (+)NCBINCBI36Build 36hg18NCBI36
Build 34632,090,549 - 32,111,173NCBI
Celera633,549,596 - 33,570,218 (+)NCBICelera
Cytogenetic Map6p21.33NCBI
HuRef631,736,844 - 31,746,589 (+)NCBIHuRef
CHM1_1631,951,915 - 31,972,655 (+)NCBICHM1_1
T2T-CHM13v2.0631,835,263 - 31,855,887 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
AA amyloidosis  (IAGP)
Abdominal pain  (IAGP)
Abnormal blistering of the skin  (IAGP)
Abnormal myocardium morphology  (IAGP)
Abnormal pigmentation of the oral mucosa  (IAGP)
Abnormal pyramidal sign  (IAGP)
Abnormality of salivation  (IAGP)
Acne  (IAGP)
Alopecia  (IAGP)
Anorexia  (IAGP)
Anti-complement component C1q antibody positivity  (IAGP)
Anti-dsDNA antibody positivity  (IAGP)
Anti-La/SS-B antibody positivity  (IAGP)
Anti-nucleoporin 62 antibody positivity  (IAGP)
Anti-phosphatidic acid antibody positivity  (IAGP)
Anti-ribosome Po antibody positivity  (IAGP)
Anti-Ro52/TRIM21 antibody positivity  (IAGP)
Anti-Sm antibody positivity  (IAGP)
Anti-titin antibody positivity  (IAGP)
Anti-U1 ribonucleoprotein antibody positivity  (IAGP)
Antineutrophil antibody positivity  (IAGP)
Antinuclear antibody positivity  (IAGP)
Aortic regurgitation  (IAGP)
Arterial thrombosis  (IAGP)
Arthralgia  (IAGP)
Arthritis  (IAGP)
Ataxia  (IAGP)
Atypical behavior  (IAGP)
Autosomal recessive inheritance  (IAGP)
Avascular necrosis  (IAGP)
Blindness  (IAGP)
Cataract  (IAGP)
Cerebral ischemia  (IAGP)
Cheilitis  (IAGP)
Chorea  (IAGP)
Confusion  (IAGP)
Cranial nerve paralysis  (IAGP)
Cutaneous photosensitivity  (IAGP)
Decreased circulating complement C3 concentration  (IAGP)
Decreased circulating complement C4 concentration  (IAGP)
Decreased circulating complement C4a concentration  (IAGP)
Depression  (IAGP)
Developmental regression  (IAGP)
Diarrhea  (IAGP)
Discoid lupus rash  (IAGP)
Elevated circulating C-reactive protein concentration  (IAGP)
Elevated erythrocyte sedimentation rate  (IAGP)
Endocarditis  (IAGP)
Epididymitis  (IAGP)
Erythema nodosum  (IAGP)
Fatigue  (IAGP)
Fever  (IAGP)
Gait disturbance  (IAGP)
Gangrene  (IAGP)
Gastrointestinal hemorrhage  (IAGP)
Genital ulcers  (IAGP)
Glomerulonephritis  (IAGP)
Glomerulopathy  (IAGP)
Headache  (IAGP)
Hematuria  (IAGP)
Hemiparesis  (IAGP)
Hemolytic anemia  (IAGP)
Hemoptysis  (IAGP)
Hyperreflexia  (IAGP)
Hypertension  (IAGP)
Immunologic hypersensitivity  (IAGP)
Increased inflammatory response  (IAGP)
Increased intracranial pressure  (IAGP)
Infectious encephalitis  (IAGP)
Irritability  (IAGP)
Keratoconjunctivitis sicca  (IAGP)
Leukopenia  (IAGP)
Lupus nephritis  (IAGP)
Lymphadenopathy  (IAGP)
Malabsorption  (IAGP)
Malaise  (IAGP)
Malar rash  (IAGP)
Memory impairment  (IAGP)
Meningitis  (IAGP)
Migraine  (IAGP)
Mitral regurgitation  (IAGP)
Myalgia  (IAGP)
Myocardial infarction  (IAGP)
Myocarditis  (IAGP)
Myositis  (IAGP)
Nasal congestion  (IAGP)
Nausea and vomiting  (IAGP)
Non-infectious meningitis  (IAGP)
Nongranulomatous uveitis  (IAGP)
Optic neuritis  (IAGP)
Oral ulcer  (IAGP)
Orchitis  (IAGP)
Pancreatitis  (IAGP)
Panuveitis  (IAGP)
Papule  (IAGP)
Paresthesia  (IAGP)
Pericarditis  (IAGP)
Photophobia  (IAGP)
Pleural effusion  (IAGP)
Pleuritis  (IAGP)
Polyarticular arthritis  (IAGP)
Positive pathergy test  (IAGP)
Proteinuria  (IAGP)
Pulmonary embolism  (IAGP)
Pulmonary infiltrates  (IAGP)
Purpura  (IAGP)
Pustule  (IAGP)
Pyuria  (IAGP)
Raynaud phenomenon  (IAGP)
Recurrent aphthous stomatitis  (IAGP)
Recurrent fever  (IAGP)
Reduced circulating CH50 activity  (IAGP)
Renal insufficiency  (IAGP)
Retinopathy  (IAGP)
Retrobulbar optic neuritis  (IAGP)
Rhinorrhea  (IAGP)
Seizure  (IAGP)
Serositis  (IAGP)
Splenomegaly  (IAGP)
Subcutaneous nodule  (IAGP)
Superficial thrombophlebitis  (IAGP)
Systemic lupus erythematosus  (IAGP)
Thrombocytopenia  (IAGP)
Vasculitis  (IAGP)
Venous thrombosis  (IAGP)
Vertigo  (IAGP)
Weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. [Enzyme immunoassay of masked complement component C4 deficiency in patients with urogenital Chlamydia infection]. Gora NV, etal., Zh Mikrobiol Epidemiol Immunobiol. 2011 May-Jun;(3):76-80.
2. [Masked deficiency of C4 component of complement in patients with chronic gastrointestinal tract diseases of different etiology]. Kozlov LV, etal., Zh Mikrobiol Epidemiol Immunobiol. 2011 Jul-Aug;(4):61-5.
3. Association between copy number variation of complement component C4 and Graves' disease. Liu YH, etal., J Biomed Sci. 2011 Sep 26;18:71.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. RGD HPO Phenotype Annotation Pipeline RGD automated import pipeline for human HPO-to-gene-to-disease annotations
8. Immunoglobulins and complement factor C4 in adult rhinosinusitis. Seppanen M, etal., Clin Exp Immunol. 2006 Aug;145(2):219-27.
9. Gene copy-number variation and associated polymorphisms of complement component C4 in human systemic lupus erythematosus (SLE): low copy number is a risk factor for and high copy number is a protective factor against SLE susceptibility in European Americans. Yang Y, etal., Am J Hum Genet. 2007 Jun;80(6):1037-54. Epub 2007 Apr 26.
10. Genetic deficiency of complement isoforms C4A or C4B predicts improved survival of metastatic renal cell carcinoma. Zafar GI, etal., J Urol. 2009 Mar;181(3):1028-34; discussion 1034. Epub 2009 Jan 16.
Additional References at PubMed
PMID:162484   PMID:1573268   PMID:1699796   PMID:1988494   PMID:2304899   PMID:2395880   PMID:2431902   PMID:2612324   PMID:2883116   PMID:3264881   PMID:3542363   PMID:3696167  
PMID:3838531   PMID:3944109   PMID:6019133   PMID:6149580   PMID:6167582   PMID:6316164   PMID:6546707   PMID:6559257   PMID:6572000   PMID:6577433   PMID:6609966   PMID:6832377  
PMID:6881182   PMID:6950384   PMID:6978711   PMID:7391573   PMID:7518568   PMID:7545960   PMID:8012361   PMID:8132574   PMID:8422437   PMID:8473511   PMID:8589688   PMID:8660986  
PMID:9725198   PMID:10072631   PMID:10092831   PMID:10529130   PMID:11168010   PMID:11367523   PMID:11773063   PMID:11803045   PMID:12133986   PMID:12224044   PMID:12226794   PMID:12367531  
PMID:12477932   PMID:12480675   PMID:12754519   PMID:12878586   PMID:12894949   PMID:14574404   PMID:14760718   PMID:15039137   PMID:15166556   PMID:15174051   PMID:15199963   PMID:15787745  
PMID:15794202   PMID:15998580   PMID:16098595   PMID:16335952   PMID:16344560   PMID:16439442   PMID:16502470   PMID:16893076   PMID:16908004   PMID:17132627   PMID:17212707   PMID:17257223  
PMID:17728371   PMID:17921792   PMID:17971360   PMID:18054386   PMID:18058064   PMID:18069935   PMID:18091514   PMID:18360261   PMID:18636124   PMID:19028829   PMID:19035512   PMID:19062096  
PMID:19135723   PMID:19137635   PMID:19167759   PMID:19302245   PMID:19665237   PMID:19913121   PMID:19923011   PMID:20139276   PMID:20346360   PMID:20409594   PMID:20498262   PMID:20506482  
PMID:20628086   PMID:20649895   PMID:20795316   PMID:20936779   PMID:21085669   PMID:21164027   PMID:21345967   PMID:21677994   PMID:21801245   PMID:21857912   PMID:21873635   PMID:21904924  
PMID:22052466   PMID:22074402   PMID:22151770   PMID:22297669   PMID:22387014   PMID:22406254   PMID:22516433   PMID:22616691   PMID:22737222   PMID:22785613   PMID:22837109   PMID:22886582  
PMID:22949645   PMID:23028341   PMID:23031360   PMID:23335107   PMID:23530559   PMID:23533145   PMID:23535732   PMID:23592783   PMID:23708385   PMID:23715124   PMID:23750785   PMID:23911397  
PMID:23918728   PMID:24349192   PMID:24638111   PMID:25544563   PMID:25573496   PMID:25645918   PMID:25744496   PMID:25963833   PMID:26119402   PMID:26186194   PMID:26359802   PMID:26493816  
PMID:26496610   PMID:26595553   PMID:26602146   PMID:26800705   PMID:26814708   PMID:26814963   PMID:27090374   PMID:27252379   PMID:27274010   PMID:27599733   PMID:27758680   PMID:28091899  
PMID:28412283   PMID:28514442   PMID:28697742   PMID:29050534   PMID:29080553   PMID:29299163   PMID:29310738   PMID:29449061   PMID:29507755   PMID:29850970   PMID:29928053   PMID:30026462  
PMID:30041577   PMID:30110629   PMID:30139746   PMID:30413534   PMID:30419947   PMID:30465166   PMID:30933047   PMID:31138153   PMID:31254974   PMID:31272400   PMID:31273033   PMID:31300519  
PMID:31594818   PMID:32132668   PMID:32176739   PMID:32187754   PMID:32499649   PMID:32635880   PMID:32691186   PMID:32807901   PMID:32893787   PMID:32961544   PMID:33133060   PMID:33459487  
PMID:33847947   PMID:33961781   PMID:34299197   PMID:34316702   PMID:34358307   PMID:34456009   PMID:34480088   PMID:34551306   PMID:34552056   PMID:34732716   PMID:35013218   PMID:35017157  
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PMID:36774506   PMID:36882872   PMID:37132043   PMID:37343697   PMID:38113892   PMID:38172120   PMID:38594415   PMID:38777146  


Genomics

Comparative Map Data
C4A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38631,982,057 - 32,002,681 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl631,982,057 - 32,002,681 (+)EnsemblGRCh38hg38GRCh38
GRCh37631,949,834 - 31,970,458 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36632,090,549 - 32,111,173 (+)NCBINCBI36Build 36hg18NCBI36
Build 34632,090,549 - 32,111,173NCBI
Celera633,549,596 - 33,570,218 (+)NCBICelera
Cytogenetic Map6p21.33NCBI
HuRef631,736,844 - 31,746,589 (+)NCBIHuRef
CHM1_1631,951,915 - 31,972,655 (+)NCBICHM1_1
T2T-CHM13v2.0631,835,263 - 31,855,887 (+)NCBIT2T-CHM13v2.0
C4a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391735,028,069 - 35,042,436 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1735,028,069 - 35,042,440 (-)EnsemblGRCm39 Ensembl
GRCm381734,809,092 - 34,823,460 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,809,092 - 34,823,464 (-)EnsemblGRCm38mm10GRCm38
MGSCv371734,946,037 - 34,960,399 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361734,417,150 - 34,431,510 (-)NCBIMGSCv36mm8
Celera1737,904,407 - 37,918,769 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.37NCBI
C4a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8204,010,306 - 4,024,707 (+)NCBIGRCr8
mRatBN7.2204,005,731 - 4,020,083 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,005,731 - 4,020,080 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,705,672 - 4,720,035 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0204,067,420 - 4,081,783 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,604,594 - 4,618,950 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0202,651,599 - 2,678,183 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl202,651,599 - 2,678,141 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0204,754,468 - 4,755,821 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0206,573,225 - 6,587,996 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,106,123 - 4,145,904NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1204,106,391 - 4,316,103NCBI
Celera204,010,655 - 4,024,973 (-)NCBICelera
Cytogenetic Map20p12NCBI
C4A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2546,457,196 - 46,471,450 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1642,418,680 - 42,432,949 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0631,648,710 - 31,655,792 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
LOC101975827
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494635,991,270 - 36,005,133 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049367271,556,204 - 1,570,084 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0

Variants

.
Variants in C4A
37 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_007293.3(C4A):c.3694_3695dup (p.Val1233fs) duplication Complement component 4a deficiency [RCV000018583]|not provided [RCV003430638] Chr6:31996844..31996845 [GRCh38]
Chr6:31964621..31964622 [GRCh37]
Chr6:6p21.33		 pathogenic|benign
NM_007293.3(C4A):c.723dup (p.Glu242Ter) duplication C4a deficiency [RCV001292793] Chr6:31983848..31983849 [GRCh38]
Chr6:31951625..31951626 [GRCh37]
Chr6:6p21.33		 pathogenic
GRCh38/hg38 6p21.33(chr6:31996089-32041483)x1 copy number loss See cases [RCV000136232] Chr6:31996089..32041483 [GRCh38]
Chr6:31963866..32009260 [GRCh37]
Chr6:32071845..32117239 [NCBI36]
Chr6:6p21.33		 benign
GRCh38/hg38 6p21.33(chr6:31996044-32040241)x3 copy number gain See cases [RCV000138685] Chr6:31996044..32040241 [GRCh38]
Chr6:31963821..32008018 [GRCh37]
Chr6:32071800..32115997 [NCBI36]
Chr6:6p21.33		 likely benign
GRCh38/hg38 6p21.33(chr6:31980353-32041234)x3 copy number gain See cases [RCV000139532] Chr6:31980353..32041234 [GRCh38]
Chr6:31948130..32009011 [GRCh37]
Chr6:32056109..32116990 [NCBI36]
Chr6:6p21.33		 likely benign
GRCh38/hg38 6p21.33(chr6:31971993-32012974)x1 copy number loss See cases [RCV000141578] Chr6:31971993..32012974 [GRCh38]
Chr6:31939770..31980751 [GRCh37]
Chr6:32047749..32088729 [NCBI36]
Chr6:6p21.33		 benign
GRCh38/hg38 6p21.33(chr6:31980422-32041505)x1 copy number loss See cases [RCV000141496] Chr6:31980422..32041505 [GRCh38]
Chr6:31948199..32009282 [GRCh37]
Chr6:32056178..32117261 [NCBI36]
Chr6:6p21.33		 benign
GRCh38/hg38 6p21.33(chr6:31996044-32041234)x3 copy number gain See cases [RCV000143035] Chr6:31996044..32041234 [GRCh38]
Chr6:31963821..32009011 [GRCh37]
Chr6:32071800..32116990 [NCBI36]
Chr6:6p21.33		 likely benign
GRCh38/hg38 6p21.33(chr6:31996044-32040430)x3 copy number gain See cases [RCV000142859] Chr6:31996044..32040430 [GRCh38]
Chr6:31963821..32008207 [GRCh37]
Chr6:32071800..32116186 [NCBI36]
Chr6:6p21.33		 likely benign
GRCh38/hg38 6p21.33(chr6:31996044-32040430)x1 copy number loss See cases [RCV000142860] Chr6:31996044..32040430 [GRCh38]
Chr6:31963821..32008207 [GRCh37]
Chr6:32071800..32116186 [NCBI36]
Chr6:6p21.33		 likely benign
GRCh38/hg38 6p25.3-12.3(chr6:156974-46789291)x3 copy number gain See cases [RCV000143497] Chr6:156974..46789291 [GRCh38]
Chr6:156974..46757028 [GRCh37]
Chr6:101974..46864987 [NCBI36]
Chr6:6p25.3-12.3		 pathogenic
NM_007293.3(C4A):c.2539G>T (p.Glu847Ter) single nucleotide variant not provided [RCV000722687] Chr6:31994331 [GRCh38]
Chr6:31962108 [GRCh37]
Chr6:6p21.33		 uncertain significance
GRCh37/hg19 6p21.33-21.32(chr6:31952482-32243155)x4 copy number gain See cases [RCV000446740] Chr6:31952482..32243155 [GRCh37]
Chr6:6p21.33-21.32		 uncertain significance
GRCh37/hg19 6p21.33(chr6:31969589-32007227) copy number loss Abnormal esophagus morphology [RCV000416642] Chr6:31969589..32007227 [GRCh37]
Chr6:6p21.33		 benign
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
NM_007293.3(C4A):c.2605G>A (p.Val869Met) single nucleotide variant Inborn genetic diseases [RCV003300058] Chr6:31994510 [GRCh38]
Chr6:31962287 [GRCh37]
Chr6:6p21.33		 uncertain significance
GRCh37/hg19 6p22.1-q14.1(chr6:29455465-81447367) copy number gain not provided [RCV000767714] Chr6:29455465..81447367 [GRCh37]
Chr6:6p22.1-q14.1		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p22.1-21.32(chr6:28130359-32108367)x3 copy number gain not provided [RCV000745592] Chr6:28130359..32108367 [GRCh37]
Chr6:6p22.1-21.32		 uncertain significance
GRCh37/hg19 6p21.33-21.31(chr6:31036397-34088832)x3 copy number gain not provided [RCV001005791] Chr6:31036397..34088832 [GRCh37]
Chr6:6p21.33-21.31		 likely pathogenic
NM_007293.3(C4A):c.2711C>T (p.Thr904Met) single nucleotide variant Inborn genetic diseases [RCV003240433] Chr6:31994616 [GRCh38]
Chr6:31962393 [GRCh37]
Chr6:6p21.33		 uncertain significance
NM_007293.3(C4A):c.3218A>G (p.Asp1073Gly) single nucleotide variant not provided [RCV001723475] Chr6:31995782 [GRCh38]
Chr6:31963559 [GRCh37]
Chr6:6p21.33		 benign|likely benign
NM_007293.3(C4A):c.3856T>G (p.Ser1286Ala) single nucleotide variant not specified [RCV001529798] Chr6:31997008 [GRCh38]
Chr6:31964785 [GRCh37]
Chr6:6p21.33		 benign
GRCh37/hg19 6p21.33-21.32(chr6:31916915-32278000)x3 copy number gain not provided [RCV001005792] Chr6:31916915..32278000 [GRCh37]
Chr6:6p21.33-21.32		 uncertain significance
NM_007293.3(C4A):c.3358C>A (p.Pro1120Thr) single nucleotide variant not provided [RCV001702273] Chr6:31996082 [GRCh38]
Chr6:31963859 [GRCh37]
Chr6:6p21.33		 likely benign
NM_007293.3(C4A):c.1040C>A (p.Ser347Tyr) single nucleotide variant not specified [RCV001537850] Chr6:31984403 [GRCh38]
Chr6:31952180 [GRCh37]
Chr6:6p21.33		 benign
NM_007293.3(C4A):c.4876+50C>T single nucleotide variant not specified [RCV001261655] Chr6:32001644 [GRCh38]
Chr6:31969421 [GRCh37]
Chr6:6p21.33		 benign
NM_007293.3(C4A):c.2944+55T>C single nucleotide variant not provided [RCV004707578]|not specified [RCV001261654] Chr6:31995249 [GRCh38]
Chr6:31963026 [GRCh37]
Chr6:6p21.33		 benign|likely benign
NM_007293.3(C4A):c.1045+70G>A single nucleotide variant not specified [RCV001261642] Chr6:31984478 [GRCh38]
Chr6:31952255 [GRCh37]
Chr6:6p21.33		 benign
NM_007293.3(C4A):c.1524+23C>A single nucleotide variant not specified [RCV001261653] Chr6:31991937 [GRCh38]
Chr6:31959714 [GRCh37]
Chr6:6p21.33		 benign
NM_007293.3(C4A):c.5064G>A (p.Leu1688=) single nucleotide variant not specified [RCV001261656] Chr6:32002226 [GRCh38]
Chr6:31970003 [GRCh37]
Chr6:6p21.33		 pathogenic|benign
NM_007293.3(C4A):c.4832del (p.Gly1611fs) deletion C4a deficiency [RCV001292876] Chr6:32001549 [GRCh38]
Chr6:31969326 [GRCh37]
Chr6:6p21.33		 pathogenic
NM_007293.2:c.3392delG deletion C4a deficiency [RCV001335543] Chr6:31996206 [GRCh38]
Chr6:31963983 [GRCh37]
Chr6:6p21.33		 pathogenic
NM_007293.3(C4A):c.3453T>G (p.His1151Gln) single nucleotide variant Complement component 4a deficiency [RCV001337079] Chr6:31996272 [GRCh38]
Chr6:31964049 [GRCh37]
Chr6:6p21.33		 uncertain significance
NM_007293.3(C4A):c.3059C>T (p.Pro1020Leu) single nucleotide variant Complement component 4a deficiency [RCV001330377] Chr6:31995444 [GRCh38]
Chr6:31963221 [GRCh37]
Chr6:6p21.33		 uncertain significance
GRCh37/hg19 6p21.33-21.32(chr6:31952482-32243155) copy number gain not specified [RCV002053565] Chr6:31952482..32243155 [GRCh37]
Chr6:6p21.33-21.32		 uncertain significance
NC_000006.11:g.(?_30695893)_(36953949_?)dup duplication Proteasome-associated autoinflammatory syndrome 1 [RCV003113679] Chr6:30695893..36953949 [GRCh37]
Chr6:6p21.33-21.2		 uncertain significance
NM_007293.3(C4A):c.4054C>A (p.Arg1352Ser) single nucleotide variant Inborn genetic diseases [RCV002773417] Chr6:31997288 [GRCh38]
Chr6:31965065 [GRCh37]
Chr6:6p21.33		 uncertain significance
NM_007293.3(C4A):c.2722G>A (p.Ala908Thr) single nucleotide variant Inborn genetic diseases [RCV002694076] Chr6:31994627 [GRCh38]
Chr6:31962404 [GRCh37]
Chr6:6p21.33		 uncertain significance
NM_007293.3(C4A):c.2741T>G (p.Val914Gly) single nucleotide variant Inborn genetic diseases [RCV002925372] Chr6:31994646 [GRCh38]
Chr6:31962423 [GRCh37]
Chr6:6p21.33		 uncertain significance
NM_007293.3(C4A):c.3640C>T (p.His1214Tyr) single nucleotide variant Inborn genetic diseases [RCV002713688] Chr6:31996564 [GRCh38]
Chr6:31964341 [GRCh37]
Chr6:6p21.33		 uncertain significance
NM_007293.3(C4A):c.2877A>C (p.Glu959Asp) single nucleotide variant Inborn genetic diseases [RCV002804919] Chr6:31995127 [GRCh38]
Chr6:31962904 [GRCh37]
Chr6:6p21.33		 likely benign
NM_007293.3(C4A):c.2477A>G (p.Gln826Arg) single nucleotide variant Inborn genetic diseases [RCV002804313] Chr6:31994269 [GRCh38]
Chr6:31962046 [GRCh37]
Chr6:6p21.33		 likely benign
NM_007293.3(C4A):c.3269A>G (p.Gln1090Arg) single nucleotide variant Inborn genetic diseases [RCV002915975] Chr6:31995993 [GRCh38]
Chr6:31963770 [GRCh37]
Chr6:6p21.33		 uncertain significance
NM_007293.3(C4A):c.3500G>C (p.Arg1167Thr) single nucleotide variant Inborn genetic diseases [RCV002919956] Chr6:31996319 [GRCh38]
Chr6:31964096 [GRCh37]
Chr6:6p21.33		 uncertain significance
NM_007293.3(C4A):c.3215G>A (p.Arg1072Gln) single nucleotide variant Inborn genetic diseases [RCV002855444] Chr6:31995779 [GRCh38]
Chr6:31963556 [GRCh37]
Chr6:6p21.33		 uncertain significance
NM_007293.3(C4A):c.3442G>A (p.Ala1148Thr) single nucleotide variant Inborn genetic diseases [RCV003209507] Chr6:31996261 [GRCh38]
Chr6:31964038 [GRCh37]
Chr6:6p21.33		 uncertain significance
NM_007293.3(C4A):c.3775G>A (p.Ala1259Thr) single nucleotide variant Inborn genetic diseases [RCV003220036] Chr6:31996927 [GRCh38]
Chr6:31964704 [GRCh37]
Chr6:6p21.33		 uncertain significance
NM_007293.3(C4A):c.3364C>T (p.Pro1122Ser) single nucleotide variant Inborn genetic diseases [RCV003208328] Chr6:31996088 [GRCh38]
Chr6:31963865 [GRCh37]
Chr6:6p21.33		 uncertain significance
NM_007293.3(C4A):c.3614C>T (p.Ala1205Val) single nucleotide variant Inborn genetic diseases [RCV003305290] Chr6:31996538 [GRCh38]
Chr6:31964315 [GRCh37]
Chr6:6p21.33		 uncertain significance
NM_007293.3(C4A):c.3185C>T (p.Ala1062Val) single nucleotide variant Inborn genetic diseases [RCV003349339] Chr6:31995749 [GRCh38]
Chr6:31963526 [GRCh37]
Chr6:6p21.33		 uncertain significance
NM_007293.3(C4A):c.3742C>T (p.Arg1248Cys) single nucleotide variant Inborn genetic diseases [RCV003354954] Chr6:31996894 [GRCh38]
Chr6:31964671 [GRCh37]
Chr6:6p21.33		 uncertain significance
NM_007293.3(C4A):c.3351C>T (p.Phe1117=) single nucleotide variant not provided [RCV003428812] Chr6:31996075 [GRCh38]
Chr6:31963852 [GRCh37]
Chr6:6p21.33		 uncertain significance
NM_007293.3(C4A):c.3505-8T>C single nucleotide variant not provided [RCV003431774] Chr6:31996421 [GRCh38]
Chr6:31964198 [GRCh37]
Chr6:6p21.33		 likely benign
NM_007293.3(C4A):c.3200C>A (p.Ala1067Glu) single nucleotide variant not provided [RCV003885295] Chr6:31995764 [GRCh38]
Chr6:31963541 [GRCh37]
Chr6:6p21.33		 uncertain significance
NM_007293.3(C4A):c.2777C>T (p.Ala926Val) single nucleotide variant Inborn genetic diseases [RCV004429800] Chr6:31994682 [GRCh38]
Chr6:31962459 [GRCh37]
Chr6:6p21.33		 uncertain significance
NM_007293.3(C4A):c.3226A>G (p.Thr1076Ala) single nucleotide variant Inborn genetic diseases [RCV004429802] Chr6:31995790 [GRCh38]
Chr6:31963567 [GRCh37]
Chr6:6p21.33		 uncertain significance
NM_007293.3(C4A):c.3587C>T (p.Thr1196Met) single nucleotide variant Inborn genetic diseases [RCV004429803] Chr6:31996511 [GRCh38]
Chr6:31964288 [GRCh37]
Chr6:6p21.33		 uncertain significance
NM_007293.3(C4A):c.3143T>G (p.Leu1048Arg) single nucleotide variant Inborn genetic diseases [RCV004429801] Chr6:31995528 [GRCh38]
Chr6:31963305 [GRCh37]
Chr6:6p21.33		 uncertain significance
NM_007293.3(C4A):c.2641G>A (p.Gly881Arg) single nucleotide variant Inborn genetic diseases [RCV004429799] Chr6:31994546 [GRCh38]
Chr6:31962323 [GRCh37]
Chr6:6p21.33		 uncertain significance
NM_007293.3(C4A):c.3163C>T (p.Arg1055Trp) single nucleotide variant Inborn genetic diseases [RCV004605994] Chr6:31995727 [GRCh38]
Chr6:31963504 [GRCh37]
Chr6:6p21.33		 uncertain significance
NM_007293.3(C4A):c.2689G>A (p.Val897Ile) single nucleotide variant Inborn genetic diseases [RCV004605995] Chr6:31994594 [GRCh38]
Chr6:31962371 [GRCh37]
Chr6:6p21.33		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:5064
Count of miRNA genes:1097
Interacting mature miRNAs:1396
Transcripts:ENST00000428956, ENST00000460060, ENST00000460841, ENST00000463034, ENST00000465724, ENST00000467749, ENST00000467948, ENST00000469975, ENST00000470365, ENST00000471624, ENST00000477424, ENST00000480795, ENST00000483974, ENST00000490663, ENST00000491876, ENST00000496659, ENST00000498271, ENST00000537134
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358854MULTSCL4_HMultiple sclerosis susceptibility QTL 4 (human)Multiple sclerosis susceptibility6691196032911960Human
1358839MULTSCL5_HMultiple sclerosis susceptibility QTL 5 (human)Multiple sclerosis susceptibility61958431145584311Human
1643377BW325_HBody weight QTL 325 (human)2.320.0005Body fat amount6691196032911960Human
1643569GLUCO21_HGlucose level QTL 21 (human)0.021Glucose levelnon-insulin-dependent6691196032911960Human
1298458BW9_HBody weight QTL 9 (human)2.70.0002Body fat amount6691196032911960Human
1298431RA11_HRheumatoid arthritis QTL 11 (human)0.0000024Joint/bone inflammationrheumatoid arthritis61991188340191709Human
1358857MULTSCL19_HMultiple sclerosis susceptibility QTL 19 (human)Multiple sclerosis susceptibility61958431145584311Human
1643399BMD5_HBone mineral density QTL 5 (human)2.320.0005Bone mineral density6691196032911960Human

Markers in Region
RH36425  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37631,981,792 - 31,981,908UniSTSGRCh37
GRCh37631,949,054 - 31,949,170UniSTSGRCh37
Build 36632,057,033 - 32,057,149RGDNCBI36
Celera633,548,816 - 33,548,932RGD
Cytogenetic Map6p21.3UniSTS
GeneMap99-GB4 RH Map6119.82UniSTS
G54031  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37632,002,659 - 32,002,952UniSTSGRCh37
GRCh37631,969,922 - 31,970,215UniSTSGRCh37
Build 36632,077,900 - 32,078,193RGDNCBI36
Celera633,569,683 - 33,569,976RGD
Cytogenetic Map6p21.3UniSTS
GDB:642029  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37632,002,550 - 32,003,217UniSTSGRCh37
GRCh37631,969,813 - 31,970,480UniSTSGRCh37
Build 36632,077,791 - 32,078,458RGDNCBI36
Celera633,569,574 - 33,570,241RGD
Cytogenetic Map6p21.3UniSTS
SHGC-31623  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37632,003,068 - 32,003,194UniSTSGRCh37
GRCh37631,970,331 - 31,970,457UniSTSGRCh37
Build 36632,078,309 - 32,078,435RGDNCBI36
Celera633,570,092 - 33,570,218RGD
Cytogenetic Map6p21.3UniSTS
TNG Radiation Hybrid Map617525.0UniSTS
Stanford-G3 RH Map61668.0UniSTS
GeneMap99-GB4 RH Map6143.88UniSTS
Whitehead-RH Map6177.7UniSTS
GeneMap99-G3 RH Map61800.0UniSTS
STK19__5340  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37631,981,520 - 31,981,998UniSTSGRCh37
GRCh37631,948,782 - 31,949,260UniSTSGRCh37
Build 36632,056,761 - 32,057,239RGDNCBI36
Celera633,548,544 - 33,549,022RGD
HuRef631,735,791 - 31,736,270UniSTS
SHGC-12566  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37631,981,575 - 31,981,908UniSTSGRCh37
GRCh37631,948,837 - 31,949,170UniSTSGRCh37
Build 36632,056,816 - 32,057,149RGDNCBI36
Celera633,548,599 - 33,548,932RGD
Cytogenetic Map6p21.3UniSTS
HuRef631,735,846 - 31,736,180UniSTS
Stanford-G3 RH Map61662.0UniSTS
GeneMap99-G3 RH Map61794.0UniSTS
RH46798  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37632,002,288 - 32,002,677UniSTSGRCh37
GRCh37631,969,551 - 31,969,940UniSTSGRCh37
Build 36632,077,529 - 32,077,918RGDNCBI36
Celera633,569,312 - 33,569,701RGD
Cytogenetic Map6p21.3UniSTS
GeneMap99-GB4 RH Map6145.45UniSTS
RH1519  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37632,002,055 - 32,002,677UniSTSGRCh37
GRCh37631,969,318 - 31,969,940UniSTSGRCh37
Celera633,569,079 - 33,569,701UniSTS
Cytogenetic Map6p21.3UniSTS
GeneMap99-GB4 RH Map6119.82UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
192 2 40 384 302 613 3 233 489 237 236 1192 577 51 158 318 319 354 5

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_011638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001252204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_007293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB209989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH004232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH013604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH013605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH013612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH013613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH013616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH013617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH013618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH013619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH013620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH013621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH013622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH013623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH013624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH013625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH013626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH013628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH013629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH013630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH013631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH013632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH013633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI065121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK293191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK293364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL645922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL844853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL929593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY224378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY379928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY379929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY379930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY379931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY379932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY379933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY379934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY379935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY379960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY379961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY379962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY379963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY379964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY379965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY379966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY379967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY379968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY379969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY379970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY379971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC012372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC016933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC063289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC146673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX452374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR753845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR936924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA304049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  K00830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  K02403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L26261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M14823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M14824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S81585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U07851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U07852 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U07853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U07855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  V00502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X77491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000428956   ⟹   ENSP00000396688
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl631,982,057 - 32,002,681 (+)Ensembl
Ensembl Acc Id: ENST00000460060
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl631,997,742 - 31,999,719 (+)Ensembl
Ensembl Acc Id: ENST00000460841
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl631,992,177 - 31,993,976 (+)Ensembl
Ensembl Acc Id: ENST00000463034
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl631,999,155 - 32,002,598 (+)Ensembl
Ensembl Acc Id: ENST00000465724
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl632,001,127 - 32,002,255 (+)Ensembl
Ensembl Acc Id: ENST00000467749
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl631,982,843 - 31,983,559 (+)Ensembl
Ensembl Acc Id: ENST00000467948
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl631,982,881 - 31,984,398 (+)Ensembl
Ensembl Acc Id: ENST00000469975
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl632,000,998 - 32,002,664 (+)Ensembl
Ensembl Acc Id: ENST00000470365
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl631,997,658 - 31,999,561 (+)Ensembl
Ensembl Acc Id: ENST00000471624
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl631,998,851 - 31,999,530 (+)Ensembl
Ensembl Acc Id: ENST00000477424
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl632,001,207 - 32,001,594 (+)Ensembl
Ensembl Acc Id: ENST00000480795
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl631,996,517 - 31,997,396 (+)Ensembl
Ensembl Acc Id: ENST00000483974
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl631,994,408 - 31,995,352 (+)Ensembl
Ensembl Acc Id: ENST00000490663
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl632,001,260 - 32,001,868 (+)Ensembl
Ensembl Acc Id: ENST00000491876
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl631,999,200 - 32,002,497 (+)Ensembl
Ensembl Acc Id: ENST00000496659
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl631,994,581 - 31,995,627 (+)Ensembl
Ensembl Acc Id: ENST00000498271   ⟹   ENSP00000420212
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl631,982,068 - 32,002,672 (+)Ensembl
Ensembl Acc Id: ENST00000696443
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl631,982,052 - 31,991,516 (+)Ensembl
Ensembl Acc Id: ENST00000696444
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl631,992,448 - 31,994,316 (+)Ensembl
Ensembl Acc Id: ENST00000698442   ⟹   ENSP00000513724
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl631,982,057 - 32,002,681 (+)Ensembl
RefSeq Acc Id: NM_001252204   ⟹   NP_001239133
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38631,982,057 - 32,002,681 (+)NCBI
GRCh37631,949,834 - 31,970,457 (+)NCBI
HuRef631,736,844 - 31,746,589 (+)NCBI
CHM1_1631,951,915 - 31,972,655 (+)NCBI
T2T-CHM13v2.0631,835,263 - 31,855,887 (+)NCBI
Sequence:
RefSeq Acc Id: NM_007293   ⟹   NP_009224
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38631,982,057 - 32,002,681 (+)NCBI
GRCh37631,949,834 - 31,970,457 (+)ENTREZGENE
Build 36632,090,550 - 32,111,173 (+)NCBI Archive
HuRef631,736,844 - 31,746,589 (+)NCBI
CHM1_1631,951,915 - 31,972,655 (+)NCBI
T2T-CHM13v2.0631,835,263 - 31,855,887 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001239133 (Get FASTA)   NCBI Sequence Viewer  
  NP_009224 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA20121 (Get FASTA)   NCBI Sequence Viewer  
  AAA35617 (Get FASTA)   NCBI Sequence Viewer  
  AAA36229 (Get FASTA)   NCBI Sequence Viewer  
  AAA51855 (Get FASTA)   NCBI Sequence Viewer  
  AAA52292 (Get FASTA)   NCBI Sequence Viewer  
  AAB26211 (Get FASTA)   NCBI Sequence Viewer  
  AAB36122 (Get FASTA)   NCBI Sequence Viewer  
  AAB59537 (Get FASTA)   NCBI Sequence Viewer  
  AAB63418 (Get FASTA)   NCBI Sequence Viewer  
  AAB63419 (Get FASTA)   NCBI Sequence Viewer  
  AAB63420 (Get FASTA)   NCBI Sequence Viewer  
  AAB63422 (Get FASTA)   NCBI Sequence Viewer  
  AAH12372 (Get FASTA)   NCBI Sequence Viewer  
  AAH63289 (Get FASTA)   NCBI Sequence Viewer  
  AAI46674 (Get FASTA)   NCBI Sequence Viewer  
  AAP83249 (Get FASTA)   NCBI Sequence Viewer  
  AAR89091 (Get FASTA)   NCBI Sequence Viewer  
  AAR89093 (Get FASTA)   NCBI Sequence Viewer  
  AAR89107 (Get FASTA)   NCBI Sequence Viewer  
  AAR89109 (Get FASTA)   NCBI Sequence Viewer  
  AAR89115 (Get FASTA)   NCBI Sequence Viewer  
  AAR89117 (Get FASTA)   NCBI Sequence Viewer  
  AAR89119 (Get FASTA)   NCBI Sequence Viewer  
  AAR89121 (Get FASTA)   NCBI Sequence Viewer  
  AAR89123 (Get FASTA)   NCBI Sequence Viewer  
  AAR89125 (Get FASTA)   NCBI Sequence Viewer  
  AAR89127 (Get FASTA)   NCBI Sequence Viewer  
  AAR89130 (Get FASTA)   NCBI Sequence Viewer  
  AAR89132 (Get FASTA)   NCBI Sequence Viewer  
  AAR89134 (Get FASTA)   NCBI Sequence Viewer  
  AAR89136 (Get FASTA)   NCBI Sequence Viewer  
  AAR89139 (Get FASTA)   NCBI Sequence Viewer  
  AAR89142 (Get FASTA)   NCBI Sequence Viewer  
  AAR89144 (Get FASTA)   NCBI Sequence Viewer  
  AAR89145 (Get FASTA)   NCBI Sequence Viewer  
  AAR89148 (Get FASTA)   NCBI Sequence Viewer  
  AAR89150 (Get FASTA)   NCBI Sequence Viewer  
  AAR89155 (Get FASTA)   NCBI Sequence Viewer  
  AAR89156 (Get FASTA)   NCBI Sequence Viewer  
  AAR89157 (Get FASTA)   NCBI Sequence Viewer  
  AAR89158 (Get FASTA)   NCBI Sequence Viewer  
  AAR89159 (Get FASTA)   NCBI Sequence Viewer  
  AAR89160 (Get FASTA)   NCBI Sequence Viewer  
  AAR89161 (Get FASTA)   NCBI Sequence Viewer  
  AAR89162 (Get FASTA)   NCBI Sequence Viewer  
  AAR89164 (Get FASTA)   NCBI Sequence Viewer  
  AAR89165 (Get FASTA)   NCBI Sequence Viewer  
  AAR89166 (Get FASTA)   NCBI Sequence Viewer  
  AAR89167 (Get FASTA)   NCBI Sequence Viewer  
  AAR89168 (Get FASTA)   NCBI Sequence Viewer  
  AAR89169 (Get FASTA)   NCBI Sequence Viewer  
  AAR89170 (Get FASTA)   NCBI Sequence Viewer  
  AAR89171 (Get FASTA)   NCBI Sequence Viewer  
  AAR89172 (Get FASTA)   NCBI Sequence Viewer  
  AAR89173 (Get FASTA)   NCBI Sequence Viewer  
  AAR89174 (Get FASTA)   NCBI Sequence Viewer  
  AAR89175 (Get FASTA)   NCBI Sequence Viewer  
  BAE06071 (Get FASTA)   NCBI Sequence Viewer  
  BAG56731 (Get FASTA)   NCBI Sequence Viewer  
  BAH11494 (Get FASTA)   NCBI Sequence Viewer  
  CAA23760 (Get FASTA)   NCBI Sequence Viewer  
  CAA54627 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000364444.4
  ENSP00000372815.4
  ENSP00000388662.2
  ENSP00000396688
  ENSP00000396688.2
  ENSP00000420212
  ENSP00000420212.1
  ENSP00000448276.1
  ENSP00000449828.1
  ENSP00000513724.1
GenBank Protein P0C0L4 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_009224   ⟸   NM_007293
- Peptide Label: isoform 1 preproprotein
- UniProtKB: Q9NPK5 (UniProtKB/Swiss-Prot),   Q96SA8 (UniProtKB/Swiss-Prot),   Q96EG2 (UniProtKB/Swiss-Prot),   Q6U2G0 (UniProtKB/Swiss-Prot),   Q6U2F8 (UniProtKB/Swiss-Prot),   Q6U2F6 (UniProtKB/Swiss-Prot),   Q6U2F4 (UniProtKB/Swiss-Prot),   Q6U2F3 (UniProtKB/Swiss-Prot),   Q6U2F0 (UniProtKB/Swiss-Prot),   Q6U2E8 (UniProtKB/Swiss-Prot),   Q6U2E5 (UniProtKB/Swiss-Prot),   Q6P4R1 (UniProtKB/Swiss-Prot),   Q5JQM8 (UniProtKB/Swiss-Prot),   Q5JNX2 (UniProtKB/Swiss-Prot),   Q4LE82 (UniProtKB/Swiss-Prot),   Q14835 (UniProtKB/Swiss-Prot),   Q14033 (UniProtKB/Swiss-Prot),   Q13906 (UniProtKB/Swiss-Prot),   Q13160 (UniProtKB/Swiss-Prot),   P78445 (UniProtKB/Swiss-Prot),   P01028 (UniProtKB/Swiss-Prot),   B7ZVZ6 (UniProtKB/Swiss-Prot),   B2RUT6 (UniProtKB/Swiss-Prot),   B0V2C8 (UniProtKB/Swiss-Prot),   B0QZR6 (UniProtKB/Swiss-Prot),   A7E2V2 (UniProtKB/Swiss-Prot),   A6NHJ5 (UniProtKB/Swiss-Prot),   A6H8M8 (UniProtKB/Swiss-Prot),   Q9UIP5 (UniProtKB/Swiss-Prot),   P0C0L4 (UniProtKB/Swiss-Prot),   A0A0G2JPR0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001239133   ⟸   NM_001252204
- Peptide Label: isoform 2 preproprotein
- UniProtKB: A0A140TA44 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000396688   ⟸   ENST00000428956
Ensembl Acc Id: ENSP00000420212   ⟸   ENST00000498271
Ensembl Acc Id: ENSP00000513724   ⟸   ENST00000698442
Protein Domains
Alpha-macroglobulin-like TED   Anaphylatoxin-like   NTR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P0C0L4-F1-model_v2 AlphaFold P0C0L4 1-1744 view protein structure

Promoters
RGD ID:6872706
Promoter ID:EPDNEW_H9518
Type:initiation region
Name:C4A_1
Description:complement C4A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H9519  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38631,980,699 - 31,980,759EPDNEW
RGD ID:6872708
Promoter ID:EPDNEW_H9519
Type:initiation region
Name:C4A_2
Description:complement C4A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H9518  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38631,982,057 - 31,982,117EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:1323 AgrOrtholog
COSMIC C4A COSMIC
Ensembl Genes ENSG00000206340 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000227746 UniProtKB/Swiss-Prot
  ENSG00000244207 UniProtKB/TrEMBL
  ENSG00000244731 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000375295.8 UniProtKB/TrEMBL
  ENST00000383325.8 UniProtKB/Swiss-Prot
  ENST00000421274.7 UniProtKB/Swiss-Prot
  ENST00000428956 ENTREZGENE
  ENST00000428956.7 UniProtKB/Swiss-Prot
  ENST00000498271 ENTREZGENE
  ENST00000498271.1 UniProtKB/Swiss-Prot
  ENST00000546746.5 UniProtKB/TrEMBL
  ENST00000549812.2 UniProtKB/TrEMBL
  ENST00000698442.1 UniProtKB/TrEMBL
Gene3D-CATH 1.50.10.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.20.130.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.40.50.120 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.120.1540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.1930 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.1940 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.690 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.20.50.160 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Anaphylotoxins (complement system) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000206340 GTEx
  ENSG00000227746 GTEx
  ENSG00000244207 GTEx
  ENSG00000244731 GTEx
HGNC ID HGNC:1323 ENTREZGENE
Human Proteome Map C4A Human Proteome Map
InterPro A-macroglobulin_rcpt-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A-macroglobulin_rcpt-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A2M/Complement_sys UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A2M_N_BRD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Alpha-macroglob_thiol-ester_cl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Alpha-macroglobulin_TED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Anaphylatoxin/fibulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Anaphylatoxin_comp_syst UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Anaphylatoxn_comp_syst_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C4_MG1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CO4A-B_CUB_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Macroglobln_a2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MacrogloblnA2_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MG2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MG3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MG4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Netrin_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Netrin_module_non-TIMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Terpenoid_cyclase/PrenylTrfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP-like_OB-fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:720 UniProtKB/Swiss-Prot
  hsa:721 UniProtKB/Swiss-Prot
NCBI Gene 720 ENTREZGENE
OMIM 120810 OMIM
PANTHER MACROGLOBULIN / COMPLEMENT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11412:SF86 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam A2M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A2M_BRD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A2M_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANATO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C4_MG1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CO4A-B_CUB_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MG2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MG3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MG4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TED_complement UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA25903 PharmGKB
PRINTS ANAPHYLATOXN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ALPHA_2_MACROGLOBULIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANAPHYLATOXIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANAPHYLATOXIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART A2M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A2M_N_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A2M_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANATO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C345C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiol-ester_cl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47686 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48239 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49410 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50242 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JPR0 ENTREZGENE, UniProtKB/TrEMBL
  A0A140TA44 ENTREZGENE, UniProtKB/TrEMBL
  A0A140TA49_HUMAN UniProtKB/TrEMBL
  A0A8V8TLP6_HUMAN UniProtKB/TrEMBL
  A6H8M8 ENTREZGENE
  A6NHJ5 ENTREZGENE
  A7E2V2 ENTREZGENE
  B0QZR6 ENTREZGENE
  B0V2C8 ENTREZGENE
  B2RUT6 ENTREZGENE
  B7ZVZ6 ENTREZGENE
  CO4A_HUMAN UniProtKB/Swiss-Prot
  P01028 ENTREZGENE
  P0C0L4 ENTREZGENE
  P78445 ENTREZGENE
  Q13160 ENTREZGENE
  Q13906 ENTREZGENE
  Q14033 ENTREZGENE
  Q14835 ENTREZGENE
  Q30211_HUMAN UniProtKB/TrEMBL
  Q4LE82 ENTREZGENE
  Q5JNX2 ENTREZGENE
  Q5JQM8 ENTREZGENE
  Q6P4R1 ENTREZGENE
  Q6U2E5 ENTREZGENE
  Q6U2E8 ENTREZGENE
  Q6U2F0 ENTREZGENE
  Q6U2F3 ENTREZGENE
  Q6U2F4 ENTREZGENE
  Q6U2F6 ENTREZGENE
  Q6U2F8 ENTREZGENE
  Q6U2G0 ENTREZGENE
  Q6U2K2_HUMAN UniProtKB/TrEMBL
  Q96EG2 ENTREZGENE
  Q96SA8 ENTREZGENE
  Q9NPK5 ENTREZGENE
  Q9UIP5 ENTREZGENE
  V9H0D6_HUMAN UniProtKB/TrEMBL
UniProt Secondary A6H8M8 UniProtKB/Swiss-Prot
  A6NHJ5 UniProtKB/Swiss-Prot
  A7E2V2 UniProtKB/Swiss-Prot
  B0QZR6 UniProtKB/Swiss-Prot
  B0V2C8 UniProtKB/Swiss-Prot
  B2RUT6 UniProtKB/Swiss-Prot
  B7ZVZ6 UniProtKB/Swiss-Prot
  P01028 UniProtKB/Swiss-Prot
  P78445 UniProtKB/Swiss-Prot
  Q13160 UniProtKB/Swiss-Prot
  Q13906 UniProtKB/Swiss-Prot
  Q14033 UniProtKB/Swiss-Prot
  Q14835 UniProtKB/Swiss-Prot
  Q4LE82 UniProtKB/Swiss-Prot
  Q5JNX2 UniProtKB/Swiss-Prot
  Q5JQM8 UniProtKB/Swiss-Prot
  Q6P4R1 UniProtKB/Swiss-Prot
  Q6U2E5 UniProtKB/Swiss-Prot
  Q6U2E8 UniProtKB/Swiss-Prot
  Q6U2F0 UniProtKB/Swiss-Prot
  Q6U2F3 UniProtKB/Swiss-Prot
  Q6U2F4 UniProtKB/Swiss-Prot
  Q6U2F6 UniProtKB/Swiss-Prot
  Q6U2F8 UniProtKB/Swiss-Prot
  Q6U2G0 UniProtKB/Swiss-Prot
  Q96EG2 UniProtKB/Swiss-Prot
  Q96SA8 UniProtKB/Swiss-Prot
  Q9NPK5 UniProtKB/Swiss-Prot
  Q9UIP5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-12-18 C4A  complement C4A (Chido/Rodgers blood group)  C4A  complement C4A (Rodgers blood group)  Symbol and/or name change 19259463 PROVISIONAL
2016-08-16 C4A  complement C4A (Rodgers blood group)    complement component 4A (Rodgers blood group)  Symbol and/or name change 5135510 APPROVED