Lrriq3 (leucine-rich repeats and IQ motif containing 3) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Lrriq3 (leucine-rich repeats and IQ motif containing 3) Mus musculus
Analyze
Symbol: Lrriq3
Name: leucine-rich repeats and IQ motif containing 3
RGD ID: 1558037
MGI Page MGI
Description: Orthologous to human LRRIQ3 (leucine rich repeats and IQ motif containing 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 4930438B07Rik; 4930511J15Rik; 4933403H06Rik; BB020367; leucine rich repeat containing 44; leucine-rich repeat and IQ domain-containing protein 3; leucine-rich repeat-containing protein 44; Lrr; Lrrc44; MGC132959
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393154,799,032 - 154,899,915 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3154,799,071 - 154,899,917 (+)EnsemblGRCm39 Ensembl
GRCm383155,093,395 - 155,194,278 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3155,093,434 - 155,194,280 (+)EnsemblGRCm38mm10GRCm38
MGSCv373154,756,398 - 154,857,242 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363155,028,832 - 155,129,442 (+)NCBIMGSCv36mm8
Celera3161,551,401 - 161,652,357 (+)NCBICelera
Cytogenetic Map3H4NCBI
cM Map379.54NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:16141072   PMID:16141073   PMID:21267068   PMID:21677750   PMID:32325033  


Genomics

Comparative Map Data
Lrriq3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393154,799,032 - 154,899,915 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3154,799,071 - 154,899,917 (+)EnsemblGRCm39 Ensembl
GRCm383155,093,395 - 155,194,278 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3155,093,434 - 155,194,280 (+)EnsemblGRCm38mm10GRCm38
MGSCv373154,756,398 - 154,857,242 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363155,028,832 - 155,129,442 (+)NCBIMGSCv36mm8
Celera3161,551,401 - 161,652,357 (+)NCBICelera
Cytogenetic Map3H4NCBI
cM Map379.54NCBI
LRRIQ3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38174,026,015 - 74,198,176 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl174,026,015 - 74,198,187 (-)EnsemblGRCh38hg38GRCh38
GRCh37174,491,699 - 74,663,860 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36174,264,287 - 74,436,459 (-)NCBINCBI36Build 36hg18NCBI36
Celera172,737,273 - 72,909,434 (-)NCBICelera
Cytogenetic Map1p31.1NCBI
HuRef172,626,631 - 72,798,771 (-)NCBIHuRef
CHM1_1174,607,397 - 74,779,550 (-)NCBICHM1_1
T2T-CHM13v2.0173,867,620 - 74,039,753 (-)NCBIT2T-CHM13v2.0
Lrriq3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82246,778,759 - 246,871,284 (+)NCBIGRCr8
mRatBN7.22244,119,975 - 244,214,590 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2244,126,200 - 244,212,339 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2251,882,192 - 251,974,502 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02249,775,996 - 249,868,305 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02244,716,369 - 244,808,592 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02261,403,040 - 261,499,893 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2261,402,980 - 261,499,891 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02280,074,848 - 280,166,764 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42252,886,022 - 253,060,065 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2235,979,540 - 236,070,905 (+)NCBICelera
Cytogenetic Map2q45NCBI
Lrriq3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542318,443,825 - 18,585,996 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542318,438,848 - 18,585,627 (+)NCBIChiLan1.0ChiLan1.0
LRRIQ3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21152,681,059 - 152,853,560 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11151,840,235 - 152,012,487 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0173,255,053 - 73,427,257 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1175,231,190 - 75,403,524 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl175,231,191 - 75,389,032 (-)Ensemblpanpan1.1panPan2
LRRIQ3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1672,138,908 - 72,306,371 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl672,157,015 - 72,305,934 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha674,804,564 - 74,974,401 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0672,734,879 - 72,904,691 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl672,752,919 - 72,905,655 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1672,255,897 - 72,425,687 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0672,175,102 - 72,344,990 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0672,670,776 - 72,840,639 (+)NCBIUU_Cfam_GSD_1.0
Lrriq3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505885,854,704 - 86,035,216 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365711,365,550 - 1,522,691 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRRIQ3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6138,964,509 - 139,151,925 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16138,950,285 - 139,152,645 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26128,722,845 - 128,766,240 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LRRIQ3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12058,953,280 - 59,116,252 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603358,332,857 - 58,498,845 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lrriq3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474222,479,053 - 22,611,635 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:96
Count of miRNA genes:83
Interacting mature miRNAs:89
Transcripts:ENSMUST00000029833
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301347Fpli_mfasting plasma insulin (mouse)Not determined3126460514159745316Mouse
1301218Letohc1_mlow ethanol consumption 1 (mouse)Not determined3126352986159745316Mouse
1301222Scc7_mcolon tumor susceptibility 7 (mouse)Not determined3143352986156364108Mouse
1301563Alcp3_malcohol preference locus 3 (mouse)Not determined3130736935159745316Mouse
4142245Pstc1_mperiosteal circumference 1 (mouse)Not determined3126270248159745316Mouse
11039523Tbbr1_mTrypanosoma brucei brucei response 1 (mouse)3130849375159745316Mouse
1301528Loco1_mlocomotor activity 1 (mouse)Not determined3133461893159745316Mouse

Markers in Region
BB020367  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383155,137,629 - 155,137,723UniSTSGRCm38
MGSCv373154,800,593 - 154,800,687UniSTSGRCm37
Celera3161,595,613 - 161,595,707UniSTS
Cytogenetic Map3H4UniSTS
Whitehead/MRC_RH31707.9UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000029833   ⟹   ENSMUSP00000029833
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3154,799,071 - 154,899,917 (+)Ensembl
GRCm38.p6 Ensembl3155,093,434 - 155,194,280 (+)Ensembl
Ensembl Acc Id: ENSMUST00000192383   ⟹   ENSMUSP00000141372
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3154,799,175 - 154,887,865 (+)Ensembl
GRCm38.p6 Ensembl3155,093,538 - 155,182,228 (+)Ensembl
Ensembl Acc Id: ENSMUST00000194376   ⟹   ENSMUSP00000142127
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3154,799,225 - 154,843,385 (+)Ensembl
GRCm38.p6 Ensembl3155,093,588 - 155,137,748 (+)Ensembl
Ensembl Acc Id: ENSMUST00000195418
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3154,799,071 - 154,808,263 (+)Ensembl
GRCm38.p6 Ensembl3155,093,434 - 155,102,626 (+)Ensembl
RefSeq Acc Id: NM_028938   ⟹   NP_083214
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393154,799,071 - 154,899,915 (+)NCBI
GRCm383155,093,434 - 155,194,278 (+)ENTREZGENE
MGSCv373154,756,398 - 154,857,242 (+)RGD
Celera3161,551,401 - 161,652,357 (+)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006502189   ⟹   XP_006502252
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393154,799,032 - 154,899,441 (+)NCBI
GRCm383155,093,395 - 155,193,804 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006502190   ⟹   XP_006502253
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393154,799,033 - 154,887,686 (+)NCBI
GRCm383155,093,396 - 155,182,046 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017319774   ⟹   XP_017175263
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393154,799,033 - 154,841,576 (+)NCBI
GRCm383155,093,396 - 155,135,940 (+)NCBI
Sequence:
RefSeq Acc Id: NP_083214   ⟸   NM_028938
- UniProtKB: Q9D562 (UniProtKB/Swiss-Prot),   Q9D4C3 (UniProtKB/Swiss-Prot),   Q9D5I0 (UniProtKB/Swiss-Prot),   Q14DL3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006502253   ⟸   XM_006502190
- Peptide Label: isoform X2
- UniProtKB: Q14DL3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006502252   ⟸   XM_006502189
- Peptide Label: isoform X1
- UniProtKB: Q9D562 (UniProtKB/Swiss-Prot),   Q9D4C3 (UniProtKB/Swiss-Prot),   Q9D5I0 (UniProtKB/Swiss-Prot),   Q14DL3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017175263   ⟸   XM_017319774
- Peptide Label: isoform X3
- Sequence:
Ensembl Acc Id: ENSMUSP00000029833   ⟸   ENSMUST00000029833
Ensembl Acc Id: ENSMUSP00000142127   ⟸   ENSMUST00000194376
Ensembl Acc Id: ENSMUSP00000141372   ⟸   ENSMUST00000192383
Protein Domains
IQ   LRRCT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q14DL3-F1-model_v2 AlphaFold Q14DL3 1-633 view protein structure

Promoters
RGD ID:6834064
Promoter ID:MM_KWN:36486
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_028938,   NM_029330,   UC008RUV.1,   UC008RUW.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv363154,756,096 - 154,756,657 (+)MPROMDB
RGD ID:6882688
Promoter ID:EPDNEW_M4795
Type:initiation region
Name:Lrriq3_1
Description:Mus musculus leucine-rich repeats and IQ motif containing 3 ,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm383155,093,538 - 155,093,598EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1921685 AgrOrtholog
Ensembl Genes ENSMUSG00000028182 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000029833 ENTREZGENE
  ENSMUST00000029833.13 UniProtKB/Swiss-Prot
  ENSMUST00000192383 ENTREZGENE
  ENSMUST00000192383.6 UniProtKB/Swiss-Prot
  ENSMUST00000194376 ENTREZGENE
  ENSMUST00000194376.2 UniProtKB/Swiss-Prot
Gene3D-CATH 3.80.10.10 UniProtKB/Swiss-Prot
InterPro Leu-rich_rpt UniProtKB/Swiss-Prot
  Leu-rich_rpt_4 UniProtKB/Swiss-Prot
  LRR-IQ_domain_protein UniProtKB/Swiss-Prot
  LRR_dom_sf UniProtKB/Swiss-Prot
KEGG Report mmu:74435 UniProtKB/Swiss-Prot
MGD MGI:1921685 ENTREZGENE
NCBI Gene 74435 ENTREZGENE
PANTHER LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 3 UniProtKB/Swiss-Prot
  LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 3 UniProtKB/Swiss-Prot
Pfam LRR_4 UniProtKB/Swiss-Prot
PhenoGen Lrriq3 PhenoGen
PROSITE LRR UniProtKB/Swiss-Prot
  PS50096 UniProtKB/Swiss-Prot
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot
UniProt LRIQ3_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q9D4C3 ENTREZGENE
  Q9D562 ENTREZGENE
  Q9D5I0 ENTREZGENE
UniProt Secondary Q9D4C3 UniProtKB/Swiss-Prot
  Q9D562 UniProtKB/Swiss-Prot
  Q9D5I0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-27 Lrriq3  leucine-rich repeats and IQ motif containing 3  Lrrc44  leucine rich repeat containing 44  Symbol and/or name change 5135510 APPROVED