Sms (spermine synthase) - Rat Genome Database

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Gene: Sms (spermine synthase) Mus musculus
Analyze
Symbol: Sms
Name: spermine synthase
RGD ID: 1557826
MGI Page MGI
Description: Predicted to enable spermine synthase activity. Acts upstream of or within spermine metabolic process. Is expressed in several structures, including central nervous system; ganglia; limb; respiratory system; and tooth. Human ortholog(s) of this gene implicated in anxiety disorder and syndromic X-linked intellectual disability Snyder type. Orthologous to human SMS (spermine synthase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI427066; Gy; gyro; Sp; spermidine aminopropyltransferase; SpmST; SPMSY
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gm17927   Gm17929   Gm6292   Gm7270   Gm7333   Gm8234   Gm8952   Sms-ps  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X156,226,847 - 156,275,283 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX156,226,851 - 156,275,283 (-)EnsemblGRCm39 Ensembl
GRCm38X157,443,851 - 157,492,287 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX157,443,855 - 157,492,287 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X153,881,886 - 153,929,978 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X152,788,059 - 152,836,139 (-)NCBIMGSCv36mm8
CeleraX140,696,273 - 140,722,448 (-)NCBICelera
Cytogenetic MapXF4NCBI
cM MapX72.48NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
SmsMouseanxiety disorder  ISORGD:1345734597621635DNA:SNPs::rs10521911,rs6654100 RGD 
SmsMousePulmonary Arterial Hypertension  ISORGD:1345734597621636protein:increased expression:pulmonary arterial smooth muscle cellRGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
SmsMouseautistic disorder  ISORGD:13457348554872ClinVar Annotator: match by term: AutismClinVarPMID:21681106|PMID:30208311
SmsMouseDevelopmental Disease  ISORGD:13457348554872ClinVar Annotator: match by term: Developmental disorderClinVarPMID:25741868
SmsMousegenetic disease  ISORGD:13457348554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:19377476|PMID:23805436|PMID:25741868|PMID:25936994|PMID:26467025|PMID:26761001|PMID:28492532|PMID:34177437|PMID:34741636
SmsMouseintellectual disability  ISORGD:13457348554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 
SmsMouseNeurodevelopmental Disorders  ISORGD:13457348554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
SmsMouseSmith-Magenis syndrome  ISORGD:13457348554872ClinVar Annotator: match by term: Smith-Magenis syndromeClinVarPMID:25741868
SmsMousesyndromic X-linked intellectual disability Lubs type  ISORGD:13457348554872ClinVar Annotator: match by term: Syndromic X-linked intellectual disability Lubs typeClinVarPMID:25741868
SmsMousesyndromic X-linked intellectual disability Snyder type  ISORGD:13457348554872ClinVar Annotator: match by term: SMS-related disorder | ClinVar Annotator: match by term: Syndromic X-linked more ...ClinVarPMID:14508504|PMID:18550699|PMID:19206178|PMID:19377476|PMID:22612257|PMID:23696453|PMID:23805436|PMID:23897707|PMID:25741868|PMID:25888122|PMID:26174906|PMID:26467025|PMID:26761001|PMID:28492532|PMID:31580924|PMID:33624935|PMID:34177437|PMID:34741636|PMID:37432431|PMID:5823961
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
SmsMouserheumatoid arthritis  ISORGD:134573411554173CTD Direct Evidence: marker/mechanismCTDPMID:19192274
SmsMousesyndromic X-linked intellectual disability Snyder type  ISORGD:134573411554173CTD Direct Evidence: marker/mechanismCTD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
SmsMousesyndromic X-linked intellectual disability Snyder type  ISORGD:13457347240710 OMIM 

1 to 20 of 86 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
SmsMouse(1->4)-beta-D-glucan multiple interactionsEXP 6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of SMS mRNACTDPMID:36331819
SmsMouse1,1-dichloroethene decreases expressionEXP 6480464vinylidene chloride results in decreased expression of SMS mRNACTDPMID:26682919
SmsMouse1,2-dichloroethane decreases expressionEXP 6480464ethylene dichloride results in decreased expression of SMS mRNACTDPMID:28960355
SmsMouse17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of SMS mRNACTDPMID:39298647
SmsMouse17beta-hydroxy-17-methylestra-4,9,11-trien-3-one increases expressionISORGD:13457346480464Metribolone results in increased expression of SMS proteinCTDPMID:17152098
SmsMouse17beta-hydroxy-5alpha-androstan-3-one increases expressionISORGD:13457346480464Dihydrotestosterone results in increased expression of SMS mRNACTDPMID:18007998|PMID:29581250
SmsMouse2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of SMS mRNACTDPMID:24680724
SmsMouse2,3,7,8-tetrachlorodibenzodioxine decreases expressionISORGD:15648266480464Tetrachlorodibenzodioxin results in decreased expression of SMS mRNACTDPMID:34747641
SmsMouse2,4,6-tribromophenol decreases expressionISORGD:134573464804642,4,6-tribromophenol results in decreased expression of SMS mRNACTDPMID:31675489
SmsMouse2-hydroxypropanoic acid decreases expressionISORGD:13457346480464Lactic Acid results in decreased expression of SMS mRNACTDPMID:30851411
SmsMouse3-isobutyl-1-methyl-7H-xanthine multiple interactionsISORGD:13457346480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] more ...CTDPMID:28628672
SmsMouse4,4'-diaminodiphenylmethane decreases expressionEXP 64804644,4'-diaminodiphenylmethane results in decreased expression of SMS mRNACTDPMID:18648102
SmsMouse4,4'-sulfonyldiphenol decreases expressionEXP 6480464bisphenol S results in decreased expression of SMS mRNACTDPMID:39298647
SmsMouse5-fluorouracil increases expressionISORGD:13457346480464Fluorouracil results in increased expression of SMS mRNACTDPMID:15152939
SmsMouse5-fluorouracil multiple interactionsISORGD:13457346480464TP53 protein affects the reaction [Fluorouracil results in decreased expression of SMS mRNA]CTDPMID:15016801
SmsMouse6-propyl-2-thiouracil increases expressionISORGD:15648266480464Propylthiouracil results in increased expression of SMS mRNACTDPMID:24780913
SmsMouse6-propyl-2-thiouracil decreases expressionISORGD:15648266480464Propylthiouracil results in decreased expression of SMS mRNACTDPMID:30047161
SmsMouse6alpha-methylprednisolone decreases expressionISORGD:13457346480464Methylprednisolone results in decreased expression of SMS mRNACTDPMID:19192274
SmsMouseactinomycin D multiple interactionsISORGD:13457346480464[Dactinomycin co-treated with nutlin 3] results in increased secretion of SMS proteinCTDPMID:38460933
SmsMouseAflatoxin B2 alpha affects methylationISORGD:13457346480464aflatoxin B2 affects the methylation of SMS intronCTDPMID:30157460

1 to 20 of 86 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
SmsMousespermine biosynthetic process  ISORGD:15648269068941 RGDPMID:8494549|REF_RGD_ID:7242928
SmsMousespermine biosynthetic process involved_inISORGD:15648262290270 GO_CentralGO_REF:0000096
SmsMousespermine biosynthetic process involved_inIEAUniPathway:UPA002492290270 UniProtGO_REF:0000041
SmsMousespermine biosynthetic process involved_inIBAPANTHER:PTN000900684|ZFIN:ZDB-GENE-040625-150|FB:FBgn0036272|RGD:15648262290270 GO_CentralGO_REF:0000033
SmsMousespermine metabolic process acts_upstream_of_or_withinIMPMGI:21803592290270 PMID:9467015MGIPMID:9467015

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
SmsMousespermine synthase activity  ISORGD:15648269068941 RGDPMID:8494549|REF_RGD_ID:7242928
SmsMousespermine synthase activity enablesISOEMBL:Z490992290270 PMID:9467015MGIPMID:9467015
SmsMousespermine synthase activity enablesISORGD:15648262290270 GO_CentralGO_REF:0000096
SmsMousespermine synthase activity enablesIBAPANTHER:PTN000900684|FB:FBgn0036272|RGD:15648262290270 GO_CentralGO_REF:0000033

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
SmsMousemethionine cycle/metabolic pathway   ISORGD:13457347242425 RGD 
SmsMousepolyamine metabolic pathway   ISORGD:13457347244193 RGD 
SmsMousespermine metabolic pathway  ISORGD:13457347242425 RGD 
SmsMousespermine metabolic pathway  ISORGD:15648267242932 RGD 

Imported Annotations - SMPDB

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
SmsMousespermidine metabolic pathway  ISORGD:134573410402751 SMPDBSMP:00445
SmsMousespermine metabolic pathway  ISORGD:134573410402751 SMPDBSMP:00445

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
SmsMousearginine and proline metabolic pathway  IEA 6907045 KEGGmmu:00330
SmsMousebeta-alanine metabolic pathway  IEA 6907045 KEGGmmu:00410
SmsMousecysteine and methionine metabolic pathway  IEA 6907045 KEGGmmu:00270
SmsMouseglutathione metabolic pathway  IEA 6907045 KEGGmmu:00480
1 to 20 of 22 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
SmsMouseabnormal fertility/fecundity  IAGP 5509061 MGIPMID:24652767
SmsMouseabnormal spine curvature  IAGP 5509061 MGIPMID:24652767
SmsMousedecreased body length  IAGP 5509061 MGIPMID:24652767
SmsMousedecreased body weight  IAGP 5509061 MGIPMID:24652767
SmsMousedecreased bone mineral content  IAGP 5509061 MGIPMID:24652767
SmsMousedecreased bone mineral density  IAGP 5509061 MGIPMID:23870131
SmsMousedecreased bone mineral density  IAGP 5509061 MGIPMID:24652767
SmsMousedecreased circulating glucose level  IEA 5509061 MGI 
SmsMousedecreased circulating potassium level  IEA 5509061 MGI 
SmsMousedecreased lean body mass  IAGP 5509061 MGIPMID:23870131
SmsMousedecreased lean body mass  IAGP 5509061 MGIPMID:24652767
SmsMouseincreased blood urea nitrogen level  IEA 5509061 MGI 
SmsMouseincreased NK cell number  IAGP 5509061 MGIPMID:24652767
SmsMouseincreased NK T cell number  IAGP 5509061 MGIPMID:24652767
SmsMouselordosis  IAGP 5509061 MGIPMID:23870131
SmsMouselordosis  IAGP 5509061 MGIPMID:24652767
SmsMousemale infertility  IAGP 5509061 MGIPMID:23870131
SmsMousemuscle weakness  IAGP 5509061 MGIPMID:23870131
SmsMouseoligozoospermia  IAGP 5509061 MGIPMID:24652767
SmsMousepostnatal growth retardation  IAGP 5509061 MGIPMID:23870131
1 to 20 of 22 rows

1 to 14 of 14 rows
#
Reference Title
Reference Citation
1. Aminooxy analogues of spermidine as inhibitors of spermine synthase and substrates of hepatic polyamine acetylating activity. Eloranta TO, etal., J Biochem. 1990 Oct;108(4):593-8.
2. Association of polyaminergic loci with anxiety, mood disorders, and attempted suicide. Fiori LM, etal., PLoS One. 2010 Nov 30;5(11):e15146. doi: 10.1371/journal.pone.0015146.
3. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
4. Hypusine Signaling Promotes Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension. Lemay SE, etal., Am J Respir Crit Care Med. 2024 Jun 1;209(11):1376-1391. doi: 10.1164/rccm.202305-0909OC.
5. S-adenosylmethionine in liver health, injury, and cancer. Lu SC and Mato JM, Physiol Rev. 2012 Oct;92(4):1515-42. doi: 10.1152/physrev.00047.2011.
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
11. Mouse MP Annotation Import Pipeline RGD automated import pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. A perspective of polyamine metabolism. Wallace HM, etal., Biochem J. 2003 Nov 15;376(Pt 1):1-14.
1 to 14 of 14 rows
PMID:9063736   PMID:9467015   PMID:9545633   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11160858   PMID:12477932   PMID:12520002   PMID:12904583   PMID:14610273  
PMID:14681479   PMID:15459188   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16602821   PMID:18583422   PMID:18799693   PMID:19001365   PMID:19131104   PMID:19641749   PMID:19859664  
PMID:21267068   PMID:21677750   PMID:21873635   PMID:23870131   PMID:24652767   PMID:27572106   PMID:30418981   PMID:30973865   PMID:38355793   PMID:38463005   PMID:39331754  



Sms
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X156,226,847 - 156,275,283 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX156,226,851 - 156,275,283 (-)EnsemblGRCm39 Ensembl
GRCm38X157,443,851 - 157,492,287 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX157,443,855 - 157,492,287 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X153,881,886 - 153,929,978 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X152,788,059 - 152,836,139 (-)NCBIMGSCv36mm8
CeleraX140,696,273 - 140,722,448 (-)NCBICelera
Cytogenetic MapXF4NCBI
cM MapX72.48NCBI
SMS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X21,940,709 - 21,994,837 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX21,940,709 - 21,994,837 (+)EnsemblGRCh38hg38GRCh38
GRCh37X21,958,827 - 22,012,955 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X21,868,763 - 21,922,876 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X21,718,498 - 21,772,611NCBI
CeleraX26,079,796 - 26,133,909 (+)NCBICelera
Cytogenetic MapXp22.11NCBI
HuRefX19,699,279 - 19,753,795 (+)NCBIHuRef
CHM1_1X21,989,118 - 22,043,385 (+)NCBICHM1_1
T2T-CHM13v2.0X21,524,038 - 21,578,161 (+)NCBIT2T-CHM13v2.0
Sms
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X41,331,693 - 41,387,713 (+)NCBIGRCr8
mRatBN7.2X37,516,949 - 37,572,657 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX37,516,931 - 37,570,822 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl3142,943,684 - 142,945,346 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX38,715,556 - 38,768,732 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X42,182,753 - 42,235,926 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X39,867,459 - 39,920,628 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X40,363,646 - 40,415,110 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX40,363,646 - 40,415,109 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X40,674,244 - 40,725,968 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X58,816,210 - 58,870,980 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX38,144,381 - 38,195,833 (+)NCBICelera
Cytogenetic MapXq21NCBI
Sms
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555092,276,878 - 2,329,620 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555092,277,501 - 2,328,612 (+)NCBIChiLan1.0ChiLan1.0
SMS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X23,749,232 - 23,816,094 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X23,752,622 - 23,819,491 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X14,571,432 - 14,625,601 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X21,952,477 - 21,980,209 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX21,949,830 - 21,980,209 (+)Ensemblpanpan1.1panPan2
SMS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X17,749,020 - 17,803,351 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX17,749,530 - 17,802,999 (+)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0X17,724,469 - 17,762,827 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X17,741,907 - 17,796,615 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X17,763,366 - 17,818,317 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X17,823,900 - 17,878,940 (+)NCBIUU_Cfam_GSD_1.0
Sms
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X10,755,764 - 10,814,207 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366242,346,018 - 2,401,893 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366242,345,573 - 2,402,157 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SMS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX18,118,256 - 18,169,390 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X18,118,332 - 18,169,396 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X19,300,734 - 19,353,814 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SMS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X20,418,435 - 20,475,227 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX20,418,494 - 20,476,276 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605622,273,775 - 22,330,746 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sms
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248296,883,027 - 6,931,389 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248296,883,018 - 6,931,646 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Sms
1507 total Variants

Predicted Target Of
Summary Value
Count of predictions:1323
Count of miRNA genes:631
Interacting mature miRNAs:793
Transcripts:ENSMUST00000112529, ENSMUST00000123770, ENSMUST00000127089, ENSMUST00000145477, ENSMUST00000146026
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
10401118Pgia39_mproteoglycan induced arthritis 39 (mouse)Not determinedX144474380169476592Mouse
1558900Bw3_mbody weight QTL 3 (mouse)Not determinedX133540040165298595Mouse
1302000Pgia25_mproteoglycan induced arthritis 2 (mouse)Not determinedX144474380169476592Mouse
12738421Lfibq17_mliver fibrosis QTL 17 (mouse)X148148453164945064Mouse
1301209Cia19_mcollagen induced arthritis 19 (mouse)Not determinedX120993165160213038Mouse
10412164Cmv2_mcytomegalovirus resistance 2 (mouse)Not determinedX125685149159685269Mouse
1357823Spha3_msperm head anomaly 3 (mouse)Not determinedX102055848162758941Mouse

AI427066  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X157,443,921 - 157,444,052UniSTSGRCm38
MGSCv37X153,881,853 - 153,881,984UniSTSGRCm37
CeleraX140,696,240 - 140,696,371UniSTS
Cytogenetic MapXF4UniSTS
cM MapX65.45UniSTS
Whitehead/MRC_RHX1807.89UniSTS
AW524902  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381031,213,502 - 31,213,688UniSTSGRCm38
GRCm38X157,443,917 - 157,444,085UniSTSGRCm38
MGSCv371030,933,308 - 30,933,494UniSTSGRCm37
MGSCv37X153,881,849 - 153,882,017UniSTSGRCm37
CeleraX140,696,236 - 140,696,404UniSTS
Celera1032,139,990 - 32,140,176UniSTS
Cytogenetic MapXF4UniSTS
Cytogenetic Map10A4UniSTS
cM MapX65.45UniSTS
Sms  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X62,775,668 - 62,776,167UniSTSGRCm38
MGSCv37X153,903,661 - 153,904,010UniSTSGRCm37
MGSCv37X153,907,903 - 153,908,080UniSTSGRCm37
MGSCv37X153,885,242 - 153,885,698UniSTSGRCm37
MGSCv37X153,898,227 - 153,898,469UniSTSGRCm37
MGSCv37X153,930,120 - 153,930,780UniSTSGRCm37
CeleraX49,185,576 - 49,186,075UniSTS
Cytogenetic MapXA6UniSTS
Cytogenetic MapXF4UniSTS
cM MapX65.45UniSTS
cM MapX65.45UniSTS
cM MapX65.45UniSTS
cM MapX65.45UniSTS
cM MapX65.45UniSTS
cM MapX65.45UniSTS
Sms  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X157,460,295 - 157,460,537UniSTSGRCm38
MGSCv37X153,898,227 - 153,898,469UniSTSGRCm37
CeleraX140,712,606 - 140,712,848UniSTS
Cytogenetic MapXF4UniSTS
cM MapX65.45UniSTS
Sms  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X157,465,729 - 157,466,078UniSTSGRCm38
MGSCv37X153,903,661 - 153,904,010UniSTSGRCm37
CeleraX140,718,034 - 140,718,383UniSTS
Cytogenetic MapXF4UniSTS
cM MapX65.45UniSTS
Sms  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X157,447,310 - 157,447,766UniSTSGRCm38
MGSCv37X153,885,242 - 153,885,698UniSTSGRCm37
CeleraX140,699,629 - 140,700,085UniSTS
Cytogenetic MapXF4UniSTS
cM MapX65.45UniSTS
Sms  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X157,469,971 - 157,470,148UniSTSGRCm38
MGSCv37X153,907,903 - 153,908,080UniSTSGRCm37
CeleraX140,722,309 - 140,722,486UniSTS
Cytogenetic MapXF4UniSTS
cM MapX65.45UniSTS
Sms  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X157,492,188 - 157,492,848UniSTSGRCm38
MGSCv37X153,930,120 - 153,930,780UniSTSGRCm37
Cytogenetic MapXF4UniSTS
cM MapX65.45UniSTS
Sms  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXF4UniSTS
Cytogenetic MapXA6UniSTS






1 to 27 of 27 rows
RefSeq Transcripts NM_001359185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_009214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF031486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF136179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ000087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ000088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ000089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ000090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ000091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ000092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ000093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK002687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK017775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK049780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK049787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK136798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK166665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL663072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC046623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC058688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y09419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 27 of 27 rows

Ensembl Acc Id: ENSMUST00000112529   ⟹   ENSMUSP00000108148
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX156,226,851 - 156,275,283 (-)Ensembl
GRCm38.p6 EnsemblX157,443,855 - 157,492,287 (-)Ensembl
Ensembl Acc Id: ENSMUST00000123770   ⟹   ENSMUSP00000115810
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX156,248,860 - 156,274,368 (-)Ensembl
GRCm38.p6 EnsemblX157,465,864 - 157,491,372 (-)Ensembl
Ensembl Acc Id: ENSMUST00000127089
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX156,241,870 - 156,275,040 (-)Ensembl
GRCm38.p6 EnsemblX157,458,874 - 157,492,044 (-)Ensembl
Ensembl Acc Id: ENSMUST00000145477   ⟹   ENSMUSP00000131254
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX156,228,692 - 156,275,062 (-)Ensembl
GRCm38.p6 EnsemblX157,445,696 - 157,492,066 (-)Ensembl
Ensembl Acc Id: ENSMUST00000146026
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX156,238,990 - 156,243,857 (-)Ensembl
GRCm38.p6 EnsemblX157,455,994 - 157,460,861 (-)Ensembl
RefSeq Acc Id: NM_001359185   ⟹   NP_001346114
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X156,226,847 - 156,274,364 (-)NCBI
GRCm38X157,443,851 - 157,491,368 (-)NCBI
Sequence:
RefSeq Acc Id: NM_009214   ⟹   NP_033240
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X156,226,847 - 156,275,283 (-)NCBI
GRCm38X157,443,851 - 157,492,287 (-)NCBI
MGSCv37X153,881,886 - 153,929,978 (-)RGD
CeleraX140,696,273 - 140,722,448 (-)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: NP_033240   ⟸   NM_009214
- Peptide Label: isoform 1
- UniProtKB: Q9CT09 (UniProtKB/Swiss-Prot),   Q8C7P4 (UniProtKB/Swiss-Prot),   Q3UDT8 (UniProtKB/Swiss-Prot),   Q3TUP0 (UniProtKB/Swiss-Prot),   Q3TL65 (UniProtKB/Swiss-Prot),   A2AC82 (UniProtKB/Swiss-Prot),   Q9R282 (UniProtKB/Swiss-Prot),   P97355 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001346114   ⟸   NM_001359185
- Peptide Label: isoform 2
Ensembl Acc Id: ENSMUSP00000131254   ⟸   ENSMUST00000145477
Ensembl Acc Id: ENSMUSP00000108148   ⟸   ENSMUST00000112529
Ensembl Acc Id: ENSMUSP00000115810   ⟸   ENSMUST00000123770
PABS   Spermine synthase N-terminal

Name Modeler Protein Id AA Range Protein Structure
AF-P97355-F1-model_v2 AlphaFold P97355 1-366 view protein structure

RGD ID:6846392
Promoter ID:MM_KWN:62526
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Spleen
Transcripts:OTTMUST00000046292
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X153,929,194 - 153,929,694 (-)MPROMDB
RGD ID:6846414
Promoter ID:MM_KWN:62527
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Lung,   MEF_B4
Transcripts:ENSMUST00000096351,   ENSMUST00000112529,   OTTMUST00000046293,   OTTMUST00000046295,   XM_001473146_1_GM14680
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X153,929,761 - 153,930,261 (-)MPROMDB
RGD ID:13681708
Promoter ID:EPDNEW_M25003
Type:initiation region
Name:Sms_1
Description:Mus musculus spermine synthase , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X157,492,046 - 157,492,106EPDNEW


1 to 40 of 43 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000071708 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000112529 ENTREZGENE
  ENSMUST00000112529.8 UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.140.10 UniProtKB/Swiss-Prot
  3.40.50.150 UniProtKB/Swiss-Prot
  Siroheme synthase, domain 2 UniProtKB/Swiss-Prot
InterPro PABS UniProtKB/Swiss-Prot
  PABS_CS UniProtKB/Swiss-Prot
  SAM-dependent_MTases UniProtKB/Swiss-Prot
  Spermidine_synt_N UniProtKB/Swiss-Prot
  Spermidine_synt_N_sf UniProtKB/Swiss-Prot
  Spermine_synthase_animal UniProtKB/Swiss-Prot
  SpmSyn_N UniProtKB/Swiss-Prot
KEGG Report mmu:20603 UniProtKB/Swiss-Prot
MGD MGI:109490 ENTREZGENE
NCBI Gene 20603 ENTREZGENE
PANTHER PTHR46315 UniProtKB/Swiss-Prot
  SPERMINE SYNTHASE UniProtKB/Swiss-Prot
Pfam Spermine_synt_N UniProtKB/Swiss-Prot
  Spermine_synth UniProtKB/Swiss-Prot
  SpmSyn_N UniProtKB/Swiss-Prot
PhenoGen Sms PhenoGen
PROSITE PABS_1 UniProtKB/Swiss-Prot
  PABS_2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53335 UniProtKB/Swiss-Prot
UniProt A2AC81_MOUSE UniProtKB/TrEMBL
  A2AC82 ENTREZGENE
  E9PZ58_MOUSE UniProtKB/TrEMBL
  P97355 ENTREZGENE
  Q3TL65 ENTREZGENE
  Q3TUP0 ENTREZGENE
  Q3UDT8 ENTREZGENE
  Q8C7P4 ENTREZGENE
  Q9CT09 ENTREZGENE
  Q9R282 ENTREZGENE
  SPSY_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary A2AC82 UniProtKB/Swiss-Prot
  Q3TL65 UniProtKB/Swiss-Prot
  Q3TUP0 UniProtKB/Swiss-Prot
  Q3UDT8 UniProtKB/Swiss-Prot
1 to 40 of 43 rows