Hsfy2 (heat shock transcription factor, Y-linked 2) - Rat Genome Database

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Gene: Hsfy2 (heat shock transcription factor, Y-linked 2) Mus musculus
Analyze
Symbol: Hsfy2
Name: heat shock transcription factor, Y-linked 2
RGD ID: 1557392
MGI Page MGI
Description: Predicted to enable sequence-specific double-stranded DNA binding activity. Predicted to be located in cytosol and nucleoplasm. Orthologous to several human genes including HSFY2 (heat shock transcription factor Y-linked 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 4933413G11Rik; heat shock transcription factor, Y linked 2 like; heat shock transcription factor, Y-linked; Hspy2l
RGD Orthologs
Human
Rat
Dog
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gm14728  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39156,675,203 - 56,676,610 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl156,675,203 - 56,676,594 (-)EnsemblGRCm39 Ensembl
GRCm38156,636,044 - 56,637,451 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl156,636,044 - 56,637,435 (-)EnsemblGRCm38mm10GRCm38
MGSCv37156,692,888 - 56,694,295 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36156,580,600 - 56,581,988 (-)NCBIMGSCv36mm8
Celera157,150,974 - 57,152,382 (-)NCBICelera
Cytogenetic Map1C1.3NCBI
cM Map128.72NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hsfy2Mouseautistic disorder  ISOHSFY2 (Homo sapiens)8554872ClinVar Annotator: match by term: AutismClinVarPMID:21681106 and PMID:30208311


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hsfy2Mouseaflatoxin B1 increases methylationISOHSFY2 (Homo sapiens)6480464Aflatoxin B1 results in increased methylation of HSFY2 geneCTDPMID:27153756
Hsfy2Mousecopper atom increases expressionISOHsfy2 (Rattus norvegicus)6480464Copper deficiency results in increased expression of HSFY2 mRNACTDPMID:26033743
Hsfy2Mousecopper(0) increases expressionISOHsfy2 (Rattus norvegicus)6480464Copper deficiency results in increased expression of HSFY2 mRNACTDPMID:26033743
Hsfy2Mousefolic acid decreases expressionEXP 6480464Folic Acid results in decreased expression of HSFY2 mRNACTDPMID:25629700
Hsfy2Mouseparacetamol increases expressionISOHSFY2 (Homo sapiens)6480464Acetaminophen results in increased expression of HSFY2 mRNACTDPMID:26690555


Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hsfy2Mousecytosol located_inISOUniProtKB:Q96LI62290270 GO_CentralGO_REF:0000119
Hsfy2Mousenucleoplasm located_inISOUniProtKB:Q96LI62290270 GO_CentralGO_REF:0000119

Molecular Function

  

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hsfy2Mouseabnormal auditory brainstem response  IEA 5509061 MGI 
Hsfy2Mouseincreased leukocyte cell number  IEA 5509061 MGI 
Hsfy2Mousemale infertility  IEA 5509061 MGI 

#
Reference Title
Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14681479   PMID:15618518   PMID:16141072   PMID:16141073   PMID:21873635   PMID:38355793   PMID:38684656  



Hsfy2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39156,675,203 - 56,676,610 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl156,675,203 - 56,676,594 (-)EnsemblGRCm39 Ensembl
GRCm38156,636,044 - 56,637,451 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl156,636,044 - 56,637,435 (-)EnsemblGRCm38mm10GRCm38
MGSCv37156,692,888 - 56,694,295 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36156,580,600 - 56,581,988 (-)NCBIMGSCv36mm8
Celera157,150,974 - 57,152,382 (-)NCBICelera
Cytogenetic Map1C1.3NCBI
cM Map128.72NCBI
HSFY2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38Y18,731,440 - 18,790,764 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblY18,546,691 - 18,588,963 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p14 EnsemblY18,731,440 - 18,773,735 (-)EnsemblGRCh38hg38GRCh38
GRCh37Y20,893,326 - 20,935,621 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36Y19,352,714 - 19,395,009 (-)NCBINCBI36Build 36hg18NCBI36
Build 34Y19,321,825 - 19,323,746NCBI
CeleraY6,839,462 - 6,881,754 (+)NCBICelera
Cytogenetic MapYq11.222NCBI
HuRefY14,604,979 - 14,647,513 (-)NCBIHuRef
T2T-CHM13v2.0Y19,637,916 - 19,697,230 (-)NCBIT2T-CHM13v2.0
Hsfy2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8965,676,744 - 65,678,157 (-)NCBIGRCr8
mRatBN7.2958,182,415 - 58,183,828 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl958,182,253 - 58,184,500 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx966,682,537 - 66,683,950 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0971,798,442 - 71,799,855 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0970,116,517 - 70,117,930 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0963,289,937 - 63,291,350 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl963,289,944 - 63,291,350 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0963,097,408 - 63,098,821 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4955,495,514 - 55,496,927 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1955,642,502 - 55,643,909 (-)NCBI
Celera955,646,697 - 55,648,110 (-)NCBICelera
Cytogenetic Map9q31NCBI
LOC119868754
(Canis lupus familiaris - dog)		 No map positions available.

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Variants in Hsfy2
57 total Variants

Predicted Target Of
Summary Value
Count of predictions:46
Count of miRNA genes:41
Interacting mature miRNAs:46
Transcripts:ENSMUST00000062085
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 41 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1357524W6q14_mweight 6 weeks QTL 14 (mouse)Not determined13476013873976915Mouse
12910788Pwgrq9_mpost-weaning growth rate QTL 9 (mouse)14086800867270256Mouse
1301714Vertcling_mvertical clinging (mouse)Not determined14293803176938167Mouse
18182931Metl1_mmetabolite locus 1, pyridoxate (mouse)14127539975275399Mouse
4141305Tgq9_mtriglyceride QTL 9 (mouse)Not determined5142160585421605Mouse
1357651Lgq5_mlate growth QTL 5 (mouse)Not determined13476013873976915Mouse
12910786Pwgrq10_mpost-weaning growth rate QTL 10 (mouse)14086800867270256Mouse
11100001Col4a1m1_mcollagen, type IV, alpha 1 modifier 1 (mouse)12555019162946882Mouse
1301211Bbaa11_mB.burgdorferi-associated arthritis 11 (mouse)Not determined14888900682889210Mouse

1 to 10 of 41 rows






Ensembl Acc Id: ENSMUST00000062085   ⟹   ENSMUSP00000049715
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl156,675,203 - 56,676,594 (-)Ensembl
GRCm38.p6 Ensembl156,636,044 - 56,637,435 (-)Ensembl
RefSeq Acc Id: NM_027661   ⟹   NP_081937
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39156,675,203 - 56,676,610 (-)NCBI
GRCm38156,636,044 - 56,637,451 (-)ENTREZGENE
MGSCv37156,692,888 - 56,694,295 (-)RGD
Celera157,150,974 - 57,152,382 (-)RGD
cM Map1 ENTREZGENE
Sequence:
Protein RefSeqs NP_081937 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH49724 (Get FASTA)   NCBI Sequence Viewer  
  BAB30438 (Get FASTA)   NCBI Sequence Viewer  
  EDL00042 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000049715
  ENSMUSP00000049715.5
RefSeq Acc Id: NP_081937   ⟸   NM_027661
- UniProtKB: Q80Y37 (UniProtKB/TrEMBL),   Q9D449 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000049715   ⟸   ENSMUST00000062085
HSF-type DNA-binding

Name Modeler Protein Id AA Range Protein Structure
AF-Q80Y37-F1-model_v2 AlphaFold Q80Y37 1-392 view protein structure

RGD ID:6873746
Promoter ID:EPDNEW_M324
Type:initiation region
Name:Hsfy2_1
Description:Mus musculus heat shock transcription factor, Y-linked 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38156,637,474 - 56,637,534EPDNEW


1 to 18 of 18 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000045336 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000062085 ENTREZGENE
  ENSMUST00000062085.6 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
InterPro HSF_DNA-bd UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
KEGG Report mmu:71066 UniProtKB/TrEMBL
MGD MGI:1918316 ENTREZGENE
NCBI Gene 71066 ENTREZGENE
PANTHER PTHR10015 UniProtKB/TrEMBL
  PTHR10015:SF336 UniProtKB/TrEMBL
Pfam HSF_DNA-bind UniProtKB/TrEMBL
PhenoGen Hsfy2 PhenoGen
SMART HSF UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/TrEMBL
UniProt Q80Y37 ENTREZGENE, UniProtKB/TrEMBL
  Q9D449 ENTREZGENE, UniProtKB/TrEMBL
1 to 18 of 18 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-10-20 Hsfy2  heat shock transcription factor, Y-linked 2    heat shock transcription factor, Y linked 2  Symbol and/or name change 5135510 APPROVED