Actrt2 (actin-related protein T2) - Rat Genome Database

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Gene: Actrt2 (actin-related protein T2) Mus musculus
Analyze
Symbol: Actrt2
Name: actin-related protein T2
RGD ID: 1557047
MGI Page MGI
Description: Predicted to be located in cytoplasm and cytoskeleton. Predicted to be active in actin cytoskeleton. Is expressed in Meckel's cartilage; liver lobe; and skeleton. Orthologous to human ACTRT2 (actin related protein T2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1700052K15Rik; actin related protein M2 (Arpm2); actin-related protein M2; Ar; Arp; Arp-T2; Arpm2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394154,750,885 - 154,752,324 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4154,750,890 - 154,752,324 (-)EnsemblGRCm39 Ensembl
GRCm384154,666,428 - 154,667,867 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4154,666,433 - 154,667,867 (-)EnsemblGRCm38mm10GRCm38
MGSCv374154,040,537 - 154,041,976 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364153,510,234 - 153,511,533 (-)NCBIMGSCv36mm8
Celera4156,945,512 - 156,946,951 (-)NCBICelera
Cytogenetic Map4E2NCBI
cM Map484.69NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 10 of 10 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Actrt2Mousechromosome 1p36 deletion syndrome  ISOACTRT2 (Homo sapiens)8554872ClinVar Annotator: match by term: Chromosome 1p36 deletion syndromeClinVar 
Actrt2Mousedilated cardiomyopathy 1LL  ISOACTRT2 (Homo sapiens)8554872ClinVar Annotator: match by term: Left ventricular noncompaction 8ClinVarPMID:28492532
Actrt2MouseEhlers-Danlos syndrome spondylodysplastic type 2  ISOACTRT2 (Homo sapiens)8554872ClinVar Annotator: match by term: Ehlers-Danlos syndrome more ...ClinVarPMID:10862081 more ...
Actrt2MouseGoldberg-Shprintzen syndrome  ISOACTRT2 (Homo sapiens)8554872ClinVar Annotator: match by term: Shprintzen-Goldberg syndromeClinVarPMID:23892090 more ...
Actrt2Mouseimmunodeficiency 16  ISOACTRT2 (Homo sapiens)8554872ClinVar Annotator: match by term: Combined immunodeficiency due to OX40 deficiencyClinVarPMID:10862081 more ...
Actrt2Mouseimmunodeficiency 38  ISOACTRT2 (Homo sapiens)8554872ClinVar Annotator: match by term: Mendelian susceptibility to mycobacterial diseases due to complete ISG15 deficiencyClinVarPMID:10862081 more ...
Actrt2MouseJoubert syndrome 25  ISOACTRT2 (Homo sapiens)8554872ClinVar Annotator: match by term: Joubert syndrome 25ClinVarPMID:10862081 more ...
Actrt2MouseNeurodevelopmental Disorders  ISOACTRT2 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
Actrt2MousePeroxisome Biogenesis Disorder, Complementation Group 7  ISOACTRT2 (Homo sapiens)8554872ClinVar Annotator: match by term: Peroxisome biogenesis disorder and complementation group 7ClinVarPMID:10862081 more ...
Actrt2MouseShprintzen-Goldberg Craniosynostosis  ISOACTRT2 (Homo sapiens)8554872ClinVar Annotator: match by term: Shprintzen-Goldberg syndromeClinVarPMID:23892090 more ...
1 to 10 of 10 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Actrt2MouseKeloid  ISOACTRT2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20128793

1 to 20 of 30 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Actrt2Mouse(S)-nicotine decreases expressionISOActrt2 (Rattus norvegicus)6480464Nicotine results in decreased expression of ACTRT2 mRNACTDPMID:27782041
Actrt2Mouse2,2',4,4'-Tetrabromodiphenyl ether decreases expressionISOACTRT2 (Homo sapiens)64804642 more ...CTDPMID:23146750
Actrt2Mouse2,3,7,8-tetrachlorodibenzodioxine multiple interactionsEXP 6480464AHR protein promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of ACTRT2 mRNA]CTDPMID:19759094
Actrt2Mouse2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of ACTRT2 mRNACTDPMID:19759094 and PMID:21354282
Actrt2Mouse3,3',4,4',5-pentachlorobiphenyl decreases expressionISOACTRT2 (Homo sapiens)64804643 more ...CTDPMID:23146750
Actrt2Mouse4,4'-diaminodiphenylmethane decreases expressionEXP 64804644 and 4'-diaminodiphenylmethane results in decreased expression of ACTRT2 mRNACTDPMID:18648102
Actrt2Mouse6-propyl-2-thiouracil decreases expressionISOActrt2 (Rattus norvegicus)6480464Propylthiouracil results in decreased expression of ACTRT2 mRNACTDPMID:24780913 and PMID:30047161
Actrt2Mouseacetamiprid decreases expressionISOActrt2 (Rattus norvegicus)6480464acetamiprid results in decreased expression of ACTRT2 mRNACTDPMID:27782041
Actrt2Mousebenzo[a]pyrene affects methylationISOACTRT2 (Homo sapiens)6480464Benzo(a)pyrene affects the methylation of ACTRT2 exonCTDPMID:27901495
Actrt2Mousebenzo[a]pyrene decreases methylationISOACTRT2 (Homo sapiens)6480464Benzo(a)pyrene results in decreased methylation of ACTRT2 promoterCTDPMID:27901495
Actrt2Mousebisphenol A decreases expressionISOACTRT2 (Homo sapiens)6480464bisphenol A results in decreased expression of ACTRT2 mRNACTDPMID:23146750
Actrt2Mousebisphenol A increases methylationISOActrt2 (Rattus norvegicus)6480464bisphenol A results in increased methylation of ACTRT2 geneCTDPMID:28505145
Actrt2Mousebisphenol A decreases expressionISOActrt2 (Rattus norvegicus)6480464bisphenol A results in decreased expression of ACTRT2 mRNACTDPMID:25181051
Actrt2MouseC60 fullerene decreases expressionISOActrt2 (Rattus norvegicus)6480464fullerene C60 results in decreased expression of ACTRT2 mRNACTDPMID:19167457
Actrt2MouseCGP 52608 multiple interactionsISOACTRT2 (Homo sapiens)6480464CGP 52608 promotes the reaction [RORA protein binds to ACTRT2 gene]CTDPMID:28238834
Actrt2MouseCuprizon decreases expressionISOActrt2 (Rattus norvegicus)6480464Cuprizone results in decreased expression of ACTRT2 mRNACTDPMID:27523638
Actrt2Mousefolic acid decreases expressionISOACTRT2 (Homo sapiens)6480464Folic Acid results in decreased expression of ACTRT2 mRNACTDPMID:21867686
Actrt2Mousemethoxychlor affects methylationISOActrt2 (Rattus norvegicus)6480464Methoxychlor affects the methylation of ACTRT2 geneCTDPMID:35440735
Actrt2Mousenicotine decreases expressionISOActrt2 (Rattus norvegicus)6480464Nicotine results in decreased expression of ACTRT2 mRNACTDPMID:27782041
Actrt2Mouseozone multiple interactionsISOACTRT2 (Homo sapiens)6480464[Air Pollutants results in increased abundance of Ozone] which affects the methylation of ACTRT2 geneCTDPMID:35835166

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Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Actrt2Mousebiological_process involved_inND 2290270 MGIGO_REF:0000015

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Actrt2Mouseactin cytoskeleton is_active_inIBAPANTHER:PTN002631484 more ...2290270 GO_CentralGO_REF:0000033
Actrt2Mousecytoplasm located_inIEAUniProtKB-KW:KW-09632290270 UniProtGO_REF:0000043
Actrt2Mousecytoskeleton located_inIEAUniProtKB-SubCell:SL-00902290270 UniProtGO_REF:0000044

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Actrt2Mousemolecular_function enablesND 2290270 MGIGO_REF:0000015
Actrt2Mouseprotein binding enablesISOUniProtKB:Q9H2J49068941 PMID:33961781IntActPMID:33961781


#
Reference Title
Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12077353   PMID:12243744   PMID:12477932   PMID:15489334   PMID:16141072   PMID:16141073   PMID:21267068   PMID:21873635  



Actrt2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394154,750,885 - 154,752,324 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4154,750,890 - 154,752,324 (-)EnsemblGRCm39 Ensembl
GRCm384154,666,428 - 154,667,867 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4154,666,433 - 154,667,867 (-)EnsemblGRCm38mm10GRCm38
MGSCv374154,040,537 - 154,041,976 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364153,510,234 - 153,511,533 (-)NCBIMGSCv36mm8
Celera4156,945,512 - 156,946,951 (-)NCBICelera
Cytogenetic Map4E2NCBI
cM Map484.69NCBI
ACTRT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813,021,467 - 3,022,903 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl13,021,467 - 3,022,903 (+)EnsemblGRCh38hg38GRCh38
GRCh3712,938,031 - 2,939,467 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612,927,906 - 2,929,327 (+)NCBINCBI36Build 36hg18NCBI36
Celera12,136,394 - 2,137,815 (+)NCBICelera
Cytogenetic Map1p36.32NCBI
HuRef12,233,024 - 2,234,445 (+)NCBIHuRef
CHM1_112,925,090 - 2,926,511 (+)NCBICHM1_1
T2T-CHM13v2.012,523,087 - 2,524,523 (+)NCBIT2T-CHM13v2.0
Actrt2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85170,518,470 - 170,519,870 (-)NCBIGRCr8
mRatBN7.25165,236,092 - 165,237,492 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5165,236,086 - 165,237,629 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5167,940,981 - 167,942,381 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05169,762,387 - 169,763,787 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05169,724,919 - 169,726,319 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05172,077,290 - 172,078,690 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5172,077,282 - 172,078,760 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05175,534,186 - 175,535,586 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45171,473,765 - 171,475,165 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15171,484,260 - 171,485,660 (-)NCBI
Celera5163,443,936 - 163,445,336 (-)NCBICelera
Cytogenetic Map5q36NCBI
Actrt2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554868,465,620 - 8,466,744 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554868,465,523 - 8,466,841 (-)NCBIChiLan1.0ChiLan1.0
ACTRT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21225,297,615 - 225,299,858 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11223,942,329 - 223,944,572 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011,680,590 - 1,682,020 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112,818,691 - 2,820,133 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12,818,917 - 2,820,050 (+)Ensemblpanpan1.1panPan2
ACTRT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1557,659,055 - 57,660,479 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl557,659,262 - 57,660,395 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha557,671,258 - 57,672,681 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0557,861,591 - 57,863,014 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl557,861,794 - 57,862,927 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1557,852,649 - 57,854,072 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0557,745,180 - 57,746,603 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0558,135,055 - 58,136,480 (+)NCBIUU_Cfam_GSD_1.0
Actrt2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505828,699,309 - 28,700,931 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936737765,125 - 766,432 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936737765,125 - 766,432 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACTRT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl664,664,641 - 64,665,774 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1664,664,484 - 64,665,774 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2659,253,686 - 59,255,135 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ACTRT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120128,660,029 - 128,665,485 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20128,660,121 - 128,661,254 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605432,946,475 - 32,947,937 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Actrt2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248187,288,304 - 7,289,434 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248187,288,206 - 7,289,499 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Actrt2
95 total Variants

Predicted Target Of
Summary Value
Count of predictions:188
Count of miRNA genes:181
Interacting mature miRNAs:188
Transcripts:ENSMUST00000060062
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 20 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
4142077Ignpq2_mIgA nephropathy QTL 2 (mouse)Not determined4133676733156860686Mouse
4142139Adip12_madiposity 12 (mouse)Not determined4124621281156860686Mouse
10043996Gct5_mgranulosa cell tumorigenesis 5 (mouse)Not determined4127784226156860686Mouse
1301108Scon2_msucrose consumption 2 (mouse)Not determined4134654451156860686Mouse
10043985Stheal12_msoft tissue heal 12 (mouse)Not determined4121342649155342753Mouse
1300858Tafat_mtally ho associated mesenteric fat pad weight (mouse)Not determined4124621281156860686Mouse
1300537Ap3q_malcohol preference 3 QTL (mouse)Not determined4134654451156860686Mouse
1301982Pltiq1_mphospholipid transfer protein inducibility QTL 1 (mouse)Not determined4124621281156860686Mouse
10045620Heal22_mwound healing/regeneration 22 (mouse)Not determined4125230872156860686Mouse

1 to 10 of 20 rows






Ensembl Acc Id: ENSMUST00000060062   ⟹   ENSMUSP00000050377
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4154,750,890 - 154,752,324 (-)Ensembl
GRCm38.p6 Ensembl4154,666,433 - 154,667,867 (-)Ensembl
RefSeq Acc Id: NM_028513   ⟹   NP_082789
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394154,750,885 - 154,752,324 (-)NCBI
GRCm384154,666,428 - 154,667,867 (-)ENTREZGENE
MGSCv374154,040,537 - 154,041,976 (-)RGD
Celera4156,945,512 - 156,946,951 (-)RGD
cM Map4 ENTREZGENE
Sequence:
Protein RefSeqs NP_082789 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH52344 (Get FASTA)   NCBI Sequence Viewer  
  BAB24733 (Get FASTA)   NCBI Sequence Viewer  
  EDL14976 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000050377
  ENSMUSP00000050377.4
GenBank Protein Q9D9L5 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_082789   ⟸   NM_028513
- UniProtKB: Q9D9L5 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000050377   ⟸   ENSMUST00000060062

Name Modeler Protein Id AA Range Protein Structure
AF-Q9D9L5-F1-model_v2 AlphaFold Q9D9L5 1-377 view protein structure

RGD ID:6885738
Promoter ID:EPDNEW_M6320
Type:multiple initiation site
Name:Actrt2_1
Description:Mus musculus actin-related protein T2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384154,667,867 - 154,667,927EPDNEW


1 to 19 of 19 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000051276 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000060062 ENTREZGENE
  ENSMUST00000060062.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.420.40 UniProtKB/Swiss-Prot
  Actin, Chain A, domain 4 UniProtKB/Swiss-Prot
InterPro Actin UniProtKB/Swiss-Prot
  Actin/actin-like_CS UniProtKB/Swiss-Prot
  ATPase_NBD UniProtKB/Swiss-Prot
KEGG Report mmu:73353 UniProtKB/Swiss-Prot
MGD MGI:1920603 ENTREZGENE
NCBI Gene 73353 ENTREZGENE
PANTHER PTHR11937 UniProtKB/Swiss-Prot
Pfam Actin UniProtKB/Swiss-Prot
PhenoGen Actrt2 PhenoGen
PRINTS ACTIN UniProtKB/Swiss-Prot
PROSITE ACTINS_ACT_LIKE UniProtKB/Swiss-Prot
SMART ACTIN UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53067 UniProtKB/Swiss-Prot
UniProt ACTT2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
1 to 19 of 19 rows