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Gene: Fbxw8 (F-box and WD-40 domain protein 8) Mus musculus

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Symbol:

Fbxw8

Name:

F-box and WD-40 domain protein 8

RGD ID:

1552356

MGI Page

MGI

Description:

Enables ubiquitin-like ligase-substrate adaptor activity. Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Acts upstream of or within labyrinthine layer blood vessel development and spongiotrophoblast layer development. Part of Cul7-RING ubiquitin ligase complex and SCF ubiquitin ligase complex. Is active in cytosol. Is expressed in several structures, including heart; liver; lung; placenta; and spleen. Orthologous to human FBXW8 (F-box and WD repeat domain containing 8).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

4930438M06Rik; F-box and WD-40 domain-containing protein 8; F-box protein FBX29; F-box/WD repeat-containing protein 8; FBW6; FBW8; Fbx29; FBXO2; FBXO29; RIKEN cDNA 4930438M06 gene

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	118,203,046 - 118,293,523 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	118,203,030 - 118,293,529 (-)	Ensembl		GRCm39 Ensembl
GRCm38	5	118,064,981 - 118,155,458 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	118,064,965 - 118,155,464 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	118,514,990 - 118,605,467 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	118,326,029 - 118,416,415 (-)	NCBI		MGSCv36	mm8
Celera	5	115,159,806 - 115,250,279 (-)	NCBI		Celera
Cytogenetic Map	5	F	NCBI
cM Map	5	57.92	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Fbxw8	Mouse	urinary bladder cancer		ISO	FBXW8 (Homo sapiens)	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:26039340

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Fbxw8	Mouse	2,2',4,4'-Tetrabromodiphenyl ether	increases expression	ISO	Fbxw8 (Rattus norvegicus)	6480464	2 more ...	CTD	PMID:27291303
Fbxw8	Mouse	2,3,7,8-tetrachlorodibenzodioxine	affects expression	EXP		6480464	Tetrachlorodibenzodioxin affects the expression of FBXW8 mRNA	CTD	PMID:21570461
Fbxw8	Mouse	2,6-dinitrotoluene	affects expression	ISO	Fbxw8 (Rattus norvegicus)	6480464	2 and 6-dinitrotoluene affects the expression of FBXW8 mRNA	CTD	PMID:21346803
Fbxw8	Mouse	3,4-methylenedioxymethamphetamine	decreases expression	EXP		6480464	N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of FBXW8 mRNA	CTD	PMID:26251327
Fbxw8	Mouse	6-propyl-2-thiouracil	decreases expression	ISO	Fbxw8 (Rattus norvegicus)	6480464	Propylthiouracil results in decreased expression of FBXW8 mRNA	CTD	PMID:24780913
Fbxw8	Mouse	aflatoxin B1	decreases methylation	ISO	FBXW8 (Homo sapiens)	6480464	Aflatoxin B1 results in decreased methylation of FBXW8 intron	CTD	PMID:30157460
Fbxw8	Mouse	all-trans-retinoic acid	decreases expression	ISO	FBXW8 (Homo sapiens)	6480464	Tretinoin results in decreased expression of FBXW8 mRNA	CTD	PMID:33167477
Fbxw8	Mouse	arsane	affects methylation	ISO	FBXW8 (Homo sapiens)	6480464	Arsenic affects the methylation of FBXW8 gene	CTD	PMID:25304211
Fbxw8	Mouse	arsenic atom	affects methylation	ISO	FBXW8 (Homo sapiens)	6480464	Arsenic affects the methylation of FBXW8 gene	CTD	PMID:25304211
Fbxw8	Mouse	arsenite(3-)	multiple interactions	ISO	FBXW8 (Homo sapiens)	6480464	arsenite inhibits the reaction [G3BP1 protein binds to FBXW8 mRNA]	CTD	PMID:32406909
Fbxw8	Mouse	benzo[a]pyrene	increases methylation	ISO	FBXW8 (Homo sapiens)	6480464	Benzo(a)pyrene results in increased methylation of FBXW8 promoter	CTD	PMID:27901495
Fbxw8	Mouse	benzo[a]pyrene	affects methylation	ISO	FBXW8 (Homo sapiens)	6480464	Benzo(a)pyrene affects the methylation of FBXW8 intron	CTD	PMID:30157460
Fbxw8	Mouse	benzo[e]pyrene	decreases methylation	ISO	FBXW8 (Homo sapiens)	6480464	benzo(e)pyrene results in decreased methylation of FBXW8 intron	CTD	PMID:30157460
Fbxw8	Mouse	bisphenol A	decreases expression	ISO	Fbxw8 (Rattus norvegicus)	6480464	bisphenol A results in decreased expression of FBXW8 mRNA	CTD	PMID:25181051
Fbxw8	Mouse	bisphenol A	increases expression	EXP		6480464	bisphenol A results in increased expression of FBXW8 mRNA	CTD	PMID:33221593
Fbxw8	Mouse	butanal	decreases expression	ISO	FBXW8 (Homo sapiens)	6480464	butyraldehyde results in decreased expression of FBXW8 mRNA	CTD	PMID:26079696
Fbxw8	Mouse	cobalt dichloride	decreases expression	ISO	FBXW8 (Homo sapiens)	6480464	cobaltous chloride results in decreased expression of FBXW8 mRNA	CTD	PMID:19320972
Fbxw8	Mouse	fenvalerate	decreases expression	ISO	Fbxw8 (Rattus norvegicus)	6480464	fenvalerate results in decreased expression of FBXW8 mRNA	CTD	PMID:30307764
Fbxw8	Mouse	glyphosate	affects methylation	ISO	Fbxw8 (Rattus norvegicus)	6480464	Glyphosate affects the methylation of FBXW8 gene	CTD	PMID:35440735
Fbxw8	Mouse	methapyrilene	decreases methylation	ISO	FBXW8 (Homo sapiens)	6480464	Methapyrilene results in decreased methylation of FBXW8 intron	CTD	PMID:30157460
Fbxw8	Mouse	methoxychlor	affects methylation	ISO	Fbxw8 (Rattus norvegicus)	6480464	Methoxychlor affects the methylation of FBXW8 gene	CTD	PMID:35440735
Fbxw8	Mouse	perfluorohexanesulfonic acid	decreases expression	EXP		6480464	perfluorohexanesulfonic acid results in decreased expression of FBXW8 mRNA	CTD	PMID:37995155
Fbxw8	Mouse	phenobarbital	affects expression	EXP		6480464	Phenobarbital affects the expression of FBXW8 mRNA	CTD	PMID:23091169
Fbxw8	Mouse	sunitinib	increases expression	ISO	FBXW8 (Homo sapiens)	6480464	Sunitinib results in increased expression of FBXW8 mRNA	CTD	PMID:31533062
Fbxw8	Mouse	testosterone	decreases expression	ISO	FBXW8 (Homo sapiens)	6480464	Testosterone results in decreased expression of FBXW8 mRNA	CTD	PMID:33359661
Fbxw8	Mouse	thioacetamide	increases expression	ISO	Fbxw8 (Rattus norvegicus)	6480464	Thioacetamide results in increased expression of FBXW8 mRNA	CTD	PMID:23411599
Fbxw8	Mouse	titanium dioxide	decreases methylation	ISO	FBXW8 (Homo sapiens)	6480464	titanium dioxide results in decreased methylation of FBXW8 gene	CTD	PMID:34973136
Fbxw8	Mouse	Tributyltin oxide	increases phosphorylation	EXP		6480464	bis(tri-n-butyltin)oxide results in increased phosphorylation of FBXW8 protein	CTD	PMID:22174045
Fbxw8	Mouse	urethane	decreases expression	ISO	FBXW8 (Homo sapiens)	6480464	Urethane results in decreased expression of FBXW8 mRNA	CTD	PMID:28818685

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Fbxw8	Mouse	cell population proliferation	involved_in	ISO	UniProtKB:Q8N3Y1	2290270		GO_Central	GO_REF:0000119
Fbxw8	Mouse	cell population proliferation	involved_in	ISS	UniProtKB:Q8N3Y1	2290270		UniProt	GO_REF:0000024
Fbxw8	Mouse	cilium assembly	involved_in	IBA	PANTHER:PTN002541592 more ...	2290270		GO_Central	GO_REF:0000033
Fbxw8	Mouse	Golgi organization	involved_in	ISS	UniProtKB:P0DL28	2290270		UniProt	GO_REF:0000024
Fbxw8	Mouse	Golgi organization	involved_in	ISO	Fbxw8 (Rattus norvegicus)	2290270		GO_Central	GO_REF:0000096
Fbxw8	Mouse	Golgi organization	involved_in	ISO	UniProtKB:Q8N3Y1	2290270		GO_Central	GO_REF:0000119
Fbxw8	Mouse	labyrinthine layer blood vessel development	acts_upstream_of_or_within	IMP	MGI:3665136	2290270	PMID:16880526	MGI	PMID:16880526
Fbxw8	Mouse	negative regulation of insulin receptor signaling pathway	involved_in	IEA	UniProtKB:Q8N3Y1 and ensembl:ENSP00000498999	2290270		Ensembl	GO_REF:0000107
Fbxw8	Mouse	positive regulation of dendrite morphogenesis	involved_in	ISO	Fbxw8 (Rattus norvegicus)	2290270		GO_Central	GO_REF:0000096
Fbxw8	Mouse	positive regulation of dendrite morphogenesis	involved_in	ISO	UniProtKB:Q8N3Y1	2290270		GO_Central	GO_REF:0000119
Fbxw8	Mouse	positive regulation of dendrite morphogenesis	involved_in	ISS	UniProtKB:P0DL28	2290270		UniProt	GO_REF:0000024
Fbxw8	Mouse	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	involved_in	IDA		2290270	PMID:29153991	UniProt	PMID:29153991
Fbxw8	Mouse	proteasome-mediated ubiquitin-dependent protein catabolic process	involved_in	ISO	FBXW8 (Homo sapiens)	9068941	PMID:17205132	UniProt	PMID:17205132
Fbxw8	Mouse	protein ubiquitination	involved_in	IEA	UniPathway:UPA00143	2290270		UniProt	GO_REF:0000041
Fbxw8	Mouse	protein ubiquitination	involved_in	IDA		2290270	PMID:29153991	UniProt	PMID:29153991
Fbxw8	Mouse	protein ubiquitination	involved_in	ISO	UniProtKB:Q8N3Y1	2290270		GO_Central	GO_REF:0000119
Fbxw8	Mouse	protein ubiquitination	involved_in	IBA	PANTHER:PTN000520403 more ...	2290270		GO_Central	GO_REF:0000033
Fbxw8	Mouse	protein ubiquitination	involved_in	ISS	UniProtKB:Q8N3Y1	2290270		UniProt	GO_REF:0000024
Fbxw8	Mouse	spongiotrophoblast layer development	acts_upstream_of_or_within	IMP	MGI:3665136	2290270	PMID:16880526	MGI	PMID:16880526
Fbxw8	Mouse	ubiquitin-dependent protein catabolic process	involved_in	IDA		2290270	PMID:23142081	UniProt	PMID:23142081
Fbxw8	Mouse	ubiquitin-dependent protein catabolic process	acts_upstream_of_or_within	IC	GO:0019005	2290270	PMID:16880526	MGI	PMID:16880526

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Fbxw8	Mouse	3M complex	part_of	ISS	UniProtKB:Q8N3Y1	2290270		UniProt	GO_REF:0000024
Fbxw8	Mouse	3M complex	located_in	ISO	FBXW8 (Homo sapiens)	9068941	PMID:24793695	UniProt	PMID:24793695
Fbxw8	Mouse	3M complex	part_of	ISO	UniProtKB:Q8N3Y1	2290270		GO_Central	GO_REF:0000119
Fbxw8	Mouse	centriole	is_active_in	IBA	PANTHER:PTN002541592 more ...	2290270		GO_Central	GO_REF:0000033
Fbxw8	Mouse	ciliary basal body	is_active_in	IBA	PANTHER:PTN002541592 more ...	2290270		GO_Central	GO_REF:0000033
Fbxw8	Mouse	Cul7-RING ubiquitin ligase complex	part_of	IDA		2290270	PMID:21572988 and PMID:23142081	UniProt	PMID:21572988 and PMID:23142081
Fbxw8	Mouse	Cul7-RING ubiquitin ligase complex	part_of	ISO	UniProtKB:Q8N3Y1	2290270		GO_Central	GO_REF:0000119
Fbxw8	Mouse	Cul7-RING ubiquitin ligase complex	part_of	IBA	PANTHER:PTN000520403 more ...	2290270		GO_Central	GO_REF:0000033
Fbxw8	Mouse	cytoplasm	is_active_in	ISO	FBXW8 (Homo sapiens)	9068941	PMID:17205132	UniProt	PMID:17205132
Fbxw8	Mouse	cytosol	is_active_in	IDA		2290270	PMID:23142081	UniProt	PMID:23142081
Fbxw8	Mouse	cytosol	located_in	ISO	UniProtKB:Q8N3Y1	2290270		GO_Central	GO_REF:0000119
Fbxw8	Mouse	Golgi apparatus	located_in	ISO	UniProtKB:Q8N3Y1	2290270		GO_Central	GO_REF:0000119
Fbxw8	Mouse	Golgi apparatus	located_in	ISO	Fbxw8 (Rattus norvegicus)	2290270		GO_Central	GO_REF:0000096
Fbxw8	Mouse	Golgi apparatus	located_in	ISS	UniProtKB:Q8N3Y1	2290270		UniProt	GO_REF:0000024
Fbxw8	Mouse	perinuclear region of cytoplasm	located_in	ISO	Fbxw8 (Rattus norvegicus)	2290270		GO_Central	GO_REF:0000096
Fbxw8	Mouse	perinuclear region of cytoplasm	located_in	ISS	UniProtKB:Q8N3Y1	2290270		UniProt	GO_REF:0000024
Fbxw8	Mouse	perinuclear region of cytoplasm	located_in	ISO	UniProtKB:Q8N3Y1	2290270		GO_Central	GO_REF:0000119
Fbxw8	Mouse	SCF ubiquitin ligase complex	part_of	IPI	PR:Q9WTX5	2290270	PMID:16880526	MGI	PMID:16880526

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Fbxw8	Mouse	protein binding	enables	IPI	UniProtKB:P20263	2290270	PMID:29153991	UniProt	PMID:29153991
Fbxw8	Mouse	protein binding	enables	IPI	PR:Q8VE73 and PR:Q9WTX5	2290270	PMID:16880526	MGI	PMID:16880526
Fbxw8	Mouse	ubiquitin protein ligase activity	enables	IC	GO:0005515	2290270	PMID:29153991	GO_Central	PMID:29153991
Fbxw8	Mouse	ubiquitin-like ligase-substrate adaptor activity	enables	IDA		2290270	PMID:23142081	UniProt	PMID:23142081
Fbxw8	Mouse	ubiquitin-protein transferase activity	contributes_to	ISO	UniProtKB:Q8N3Y1	2290270		GO_Central	GO_REF:0000119
Fbxw8	Mouse	ubiquitin-protein transferase activity	contributes_to	ISS	UniProtKB:Q8N3Y1	2290270		UniProt	GO_REF:0000024

Imported Annotations - KEGG (archival)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Fbxw8	Mouse	ubiquitin/proteasome degradation pathway		IEA		6907045		KEGG	mmu:04120

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Fbxw8	Mouse	abnormal brain size		IAGP		5509061		MGI	PMID:17998335
Fbxw8	Mouse	abnormal placenta labyrinth morphology		IAGP		5509061		MGI	PMID:16880526
Fbxw8	Mouse	abnormal placenta morphology		IAGP		5509061		MGI	PMID:16880526
Fbxw8	Mouse	abnormal placental labyrinth vasculature morphology		IAGP		5509061		MGI	PMID:16880526
Fbxw8	Mouse	abnormal spongiotrophoblast layer morphology		IAGP		5509061		MGI	PMID:16880526
Fbxw8	Mouse	atelectasis		IAGP		5509061		MGI	PMID:17998335
Fbxw8	Mouse	cyanosis		IAGP		5509061		MGI	PMID:17998335
Fbxw8	Mouse	decreased body weight		IAGP		5509061		MGI	PMID:17998335
Fbxw8	Mouse	decreased embryo size		IAGP		5509061		MGI	PMID:16880526
Fbxw8	Mouse	decreased embryo size		IAGP		5509061		MGI	PMID:17998335
Fbxw8	Mouse	decreased fetal size		IAGP		5509061		MGI	PMID:17998335
Fbxw8	Mouse	decreased lymphocyte cell number		IEA		5509061		MGI
Fbxw8	Mouse	decreased placenta weight		IAGP		5509061		MGI	PMID:17998335
Fbxw8	Mouse	decreased survivor rate		IAGP		5509061		MGI	PMID:17998335
Fbxw8	Mouse	embryonic growth retardation		IAGP		5509061		MGI	PMID:16880526
Fbxw8	Mouse	embryonic lethality during organogenesis, incomplete penetrance		IAGP		5509061		MGI	PMID:16880526
Fbxw8	Mouse	increased basophil cell number		IEA		5509061		MGI
Fbxw8	Mouse	increased blood urea nitrogen level		IEA		5509061		MGI
Fbxw8	Mouse	increased circulating creatinine level		IEA		5509061		MGI
Fbxw8	Mouse	increased eosinophil cell number		IEA		5509061		MGI
Fbxw8	Mouse	increased neutrophil cell number		IEA		5509061		MGI
Fbxw8	Mouse	lethality throughout fetal growth and development, incomplete penetrance		IAGP		5509061		MGI	PMID:16880526
Fbxw8	Mouse	neonatal lethality, incomplete penetrance		IAGP		5509061		MGI	PMID:17998335
Fbxw8	Mouse	preweaning lethality, incomplete penetrance		IEA		5509061		MGI
Fbxw8	Mouse	respiratory distress		IAGP		5509061		MGI	PMID:17998335
Fbxw8	Mouse	slow postnatal weight gain		IAGP		5509061		MGI	PMID:17998335

#	Reference Title	Reference Citation
1.	Functional annotation of a full-length mouse cDNA collection.	Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2.	MGDs mouse GO annotations	MGD data from the GO Consortium
3.	Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	Mouse MP Annotation Import Pipeline	RGD automated import pipeline
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

PMID:7671812	PMID:8889548	PMID:10349636	PMID:11042159	PMID:11076861	PMID:12477932	PMID:12520002	PMID:12904583	PMID:14610273	PMID:15489334	PMID:15520277	PMID:15782199
PMID:16141072	PMID:16141073	PMID:16880526	PMID:17205132	PMID:17332328	PMID:17998335	PMID:21070969	PMID:21267068	PMID:21572988	PMID:21873635	PMID:22124152	PMID:22956915
PMID:23142081	PMID:24219910	PMID:24793005	PMID:25790475	PMID:27626380	PMID:28378742	PMID:29153991	PMID:30735494	PMID:32098917	PMID:35115401	PMID:38355793

Fbxw8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	118,203,046 - 118,293,523 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	118,203,030 - 118,293,529 (-)	Ensembl		GRCm39 Ensembl
GRCm38	5	118,064,981 - 118,155,458 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	118,064,965 - 118,155,464 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	118,514,990 - 118,605,467 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	118,326,029 - 118,416,415 (-)	NCBI		MGSCv36	mm8
Celera	5	115,159,806 - 115,250,279 (-)	NCBI		Celera
Cytogenetic Map	5	F	NCBI
cM Map	5	57.92	NCBI

FBXW8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	116,910,950 - 117,031,148 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	116,910,950 - 117,032,498 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	117,348,755 - 117,468,953 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	115,833,144 - 115,953,336 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	12	116,978,296 - 117,098,473 (+)	NCBI		Celera
Cytogenetic Map	12	q24.22	NCBI
HuRef	12	114,357,862 - 114,477,782 (+)	NCBI		HuRef
CHM1_1	12	117,316,410 - 117,436,644 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	116,892,024 - 117,012,205 (+)	NCBI		T2T-CHM13v2.0

Fbxw8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	44,087,375 - 44,177,985 (+)	NCBI		GRCr8
mRatBN7.2	12	38,426,466 - 38,517,076 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	38,426,444 - 38,516,424 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	39,601,817 - 39,692,425 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	40,215,614 - 40,306,221 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	39,268,570 - 39,359,182 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	44,046,204 - 44,138,138 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	44,046,217 - 44,138,138 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	45,877,860 - 45,969,762 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	39,574,258 - 39,666,586 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	12	39,437,667 - 39,526,703 (+)	NCBI
Celera	12	40,085,063 - 40,177,071 (+)	NCBI		Celera
Cytogenetic Map	12	q16	NCBI

Fbxw8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955455	14,100,636 - 14,204,792 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955455	14,099,888 - 14,204,889 (-)	NCBI	ChiLan1.0	ChiLan1.0

FBXW8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	124,972,139 - 125,093,431 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	124,968,537 - 125,089,813 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	114,487,476 - 114,607,384 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	117,863,254 - 117,983,269 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	117,863,254 - 117,983,269 (+)	Ensembl	panpan1.1		panPan2

FBXW8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	13,520,605 - 13,640,975 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	13,412,189 - 13,638,258 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	13,515,165 - 13,635,427 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	13,780,524 - 13,901,191 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	13,780,556 - 13,901,188 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	13,742,170 - 13,863,012 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	13,820,084 - 13,940,246 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	13,854,501 - 13,975,455 (+)	NCBI		UU_Cfam_GSD_1.0

Fbxw8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	153,955,104 - 154,055,611 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936558	5,421,976 - 5,523,676 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936558	5,423,815 - 5,523,649 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FBXW8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	35,444,281 - 35,575,705 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	35,445,020 - 35,613,725 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	37,665,000 - 37,833,502 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

FBXW8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	112,226,545 - 112,337,164 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	112,226,594 - 112,341,225 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	132,740,395 - 132,851,867 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Fbxw8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	16,233,312 - 16,343,824 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624747	16,226,025 - 16,343,839 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in Fbxw8
3968 total Variants

Predicted Target Of

	Summary Value
Count of predictions:	1349
Count of miRNA genes:	642
Interacting mature miRNAs:	772
Transcripts:	ENSMUST00000049474
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1301399	Cpfd3_m	cerebellum pattern fissures (mouse)			Not determined		5	87386871	121387065	Mouse
25314315	Mlh1fc4_m	MLH1 foci count 4 (mouse)					5	74460661	132528839	Mouse
1357725	Eae39_m	experimental allergic encephalomyelitis 39 (mouse)			Not determined		5	89418876	118864028	Mouse
14746986	Manh58_m	mandible shape 58 (mouse)					5	102446283	136446283	Mouse
1300993	Hycdc_m	hypercapnic duty cycle (mouse)			Not determined		5	90561006	124561151	Mouse
1301126	Bwem1_m	body weight day 30 males 1 (mouse)			Not determined		5	87386871	121387065	Mouse
1300659	Pcd8ts1_m	p-glycoprotein positive CD8 T cell subset 1 (mouse)			Not determined		5	97021753	131021986	Mouse
1300913	Bwefm_m	body weight females and males day 10 (mouse)			Not determined		5	109439348	143439459	Mouse
10402486	Dipa1_m	drug induced psychomotor activation 1 (mouse)			Not determined		5	95465549	129465722	Mouse
10043958	Chldq12_m	cholesterol and HDL QTL 12 (mouse)			Not determined		5	87386871	121387065	Mouse
26884395	Humsd2_m	humerus midshaft diameter 2, 10 week (mouse)					5	70057343	132528839	Mouse
10412202	Bbaa26_m	B.burgdorferi-associated arthritis 26 (mouse)			Not determined		5	104583688	138555455	Mouse
1301543	Hypch_m	hypercholesterolemia (mouse)			Not determined		5	109238624	139118905	Mouse
12904945	Tammq2_m	tibialis anterior muscle mass QTL 2 (mouse)					5	100665965	134665965	Mouse
4142473	Chlq11_m	circulating hormone level QTL 11 (mouse)			Not determined		5	107906299	141906412	Mouse
11341716	Rvfs3_m	Rift Valley fever susceptibility 3 (mouse)					5	26441234	138455402	Mouse
12904959	Smmq1_m	soleus muscle mass QTL 1 (mouse)					5	100665965	134665965	Mouse
10412197	Bbaa25_m	B.burgdorferi-associated arthritis 25 (mouse)			Not determined		5	109167240	143167381	Mouse
13506928	Recrq8_m	recombination rate in male meiosis QTL 8 (mouse)					5	74460661	132528839	Mouse
27226719	Tibw6_m	tibia width 6, proximal, 16 week (mouse)					5	72857343	139985755	Mouse
1301457	Cfsw2_m	cystic fibrosis survival to weaning 2 (mouse)			Not determined		5	90561006	124561151	Mouse
1301974	Chab7_m	cholesterol absorption 7 (mouse)			Not determined		5	95233214	129233330	Mouse
1300827	Cora1_m	correlation in cytokine production 1 (mouse)			Not determined		5	115156883	149157015	Mouse
11528550	Sluc33_m	susceptibility to lung cancer 33 (mouse)					5	104386871	120711986	Mouse
1357662	Lprq4_m	lipoprotein QTL 4 (mouse)			Not determined		5	114021753	129632606	Mouse
4142064	Tmc1m4_m	Tmc1 modifier 4 (mouse)			Not determined		5	54500177	127001072	Mouse
10412239	Alpq7_m	alcohol preference QTL 7 (mouse)			Not determined		5	104705939	138705939	Mouse
1300801	Drb2_m	dopamine receptor binding 2 (mouse)			Not determined		5	87386871	121387065	Mouse
9587780	Afw16_m	abdominal fat weight QTL 16 (mouse)			Not determined		5	92830166	126830285	Mouse
1357644	Egrd1_m	early growth rate, direct effect 1 (mouse)			Not determined		5	95434580	129434786	Mouse
12859290	Criq2_m	Citrobacter rodentium infection QTL 2 (mouse)					5	101332579	135332579	Mouse
1300940	Actd3_m	activity-distance traveled 3 (mouse)			Not determined		5	96320385	130320533	Mouse
1301362	Prnr1_m	prion resistance 1 (mouse)			Not determined		5	89418876	146787935	Mouse
1558774	Lith17_m	lithogenic gene 17 (mouse)			Not determined		5	95465549	129465722	Mouse
1357431	Cia27_m	collagen induced arthritis 27 (mouse)			Not determined		5	75315348	120018629	Mouse
1301624	Aevm2_m	autoimmune extremity vasculitis in MRL mice 2 (mouse)			Not determined		5	101863832	135864028	Mouse
10043890	Trigq4_m	triglyceride QTL 4 (mouse)			Not determined		5	107906299	141906412	Mouse
4141139	Hmtb4_m	hemostasis and thrombosis rebleeding time 4 (mouse)			Not determined			108762509	126882944	Mouse
11532736	Sluc33b_m	susceptibility to lung cancer 33b (mouse)					5	102945037	136945196	Mouse
4141519	Hmtb5_m	hemostasis and thrombosis bleeding time 5 (mouse)			Not determined			99949422	126882944	Mouse
1301858	Smdq1_m	segregation of mitochondrial DNA QTL 1 (mouse)			Not determined		5	97021753	131021986	Mouse
11049562	Lmr24f_m	leishmaniasis resistance 24f (mouse)					5	90320962	124321041	Mouse
13464251	Ahl21_m	age related hearing loss, early onset 21 (mouse)					5	109167240	143167381	Mouse
13464244	Ahl19_m	age related hearing loss, early onset 19 (mouse)					5	95465549	129465722	Mouse
1301226	Bbaa2_m	B.burgdorferi-associated arthritis 2 (mouse)			Not determined		5	115156883	149157015	Mouse
1300968	Skts4_m	skin tumor susceptibility 4 (mouse)			Not determined		5	89418876	124238239	Mouse
13464241	Ahl18_m	age related hearing loss, early onset 18 (mouse)					5	87386871	121387065	Mouse
1301102	Cia14_m	collagen induced arthritis 14 (mouse)			Not determined		5	113320385	138555455	Mouse
13464243	Ahl20_m	age related hearing loss, early onset 20 (mouse)					5	107906299	141906412	Mouse

BB357976

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	5	118,077,146 - 118,077,252	UniSTS	GRCm38
MGSCv37	5	118,527,155 - 118,527,261	UniSTS	GRCm37
Celera	5	115,171,969 - 115,172,075	UniSTS
Cytogenetic Map	5	F	UniSTS
Whitehead/MRC_RH	5	1428.6	UniSTS

UniSTS:235289

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	5	118,066,987 - 118,067,128	UniSTS	GRCm38
MGSCv37	5	118,516,996 - 118,517,137	UniSTS	GRCm37
Celera	5	115,161,810 - 115,161,951	UniSTS
Cytogenetic Map	5	F	UniSTS

UniSTS:235291

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	5	118,067,930 - 118,068,016	UniSTS	GRCm38
MGSCv37	5	118,517,939 - 118,518,025	UniSTS	GRCm37
Celera	5	115,162,753 - 115,162,839	UniSTS
Cytogenetic Map	5	F	UniSTS

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.


RefSeq Transcripts	NM_172721	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC110254	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC114993	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK031815	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK034447	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK047695	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK047756	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK053794	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK134291	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK163976	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK194533	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK197164	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK202489	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK209645	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK210434	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK214176	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK215147	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK215899	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK219233	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC009095	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC024091	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BY468586	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466529	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSMUST00000049474 ⟹ ENSMUSP00000047012

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	5	118,203,030 - 118,293,529 (-)	Ensembl
GRCm38.p6 Ensembl	5	118,064,965 - 118,155,464 (-)	Ensembl

Ensembl Acc Id:

ENSMUST00000201545

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	5	118,215,117 - 118,293,491 (-)	Ensembl
GRCm38.p6 Ensembl	5	118,077,052 - 118,155,426 (-)	Ensembl

RefSeq Acc Id:

NM_172721 ⟹ NP_766309

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	5	118,203,046 - 118,293,523 (-)	NCBI
GRCm38	5	118,064,981 - 118,155,458 (-)	ENTREZGENE
MGSCv37	5	118,514,990 - 118,605,467 (-)	RGD
Celera	5	115,159,806 - 115,250,279 (-)	RGD
cM Map	5		ENTREZGENE

Sequence:

show sequence

GGACACTTCCGGCGGATGGACAGTCCGTCCCCATTCTGGCAGCCCCTGGGTGCCGCGTCGGCCTGGGCGCGTCAAGCATGGACGACCACAACCTGGAGGAGTTCCGCCGGCACTGGCAGGAGGAGTTG
GCGCAGTCACAGGCGCTGAGGCGACGGCGGCGGCTCGAGGCTGGGGAGCGGCGGTCGCCGCGAAGGCCCGAGGCGGGAGCGCGAGGCGAGCCGGCCTCGGGCTACCTGGGGCTGGCGCAGGGGCTGCT
GGAGGGCGCGGGCCGACCCCCGGCGCCCAGGCCTGGCCGGGGAGGCGACAGGAAGGATACGTCCAGCCGATCGCGCTCACCCCCAGACCGCGACGCCACGGAGCCCGAGCCGCTGGTGGATCAGCTCA
TCCGCGACTTGAATGAGCTGGATGACGTGCCCTTCTTTGATGTCCGTCTGCCTTACGAACTGGCCATCAATATATTCCAGTATCTGAACAGAAGAGAGCTGGGACTGTGTGCTCAGGTGAGCAAGACA
TGGAAGGTGATTGCTGAAGACGAGGTGCTGTGGTACCGGCTGTGCCGACAGGAGGGGCACCTTCCCCACAGCAGATTCTCCGATTACACCTGCTGGAAGCTCATCTTGCAAGAGTGCCTCGCCAAGGA
GCACACATTAAGAGCCAACTGGAAGAATCGCAAAGGTGCCGTGAGCGAGCTGGAGCATGTTCCCGACGCTGTTTTGTGTGACGTGCGTTCTCACGATGGTGTGGTCATTGCTGGATACACGTCAGGGG
ATGTGCGGGTGTGGGACACCCGCACCTGGGACTACGTGGCCCCCTTCCTGGAGTCTGAGTCTGAGGAGGAGGATCCTGGAATGCAGCCATATGTCTCCTTTGTGAGGATCAACAGCTCGCTGGCAGTG
GCGGCTTACGAGGATGGGATCCTTAACATTTGGGACCTGAGAACCGGAAGGTTCCCTATCTTTCGTTTTGAGCATGACGCAAGAATACAAGCCCTTGCGCTGAGCCAAGAAAAGCCCATTGTTGCCAC
GGCTTCTGCTTTTGACGTTGTGATGTTGTACCCCAACGAGGAGGGGCATTGGCATGTGGCCTCGGAGTTTGAAGTTCAGAAGCTGGTTGACTACCTTGAAATAGTTCCGAATACTGGGAGGTACCCTG
TGGCAATAGCCACAGCCGGGGATCTGGTGTACCTGCTGAAGGCCGACGACTCAGCCAGAACCCTTCATTATGTCTATGGCCAGCCTGCCACATGTCTGGATGTCTCAGCCAGCCAGGTTGCCTTTGGA
GTGAAGAGTCTAGGATGGGTGTATGAAGGAAACAAGATCCTGGTGTACAGCCTGGAAGCAGAGCGCTGCCTCTCGAAGCTGGGCAATGCACTTGGAGACTTTACCTGTGTCAACATCCGGGATAGCCC
TCCCAACCTCATGGTCAGCGGCAACATGGACAGGAGAGTGAGGATCCATGACCTCCGCAGCGATAAGATCGCCCTGTCGCTGTCTGCCCATCAGCTGGGGGTGTCCGCAGTCCAGATGGATGACTGGA
AGGTTGTCAGTGGAGGCGAGGAGGGGCTGGTGTCTGTGTGGGATTACCGCATGAACCAGAAGCTGTGGGAAGTGCACTCCAGGCACCCTGTGCGCTATCTCTCCTTCAATAGCCACAGCCTCATCACT
GCCAACGTGCCCTACGAGAAGGTGCTGCGAAACTCCGACCTCGACAACTTTGCCTGTCACAGGAGACATCGTGGCCTGATCCATGCCTATGAATTTGCTGTGGACCAGCTGGCCTTTCAGAGCCCCCT
TCCTGTCTGCCGCTTACCCCGTGACATCATGGCTGGATACAGCTATGACCTCGCACTGTCTTTCCCCCATGACAGTATTTAGGGTGTCACCTCATGTAGACGTGGAAAGGGCAGTTTTACAAATGTTA
GAGTTGGAGAGAGGCTCTGCAGCACATGGTGGGAGTTTGGGGACAGTGTCCTGTATGACTGTGGCCACACAGCCCTGTTGCCCTGTACAGAACCAGACTCCATTGCTGCCTTTCTCCTCCTCCTCCTC
CTCCTCAGGCTTTGGTAGGACTGGCTGATGACTCAGAGTTAACCTTTCCAGGGGTGGCTCCTCCCCCTCAGCCTATGGCAGCAGTGACACCCCCCCTCGTTCCATAGGCCAGGGACACAGGGCCTTCA
CTTGCACTGTCTCCTGGGTGTGGTGCTGAGGGTGGAACCAGAATCTCACACGCATAGGCAAGCGTCAGCCTCCAAGCTGCCTCCCCAGCTGTCAGCCTCCCCAGCTGTCTCCTCCAGGCACCCTCCAG
TGCAGCCCCTCCTCTGGGATTCACACCGTTGATAATTATAGGGCCACCTTACCTGTAGGAGCTGTTCTGTCCTGTACATGTGCTATGAAGGAGACAGCCATCCTTCCTGCAGAGGGAAAGGGTCATTG
CACAGGGATAGGGTCAGTCTCCAAGCCTAGCCGGTGGTGTCTCTTCCTGACAAACGCAGCCATAGCTCACCCACTCTGCCTTCAGAGTGTCATGGACAAATCCACACATAGTGGCCAGGAGACCCAGT
CAGAGCTCTTCAGAATCCCCACAGACCAGGCACCTAACACACCTGCACAGAGGCCACCAGGTCTCAGGAGACAAAGTTCCTCTCCCAGGGAATACCAGCTCAAAAAACAAGTGGGCTGGCAAACTCCA
CATTGGGTCTGCCGAGAGCAAGAAAAAAGAGGGGGGTGGGGGAGCTCCATGGGGTGGATCCCAGGCTGGCAGCAGGAAGGTGCTGGAAGGCCTGAGAGGGTGTGCAGTGCCCTCCCCGAGCCCTGGTG
GTCTCCTCCTGTGTGCTGGGATGGAGTCTAGTGGGTTTGTGGCATGATCTCAGATCTTGGCATTGAGGCCTCTCCCCATGCACAAGTGCCCAGGGGAGCTCACCTCCCTCTTGCTGGGCTGGCGCCCC
CTGCTGGCCTGGTCTTGCTGTGTCCTCACTCGAGCATTCCCAGTCCTAAGCTGTCCACTGGAGACATTTCTGTCAGAGAAATTGGCTGTGCGGTCAGCTCCTTTCTGGGCTTCGCAGCCATGAAAGGC
CACTGAAGAGCAGAGGTGACTAGAGTAGTTTCAAGCATACATGCCCTTCTAGCCCCCAATCCCTGCCCCCTACCCCCACAGAGCATCTGTCCTCGCTGGCTCCTGCCACTGCACCTGCTCCCAGGGTG
GGGGACAGGCTGGCTCCCTGTGCTGCCTCTGAAGCCAGAAGACACCAGGACACAGCCCTGGGAGCCAGGGGTGGTCACACATCTGCAGCTTGCCTTTTGCCTTAAGCGGCCACTTCTGCTCTGTTATT
AAAGGTTCTACACTGATGAGCGTGTGTGCTGCTCCTGTAAGGACTCGTTTGAAGTCTTCCTCTGCCCTGTGTAGTCTGGTTTATTTCCCCCGGCTGGGGGTGCAGGGGCACAACATGACATGTGCACA
CAGACTAGGCTGTCCATGCAGGCGACATGCTGCTCCTGAAGCTCAGACAGCAGTTCCCATGGCAGAGTCTAGGGTACTGTGGTGTCTTTCAGCTGAGCGACAGGATTGCCAGCCTCCCTCAGCAGGGG
CACTTGGTACCCCCATAAGGGTGGCATGCCCCAGTCCACTTGTTACAGGGCAGGGCAGTACCACGAGCTAGTTAGTTGCTTGGAATTAAGAACAGCCTCCCCTAGTGAGGGGTTTCAGGTGATGACTG
CCCCGTGACAGTGGCTCAGATGGAGACACTACCCATGGGCTCTTGCTTGAAGCAGCAGATGGCACGGGCCATGGCACCGTGGCCCACACAGCCAAGCCAGATGGGTTACCTGGCTCCTGCGGCAGGCC
TGCGGTGACTTGGCCAGCACTGCCCGTGTGCGAGGTGGCAGAGCCCCTCCTGTGCAGCAGCCTGGGCCTACTGCGGTGCACTAGGGAACTTCTCCCTGGAACAGAAGAGGAGCACCAGCCTGTGCCTG
GCCGAGCCGAGCTTGTGCTGTGGCAGCTGCCCTTCCCAAGACAGACGTGCTGCCTCTCACCGCGGCAGGGGCCCTTTGAGTCCCCCCACTTTCCCTGTGGGGACAAGCCTGTCCCTTGCTGGCTTAGT
GTTACTGTTTTGCCACCCTGCCCTGGCCAGAGTTCCGAGTCCTCCTGTGGCCATGTTCCTGCCCCAAGCCCTGTTGGCATTTGTCCAACTCATGAAGACAAAGGTGCCAGTGATGCCATCGGGAGTGG
CCTGGTTCCGGCACTGGCTCCCTCAAGGTCACGGCATACAAGGACAGCCTTTATGGCAGGTGTTTGCCAAACCTCAAGGTGACTTGCACTTCTGCCTCTCCTTCCACCAACTTGGGCCTCTTCCAGCA
CAGTGGAACTTGGACTGGTCAACTGCAGAGGATCAGACCTGAGGGCCTGCCCTCTCCCACCTAACAGAGGGGCTTTGTTCACGTCTCGAAGAGCCTGGTTTGCCAAGTGGTCAGAGTGGCAGGCTGCT
CTGGGCTTGCTCTGTTTCTTACCCATAAGTTCTGTGTCACTAGGCTGCAGGTATCCATCCAGCCATGTCTATGAGGTTTGTATCACACAGCCCTCCGGGGAAAGTATCAGATTAAACATTAGCCTCCA
ACCACCACCAAACTGGGGGAGGGGACAACTTTATAAGTAGAGCATTGTGATGCCACACACACACACTCGCTGAGTGTCCCACCACTCAGGAGGATTTTAAGTTTGAGGACCAATCTCTAGAATCAATT
GTCAGTAACAGGACAGTACTGTAGGGTAGATCTCGCTTTCAGTCTGCTACAGAATAGAGAGCACACCCAACCTCCACCCAGCCACTGAGGCCCCAGCTCTGCCTGCTTCTCTACCCACAGCCCTACTC
CCAGCTCCTCAGCAGTAGCCTTGGGTGCCACCAAGTCAGCTTCAGTGTGGTTGATGAAGAGCCTGTACTTACCTGTCCCCAAATAAATGTTAGCACAAAGCCTGCTTCACACTG

hide sequence


Protein RefSeqs	NP_766309	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH09095	(Get FASTA)	NCBI Sequence Viewer
	AAH24091	(Get FASTA)	NCBI Sequence Viewer
	BAC28712	(Get FASTA)	NCBI Sequence Viewer
	BAC33128	(Get FASTA)	NCBI Sequence Viewer
	BAC33147	(Get FASTA)	NCBI Sequence Viewer
	BAC35527	(Get FASTA)	NCBI Sequence Viewer
	BAE37563	(Get FASTA)	NCBI Sequence Viewer
	EDL19798	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000047012
	ENSMUSP00000047012.8
GenBank Protein	Q8BIA4	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_766309 ⟸ NM_172721

- UniProtKB:

Q921Z1 (UniProtKB/Swiss-Prot), Q8CID8 (UniProtKB/Swiss-Prot), Q8BIA4 (UniProtKB/Swiss-Prot), Q8BI76 (UniProtKB/Swiss-Prot), Q8BI75 (UniProtKB/Swiss-Prot), Q8BI62 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MDDHNLEEFRRHWQEELAQSQALRRRRRLEAGERRSPRRPEAGARGEPASGYLGLAQGLLEGAGRPPAPRPGRGGDRKDTSSRSRSPPDRDATEPEPLVDQLIRDLNELDDVPFFDVRLPYELAINIF
QYLNRRELGLCAQVSKTWKVIAEDEVLWYRLCRQEGHLPHSRFSDYTCWKLILQECLAKEHTLRANWKNRKGAVSELEHVPDAVLCDVRSHDGVVIAGYTSGDVRVWDTRTWDYVAPFLESESEEEDP
GMQPYVSFVRINSSLAVAAYEDGILNIWDLRTGRFPIFRFEHDARIQALALSQEKPIVATASAFDVVMLYPNEEGHWHVASEFEVQKLVDYLEIVPNTGRYPVAIATAGDLVYLLKADDSARTLHYVY
GQPATCLDVSASQVAFGVKSLGWVYEGNKILVYSLEAERCLSKLGNALGDFTCVNIRDSPPNLMVSGNMDRRVRIHDLRSDKIALSLSAHQLGVSAVQMDDWKVVSGGEEGLVSVWDYRMNQKLWEVH
SRHPVRYLSFNSHSLITANVPYEKVLRNSDLDNFACHRRHRGLIHAYEFAVDQLAFQSPLPVCRLPRDIMAGYSYDLALSFPHDSI

hide sequence

Ensembl Acc Id:

ENSMUSP00000047012 ⟸ ENSMUST00000049474

Protein Domains

F-box

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q8BIA4-F1-model_v2	AlphaFold	Q8BIA4	1-598	view protein structure

RGD ID:

6887828

Promoter ID:

EPDNEW_M7365

Type:

initiation region

Name:

Fbxw8_1

Description:

Mus musculus F-box and WD-40 domain protein 8 , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	5	118,155,426 - 118,155,486	EPDNEW

RGD ID:

6837509

Promoter ID:

MM_KWN:43774

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

3T3L1_Day2, BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Brain, ES_Cell, Liver, Lung, MEF_B4, MEF_B6

Transcripts:

NM_172721, UC008ZGF.1

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	5	118,605,164 - 118,605,664 (-)	MPROMDB

Database	Acc Id	Source(s)
Ensembl Genes	ENSMUSG00000032867	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSMUST00000049474	ENTREZGENE
	ENSMUST00000049474.9	UniProtKB/Swiss-Prot
Gene3D-CATH	1.20.1280.50	UniProtKB/Swiss-Prot
	2.130.10.10	UniProtKB/Swiss-Prot
InterPro	F-box-like_dom_sf	UniProtKB/Swiss-Prot
	F-box_dom	UniProtKB/Swiss-Prot
	WD40/YVTN_repeat-like_dom_sf	UniProtKB/Swiss-Prot
	WD40_repeat	UniProtKB/Swiss-Prot
	WD40_repeat_dom_sf	UniProtKB/Swiss-Prot
	WDR55_POC1	UniProtKB/Swiss-Prot
KEGG Report	mmu:231672	UniProtKB/Swiss-Prot
MGD	MGI:1923041	ENTREZGENE
NCBI Gene	Fbxw8	ENTREZGENE
PANTHER	POC1 CENTRIOLAR PROTEIN HOMOLOG	UniProtKB/Swiss-Prot
	WD REPEAT-CONTAINING PROTEIN 55	UniProtKB/Swiss-Prot
Pfam	F-box-like	UniProtKB/Swiss-Prot
PhenoGen	Fbxw8	PhenoGen
PROSITE	FBOX	UniProtKB/Swiss-Prot
	WD_REPEATS_1	UniProtKB/Swiss-Prot
	WD_REPEATS_2	UniProtKB/Swiss-Prot
	WD_REPEATS_REGION	UniProtKB/Swiss-Prot
SMART	FBOX	UniProtKB/Swiss-Prot
	WD40	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF50978	UniProtKB/Swiss-Prot
	SSF81383	UniProtKB/Swiss-Prot
UniProt	FBXW8_MOUSE	UniProtKB/Swiss-Prot
	Q3TQ22_MOUSE	UniProtKB/TrEMBL
	Q8BI62	ENTREZGENE
	Q8BI75	ENTREZGENE
	Q8BI76	ENTREZGENE
	Q8BIA4	ENTREZGENE
	Q8CID8	ENTREZGENE
	Q921Z1	ENTREZGENE
UniProt Secondary	Q8BI62	UniProtKB/Swiss-Prot
	Q8BI75	UniProtKB/Swiss-Prot
	Q8BI76	UniProtKB/Swiss-Prot
	Q8CID8	UniProtKB/Swiss-Prot
	Q921Z1	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2024-08-21	Fbxw8	F-box and WD-40 domain protein 8	4930438M06Rik	RIKEN cDNA 4930438M06 gene	Symbol and/or name change	5135510	APPROVED
2024-08-21	4930438M06Rik	RIKEN cDNA 4930438M06 gene	Fbxw8	F-box and WD-40 domain protein 8	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

Mammalian Phenotype