TXNIP (thioredoxin interacting protein) - Rat Genome Database

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Gene: TXNIP (thioredoxin interacting protein) Sus scrofa
Analyze
Symbol: TXNIP
Name: thioredoxin interacting protein
RGD ID: 14208657
Description: ENCODES a protein that exhibits enzyme inhibitor activity (inferred); ubiquitin protein ligase binding (inferred); INVOLVED IN cellular response to tumor cell (ortholog); negative regulation of cell division (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH colorectal cancer (ortholog); COVID-19 (ortholog); Diabetic Nephropathies (ortholog); FOUND IN cytoplasm (inferred); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: thioredoxin-interacting protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl499,348,490 - 99,352,755 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1499,348,589 - 99,351,760 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24108,991,390 - 108,994,561 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA)

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:17406940   PMID:23053948   PMID:30032202  


Genomics

Comparative Map Data
TXNIP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl499,348,490 - 99,352,755 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1499,348,589 - 99,351,760 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24108,991,390 - 108,994,561 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TXNIP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381145,992,435 - 145,996,579 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1145,992,435 - 145,996,579 (-)EnsemblGRCh38hg38GRCh38
GRCh371145,438,490 - 145,442,635 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361144,149,939 - 144,153,882 (+)NCBINCBI36Build 36hg18NCBI36
Build 341142,927,625 - 142,931,567NCBI
Celera1119,641,815 - 119,645,987 (+)NCBICelera
Cytogenetic Map1q21.1NCBI
HuRef1119,402,325 - 119,406,521 (+)NCBIHuRef
CHM1_11147,360,561 - 147,364,757 (-)NCBICHM1_1
T2T-CHM13v2.01145,109,270 - 145,113,414 (-)NCBIT2T-CHM13v2.0
Txnip
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39396,465,273 - 96,469,173 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl396,465,273 - 96,469,199 (+)EnsemblGRCm39 Ensembl
GRCm38396,557,957 - 96,561,857 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl396,557,957 - 96,561,883 (+)EnsemblGRCm38mm10GRCm38
MGSCv37396,361,880 - 96,365,780 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36396,643,362 - 96,647,271 (+)NCBIMGSCv36mm8
Celera397,964,967 - 97,968,875 (+)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map341.93NCBI
Txnip
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82186,781,933 - 186,785,736 (+)NCBIGRCr8
mRatBN7.22184,093,079 - 184,096,882 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2184,092,991 - 184,096,886 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2191,764,537 - 191,768,337 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02189,557,131 - 189,560,931 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02184,397,095 - 184,400,895 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02198,683,168 - 198,686,971 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2198,683,159 - 198,686,974 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02218,170,102 - 218,173,905 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42191,356,954 - 191,360,757 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12191,319,631 - 191,323,506 (+)NCBI
Celera2176,618,301 - 176,622,104 (+)NCBICelera
Cytogenetic Map2q34NCBI
Txnip
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955568103,762 - 107,785 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955568103,801 - 107,791 (+)NCBIChiLan1.0ChiLan1.0
LOC100971374
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21105,244,606 - 105,248,842 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11104,844,009 - 104,850,270 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0190,007,878 - 90,012,055 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11113,902,839 - 113,906,239 (-)NCBIpanpan1.1PanPan1.1panPan2
TXNIP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11758,775,588 - 58,779,730 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1758,776,871 - 58,779,531 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1758,243,550 - 58,247,684 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01759,772,252 - 59,776,384 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1759,772,252 - 59,776,378 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11758,645,076 - 58,649,209 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01758,706,219 - 58,710,353 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01759,432,672 - 59,436,806 (-)NCBIUU_Cfam_GSD_1.0
Txnip
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505820,846,422 - 20,850,485 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936867722,514 - 726,617 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936867722,544 - 726,595 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TXNIP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12012,756,145 - 12,759,853 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2012,756,053 - 12,761,177 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603815,433,418 - 15,437,640 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Txnip
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477217,341,630 - 17,345,960 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477217,341,918 - 17,345,964 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TXNIP
49 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 4 3 5 2 15 2 3 3
Low 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001044614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AEMK02000022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK345649 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK349227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK389176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK389247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK395712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK395910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK396093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK396682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK399333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK400522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK400942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU151864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ278874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ365929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ991395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GFLN01030341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSSCT00000055984   ⟹   ENSSSCP00000035217
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl499,348,490 - 99,352,755 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000083441   ⟹   ENSSSCP00000062506
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl499,349,528 - 99,352,241 (+)Ensembl
RefSeq Acc Id: NM_001044614   ⟹   NP_001038079
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1499,348,589 - 99,351,760 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001038079   ⟸   NM_001044614
- UniProtKB: A5J2A7 (UniProtKB/Swiss-Prot),   Q09W51 (UniProtKB/Swiss-Prot),   Q2HY40 (UniProtKB/Swiss-Prot),   A0A480K2Q0 (UniProtKB/TrEMBL),   A0A480TS04 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000062506   ⟸   ENSSSCT00000083441
RefSeq Acc Id: ENSSSCP00000035217   ⟸   ENSSSCT00000055984
Protein Domains
Arrestin C-terminal-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000031262 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCG00005023907 UniProtKB/Swiss-Prot
  ENSSSCG00015036534 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00025069926 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00030069782 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00035069373 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00040049344 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00045031705 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00050074320 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00055027208 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00060023252 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00065000466 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00070001501 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000055984 ENTREZGENE
  ENSSSCT00000055984.3 UniProtKB/Swiss-Prot
  ENSSSCT00005038053.1 UniProtKB/Swiss-Prot
  ENSSSCT00015048815.1 UniProtKB/Swiss-Prot
  ENSSSCT00015049042.1 UniProtKB/TrEMBL
  ENSSSCT00025096104.1 UniProtKB/TrEMBL
  ENSSSCT00025096449.1 UniProtKB/Swiss-Prot
  ENSSSCT00030097657.1 UniProtKB/Swiss-Prot
  ENSSSCT00030097685.1 UniProtKB/TrEMBL
  ENSSSCT00035093696.1 UniProtKB/Swiss-Prot
  ENSSSCT00035093743.1 UniProtKB/TrEMBL
  ENSSSCT00040067050.1 UniProtKB/Swiss-Prot
  ENSSSCT00040067241.1 UniProtKB/TrEMBL
  ENSSSCT00045054219.1 UniProtKB/TrEMBL
  ENSSSCT00045054397.1 UniProtKB/Swiss-Prot
  ENSSSCT00050101744.1 UniProtKB/Swiss-Prot
  ENSSSCT00050101749.1 UniProtKB/TrEMBL
  ENSSSCT00055053979.1 UniProtKB/Swiss-Prot
  ENSSSCT00055054044.1 UniProtKB/TrEMBL
  ENSSSCT00060031550.1 UniProtKB/Swiss-Prot
  ENSSSCT00060031553.1 UniProtKB/TrEMBL
  ENSSSCT00065000529.1 UniProtKB/Swiss-Prot
  ENSSSCT00065000540.1 UniProtKB/TrEMBL
  ENSSSCT00070002822.1 UniProtKB/Swiss-Prot
  ENSSSCT00070002833.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.640 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Arrestin-like_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Arrestin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Arrestin_C-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_E-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:733688 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene TXNIP ENTREZGENE
PANTHER ARRESTIN DOMAIN CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOREDOXIN-INTERACTING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Arrestin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Arrestin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Arrestin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF81296 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A480K2Q0 ENTREZGENE, UniProtKB/TrEMBL
  A0A480TS04 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0NN56_PIG UniProtKB/TrEMBL
  A5J2A7 ENTREZGENE
  Q09W51 ENTREZGENE
  Q2HY40 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A5J2A7 UniProtKB/Swiss-Prot
  Q09W51 UniProtKB/Swiss-Prot
VGNC ID VGNC:94610 ENTREZGENE