PTPN7 (protein tyrosine phosphatase non-receptor type 7) - Rat Genome Database

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Gene: PTPN7 (protein tyrosine phosphatase non-receptor type 7) Sus scrofa
Analyze
Symbol: PTPN7
Name: protein tyrosine phosphatase non-receptor type 7
RGD ID: 14077260
Description: ENCODES a protein that exhibits hydrolase activity (inferred); phosphoprotein phosphatase activity (inferred); protein tyrosine phosphatase activity (inferred); INVOLVED IN protein dephosphorylation (ortholog); ASSOCIATED WITH familial adult myoclonic epilepsy 5 (ortholog); gastrointestinal stromal tumor (ortholog); Hypokalemic Periodic Paralysis, Type 1 (ortholog); FOUND IN cytoplasm (inferred); cytoplasmic side of plasma membrane (inferred); cytosol (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: splicing factor, proline- and glutamine-rich; tyrosine-protein phosphatase non-receptor type 7
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1024,325,293 - 24,336,419 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11024,325,289 - 24,336,426 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21028,744,132 - 28,748,147 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PTPN7Pigfamilial adult myoclonic epilepsy 5  ISOPTPN7 (Homo sapiens)8554872ClinVar Annotator: match by term: Epilepsy more ...ClinVarPMID:28492532
PTPN7Piggastrointestinal stromal tumor  ISOPTPN7 (Homo sapiens)8554872ClinVar Annotator: match by term: Gastrointestinal stromal tumorClinVarPMID:28492532
PTPN7PigHypokalemic Periodic Paralysis, Type 1  ISOPTPN7 (Homo sapiens)8554872ClinVar Annotator: match by term: Hypokalemic periodic paralysis and type 1ClinVarPMID:28492532
PTPN7Pigparathyroid carcinoma  ISOPTPN7 (Homo sapiens)8554872ClinVar Annotator: match by term: Parathyroid carcinomaClinVarPMID:28492532


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PTPN7Pigprotein dephosphorylation acts_upstream_of_or_withinISOMGI:21789569068941 PMID:11564869MGIPMID:11564869
PTPN7Pigsignal transduction involved_inIBAPANTHER:PTN002317746 and UniProtKB:Q15256150520179 GO_CentralGO_REF:0000033

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PTPN7Pigcell junction is_active_inIBAPANTHER:PTN002317746 more ...150520179 GO_CentralGO_REF:0000033
PTPN7Pigcytoplasm located_inIEAUniProtKB:P35236 and ensembl:ENSP00000509436150520179 EnsemblGO_REF:0000107
PTPN7Pigcytoplasmic side of plasma membrane located_inIEAUniProtKB:P35236 and ensembl:ENSP00000509436150520179 EnsemblGO_REF:0000107
PTPN7Pigcytosol is_active_inIBAPANTHER:PTN002317746 and UniProtKB:Q15256150520179 GO_CentralGO_REF:0000033
PTPN7Pigcytosol located_inIEAUniProtKB:P35236 and ensembl:ENSP00000509436150520179 EnsemblGO_REF:0000107
PTPN7Pigmicrotubule cytoskeleton located_inIEAUniProtKB:P35236 and ensembl:ENSP00000509436150520179 EnsemblGO_REF:0000107
PTPN7Pigmitotic spindle located_inIEAUniProtKB:P35236 and ensembl:ENSP00000509436150520179 EnsemblGO_REF:0000107
PTPN7Pigplasma membrane is_active_inIBAPANTHER:PTN002317746 more ...150520179 GO_CentralGO_REF:0000033

Molecular Function
1 to 11 of 11 rows

  
1 to 11 of 11 rows

PMID:14681463   PMID:22301074   PMID:30032202  



PTPN7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1024,325,293 - 24,336,419 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11024,325,289 - 24,336,426 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21028,744,132 - 28,748,147 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTPN7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381202,147,013 - 202,161,588 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1202,147,012 - 202,161,588 (-)EnsemblGRCh38hg38GRCh38
GRCh371202,116,141 - 202,130,716 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361200,382,766 - 200,396,374 (-)NCBINCBI36Build 36hg18NCBI36
Celera1175,240,001 - 175,253,609 (-)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1173,281,692 - 173,296,269 (-)NCBIHuRef
CHM1_11203,538,425 - 203,553,000 (-)NCBICHM1_1
T2T-CHM13v2.01201,404,580 - 201,419,169 (-)NCBIT2T-CHM13v2.0
Ptpn7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391135,059,577 - 135,073,064 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1135,060,438 - 135,073,055 (+)EnsemblGRCm39 Ensembl
GRCm381135,131,838 - 135,145,328 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1135,132,700 - 135,145,317 (+)EnsemblGRCm38mm10GRCm38
MGSCv371137,029,302 - 137,041,897 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361136,949,136 - 136,961,731 (+)NCBIMGSCv36mm8
Celera1137,759,680 - 137,772,179 (+)NCBICelera
Cytogenetic Map1E4NCBI
cM Map158.24NCBI
Ptpn7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81349,122,679 - 49,136,096 (+)NCBIGRCr8
mRatBN7.21346,570,904 - 46,584,048 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1346,571,712 - 46,583,308 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1349,178,503 - 49,190,055 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01350,466,576 - 50,478,127 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01347,732,661 - 47,744,208 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01351,958,023 - 51,971,431 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1351,958,834 - 51,972,777 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01357,009,427 - 57,023,148 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41348,094,119 - 48,105,707 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11348,108,161 - 48,119,750 (+)NCBI
Celera1346,897,613 - 46,908,578 (+)NCBICelera
Cytogenetic Map13q13NCBI
Ptpn7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540638,232,589 - 38,250,195 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540638,233,409 - 38,249,940 (-)NCBIChiLan1.0ChiLan1.0
PTPN7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2147,220,186 - 47,234,828 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1147,184,863 - 47,199,505 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01177,744,963 - 177,759,611 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11182,047,418 - 182,061,889 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1182,049,084 - 182,061,151 (-)Ensemblpanpan1.1panPan2
PTPN7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.17859,124 - 869,168 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl7859,214 - 869,183 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha7911,497 - 921,564 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.07867,172 - 877,245 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl7867,266 - 877,241 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.17855,561 - 865,624 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.07963,852 - 973,174 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.07987,836 - 997,900 (+)NCBIUU_Cfam_GSD_1.0
Ptpn7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934473,146,132 - 73,158,479 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365672,382,931 - 2,391,542 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365672,381,519 - 2,392,562 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPN7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12527,243,907 - 27,258,088 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605528,023,104 - 28,038,993 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptpn7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248078,575,371 - 8,593,552 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248078,575,414 - 8,593,063 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in PTPN7
264 total Variants



alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 17 3 2 5 14 12 17 3 6 3



Ensembl Acc Id: ENSSSCT00000040718   ⟹   ENSSSCP00000054017
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1024,325,292 - 24,335,193 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000045897   ⟹   ENSSSCP00000058871
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1024,325,293 - 24,336,419 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000082552   ⟹   ENSSSCP00000066944
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1024,324,436 - 24,335,776 (-)Ensembl
RefSeq Acc Id: XM_021064534   ⟹   XP_020920193
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11024,325,289 - 24,336,426 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021064535   ⟹   XP_020920194
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11024,325,289 - 24,336,030 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021064536   ⟹   XP_020920195
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11024,325,289 - 24,336,032 (-)NCBI
Sequence:
1 to 12 of 12 rows
Protein RefSeqs XP_020920193 (Get FASTA)   NCBI Sequence Viewer  
  XP_020920194 (Get FASTA)   NCBI Sequence Viewer  
  XP_020920195 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000058871
  ENSSSCP00000058871.1
  ENSSSCP00015037898.1
  ENSSSCP00040024932.1
  ENSSSCP00045020566.1
  ENSSSCP00045020612.1
  ENSSSCP00055025418.1
  ENSSSCP00055025464.1
  ENSSSCP00065031499.1
1 to 12 of 12 rows
RefSeq Acc Id: XP_020920193   ⟸   XM_021064534
- Peptide Label: isoform X1
- UniProtKB: A0A8D1Z4D6 (UniProtKB/TrEMBL),   A0A287BQT1 (UniProtKB/TrEMBL),   A0A8D0PQN0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020920195   ⟸   XM_021064536
- Peptide Label: isoform X2
- UniProtKB: A0A8D0PQN0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020920194   ⟸   XM_021064535
- Peptide Label: isoform X1
- UniProtKB: A0A8D1Z4D6 (UniProtKB/TrEMBL),   A0A287BQT1 (UniProtKB/TrEMBL),   A0A8D0PQN0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000054017   ⟸   ENSSSCT00000040718
Ensembl Acc Id: ENSSSCP00000058871   ⟸   ENSSSCT00000045897


1 to 39 of 39 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSSSCG00000037669 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015069034 UniProtKB/TrEMBL
  ENSSSCG00040044330 UniProtKB/TrEMBL
  ENSSSCG00045017427 UniProtKB/TrEMBL
  ENSSSCG00055016216 UniProtKB/TrEMBL
  ENSSSCG00065052821 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000045897 ENTREZGENE
  ENSSSCT00000045897.2 UniProtKB/TrEMBL
  ENSSSCT00015092691.1 UniProtKB/TrEMBL
  ENSSSCT00040059441.1 UniProtKB/TrEMBL
  ENSSSCT00045029661.1 UniProtKB/TrEMBL
  ENSSSCT00045029727.1 UniProtKB/TrEMBL
  ENSSSCT00055031929.1 UniProtKB/TrEMBL
  ENSSSCT00055031984.1 UniProtKB/TrEMBL
  ENSSSCT00065072326.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.190.10 UniProtKB/TrEMBL
InterPro Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  PTPase_domain UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/TrEMBL
  Tyr_Pase_KIM-con UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/TrEMBL
NCBI Gene PTPN7 ENTREZGENE
PANTHER PROTEIN-TYROSINE-PHOSPHATASE UniProtKB/TrEMBL
  PTHR46198 UniProtKB/TrEMBL
Pfam Y_phosphatase UniProtKB/TrEMBL
PRINTS KIMPTPASE UniProtKB/TrEMBL
  PRTYPHPHTASE UniProtKB/TrEMBL
PROSITE TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_PTP UniProtKB/TrEMBL
SMART PTPc UniProtKB/TrEMBL
  PTPc_motif UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/TrEMBL
UniProt A0A287BQT1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0PQN0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1QVF4_PIG UniProtKB/TrEMBL
  A0A8D1Z4D6 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:108279 ENTREZGENE
1 to 39 of 39 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-02-19 PTPN7  protein tyrosine phosphatase non-receptor type 7    protein tyrosine phosphatase, non-receptor type 7  Symbol and/or name change 5135510 APPROVED