DPEP2 (dipeptidase 2) - Rat Genome Database

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Gene: DPEP2 (dipeptidase 2) Sus scrofa
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Symbol: DPEP2
Name: dipeptidase 2
RGD ID: 14057831
Description: ENCODES a protein that exhibits dipeptidase activity (inferred); exopeptidase activity (inferred); metal ion binding (inferred); INVOLVED IN leukotriene D4 catabolic process (inferred); leukotriene metabolic process (inferred); proteolysis (inferred); ASSOCIATED WITH autosomal dominant dyskeratosis congenita 6 (ortholog); genetic disease (ortholog); FOUND IN membrane (inferred); side of membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC100621778
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl628,593,546 - 28,599,051 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1628,593,542 - 28,599,076 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2626,020,128 - 26,025,817 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
DPEP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl628,593,546 - 28,599,051 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1628,593,542 - 28,599,076 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2626,020,128 - 26,025,817 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DPEP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381667,987,390 - 68,000,619 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1667,987,394 - 68,000,586 (-)EnsemblGRCh38hg38GRCh38
GRCh371668,021,293 - 68,034,522 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361666,578,798 - 66,590,857 (-)NCBINCBI36Build 36hg18NCBI36
Build 341666,578,800 - 66,590,857NCBI
Celera1652,529,750 - 52,541,821 (-)NCBICelera
Cytogenetic Map16q22.1NCBI
HuRef1653,894,885 - 53,907,048 (-)NCBIHuRef
CHM1_11669,429,363 - 69,441,488 (-)NCBICHM1_1
T2T-CHM13v2.01673,783,178 - 73,796,408 (-)NCBIT2T-CHM13v2.0
Dpep2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398106,711,577 - 106,732,658 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8106,711,577 - 106,723,055 (-)EnsemblGRCm39 Ensembl
GRCm39 Ensembl8106,711,576 - 106,718,391 (-)EnsemblGRCm39 Ensembl
GRCm388105,984,945 - 106,006,026 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8105,984,944 - 105,991,759 (-)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl8105,984,945 - 105,996,423 (-)EnsemblGRCm38mm10GRCm38
MGSCv378108,508,957 - 108,520,323 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368108,874,186 - 108,885,552 (-)NCBIMGSCv36mm8
Celera8110,213,109 - 110,224,474 (-)NCBICelera
Cytogenetic Map8D3NCBI
cM Map853.07NCBI
Dpep2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81950,795,322 - 50,806,320 (-)NCBIGRCr8
mRatBN7.21933,883,557 - 33,896,487 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1933,885,478 - 33,891,954 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1940,701,008 - 40,707,443 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01941,354,322 - 41,360,757 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01943,653,038 - 43,659,469 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01937,964,098 - 37,975,154 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1937,964,105 - 37,970,537 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01948,831,084 - 48,851,920 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41935,832,224 - 35,838,659 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11935,837,105 - 35,843,540 (-)NCBI
Celera1933,313,021 - 33,319,456 (-)NCBICelera
Cytogenetic Map19q12NCBI
DPEP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21877,510,359 - 77,526,862 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11683,421,784 - 83,438,196 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01648,328,281 - 48,341,510 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11667,715,805 - 67,729,164 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1667,715,805 - 67,729,164 (-)Ensemblpanpan1.1panPan2
LOC489748
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1581,517,919 - 81,522,098 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl581,518,072 - 81,522,075 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha581,508,182 - 81,512,060 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0581,953,364 - 81,957,393 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl581,953,204 - 81,957,389 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1581,779,586 - 81,783,615 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0581,461,884 - 81,465,762 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0582,104,060 - 82,107,938 (+)NCBIUU_Cfam_GSD_1.0
DPEP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1559,439,237 - 59,447,400 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl559,440,951 - 59,447,698 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604722,172,991 - 22,187,738 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in DPEP2
124 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system reproductive system respiratory system
High
Medium 1 1
Low 4 1 3 4 15 3 1
Below cutoff 5 1 1 7

Sequence


RefSeq Acc Id: ENSSSCT00000027498   ⟹   ENSSSCP00000022909
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl628,593,546 - 28,599,051 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000059586   ⟹   ENSSSCP00000051448
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl628,593,542 - 28,599,368 (-)Ensembl
RefSeq Acc Id: XM_003355779   ⟹   XP_003355827
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1628,593,542 - 28,599,070 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013988512   ⟹   XP_013843966
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1628,593,542 - 28,598,998 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021094120   ⟹   XP_020949779
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1628,593,542 - 28,599,063 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021094121   ⟹   XP_020949780
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1628,593,542 - 28,598,987 (-)NCBI
Sequence:
RefSeq Acc Id: XR_001303628
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1628,593,765 - 28,599,076 (-)NCBI
Sequence:
RefSeq Acc Id: XP_003355827   ⟸   XM_003355779
- Peptide Label: isoform X1
- UniProtKB: I3LFR7 (UniProtKB/TrEMBL),   A0A8D0SZK8 (UniProtKB/TrEMBL),   A0A8D1X056 (UniProtKB/TrEMBL),   A0A8D1IVT0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020949779   ⟸   XM_021094120
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_013843966   ⟸   XM_013988512
- Peptide Label: isoform X2
- UniProtKB: A0A4X1UFT4 (UniProtKB/TrEMBL),   A0A8D1X056 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020949780   ⟸   XM_021094121
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSSSCP00000051448   ⟸   ENSSSCT00000059586
RefSeq Acc Id: ENSSSCP00000022909   ⟸   ENSSSCT00000027498


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000021105 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005015630 UniProtKB/TrEMBL
  ENSSSCG00015078228 UniProtKB/TrEMBL
  ENSSSCG00025064645 UniProtKB/TrEMBL
  ENSSSCG00030003489 UniProtKB/TrEMBL
  ENSSSCG00035039396 UniProtKB/TrEMBL
  ENSSSCG00040004320 UniProtKB/TrEMBL
  ENSSSCG00045031226 UniProtKB/TrEMBL
  ENSSSCG00050054717 UniProtKB/TrEMBL
  ENSSSCG00055010906 UniProtKB/TrEMBL
  ENSSSCG00060077789 UniProtKB/TrEMBL
  ENSSSCG00065069402 UniProtKB/TrEMBL
  ENSSSCG00070016595 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000027498 ENTREZGENE
  ENSSSCT00000027498.4 UniProtKB/TrEMBL
  ENSSSCT00005024404.1 UniProtKB/TrEMBL
  ENSSSCT00015105856.1 UniProtKB/TrEMBL
  ENSSSCT00015105892.1 UniProtKB/TrEMBL
  ENSSSCT00025088659.1 UniProtKB/TrEMBL
  ENSSSCT00030004552.1 UniProtKB/TrEMBL
  ENSSSCT00035052334.1 UniProtKB/TrEMBL
  ENSSSCT00040005687.1 UniProtKB/TrEMBL
  ENSSSCT00045053211.1 UniProtKB/TrEMBL
  ENSSSCT00050074640.1 UniProtKB/TrEMBL
  ENSSSCT00055021419.1 UniProtKB/TrEMBL
  ENSSSCT00060107229.1 UniProtKB/TrEMBL
  ENSSSCT00065095286.1 UniProtKB/TrEMBL
  ENSSSCT00070032716.1 UniProtKB/TrEMBL
Gene3D-CATH Metal-dependent hydrolases UniProtKB/TrEMBL
InterPro Dipep_AS UniProtKB/TrEMBL
  Metal_Hydrolase UniProtKB/TrEMBL
  Pept_M19 UniProtKB/TrEMBL
KEGG Report ssc:100621778 UniProtKB/TrEMBL
NCBI Gene LOC100621778 ENTREZGENE
PANTHER DIPEPTIDASE 2 UniProtKB/TrEMBL
  PTHR10443 UniProtKB/TrEMBL
Pfam Peptidase_M19 UniProtKB/TrEMBL
PROSITE RENAL_DIPEPTIDASE_1 UniProtKB/TrEMBL
  RENAL_DIPEPTIDASE_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF51556 UniProtKB/TrEMBL
UniProt A0A4X1UFT4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0SZK8 ENTREZGENE
  A0A8D1IVT0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1X056 ENTREZGENE, UniProtKB/TrEMBL
  I3LFR7 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A8D0SZK8 UniProtKB/TrEMBL
VGNC ID VGNC:96983 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-03-04 DPEP2  dipeptidase 2  LOC100621778  dipeptidase 2  Symbol and/or name change 5135510 APPROVED