GATA6 (GATA binding protein 6) - Rat Genome Database

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Gene: GATA6 (GATA binding protein 6) Sus scrofa
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Symbol: GATA6
Name: GATA binding protein 6
RGD ID: 14047280
Description: ENCODES a protein that exhibits chromatin binding (ortholog); cis-regulatory region sequence-specific DNA binding (ortholog); DNA binding (ortholog); INVOLVED IN animal organ formation (ortholog); cardiac muscle cell differentiation (ortholog); cardiac muscle hypertrophy in response to stress (ortholog); ASSOCIATED WITH Aortic Coarctation (ortholog); atrial heart septal defect 9 (ortholog); atrioventricular septal defect (ortholog); FOUND IN nucleus (ortholog); transcription regulator complex (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: GATA-6; GATA-binding factor 6; transcription factor GATA-6
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6107,282,847 - 107,314,634 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16107,282,709 - 107,314,725 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2699,758,773 - 99,790,688 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ formation  (ISO)
cardiac muscle cell differentiation  (ISO)
cardiac muscle hypertrophy in response to stress  (ISO)
cardiac muscle tissue development  (ISO)
cardiac vascular smooth muscle cell differentiation  (IEA)
cell fate commitment  (IBA)
cellular response to BMP stimulus  (ISO)
cellular response to gonadotropin stimulus  (ISO)
cellular response to hypoxia  (IEA)
club cell differentiation  (ISO)
endodermal cell differentiation  (ISO)
endodermal cell fate determination  (ISO)
epithelial cell differentiation  (IBA,ISO)
gene expression  (ISO)
heart contraction  (ISO)
in utero embryonic development  (ISO)
intestinal epithelial cell differentiation  (IEA,ISO)
liver development  (ISO)
lung saccule development  (ISO)
male gonad development  (IEA)
negative regulation of apoptotic process  (IEA)
negative regulation of pri-miRNA transcription by RNA polymerase II  (ISO)
negative regulation of sebum secreting cell proliferation  (IEA)
negative regulation of transcription by RNA polymerase II  (IBA,IEA)
negative regulation of transcription, DNA-templated  (ISO)
negative regulation of transforming growth factor beta1 production  (IEA)
negative regulation of transforming growth factor beta2 production  (IEA)
odontogenesis of dentin-containing tooth  (ISO)
outflow tract septum morphogenesis  (IEA)
pancreas development  (ISO)
pancreatic A cell differentiation  (ISO)
phospholipid metabolic process  (ISO)
positive regulation of angiogenesis  (IEA)
positive regulation of apoptotic process  (ISO)
positive regulation of BMP signaling pathway  (ISO)
positive regulation of cardiac muscle cell apoptotic process  (ISO)
positive regulation of cardiac muscle cell proliferation  (ISO)
positive regulation of cardiac muscle myoblast proliferation  (IEA)
positive regulation of cardioblast differentiation  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of transcription, DNA-templated  (ISO,ISS)
positive regulation of transforming growth factor beta activation  (IEA)
regulation of antimicrobial humoral response  (IEA)
regulation of cell cycle  (IEA)
regulation of gene expression  (ISO)
regulation of transcription by RNA polymerase II  (IBA)
response to cAMP  (ISO)
response to estrogen  (ISO)
response to growth factor  (IEA)
response to retinoic acid  (IEA)
response to toxic substance  (ISO)
response to xenobiotic stimulus  (IEA,ISO)
sebaceous gland cell differentiation  (IEA)
sinoatrial node development  (ISO)
skin epidermis development  (IEA)
smooth muscle cell differentiation  (ISO)
tube morphogenesis  (ISO)
type B pancreatic cell differentiation  (ISO)
type II pneumocyte differentiation  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:17407547   PMID:18653717   PMID:20739664  


Genomics

Comparative Map Data
GATA6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6107,282,847 - 107,314,634 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16107,282,709 - 107,314,725 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2699,758,773 - 99,790,688 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GATA6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1822,169,589 - 22,202,528 (+)EnsemblGRCh38hg38GRCh38
GRCh381822,169,589 - 22,202,528 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371819,749,550 - 19,782,491 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361818,003,414 - 18,036,225 (+)NCBINCBI36hg18NCBI36
Build 341818,003,413 - 18,036,225NCBI
Celera1816,555,843 - 16,588,650 (+)NCBI
Cytogenetic Map18q11.2NCBI
HuRef1816,596,234 - 16,629,323 (+)NCBIHuRef
CHM1_11819,676,426 - 19,709,511 (+)NCBICHM1_1
Gata6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391811,052,510 - 11,085,636 (+)NCBIGRCm39mm39
GRCm39 Ensembl1811,052,064 - 11,085,635 (+)Ensembl
GRCm381811,052,510 - 11,085,636 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1811,052,064 - 11,085,635 (+)EnsemblGRCm38mm10GRCm38
MGSCv371811,052,508 - 11,085,633 (+)NCBIGRCm37mm9NCBIm37
MGSCv361811,052,506 - 11,085,628 (+)NCBImm8
Celera1811,079,782 - 11,114,690 (+)NCBICelera
Cytogenetic Map18A1NCBI
cM Map185.63NCBI
Gata6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2182,188,121 - 2,219,532 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl182,188,121 - 2,219,532 (+)Ensembl
Rnor_6.0182,415,821 - 2,447,087 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl182,416,552 - 2,446,338 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0182,436,500 - 2,465,966 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4182,504,264 - 2,534,648 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1182,504,263 - 2,534,648 (+)NCBI
Celera182,065,111 - 2,096,513 (+)NCBICelera
RH 3.4 Map1810.8RGD
Cytogenetic Map18p13NCBI
GATA6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11819,046,132 - 19,078,398 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01815,411,764 - 15,444,402 (+)NCBIMhudiblu_PPA_v0panPan3
GATA6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1765,932,114 - 65,962,574 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha765,386,151 - 65,418,363 (-)NCBI
ROS_Cfam_1.0765,995,800 - 66,028,019 (-)NCBI
UMICH_Zoey_3.1765,662,867 - 65,695,075 (-)NCBI
UNSW_CanFamBas_1.0765,685,301 - 65,716,538 (-)NCBI
UU_Cfam_GSD_1.0765,985,181 - 66,017,395 (-)NCBI
Gata6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494461,971,676 - 62,001,620 (-)NCBI
SpeTri2.0NW_0049365501,814,336 - 1,844,399 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GATA6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11858,312,328 - 58,345,472 (-)NCBI
ChlSab1.1 Ensembl1858,311,482 - 58,343,746 (-)Ensembl
Vero_WHO_p1.0NW_02366605033,085,880 - 33,119,030 (-)NCBI
Gata6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247709,772,818 - 9,799,837 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2 2
Low 7 2 4 1 2 2
Below cutoff 1 3 1 1 3 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000004101   ⟹   ENSSSCP00000004009
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl6107,282,847 - 107,314,634 (+)Ensembl
RefSeq Acc Id: NM_214328   ⟹   NP_999493
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.16107,284,327 - 107,314,644 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005656112   ⟹   XP_005656169
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.16107,282,709 - 107,314,644 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005656113   ⟹   XP_005656170
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.16107,282,960 - 107,314,725 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005656114   ⟹   XP_005656171
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.16107,283,654 - 107,314,725 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021093576   ⟹   XP_020949235
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.16107,282,709 - 107,314,644 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005656169   ⟸   XM_005656112
- Peptide Label: isoform X1
- UniProtKB: F1SBC0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020949235   ⟸   XM_021093576
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005656170   ⟸   XM_005656113
- Peptide Label: isoform X1
- UniProtKB: F1SBC0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005656171   ⟸   XM_005656114
- Peptide Label: isoform X1
- UniProtKB: F1SBC0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_999493   ⟸   NM_214328
- UniProtKB: Q95JA5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSSSCP00000004009   ⟸   ENSSSCT00000004101
Protein Domains
GATA-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000003702 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070025631 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000004009 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070043339 UniProtKB/TrEMBL
  ENSSSCP00070043340 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000004101 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070051240 UniProtKB/TrEMBL
  ENSSSCT00070051241 UniProtKB/TrEMBL
Gene3D-CATH 3.30.50.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GATA_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TF_GATA_4/5/6 UniProtKB/Swiss-Prot
  TF_GATA_6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transcription_factor_GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397600 UniProtKB/Swiss-Prot
NCBI Gene GATA6 ENTREZGENE
PANTHER PTHR10071 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10071:SF23 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GATA-N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF TF_GATA_4/5/6 UniProtKB/Swiss-Prot
PRINTS GATAZNFINGER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GATA_ZN_FINGER_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GATA_ZN_FINGER_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ZnF_GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A4X1VNF0_PIG UniProtKB/TrEMBL
  A0A4X1VQI0_PIG UniProtKB/TrEMBL
  B0JFA1_PIG UniProtKB/TrEMBL
  F1SBC0 ENTREZGENE, UniProtKB/TrEMBL
  GATA6_PIG UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:88366 ENTREZGENE