ABHD17B (abhydrolase domain containing 17B, depalmitoylase) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: ABHD17B (abhydrolase domain containing 17B, depalmitoylase) Sus scrofa
Analyze
Symbol: ABHD17B
Name: abhydrolase domain containing 17B, depalmitoylase
RGD ID: 14011341
Description: ENCODES a protein that exhibits hydrolase activity (inferred); palmitoyl-(protein) hydrolase activity (inferred); INVOLVED IN macromolecule depalmitoylation (inferred); negative regulation of protein localization to microtubule (inferred); positive regulation of protein localization to endosome (inferred); ASSOCIATED WITH genetic disease (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic density membrane (ortholog); postsynaptic recycling endosome membrane (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: abhydrolase domain containing 17B; abhydrolase domain-containing protein FAM108B1; alpha/beta hydrolase domain-containing protein 17B; FAM108B1; family with sequence similarity 108, member B1; protein ABHD17B
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1225,150,682 - 225,193,287 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11225,149,922 - 225,193,329 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21251,717,264 - 251,759,183 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:30032202  


Genomics

Comparative Map Data
ABHD17B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1225,150,682 - 225,193,287 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11225,149,922 - 225,193,329 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21251,717,264 - 251,759,183 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ABHD17B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38971,862,452 - 71,911,193 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl971,862,452 - 71,911,193 (-)EnsemblGRCh38hg38GRCh38
GRCh37974,477,368 - 74,526,109 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36973,667,188 - 73,715,968 (-)NCBINCBI36Build 36hg18NCBI36
Build 34971,706,921 - 71,755,401NCBI
Celera945,050,096 - 45,098,877 (-)NCBICelera
Cytogenetic Map9q21.13NCBI
HuRef944,300,326 - 44,349,103 (-)NCBIHuRef
CHM1_1974,623,937 - 74,672,713 (-)NCBICHM1_1
T2T-CHM13v2.0984,012,803 - 84,061,543 (-)NCBIT2T-CHM13v2.0
Abhd17b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391921,630,483 - 21,663,002 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1921,630,549 - 21,663,001 (+)EnsemblGRCm39 Ensembl
GRCm381921,653,267 - 21,685,638 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1921,653,185 - 21,685,637 (+)EnsemblGRCm38mm10GRCm38
MGSCv371921,727,799 - 21,760,127 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361921,720,406 - 21,752,734 (+)NCBIMGSCv36mm8
Celera1922,389,536 - 22,422,132 (+)NCBICelera
Cytogenetic Map19BNCBI
cM Map1915.54NCBI
Abhd17b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81228,624,821 - 228,659,254 (+)NCBIGRCr8
mRatBN7.21219,198,294 - 219,232,733 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1219,198,471 - 219,231,933 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1227,652,892 - 227,686,312 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01234,583,011 - 234,616,431 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01227,401,034 - 227,434,458 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01239,266,140 - 239,301,133 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1239,266,921 - 239,301,176 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01246,553,836 - 246,588,442 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41224,888,152 - 224,921,533 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11225,052,174 - 225,085,544 (+)NCBI
Celera1216,435,970 - 216,469,337 (+)NCBICelera
Cytogenetic Map1q51NCBI
Abhd17b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554341,262,264 - 1,302,496 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554341,262,956 - 1,302,877 (+)NCBIChiLan1.0ChiLan1.0
ABHD17B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21171,055,414 - 71,101,024 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1971,061,353 - 71,107,512 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0952,900,834 - 52,946,917 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1970,609,077 - 70,654,637 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl970,606,487 - 70,654,637 (-)Ensemblpanpan1.1panPan2
ABHD17B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1185,806,873 - 85,861,051 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl185,807,511 - 85,863,551 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha186,271,917 - 86,326,062 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0186,257,345 - 86,311,553 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl186,302,240 - 86,343,493 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1186,018,650 - 86,073,041 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0185,723,163 - 85,777,345 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0186,482,389 - 86,536,573 (+)NCBIUU_Cfam_GSD_1.0
Abhd17b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947133,229,709 - 133,270,888 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365037,901,522 - 7,943,300 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365037,902,116 - 7,943,300 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABHD17B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11282,937,311 - 82,985,263 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1282,937,238 - 82,985,283 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603871,357,454 - 71,405,343 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abhd17b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247361,201,988 - 1,214,971 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247361,175,103 - 1,218,251 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ABHD17B
948 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 7 1 3 4 21 2 1 2
Low 3 3 1 2 2 2 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000026305   ⟹   ENSSSCP00000019206
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1225,150,682 - 225,193,287 (-)Ensembl
RefSeq Acc Id: NM_001243558   ⟹   NP_001230487
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11225,150,729 - 225,193,286 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005660158   ⟹   XP_005660215
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11225,149,922 - 225,193,329 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_005660215   ⟸   XM_005660158
- Peptide Label: isoform X1
- UniProtKB: F2Z5P7 (UniProtKB/TrEMBL),   A0A480EMP7 (UniProtKB/TrEMBL),   A0A4X1W3H4 (UniProtKB/TrEMBL),   A0A8D0S7X1 (UniProtKB/TrEMBL),   A0A4X1W2K1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001230487   ⟸   NM_001243558
- UniProtKB: F2Z5P7 (UniProtKB/TrEMBL),   A0A480EMP7 (UniProtKB/TrEMBL),   A0A4X1W3H4 (UniProtKB/TrEMBL),   A0A8D0S7X1 (UniProtKB/TrEMBL),   A0A4X1W2K1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000019206   ⟸   ENSSSCT00000026305
Protein Domains
Serine aminopeptidase S33


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000021802 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005036476 UniProtKB/TrEMBL
  ENSSSCG00015046929 UniProtKB/TrEMBL
  ENSSSCG00025048340 UniProtKB/TrEMBL
  ENSSSCG00035033108 UniProtKB/TrEMBL
  ENSSSCG00040036014 UniProtKB/TrEMBL
  ENSSSCG00045009006 UniProtKB/TrEMBL
  ENSSSCG00050010404 UniProtKB/TrEMBL
  ENSSSCG00055000738 UniProtKB/TrEMBL
  ENSSSCG00060053832 UniProtKB/TrEMBL
  ENSSSCG00065000767 UniProtKB/TrEMBL
  ENSSSCG00070028547 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000026305 ENTREZGENE
  ENSSSCT00000026305.4 UniProtKB/TrEMBL
  ENSSSCT00005058215.1 UniProtKB/TrEMBL
  ENSSSCT00005058285.1 UniProtKB/TrEMBL
  ENSSSCT00005058302.1 UniProtKB/TrEMBL
  ENSSSCT00015062650.1 UniProtKB/TrEMBL
  ENSSSCT00025065788.1 UniProtKB/TrEMBL
  ENSSSCT00035043873.1 UniProtKB/TrEMBL
  ENSSSCT00040048345.1 UniProtKB/TrEMBL
  ENSSSCT00045015251.1 UniProtKB/TrEMBL
  ENSSSCT00050013993.1 UniProtKB/TrEMBL
  ENSSSCT00055001278.1 UniProtKB/TrEMBL
  ENSSSCT00060073288.1 UniProtKB/TrEMBL
  ENSSSCT00065000904.1 UniProtKB/TrEMBL
  ENSSSCT00070057273.1 UniProtKB/TrEMBL
  ENSSSCT00070057275.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/TrEMBL
  Hydrolase_4 UniProtKB/TrEMBL
KEGG Report ssc:100155547 UniProtKB/TrEMBL
NCBI Gene ABHD17B ENTREZGENE
PANTHER ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN 17B UniProtKB/TrEMBL
Pfam Hydrolase_4 UniProtKB/TrEMBL
Superfamily-SCOP SSF53474 UniProtKB/TrEMBL
UniProt A0A480EMP7 ENTREZGENE
  A0A4X1W2K1 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1W3H4 ENTREZGENE
  A0A8D0K6H5_PIG UniProtKB/TrEMBL
  A0A8D0S7X1 ENTREZGENE, UniProtKB/TrEMBL
  F2Z5P7 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A480EMP7 UniProtKB/TrEMBL
  A0A4X1W3H4 UniProtKB/TrEMBL
VGNC ID VGNC:84977 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-01-28 ABHD17B  abhydrolase domain containing 17B, depalmitoylase  ABHD17B  abhydrolase domain containing 17B  Symbol and/or name change 5135510 APPROVED