WNK4 (WNK lysine deficient protein kinase 4) - Rat Genome Database

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Gene: WNK4 (WNK lysine deficient protein kinase 4) Sus scrofa
Analyze
Symbol: WNK4
Name: WNK lysine deficient protein kinase 4
RGD ID: 13929163
Description: ENCODES a protein that exhibits protein serine/threonine kinase activity (ortholog); INVOLVED IN activation of protein kinase activity (ortholog); chloride transport (ortholog); negative regulation of pancreatic juice secretion (ortholog); ASSOCIATED WITH genetic disease (ortholog); Gitelman syndrome (ortholog); hypertension (ortholog); FOUND IN cell body (ortholog); cytosol (ortholog); membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: serine/threonine-protein kinase WNK4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,065,061 - 20,081,762 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11220,064,688 - 20,081,781 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21220,279,617 - 20,296,819 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
WNK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,065,061 - 20,081,762 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11220,064,688 - 20,081,781 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21220,279,617 - 20,296,819 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WNK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381742,780,610 - 42,797,066 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1742,780,610 - 42,797,066 (+)EnsemblGRCh38hg38GRCh38
GRCh371740,932,628 - 40,949,084 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361738,186,222 - 38,202,610 (+)NCBINCBI36Build 36hg18NCBI36
Build 341738,186,221 - 38,202,605NCBI
Celera1737,588,637 - 37,605,071 (+)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1736,697,144 - 36,713,472 (+)NCBIHuRef
CHM1_11741,168,235 - 41,184,670 (+)NCBICHM1_1
T2T-CHM13v2.01743,637,750 - 43,654,206 (+)NCBIT2T-CHM13v2.0
Wnk4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911101,151,363 - 101,168,235 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11101,151,393 - 101,168,235 (+)EnsemblGRCm39 Ensembl
GRCm3811101,260,537 - 101,277,409 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11101,260,567 - 101,277,409 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711101,121,881 - 101,138,723 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611101,076,701 - 101,093,499 (+)NCBIMGSCv36mm8
MGSCv3611102,039,322 - 102,056,494 (+)NCBIMGSCv36mm8
Cytogenetic Map11DNCBI
cM Map1164.51NCBI
Wnk4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,702,828 - 86,719,917 (+)NCBIGRCr8
mRatBN7.21086,202,552 - 86,219,655 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,188,812 - 86,231,829 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1091,240,610 - 91,257,398 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,715,120 - 90,731,930 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01086,108,283 - 86,125,098 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01089,181,139 - 89,198,213 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,181,165 - 89,198,213 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,979,661 - 88,997,344 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41090,289,273 - 90,306,225 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11090,303,667 - 90,320,558 (+)NCBI
Celera1084,920,709 - 84,937,662 (+)NCBICelera
Cytogenetic Map10q31NCBI
Wnk4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545116,594,408 - 16,606,410 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545116,593,840 - 16,606,817 (+)NCBIChiLan1.0ChiLan1.0
WNK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21922,188,275 - 22,205,551 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11724,078,401 - 24,095,648 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01714,520,448 - 14,537,799 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11714,746,058 - 14,762,513 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1714,746,365 - 14,762,423 (-)Ensemblpanpan1.1panPan2
VPS25
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,242,230 - 20,247,396 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha919,703,536 - 19,708,691 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0920,960,604 - 20,965,761 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl920,960,860 - 20,965,682 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1919,745,515 - 19,750,667 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0920,011,720 - 20,016,876 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0920,114,439 - 20,119,596 (-)NCBIUU_Cfam_GSD_1.0
Wnk4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560219,567,157 - 19,582,658 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649017,492,753 - 17,509,582 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649017,492,718 - 17,508,571 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WNK4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11663,494,090 - 63,512,068 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607734,286,917 - 34,303,255 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wnk4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247951,416,886 - 1,427,811 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247951,416,479 - 1,428,350 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in WNK4
523 total Variants

Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSSCT00000079440   ⟹   ENSSSCP00000066819
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1220,077,120 - 20,081,762 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000097921   ⟹   ENSSSCP00000074674
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1220,065,061 - 20,081,762 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000098370   ⟹   ENSSSCP00000078104
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1220,065,061 - 20,081,762 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000098911   ⟹   ENSSSCP00000078429
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1220,065,172 - 20,081,762 (-)Ensembl
RefSeq Acc Id: XM_003358035   ⟹   XP_003358083
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11220,064,688 - 20,081,781 (-)NCBI
Sequence:
RefSeq Acc Id: XP_003358083   ⟸   XM_003358035
- UniProtKB: A0A481B8A0 (UniProtKB/TrEMBL),   A0A8D1KRR0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000078104   ⟸   ENSSSCT00000098370
Ensembl Acc Id: ENSSSCP00000066819   ⟸   ENSSSCT00000079440
Ensembl Acc Id: ENSSSCP00000074674   ⟸   ENSSSCT00000097921
Ensembl Acc Id: ENSSSCP00000078429   ⟸   ENSSSCT00000098911
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000060121 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025055288 UniProtKB/TrEMBL
  ENSSSCG00030071441 UniProtKB/TrEMBL
  ENSSSCG00040026684 UniProtKB/TrEMBL
  ENSSSCG00045007086 UniProtKB/TrEMBL
  ENSSSCG00050061794 UniProtKB/TrEMBL
  ENSSSCG00055025663 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000079440.2 UniProtKB/TrEMBL
  ENSSSCT00000097921.1 UniProtKB/TrEMBL
  ENSSSCT00000098370 ENTREZGENE
  ENSSSCT00000098370.1 UniProtKB/TrEMBL
  ENSSSCT00000098911.1 UniProtKB/TrEMBL
  ENSSSCT00025075672.1 UniProtKB/TrEMBL
  ENSSSCT00025076028.1 UniProtKB/TrEMBL
  ENSSSCT00025076322.1 UniProtKB/TrEMBL
  ENSSSCT00030100083.1 UniProtKB/TrEMBL
  ENSSSCT00040035693.1 UniProtKB/TrEMBL
  ENSSSCT00040035841.1 UniProtKB/TrEMBL
  ENSSSCT00040035964.1 UniProtKB/TrEMBL
  ENSSSCT00045011801.1 UniProtKB/TrEMBL
  ENSSSCT00050084200.1 UniProtKB/TrEMBL
  ENSSSCT00055051112.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Kinase_OSR1/WNK_CCT UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  WNK_Ser-Thr_kinase UniProtKB/TrEMBL
KEGG Report ssc:100520693 UniProtKB/TrEMBL
NCBI Gene WNK4 ENTREZGENE
PANTHER SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE WNK4 UniProtKB/TrEMBL
Pfam OSR1_C UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A481B8A0 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2QXZ6_PIG UniProtKB/TrEMBL
  A0A8D0SRP7_PIG UniProtKB/TrEMBL
  A0A8D0UVQ8_PIG UniProtKB/TrEMBL
  A0A8D0Y8N5_PIG UniProtKB/TrEMBL
  A0A8D1E2Y8_PIG UniProtKB/TrEMBL
  A0A8D1KRR0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8W4F6B3_PIG UniProtKB/TrEMBL
  A0A8W4FF99_PIG UniProtKB/TrEMBL
  A0A8W4FG74_PIG UniProtKB/TrEMBL