LIN28B (lin-28 homolog B) - Rat Genome Database

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Gene: LIN28B (lin-28 homolog B) Sus scrofa
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Symbol: LIN28B
Name: lin-28 homolog B
RGD ID: 13921140
Description: ENCODES a protein that exhibits nucleic acid binding (inferred); RNA binding (inferred); sequence-specific double-stranded DNA binding (inferred); INVOLVED IN miRNA catabolic process (inferred); negative regulation of gene expression (inferred); negative regulation of pre-miRNA processing (inferred); ASSOCIATED WITH disease of cellular proliferation (ortholog); Neoplastic Cell Transformation (ortholog); neuroblastoma (ortholog); FOUND IN cytosol (inferred); nucleolus (inferred); nucleoplasm (inferred)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: lin-28-like protein; protein lin-28 homolog B
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl171,159,251 - 71,296,217 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1171,173,291 - 71,296,131 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2180,544,640 - 80,620,604 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IEA)
nucleolus  (IEA)
nucleoplasm  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
LIN28B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl171,159,251 - 71,296,217 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1171,173,291 - 71,296,131 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2180,544,640 - 80,620,604 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LIN28B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386104,937,026 - 105,083,332 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6104,936,616 - 105,083,332 (+)EnsemblGRCh38hg38GRCh38
GRCh376105,388,840 - 105,531,207 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366105,511,616 - 105,637,899 (+)NCBINCBI36Build 36hg18NCBI36
Celera6106,027,398 - 106,153,711 (+)NCBICelera
Cytogenetic Map6q16.3-q21NCBI
HuRef6102,848,044 - 102,974,520 (+)NCBIHuRef
CHM1_16105,666,790 - 105,793,230 (+)NCBICHM1_1
T2T-CHM13v2.06106,113,007 - 106,259,422 (+)NCBIT2T-CHM13v2.0
Lin28b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391045,252,713 - 45,362,410 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1045,252,716 - 45,362,491 (-)EnsemblGRCm39 Ensembl
GRCm381045,376,617 - 45,486,314 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1045,376,620 - 45,486,395 (-)EnsemblGRCm38mm10GRCm38
MGSCv371045,096,425 - 45,190,007 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361045,065,048 - 45,158,616 (-)NCBIMGSCv36mm8
Celera1046,249,152 - 46,342,378 (-)NCBICelera
Cytogenetic Map10B2NCBI
cM Map1023.5NCBI
Lin28b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82050,447,700 - 50,547,135 (-)NCBIGRCr8
mRatBN7.22048,865,329 - 48,964,769 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2048,869,485 - 48,955,077 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.02050,482,536 - 50,580,273 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2050,486,809 - 50,564,987 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02052,094,397 - 52,182,964 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42049,685,524 - 49,765,967 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2051,065,112 - 51,157,124 (+)NCBICelera
Cytogenetic Map20q13NCBI
Lin28b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541130,381,208 - 30,499,678 (+)NCBIChiLan1.0ChiLan1.0
LIN28B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25124,960,620 - 125,103,365 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16122,847,067 - 122,989,850 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06102,755,256 - 102,897,739 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16106,646,991 - 106,772,374 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6106,640,448 - 106,772,374 (+)Ensemblpanpan1.1panPan2
LIN28B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11262,403,831 - 62,529,435 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1262,403,333 - 62,524,838 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1262,192,981 - 62,315,060 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01263,254,885 - 63,380,812 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1263,245,774 - 63,376,607 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11262,610,319 - 62,736,100 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01262,451,489 - 62,577,218 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01262,730,358 - 62,855,996 (+)NCBIUU_Cfam_GSD_1.0
Lin28b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494697,371,614 - 97,497,852 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365641,663,068 - 1,768,283 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365641,646,469 - 1,768,879 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LIN28B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11368,721,209 - 68,859,257 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1368,725,392 - 68,839,811 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604041,068,949 - 41,187,159 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lin28b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624952193,395 - 309,102 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in LIN28B
2658 total Variants

Expression

RNA-SEQ Expression

ectoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
10 1 1 1 10

Sequence


Ensembl Acc Id: ENSSSCT00000043008   ⟹   ENSSSCP00000054285
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl171,159,251 - 71,296,217 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000088401   ⟹   ENSSSCP00000061562
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl171,173,472 - 71,296,217 (+)Ensembl
RefSeq Acc Id: NM_001315786   ⟹   NP_001302715
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1171,174,509 - 71,295,216 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021079438   ⟹   XP_020935097
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1171,173,291 - 71,296,131 (+)NCBI
Sequence:
RefSeq Acc Id: XP_020935097   ⟸   XM_021079438
- Peptide Label: isoform X1
- UniProtKB: A0A4X1VH17 (UniProtKB/TrEMBL),   A0A5G2QAW5 (UniProtKB/TrEMBL),   A0A8D1JG04 (UniProtKB/TrEMBL),   A0A8D0P4C4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001302715   ⟸   NM_001315786
- Peptide Label: precursor
- UniProtKB: F1RYQ5 (UniProtKB/TrEMBL),   F8UV44 (UniProtKB/TrEMBL),   A0A8D1JG04 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000061562   ⟸   ENSSSCT00000088401
Ensembl Acc Id: ENSSSCP00000054285   ⟸   ENSSSCT00000043008
Protein Domains
CCHC-type   CSD


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000037612 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015052645 UniProtKB/TrEMBL
  ENSSSCG00025026799 UniProtKB/TrEMBL
  ENSSSCG00030072689 UniProtKB/TrEMBL
  ENSSSCG00035003694 UniProtKB/TrEMBL
  ENSSSCG00040029970 UniProtKB/TrEMBL
  ENSSSCG00045038287 UniProtKB/TrEMBL
  ENSSSCG00060077228 UniProtKB/TrEMBL
  ENSSSCG00070023800 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000043008.3 UniProtKB/TrEMBL
  ENSSSCT00000088401 ENTREZGENE
  ENSSSCT00000088401.2 UniProtKB/TrEMBL
  ENSSSCT00015070259.1 UniProtKB/TrEMBL
  ENSSSCT00015070336.1 UniProtKB/TrEMBL
  ENSSSCT00025036294.1 UniProtKB/TrEMBL
  ENSSSCT00025036342.1 UniProtKB/TrEMBL
  ENSSSCT00030101809.1 UniProtKB/TrEMBL
  ENSSSCT00030101824.1 UniProtKB/TrEMBL
  ENSSSCT00035004587.1 UniProtKB/TrEMBL
  ENSSSCT00035004594.1 UniProtKB/TrEMBL
  ENSSSCT00040040414.1 UniProtKB/TrEMBL
  ENSSSCT00040040474.1 UniProtKB/TrEMBL
  ENSSSCT00045066370.1 UniProtKB/TrEMBL
  ENSSSCT00060106279.1 UniProtKB/TrEMBL
  ENSSSCT00060106319.1 UniProtKB/TrEMBL
  ENSSSCT00070047490.1 UniProtKB/TrEMBL
  ENSSSCT00070047494.1 UniProtKB/TrEMBL
  ENSSSCT00070047496.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.140 UniProtKB/TrEMBL
  Zinc finger, CCHC-type UniProtKB/TrEMBL
InterPro CSD UniProtKB/TrEMBL
  CSP_DNA-bd UniProtKB/TrEMBL
  Lin-28_RNA-binding UniProtKB/TrEMBL
  Lin-28A-like_Znf-CCHC_2 UniProtKB/TrEMBL
  NA-bd_OB-fold UniProtKB/TrEMBL
  Znf_CCHC UniProtKB/TrEMBL
  Znf_CCHC_sf UniProtKB/TrEMBL
KEGG Report ssc:100738513 UniProtKB/TrEMBL
NCBI Gene LIN28B ENTREZGENE
PANTHER PROTEIN LIN-28 UniProtKB/TrEMBL
  PROTEIN LIN-28 HOMOLOG B UniProtKB/TrEMBL
Pfam CSD UniProtKB/TrEMBL
  Lin-28A-like_zf-CCHC_2 UniProtKB/TrEMBL
  zf-CCHC UniProtKB/TrEMBL
PRINTS COLDSHOCK UniProtKB/TrEMBL
PROSITE CSD_2 UniProtKB/TrEMBL
  ZF_CCHC UniProtKB/TrEMBL
SMART CSP UniProtKB/TrEMBL
  ZnF_C2HC UniProtKB/TrEMBL
Superfamily-SCOP SSF50249 UniProtKB/TrEMBL
  SSF57756 UniProtKB/TrEMBL
UniProt A0A4X1VED0_PIG UniProtKB/TrEMBL
  A0A4X1VH17 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2QAW5 ENTREZGENE
  A0A8D0JPJ7_PIG UniProtKB/TrEMBL
  A0A8D0P4C4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1JG04 ENTREZGENE, UniProtKB/TrEMBL
  F1RYQ5 ENTREZGENE, UniProtKB/TrEMBL
  F8UV44 ENTREZGENE
UniProt Secondary A0A287BCN2 UniProtKB/TrEMBL
  A0A5G2QAW5 UniProtKB/TrEMBL
  F8UV44 UniProtKB/TrEMBL
VGNC ID VGNC:89729 ENTREZGENE