Lin28b (lin-28 homolog B) - Rat Genome Database

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Gene: Lin28b (lin-28 homolog B) Ictidomys tridecemlineatus
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Symbol: Lin28b
Name: lin-28 homolog B
RGD ID: 12490038
Description: ENCODES a protein that exhibits mRNA binding (inferred); nucleic acid binding (inferred); RNA binding (inferred); INVOLVED IN miRNA catabolic process (inferred); negative regulation of gene expression (inferred); negative regulation of pre-miRNA processing (inferred); ASSOCIATED WITH disease of cellular proliferation (ortholog); Neoplastic Cell Transformation (ortholog); neuroblastoma (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleolus (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494697,371,614 - 97,497,852 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365641,663,068 - 1,768,283 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365641,646,469 - 1,768,879 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA)
nucleolus  (IEA)
nucleoplasm  (IEA)
nucleus  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Lin28b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494697,371,614 - 97,497,852 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365641,663,068 - 1,768,283 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365641,646,469 - 1,768,879 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LIN28B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386104,937,026 - 105,083,332 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6104,936,616 - 105,083,332 (+)EnsemblGRCh38hg38GRCh38
GRCh376105,388,840 - 105,531,207 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366105,511,616 - 105,637,899 (+)NCBINCBI36Build 36hg18NCBI36
Celera6106,027,398 - 106,153,711 (+)NCBICelera
Cytogenetic Map6q16.3-q21NCBI
HuRef6102,848,044 - 102,974,520 (+)NCBIHuRef
CHM1_16105,666,790 - 105,793,230 (+)NCBICHM1_1
T2T-CHM13v2.06106,113,007 - 106,259,422 (+)NCBIT2T-CHM13v2.0
Lin28b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391045,252,713 - 45,362,410 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1045,252,716 - 45,362,491 (-)EnsemblGRCm39 Ensembl
GRCm381045,376,617 - 45,486,314 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1045,376,620 - 45,486,395 (-)EnsemblGRCm38mm10GRCm38
MGSCv371045,096,425 - 45,190,007 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361045,065,048 - 45,158,616 (-)NCBIMGSCv36mm8
Celera1046,249,152 - 46,342,378 (-)NCBICelera
Cytogenetic Map10B2NCBI
cM Map1023.5NCBI
Lin28b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82050,447,700 - 50,547,135 (-)NCBIGRCr8
mRatBN7.22048,865,329 - 48,964,769 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2048,869,485 - 48,955,077 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.02050,482,536 - 50,580,273 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2050,486,809 - 50,564,987 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02052,094,397 - 52,182,964 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42049,685,524 - 49,765,967 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2051,065,112 - 51,157,124 (+)NCBICelera
Cytogenetic Map20q13NCBI
Lin28b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541130,381,208 - 30,499,678 (+)NCBIChiLan1.0ChiLan1.0
LIN28B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25124,960,620 - 125,103,365 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16122,847,067 - 122,989,850 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06102,755,256 - 102,897,739 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16106,646,991 - 106,772,374 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6106,640,448 - 106,772,374 (+)Ensemblpanpan1.1panPan2
LIN28B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11262,403,831 - 62,529,435 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1262,403,333 - 62,524,838 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1262,192,981 - 62,315,060 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01263,254,885 - 63,380,812 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1263,245,774 - 63,376,607 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11262,610,319 - 62,736,100 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01262,451,489 - 62,577,218 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01262,730,358 - 62,855,996 (+)NCBIUU_Cfam_GSD_1.0
LIN28B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl171,159,251 - 71,296,217 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1171,173,291 - 71,296,131 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2180,544,640 - 80,620,604 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LIN28B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11368,721,209 - 68,859,257 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1368,725,392 - 68,839,811 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604041,068,949 - 41,187,159 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lin28b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624952193,395 - 309,102 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000002684   ⟹   ENSSTOP00000002400
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365641,663,068 - 1,768,283 (+)Ensembl
RefSeq Acc Id: XM_021729716   ⟹   XP_021585391
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494697,386,789 - 97,497,852 (+)NCBI
SpeTri2.0NW_0049365641,663,821 - 1,768,879 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021729717   ⟹   XP_021585392
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494697,371,614 - 97,497,852 (+)NCBI
SpeTri2.0NW_0049365641,646,469 - 1,768,879 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040283149   ⟹   XP_040139083
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494697,372,442 - 97,497,852 (+)NCBI
RefSeq Acc Id: XM_040283150   ⟹   XP_040139084
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494697,371,614 - 97,497,852 (+)NCBI
RefSeq Acc Id: XM_040283151   ⟹   XP_040139085
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494697,372,442 - 97,497,852 (+)NCBI
RefSeq Acc Id: XM_040283152   ⟹   XP_040139086
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494697,371,614 - 97,497,852 (+)NCBI
RefSeq Acc Id: XM_040283153   ⟹   XP_040139087
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494697,371,614 - 97,497,852 (+)NCBI
RefSeq Acc Id: XM_040283154   ⟹   XP_040139088
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494697,371,614 - 97,497,852 (+)NCBI
RefSeq Acc Id: XP_021585392   ⟸   XM_021729717
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_021585391   ⟸   XM_021729716
- Peptide Label: isoform X2
- UniProtKB: I3M0W6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040139084   ⟸   XM_040283150
- Peptide Label: isoform X2
- UniProtKB: I3M0W6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040139088   ⟸   XM_040283154
- Peptide Label: isoform X4
RefSeq Acc Id: XP_040139086   ⟸   XM_040283152
- Peptide Label: isoform X2
- UniProtKB: I3M0W6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040139087   ⟸   XM_040283153
- Peptide Label: isoform X3
RefSeq Acc Id: XP_040139085   ⟸   XM_040283151
- Peptide Label: isoform X2
- UniProtKB: I3M0W6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040139083   ⟸   XM_040283149
- Peptide Label: isoform X1
Ensembl Acc Id: ENSSTOP00000002400   ⟸   ENSSTOT00000002684
Protein Domains
CCHC-type   CSD


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000002692 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000002684.3 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.140 UniProtKB/TrEMBL
  Zinc finger, CCHC-type UniProtKB/TrEMBL
InterPro CSD UniProtKB/TrEMBL
  CSP_DNA-bd UniProtKB/TrEMBL
  Lin-28_RNA-binding UniProtKB/TrEMBL
  Lin-28A-like_Znf-CCHC_2 UniProtKB/TrEMBL
  NA-bd_OB-fold UniProtKB/TrEMBL
  Znf_CCHC UniProtKB/TrEMBL
  Znf_CCHC_sf UniProtKB/TrEMBL
NCBI Gene Lin28b ENTREZGENE
PANTHER PROTEIN LIN-28 UniProtKB/TrEMBL
  PROTEIN LIN-28 HOMOLOG B UniProtKB/TrEMBL
Pfam CSD UniProtKB/TrEMBL
  Lin-28A-like_zf-CCHC_2 UniProtKB/TrEMBL
  zf-CCHC UniProtKB/TrEMBL
PRINTS COLDSHOCK UniProtKB/TrEMBL
PROSITE CSD_2 UniProtKB/TrEMBL
  ZF_CCHC UniProtKB/TrEMBL
SMART CSP UniProtKB/TrEMBL
  ZnF_C2HC UniProtKB/TrEMBL
Superfamily-SCOP SSF50249 UniProtKB/TrEMBL
  SSF57756 UniProtKB/TrEMBL
UniProt I3M0W6 ENTREZGENE, UniProtKB/TrEMBL