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Gene: CRLF2 (cytokine receptor like factor 2) Homo sapiens
Symbol: CRLF2
Name: cytokine receptor like factor 2
Description: Exhibits cytokine receptor activity. Involved in several processes, including positive regulation of interleukin-5 secretion; positive regulation of mast cell activation; and positive regulation of receptor signaling pathway via STAT. Predicted to localize to the external side of plasma membrane and receptor complex.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CRL2; CRLF2Y; cytokine receptor CRL2 precusor; cytokine receptor-like 2; cytokine receptor-like factor 2; IL-XR; P2RY8/CRLF2 fusion; thymic stromal lymphopoietin protein receptor; thymic stromal lymphopoietin receptor; thymic stromal-derived lymphopoietin receptor; TSLP receptor; TSLPR
Mus musculus (house mouse) : Crlf2 (cytokine receptor-like factor 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Crlf2 (cytokine receptor-like factor 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Crlf2 (cytokine receptor like factor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : CRLF2 (cytokine receptor like factor 2)
Canis lupus familiaris (dog) : CRLF2 (cytokine receptor like factor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Crlf2 (cytokine receptor like factor 2)
Sus scrofa (pig) : CRLF2 (cytokine receptor-like factor 2)
Chlorocebus sabaeus (green monkey) : CRLF2 (cytokine receptor like factor 2)
Heterocephalus glaber (naked mole-rat) : Crlf2 (cytokine receptor like factor 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 EnsemblX1,187,549 - 1,212,723 (-)Ensembl
GRCh38Y1,190,437 - 1,212,762 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38X1,190,437 - 1,212,762 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X1,314,869 - 1,331,529 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh37Y1,264,869 - 1,281,529 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X1,274,894 - 1,291,529 (-)NCBINCBI36hg18NCBI36
Build 36Y1,274,894 - 1,291,529 (-)NCBINCBI36hg18NCBI36
CeleraX5,605,262 - 5,605,961 (-)NCBI
Cytogenetic MapXp22.33 and Yp11.2NCBI
CHM1_1X1,345,456 - 1,361,668 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CRLF2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1352132
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.