TREML4 (triggering receptor expressed on myeloid cells like 4) - Rat Genome Database

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Gene: TREML4 (triggering receptor expressed on myeloid cells like 4) Homo sapiens
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Symbol: TREML4
Name: triggering receptor expressed on myeloid cells like 4
RGD ID: 1347933
HGNC Page HGNC:30807
Description: Predicted to enable signaling receptor activity. Involved in positive regulation of toll-like receptor 7 signaling pathway. Predicted to be located in endoplasmic reticulum; endosome membrane; and lysosomal membrane. Predicted to be active in cell surface.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC126829; TLT-4; TLT4; TREM like transcript 4; trem-like transcript 4 protein; triggering receptor expressed on myeloid cells-like 4; triggering receptor expressed on myeloid cells-like protein 4
RGD Orthologs
Mouse
Rat
Chinchilla
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: TREML3P  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38641,228,349 - 41,238,882 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl641,228,339 - 41,238,882 (+)EnsemblGRCh38hg38GRCh38
GRCh37641,196,087 - 41,206,620 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36641,304,040 - 41,314,098 (+)NCBINCBI36Build 36hg18NCBI36
Build 34641,304,039 - 41,314,097NCBI
Celera642,749,509 - 42,759,573 (+)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef640,914,595 - 40,924,658 (+)NCBIHuRef
CHM1_1641,199,332 - 41,209,396 (+)NCBICHM1_1
T2T-CHM13v2.0641,057,643 - 41,068,182 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:12645956   PMID:12975309   PMID:14702039   PMID:20237496   PMID:21873635   PMID:24975946   PMID:25848864   PMID:31076644   PMID:32292401   PMID:36329152  


Genomics

Comparative Map Data
TREML4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38641,228,349 - 41,238,882 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl641,228,339 - 41,238,882 (+)EnsemblGRCh38hg38GRCh38
GRCh37641,196,087 - 41,206,620 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36641,304,040 - 41,314,098 (+)NCBINCBI36Build 36hg18NCBI36
Build 34641,304,039 - 41,314,097NCBI
Celera642,749,509 - 42,759,573 (+)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef640,914,595 - 40,924,658 (+)NCBIHuRef
CHM1_1641,199,332 - 41,209,396 (+)NCBICHM1_1
T2T-CHM13v2.0641,057,643 - 41,068,182 (+)NCBIT2T-CHM13v2.0
Treml4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391748,571,229 - 48,582,635 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1748,571,323 - 48,582,388 (+)EnsemblGRCm39 Ensembl
GRCm381748,264,200 - 48,275,607 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1748,264,295 - 48,275,360 (+)EnsemblGRCm38mm10GRCm38
MGSCv371748,403,661 - 48,414,724 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361747,729,903 - 47,740,966 (+)NCBIMGSCv36mm8
Celera1751,699,791 - 51,710,858 (+)NCBICelera
Cytogenetic Map17CNCBI
cM Map1723.99NCBI
Treml4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8920,216,569 - 20,241,476 (-)NCBIGRCr8
mRatBN7.2912,718,968 - 12,743,879 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl912,721,815 - 12,743,253 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0914,668,691 - 14,707,122 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl914,685,900 - 14,706,557 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0913,590,054 - 13,628,343 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.498,133,088 - 8,160,100 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera910,477,182 - 10,514,752 (-)NCBICelera
Cytogenetic Map9q12NCBI
Treml4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554377,827,329 - 7,846,406 (-)NCBIChiLan1.0ChiLan1.0
Treml4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494645,353,914 - 45,356,695 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493647618,603,620 - 18,612,050 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC103222345
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11730,907,797 - 30,923,226 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1730,915,052 - 30,923,486 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604441,229,991 - 41,246,010 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Treml4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475417,600,341 - 17,608,766 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TREML4
11 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6p21.2-21.1(chr6:37777369-45653843)x1 copy number loss See cases [RCV000052181] Chr6:37777369..45653843 [GRCh38]
Chr6:37745145..45621580 [GRCh37]
Chr6:37853123..45729558 [NCBI36]
Chr6:6p21.2-21.1		 pathogenic
GRCh38/hg38 6p25.3-12.3(chr6:156974-46789291)x3 copy number gain See cases [RCV000143497] Chr6:156974..46789291 [GRCh38]
Chr6:156974..46757028 [GRCh37]
Chr6:101974..46864987 [NCBI36]
Chr6:6p25.3-12.3		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
NM_198153.3(TREML4):c.66T>C (p.Gly22=) single nucleotide variant not provided [RCV001532547] Chr6:41228716 [GRCh38]
Chr6:41196454 [GRCh37]
Chr6:6p21.1		 likely benign
GRCh37/hg19 6p22.1-q14.1(chr6:29455465-81447367) copy number gain not provided [RCV000767714] Chr6:29455465..81447367 [GRCh37]
Chr6:6p22.1-q14.1		 pathogenic
GRCh37/hg19 6p21.1(chr6:41200840-41331797)x1 copy number loss not provided [RCV001005794] Chr6:41200840..41331797 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_198153.3(TREML4):c.163T>C (p.Cys55Arg) single nucleotide variant not specified [RCV004332087] Chr6:41228813 [GRCh38]
Chr6:41196551 [GRCh37]
Chr6:6p21.1		 uncertain significance
NC_000006.11:g.(?_41126341)_(43737486_?)dup duplication PRPH2-related disorder [RCV003111022] Chr6:41126341..43737486 [GRCh37]
Chr6:6p21.1		 uncertain significance
NC_000006.11:g.(?_41126341)_(43752536_?)del deletion Peroxisome biogenesis disorder [RCV003110948] Chr6:41126341..43752536 [GRCh37]
Chr6:6p21.1		 pathogenic
NM_198153.3(TREML4):c.212A>G (p.Lys71Arg) single nucleotide variant not specified [RCV004307508] Chr6:41228862 [GRCh38]
Chr6:41196600 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_198153.3(TREML4):c.131C>T (p.Pro44Leu) single nucleotide variant not specified [RCV004086182] Chr6:41228781 [GRCh38]
Chr6:41196519 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_198153.3(TREML4):c.220A>T (p.Thr74Ser) single nucleotide variant not specified [RCV004109911] Chr6:41228870 [GRCh38]
Chr6:41196608 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_198153.3(TREML4):c.255C>G (p.Asp85Glu) single nucleotide variant not specified [RCV004079790] Chr6:41228905 [GRCh38]
Chr6:41196643 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_198153.3(TREML4):c.487A>G (p.Ile163Val) single nucleotide variant not specified [RCV004179019] Chr6:41230103 [GRCh38]
Chr6:41197841 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_198153.3(TREML4):c.346G>A (p.Glu116Lys) single nucleotide variant not specified [RCV004357691] Chr6:41228996 [GRCh38]
Chr6:41196734 [GRCh37]
Chr6:6p21.1		 likely benign
GRCh37/hg19 6p21.31-21.1(chr6:35562152-42003452)x1 copy number loss not provided [RCV003485510] Chr6:35562152..42003452 [GRCh37]
Chr6:6p21.31-21.1		 pathogenic
NM_198153.3(TREML4):c.345C>T (p.Ser115=) single nucleotide variant not provided [RCV003428847] Chr6:41228995 [GRCh38]
Chr6:41196733 [GRCh37]
Chr6:6p21.1		 likely benign
NM_198153.3(TREML4):c.221C>A (p.Thr74Lys) single nucleotide variant not specified [RCV004473521] Chr6:41228871 [GRCh38]
Chr6:41196609 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_198153.3(TREML4):c.588G>C (p.Lys196Asn) single nucleotide variant not specified [RCV004473522] Chr6:41236567 [GRCh38]
Chr6:41204305 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_198153.3(TREML4):c.311C>T (p.Ser104Leu) single nucleotide variant not specified [RCV004677559] Chr6:41228961 [GRCh38]
Chr6:41196699 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_198153.3(TREML4):c.375C>G (p.Ile125Met) single nucleotide variant not specified [RCV004677560] Chr6:41229025 [GRCh38]
Chr6:41196763 [GRCh37]
Chr6:6p21.1		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1699
Count of miRNA genes:706
Interacting mature miRNAs:782
Transcripts:ENST00000341495, ENST00000448827, ENST00000461240
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
406895730GWAS544706_Hmalaria QTL GWAS544706 (human)0.0000001malaria64123795241237953Human
1358839MULTSCL5_HMultiple sclerosis susceptibility QTL 5 (human)Multiple sclerosis susceptibility61958431145584311Human
406895925GWAS544901_Hmalaria QTL GWAS544901 (human)0.0000004malaria64123795241237953Human
1358857MULTSCL19_HMultiple sclerosis susceptibility QTL 19 (human)Multiple sclerosis susceptibility61958431145584311Human


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
934 1188 1225 1329 1667 864 1406 2 298 1343 198 802 3880 4082 5 1674 322 769 1083 104

Sequence


Ensembl Acc Id: ENST00000341495   ⟹   ENSP00000342570
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl641,228,349 - 41,238,882 (+)Ensembl
Ensembl Acc Id: ENST00000448827   ⟹   ENSP00000418078
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl641,228,339 - 41,237,100 (+)Ensembl
Ensembl Acc Id: ENST00000461240   ⟹   ENSP00000418480
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl641,228,955 - 41,238,882 (+)Ensembl
RefSeq Acc Id: NM_198153   ⟹   NP_937796
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38641,228,349 - 41,238,882 (+)NCBI
GRCh37641,196,062 - 41,206,120 (+)RGD
Build 36641,304,040 - 41,314,098 (+)NCBI Archive
Celera642,749,509 - 42,759,573 (+)RGD
HuRef640,914,595 - 40,924,658 (+)ENTREZGENE
CHM1_1641,199,332 - 41,209,396 (+)NCBI
T2T-CHM13v2.0641,057,643 - 41,068,182 (+)NCBI
Sequence:
RefSeq Acc Id: NP_937796   ⟸   NM_198153
- Peptide Label: precursor
- UniProtKB: B7ZL92 (UniProtKB/Swiss-Prot),   Q6UXN2 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000342570   ⟸   ENST00000341495
Ensembl Acc Id: ENSP00000418078   ⟸   ENST00000448827
Ensembl Acc Id: ENSP00000418480   ⟸   ENST00000461240
Protein Domains
Ig-like V-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6UXN2-F1-model_v2 AlphaFold Q6UXN2 1-200 view protein structure

Promoters
RGD ID:7207987
Promoter ID:EPDNEW_H9739
Type:initiation region
Name:TREML4_1
Description:triggering receptor expressed on myeloid cells like 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38641,228,349 - 41,228,409EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:30807 AgrOrtholog
COSMIC TREML4 COSMIC
Ensembl Genes ENSG00000188056 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000341495 ENTREZGENE
  ENST00000341495.7 UniProtKB/Swiss-Prot
  ENST00000448827.6 UniProtKB/Swiss-Prot
  ENST00000461240.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
GTEx ENSG00000188056 GTEx
HGNC ID HGNC:30807 ENTREZGENE
Human Proteome Map TREML4 Human Proteome Map
InterPro Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_sub UniProtKB/Swiss-Prot
  Ig_V-set UniProtKB/Swiss-Prot
  Immune_rcpt_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:285852 UniProtKB/Swiss-Prot
NCBI Gene 285852 ENTREZGENE
OMIM 614664 OMIM
PANTHER TREM-LIKE TRANSCRIPT 4 PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TREM-LIKE TRANSCRIPT PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam V-set UniProtKB/Swiss-Prot
PharmGKB PA134993202 PharmGKB
PROSITE IG_LIKE UniProtKB/Swiss-Prot
SMART SM00409 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
UniProt B7ZL92 ENTREZGENE
  H7C4X5_HUMAN UniProtKB/TrEMBL
  Q6UXN2 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary B7ZL92 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-01 TREML4  triggering receptor expressed on myeloid cells like 4    triggering receptor expressed on myeloid cells-like 4  Symbol and/or name change 5135510 APPROVED