Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | multiple interactions | EXP | | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of ZKSCAN1 mRNA | CTD | PMID:22079256 | 1,2-dimethylhydrazine | decreases expression | ISO | Zkscan1 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of ZKSCAN1 mRNA | CTD | PMID:22206623 | 1,2-dimethylhydrazine | multiple interactions | ISO | Zkscan1 (Mus musculus) | 6480464 | Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in decreased expression of ZKSCAN1 mRNA] | CTD | PMID:22206623 | 1-naphthyl isothiocyanate | increases expression | ISO | Zkscan1 (Rattus norvegicus) | 6480464 | 1-Naphthylisothiocyanate results in increased expression of ZKSCAN1 mRNA | CTD | PMID:30723492 | 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of ZKSCAN1 mRNA | CTD | PMID:19167446 | 17beta-estradiol | decreases expression | ISO | Zkscan1 (Rattus norvegicus) | 6480464 | Estradiol results in decreased expression of ZKSCAN1 mRNA | CTD | PMID:32145629 | 17beta-estradiol | decreases expression | ISO | Zkscan1 (Mus musculus) | 6480464 | Estradiol results in decreased expression of ZKSCAN1 mRNA | CTD | PMID:19484750 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Zkscan1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of ZKSCAN1 mRNA | CTD | PMID:24058054 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Zkscan1 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of ZKSCAN1 mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Zkscan1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of ZKSCAN1 mRNA | CTD | PMID:21570461 | 2-hydroxypropanoic acid | decreases expression | EXP | | 6480464 | Lactic Acid results in decreased expression of ZKSCAN1 mRNA | CTD | PMID:30851411 | acetamide | decreases expression | ISO | Zkscan1 (Rattus norvegicus) | 6480464 | acetamide results in decreased expression of ZKSCAN1 mRNA | CTD | PMID:31881176 | all-trans-retinoic acid | increases expression | EXP | | 6480464 | Tretinoin results in increased expression of ZKSCAN1 mRNA | CTD | PMID:23724009 | alpha-Zearalanol | multiple interactions | ISO | Zkscan1 (Rattus norvegicus) | 6480464 | [Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of ZKSCAN1 mRNA | CTD | PMID:35163327 | arsenite(3-) | multiple interactions | EXP | | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to ZKSCAN1 mRNA] | CTD | PMID:32406909 | benzo[a]pyrene | increases mutagenesis | EXP | | 6480464 | Benzo(a)pyrene results in increased mutagenesis of ZKSCAN1 gene | CTD | PMID:25435355 | benzo[a]pyrene | decreases methylation | EXP | | 6480464 | Benzo(a)pyrene results in decreased methylation of ZKSCAN1 5' UTR and Benzo(a)pyrene results in decreased methylation of ZKSCAN1 promoter | CTD | PMID:27901495 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of ZKSCAN1 mRNA | CTD | PMID:26238291 | benzo[a]pyrene | increases expression | ISO | Zkscan1 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of ZKSCAN1 mRNA | CTD | PMID:22228805 | benzo[a]pyrene diol epoxide I | decreases expression | EXP | | 6480464 | 7 more ... | CTD | PMID:20018196 | benzo[a]pyrene diol epoxide I | increases expression | EXP | | 6480464 | 7 more ... | CTD | PMID:19150397 and PMID:26238291 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of ZKSCAN1 mRNA | CTD | PMID:25047013 and PMID:36232920 | bisphenol A | increases expression | ISO | Zkscan1 (Mus musculus) | 6480464 | bisphenol A results in increased expression of ZKSCAN1 mRNA | CTD | PMID:35598803 | bisphenol A | affects expression | ISO | Zkscan1 (Rattus norvegicus) | 6480464 | bisphenol A affects the expression of ZKSCAN1 mRNA | CTD | PMID:32145629 | bisphenol A | multiple interactions | ISO | Zkscan1 (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with tributyltin] results in increased expression of ZKSCAN1 mRNA | CTD | PMID:31129395 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of ZKSCAN1 mRNA | CTD | PMID:29275510 | bisphenol A | affects methylation | ISO | Zkscan1 (Mus musculus) | 6480464 | bisphenol A affects the methylation of ZKSCAN1 promoter | CTD | PMID:27334623 | bisphenol A | increases methylation | ISO | Zkscan1 (Rattus norvegicus) | 6480464 | bisphenol A results in increased methylation of ZKSCAN1 gene | CTD | PMID:28505145 | bisphenol A | decreases expression | ISO | Zkscan1 (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of ZKSCAN1 mRNA | CTD | PMID:25181051 | caffeine | decreases phosphorylation | EXP | | 6480464 | Caffeine results in decreased phosphorylation of ZKSCAN1 protein | CTD | PMID:35688186 | carbon nanotube | affects expression | ISO | Zkscan1 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 and PMID:25620056 | carbon nanotube | increases expression | ISO | Zkscan1 (Mus musculus) | 6480464 | Nanotubes and Carbon analog results in increased expression of ZKSCAN1 mRNA | CTD | PMID:25620056 | casticin | increases expression | ISO | Zkscan1 (Mus musculus) | 6480464 | casticin results in increased expression of ZKSCAN1 mRNA | CTD | PMID:28444820 | chlorpyrifos | decreases expression | ISO | Zkscan1 (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of ZKSCAN1 mRNA | CTD | PMID:37019170 | copper atom | increases expression | ISO | Zkscan1 (Rattus norvegicus) | 6480464 | Copper results in increased expression of ZKSCAN1 mRNA | CTD | PMID:30556269 | copper(0) | increases expression | ISO | Zkscan1 (Rattus norvegicus) | 6480464 | Copper results in increased expression of ZKSCAN1 mRNA | CTD | PMID:30556269 | copper(II) sulfate | increases expression | EXP | | 6480464 | Copper Sulfate results in increased expression of ZKSCAN1 mRNA | CTD | PMID:19549813 | coumestrol | decreases expression | EXP | | 6480464 | Coumestrol results in decreased expression of ZKSCAN1 mRNA | CTD | PMID:19167446 | coumestrol | multiple interactions | EXP | | 6480464 | [Coumestrol co-treated with 2 more ... | CTD | PMID:19167446 | crotonaldehyde | decreases expression | EXP | | 6480464 | 2-butenal results in decreased expression of ZKSCAN1 mRNA | CTD | PMID:20471460 | cyclosporin A | decreases expression | EXP | | 6480464 | Cyclosporine results in decreased expression of ZKSCAN1 mRNA | CTD | PMID:25562108 | dicrotophos | increases expression | EXP | | 6480464 | dicrotophos results in increased expression of ZKSCAN1 mRNA | CTD | PMID:28302478 | dioxygen | multiple interactions | ISO | Zkscan1 (Rattus norvegicus) | 6480464 | [Oxygen deficiency co-treated with Blood Glucose deficiency co-treated with Particulate Matter] results in decreased expression of ZKSCAN1 mRNA | CTD | PMID:33729688 | dorsomorphin | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZKSCAN1 mRNA | CTD | PMID:27188386 | elemental selenium | decreases expression | EXP | | 6480464 | Selenium results in decreased expression of ZKSCAN1 mRNA | CTD | PMID:19244175 | Enterolactone | multiple interactions | EXP | | 6480464 | [Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of ZKSCAN1 mRNA | CTD | PMID:19167446 | epoxiconazole | decreases expression | ISO | Zkscan1 (Mus musculus) | 6480464 | epoxiconazole results in decreased expression of ZKSCAN1 mRNA | CTD | PMID:35436446 | folic acid | multiple interactions | ISO | Zkscan1 (Mus musculus) | 6480464 | Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in decreased expression of ZKSCAN1 mRNA] | CTD | PMID:22206623 | FR900359 | decreases phosphorylation | EXP | | 6480464 | FR900359 results in decreased phosphorylation of ZKSCAN1 protein | CTD | PMID:37730182 | furan | increases methylation | ISO | Zkscan1 (Rattus norvegicus) | 6480464 | furan results in increased methylation of ZKSCAN1 gene | CTD | PMID:22079235 | gallic acid | increases expression | EXP | | 6480464 | Gallic Acid results in increased expression of ZKSCAN1 mRNA | CTD | PMID:34408198 | nickel atom | decreases expression | EXP | | 6480464 | Nickel results in decreased expression of ZKSCAN1 mRNA | CTD | PMID:23195993 | p-toluidine | increases expression | ISO | Zkscan1 (Rattus norvegicus) | 6480464 | 4-toluidine results in increased expression of ZKSCAN1 mRNA | CTD | PMID:27638505 | paracetamol | increases expression | ISO | Zkscan1 (Rattus norvegicus) | 6480464 | Acetaminophen results in increased expression of ZKSCAN1 mRNA | CTD | PMID:33387578 | paraquat | decreases expression | ISO | Zkscan1 (Rattus norvegicus) | 6480464 | Paraquat results in decreased expression of ZKSCAN1 mRNA | CTD | PMID:32680482 | perfluorohexanesulfonic acid | decreases expression | ISO | Zkscan1 (Mus musculus) | 6480464 | perfluorohexanesulfonic acid results in decreased expression of ZKSCAN1 mRNA | CTD | PMID:37995155 | perfluorooctanoic acid | multiple interactions | ISO | Zkscan1 (Rattus norvegicus) | 6480464 | [Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of ZKSCAN1 mRNA | CTD | PMID:35163327 | phenobarbital | affects expression | ISO | Zkscan1 (Mus musculus) | 6480464 | Phenobarbital affects the expression of ZKSCAN1 mRNA | CTD | PMID:23091169 | pirinixic acid | decreases expression | ISO | Zkscan1 (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of ZKSCAN1 mRNA | CTD | PMID:20813756 | potassium chromate | multiple interactions | EXP | | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of ZKSCAN1 mRNA | CTD | PMID:22079256 | potassium chromate | increases expression | EXP | | 6480464 | potassium chromate(VI) results in increased expression of ZKSCAN1 mRNA | CTD | PMID:22079256 | rac-lactic acid | decreases expression | EXP | | 6480464 | Lactic Acid results in decreased expression of ZKSCAN1 mRNA | CTD | PMID:30851411 | resveratrol | multiple interactions | EXP | | 6480464 | [Coumestrol co-treated with Resveratrol] results in decreased expression of ZKSCAN1 mRNA and [Plant Extracts co-treated with Resveratrol] results in increased expression of ZKSCAN1 mRNA | CTD | PMID:19167446 and PMID:23557933 | SB 431542 | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZKSCAN1 mRNA | CTD | PMID:27188386 | selenium atom | decreases expression | EXP | | 6480464 | Selenium results in decreased expression of ZKSCAN1 mRNA | CTD | PMID:19244175 | silicon dioxide | increases methylation | EXP | | 6480464 | Silicon Dioxide results in increased methylation of ZKSCAN1 promoter | CTD | PMID:34973136 | sodium arsenate | increases expression | ISO | Zkscan1 (Mus musculus) | 6480464 | sodium arsenate results in increased expression of ZKSCAN1 mRNA | CTD | PMID:21795629 | sodium arsenate | decreases expression | ISO | Zkscan1 (Mus musculus) | 6480464 | sodium arsenate results in decreased expression of ZKSCAN1 mRNA | CTD | PMID:21795629 | sodium arsenite | decreases expression | EXP | | 6480464 | sodium arsenite results in decreased expression of ZKSCAN1 mRNA | CTD | PMID:28595984 more ... | succimer | multiple interactions | ISO | Zkscan1 (Mus musculus) | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of ZKSCAN1 mRNA and [Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of ZKSCAN1 mRNA | CTD | PMID:21641980 and PMID:26378955 | tributylstannane | multiple interactions | ISO | Zkscan1 (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with tributyltin] results in increased expression of ZKSCAN1 mRNA | CTD | PMID:31129395 | trichostatin A | increases expression | EXP | | 6480464 | trichostatin A results in increased expression of ZKSCAN1 mRNA | CTD | PMID:24935251 | triphenyl phosphate | increases expression | ISO | Zkscan1 (Rattus norvegicus) | 6480464 | triphenyl phosphate results in increased expression of ZKSCAN1 mRNA | CTD | PMID:30589522 | troglitazone | decreases expression | ISO | Zkscan1 (Mus musculus) | 6480464 | troglitazone results in decreased expression of ZKSCAN1 mRNA | CTD | PMID:28973697 | valproic acid | decreases methylation | EXP | | 6480464 | Valproic Acid results in decreased methylation of ZKSCAN1 gene | CTD | PMID:29154799 | valproic acid | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZKSCAN1 mRNA | CTD | PMID:27188386 | valproic acid | decreases expression | EXP | | 6480464 | Valproic Acid results in decreased expression of ZKSCAN1 mRNA | CTD | PMID:23527032 more ... | valproic acid | increases expression | EXP | | 6480464 | Valproic Acid results in increased expression of ZKSCAN1 mRNA | CTD | PMID:24935251 | vinclozolin | decreases expression | ISO | Zkscan1 (Rattus norvegicus) | 6480464 | vinclozolin results in decreased expression of ZKSCAN1 mRNA | CTD | PMID:18042343 | vitamin E | decreases expression | EXP | | 6480464 | Vitamin E results in decreased expression of ZKSCAN1 mRNA | CTD | PMID:19244175 | |