Symbol:
MIR208A
Name:
microRNA 208a
RGD ID:
1346072
HGNC Page
HGNC:31585
Description:
Enables mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in several processes, including miRNA-mediated gene silencing by inhibition of translation; negative regulation of calcium ion transmembrane transport; and positive regulation of cell migration. Located in extracellular exosome. Biomarker of coronary artery disease.
Type:
ncrna (Ensembl: miRNA)
RefSeq Status:
PROVISIONAL
Previously known as:
hsa-mir-208a; MIR208; MIRN208; MIRN208A; miRNA208
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Allele / Splice:
See ClinVar data
Latest Assembly:
GRCh38 - Human Genome Assembly GRCh38
Position:
Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 14 23,388,596 - 23,388,666 (-) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh38.p14 Ensembl 14 23,388,596 - 23,388,666 (-) Ensembl GRCh38 hg38 GRCh38 GRCh37 14 23,857,805 - 23,857,875 (-) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 14 22,927,644 - 22,927,714 (-) NCBI NCBI36 Build 36 hg18 NCBI36 Celera 14 3,720,516 - 3,720,586 (-) NCBI Celera Cytogenetic Map 14 q11.2 NCBI HuRef 14 3,974,223 - 3,974,293 (-) NCBI HuRef CHM1_1 14 23,856,477 - 23,856,547 (-) NCBI CHM1_1 T2T-CHM13v2.0 14 17,589,612 - 17,589,682 (-) NCBI T2T-CHM13v2.0
JBrowse:
View Region in Genome Browser (JBrowse)
Model
1.
MiR-320a contributes to atherogenesis by augmenting multiple risk factors and down-regulating SRF.
Chen C, etal., J Cell Mol Med. 2015 May;19(5):970-85. doi: 10.1111/jcmm.12483. Epub 2015 Feb 27.
2.
Cyclic stretching boosts microRNA-499 to regulate Bcl-2 via microRNA-208a in atrial fibroblasts.
Chua SK, etal., J Cell Mol Med. 2021 Mar;25(6):3113-3123. doi: 10.1111/jcmm.16373. Epub 2021 Feb 18.
3.
Trbp regulates heart function through microRNA-mediated Sox6 repression.
Ding J, etal., Nat Genet. 2015 Jul;47(7):776-83. doi: 10.1038/ng.3324. Epub 2015 Jun 1.
4.
MicroRNA-208a Potentiates Angiotensin II-triggered Cardiac Myoblasts Apoptosis via Inhibiting Nemo-like Kinase (NLK).
Huang Y, etal., Curr Pharm Des. 2016;22(31):4868-4875. doi: 10.2174/1381612822666160210143047.
5.
ClinVar Automated Import and Annotation Pipeline
RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.
Data Import for Chemical-Gene Interactions
RGD automated import pipeline for gene-chemical interactions
7.
MicroRNA-208a: a Good Diagnostic Marker and a Predictor of no-Reflow in STEMI Patients Undergoing Primary Percutaneuos Coronary Intervention.
Salama AM, etal., J Cardiovasc Transl Res. 2020 Dec;13(6):988-995. doi: 10.1007/s12265-020-10020-9. Epub 2020 May 26.
8.
MicroRNA-208a Dysregulates Apoptosis Genes Expression and Promotes Cardiomyocyte Apoptosis during Ischemia and Its Silencing Improves Cardiac Function after Myocardial Infarction.
Tony H, etal., Mediators Inflamm. 2015;2015:479123. doi: 10.1155/2015/479123. Epub 2015 Nov 25.
MIR208A Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 14 23,388,596 - 23,388,666 (-) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh38.p14 Ensembl 14 23,388,596 - 23,388,666 (-) Ensembl GRCh38 hg38 GRCh38 GRCh37 14 23,857,805 - 23,857,875 (-) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 14 22,927,644 - 22,927,714 (-) NCBI NCBI36 Build 36 hg18 NCBI36 Celera 14 3,720,516 - 3,720,586 (-) NCBI Celera Cytogenetic Map 14 q11.2 NCBI HuRef 14 3,974,223 - 3,974,293 (-) NCBI HuRef CHM1_1 14 23,856,477 - 23,856,547 (-) NCBI CHM1_1 T2T-CHM13v2.0 14 17,589,612 - 17,589,682 (-) NCBI T2T-CHM13v2.0
Mir208a Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm39 14 55,186,517 - 55,186,599 (-) NCBI GRCm39 GRCm39 mm39 GRCm39 Ensembl 14 55,186,517 - 55,186,599 (-) Ensembl GRCm39 Ensembl GRCm38 14 54,949,060 - 54,949,142 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 GRCm38.p6 Ensembl 14 54,949,060 - 54,949,142 (-) Ensembl GRCm38 mm10 GRCm38 MGSCv37 14 55,567,897 - 55,567,979 (-) NCBI GRCm37 MGSCv37 mm9 NCBIm37 Celera 14 52,755,093 - 52,755,175 (-) NCBI Celera Cytogenetic Map 14 C3 NCBI cM Map 14 28.0 NCBI
Mir208a Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 15 32,395,552 - 32,395,634 (-) NCBI GRCr8 mRatBN7.2 15 28,425,570 - 28,425,652 (-) NCBI mRatBN7.2 mRatBN7.2 UTH_Rnor_SHR_Utx 15 30,271,287 - 30,271,369 (-) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 15 31,418,489 - 31,418,571 (-) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 15 29,661,159 - 29,661,241 (-) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 15 33,613,451 - 33,613,533 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Celera 15 28,003,251 - 28,003,333 (-) NCBI Celera Cytogenetic Map 15 p13 NCBI
MIR208A Dog Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl CanFam3.1 8 3,636,919 - 3,636,987 (-) NCBI CanFam3.1 CanFam3.1 canFam3 CanFam3.1 CanFam3.1 Ensembl 8 3,636,919 - 3,636,987 (-) Ensembl CanFam3.1 canFam3 CanFam3.1 Dog10K_Boxer_Tasha 8 3,585,129 - 3,585,197 (-) NCBI Dog10K_Boxer_Tasha ROS_Cfam_1.0 8 3,744,651 - 3,744,719 (-) NCBI ROS_Cfam_1.0 UMICH_Zoey_3.1 8 3,436,201 - 3,436,269 (-) NCBI UMICH_Zoey_3.1 UNSW_CanFamBas_1.0 8 3,497,685 - 3,497,753 (-) NCBI UNSW_CanFamBas_1.0 UU_Cfam_GSD_1.0 8 3,759,684 - 3,759,752 (-) NCBI UU_Cfam_GSD_1.0
.
Confirmed Targets
CDKN1A hsa-miR-208a-3p Mirtarbase external_info qRT-PCR//Luciferase reporter assay//Western blot Functional MTI 20190813 MED13 hsa-miR-208a-3p Mirtarbase external_info Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 17379774 ETS1 hsa-miR-208a-3p Mirtarbase external_info Luciferase reporter assay//Microarray//qRT-PCR//We Functional MTI 20576608
Predicted Targets
Count of predictions: 18344 Count of gene targets: 6889 Count of transcripts: 13062 Interacting mature miRNAs: hsa-miR-208a-3p, hsa-miR-208a-5p Prediction methods: Microtar, Miranda, Pita, Rnahybrid, Targetscan Result types: miRGate_prediction
Click on a value in the shaded box below the category label to view a detailed expression data table for that system.
alimentary part of gastrointestinal system
29
38
97
167
93
24
26
4
30
2
53
259
233
72
7
25
21
2
Too many to show, limit is 500. Download them if you would like to view them all.
Ensembl Acc Id:
ENST00000362287
Type:
CODING
Position:
Human Assembly Chr Position (strand) Source GRCh38.p14 Ensembl 14 23,388,596 - 23,388,666 (-) Ensembl
RefSeq Acc Id:
NR_029595
RefSeq Status:
PROVISIONAL
Type:
NON-CODING
Position:
Human Assembly Chr Position (strand) Source GRCh38 14 23,388,596 - 23,388,666 (-) NCBI GRCh37 14 23,857,805 - 23,857,875 (-) RGD Celera 14 3,720,516 - 3,720,586 (-) RGD HuRef 14 3,974,223 - 3,974,293 (-) RGD CHM1_1 14 23,856,477 - 23,856,547 (-) NCBI T2T-CHM13v2.0 14 17,589,612 - 17,589,682 (-) NCBI
Sequence:
TGACGGGCGAGCTTTTGGCCCGGGTTATACCTGATGCTCACGTATAAGACGAGCAAAAAGCTTGTTGGTCA
hide sequence
