ALPK2 (alpha kinase 2) - Rat Genome Database

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Gene: ALPK2 (alpha kinase 2) Homo sapiens
Analyze
Symbol: ALPK2
Name: alpha kinase 2
RGD ID: 1343226
HGNC Page HGNC:20565
Description: Predicted to enable ATP binding activity; protein serine kinase activity; and protein serine/threonine kinase activity. Involved in several processes, including epicardium morphogenesis; heart development; and negative regulation of Wnt signaling pathway involved in heart development. Acts upstream of or within regulation of gene expression. Located in basolateral plasma membrane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: alpha-kinase 2; alpha-protein kinase 2; FLJ34875; FLJ43253; HAK; heart alpha-kinase; heart alpha-protein kinase
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381858,481,247 - 58,629,091 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1858,481,247 - 58,629,091 (-)EnsemblGRCh38hg38GRCh38
GRCh371856,148,479 - 56,296,323 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361854,299,459 - 54,447,169 (-)NCBINCBI36Build 36hg18NCBI36
Build 341854,299,463 - 54,398,381NCBI
Celera1852,864,790 - 53,011,746 (-)NCBICelera
Cytogenetic Map18q21.31-q21.32NCBI
HuRef1852,856,619 - 53,004,353 (-)NCBIHuRef
CHM1_11856,143,681 - 56,291,408 (-)NCBICHM1_1
T2T-CHM13v2.01858,681,900 - 58,830,246 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
ALPK2Humanimmunodeficiency 12  IAGPRGD:1564396038554872ClinVar Annotator: match by term: Combined immunodeficiency due to MALT1 deficiencyClinVarPMID:28492532
ALPK2Humanisolated microphthalmia 3  IAGPRGD:1564457068554872ClinVar Annotator: match by term: Isolated microphthalmia 3ClinVarPMID:14662654|PMID:18783408|PMID:19935664|PMID:21778431|PMID:24033328|PMID:26686525|PMID:28492532

1 to 20 of 102 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
ALPK2Human(-)-demecolcine increases expressionEXP 6480464Demecolcine results in increased expression of ALPK2 mRNACTDPMID:23649840
ALPK2Human(-)-epigallocatechin 3-gallate multiple interactionsEXP 6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ALPK2 mRNACTDPMID:22079256
ALPK2Human1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane decreases expressionEXP 6480464o,p'-DDT results in decreased expression of ALPK2 mRNACTDPMID:18204070
ALPK2Human1,2-dichloroethane decreases expressionISORGD:15579786480464ethylene dichloride results in decreased expression of ALPK2 mRNACTDPMID:28960355
ALPK2Human17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of ALPK2 mRNACTDPMID:20106945
ALPK2Human17beta-estradiol multiple interactionsEXP 6480464[Estradiol co-treated with TGFB1 protein] results in increased expression of ALPK2 mRNACTDPMID:30165855
ALPK2Human17beta-estradiol multiple interactionsISORGD:15644316480464[bisphenol A co-treated with Estradiol] results in increased expression of ALPK2 mRNACTDPMID:26496021
ALPK2Human17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of ALPK2 mRNACTDPMID:21632981
ALPK2Human17beta-hydroxy-5alpha-androstan-3-one increases expressionEXP 6480464Dihydrotestosterone results in increased expression of ALPK2 mRNACTDPMID:29581250
ALPK2Human2,2',4,4'-Tetrabromodiphenyl ether increases expressionISORGD:156443164804642,2',4,4'-tetrabromodiphenyl ether results in increased expression of ALPK2 mRNACTDPMID:27291303
ALPK2Human2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of ALPK2 mRNACTDPMID:20106945|PMID:21632981
ALPK2Human2,3,7,8-tetrachlorodibenzodioxine increases expressionISORGD:15644316480464Tetrachlorodibenzodioxin results in increased expression of ALPK2 mRNACTDPMID:33387578
ALPK2Human2,4-dibromophenyl 2,4,5-tribromophenyl ether increases expressionEXP 64804642,2',4,4',5-brominated diphenyl ether results in increased expression of ALPK2 mRNACTDPMID:26705709
ALPK2Human4,4'-sulfonyldiphenol increases expressionISORGD:15579786480464bisphenol S results in increased expression of ALPK2 mRNACTDPMID:30951980
ALPK2Human4,4'-sulfonyldiphenol affects methylationISORGD:15579786480464bisphenol S affects the methylation of ALPK2 geneCTDPMID:31683443
ALPK2Human4,4'-sulfonyldiphenol increases methylationEXP 6480464bisphenol S results in increased methylation of ALPK2 geneCTDPMID:31601247
ALPK2Humanaflatoxin B1 increases methylationEXP 6480464Aflatoxin B1 results in increased methylation of ALPK2 geneCTDPMID:27153756
ALPK2Humanall-trans-retinoic acid decreases expressionEXP 6480464Tretinoin results in decreased expression of ALPK2 mRNACTDPMID:21934132
ALPK2Humanalpha-Zearalanol multiple interactionsISORGD:15644316480464[Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of ALPK2 mRNACTDPMID:35163327
ALPK2Humanalpha-Zearalanol decreases expressionISORGD:15644316480464Zeranol results in decreased expression of ALPK2 mRNACTDPMID:35163327

1 to 20 of 102 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
ALPK2Humancardiac muscle cell development involved_inIMP 150520179 PMID:29888752UniProtPMID:29888752
ALPK2Humanepicardium morphogenesis involved_inIMP 150520179 PMID:29888752UniProtPMID:29888752
ALPK2Humanestablishment of cell polarity involved_inIMP 150520179 PMID:28668886UniProtPMID:28668886
ALPK2Humanheart morphogenesis involved_inIMP 150520179 PMID:29888752UniProtPMID:29888752
ALPK2Humannegative regulation of Wnt signaling pathway involved in heart development involved_inIMP 150520179 PMID:29888752UniProtPMID:29888752
ALPK2Humanregulation of apoptotic process involved_inIMP 150520179 PMID:22641666UniProtPMID:22641666
ALPK2Humanregulation of gene expression acts_upstream_of_or_withinIMP 150520179 PMID:22641666UniProtPMID:22641666

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
ALPK2Humanbasolateral plasma membrane located_inIMP 150520179 PMID:28668886UniProtPMID:28668886
ALPK2Humanbasolateral plasma membrane located_inIEAUniProtKB-SubCell:SL-0026150520179 UniProtGO_REF:0000044
ALPK2Humanmembrane located_inIEAUniProtKB-KW:KW-0472150520179 UniProtGO_REF:0000043
ALPK2Humanplasma membrane located_inIEAUniProtKB-KW:KW-1003150520179 UniProtGO_REF:0000043

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
ALPK2HumanATP binding enablesIEAInterPro:IPR004166150520179 InterProGO_REF:0000002
ALPK2Humankinase activity enablesIEAUniProtKB-KW:KW-0418150520179 UniProtGO_REF:0000043
ALPK2Humanprotein serine kinase activity enablesIEARHEA:17989150520179 RHEAGO_REF:0000116
ALPK2Humanprotein serine/threonine kinase activity enablesIEAUniProtKB-KW:KW-0723150520179 UniProtGO_REF:0000043
ALPK2Humanprotein serine/threonine kinase activity enablesIEAEC:2.7.11.1150520179 UniProtGO_REF:0000003
ALPK2Humanprotein serine/threonine kinase activity enablesIEAInterPro:IPR004166150520179 InterProGO_REF:0000002
ALPK2Humantransferase activity enablesIEAUniProtKB-KW:KW-0808150520179 UniProtGO_REF:0000043


#
Reference Title
Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:10021370   PMID:14702039   PMID:19690890   PMID:21833088   PMID:22641666   PMID:25798074   PMID:28668886   PMID:29507755   PMID:29888752   PMID:29987050   PMID:30021884   PMID:32129710  
PMID:32330508   PMID:33705408   PMID:33961781   PMID:34210956   PMID:34705617   PMID:37071682   PMID:37433992  



ALPK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381858,481,247 - 58,629,091 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1858,481,247 - 58,629,091 (-)EnsemblGRCh38hg38GRCh38
GRCh371856,148,479 - 56,296,323 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361854,299,459 - 54,447,169 (-)NCBINCBI36Build 36hg18NCBI36
Build 341854,299,463 - 54,398,381NCBI
Celera1852,864,790 - 53,011,746 (-)NCBICelera
Cytogenetic Map18q21.31-q21.32NCBI
HuRef1852,856,619 - 53,004,353 (-)NCBIHuRef
CHM1_11856,143,681 - 56,291,408 (-)NCBICHM1_1
T2T-CHM13v2.01858,681,900 - 58,830,246 (-)NCBIT2T-CHM13v2.0
Alpk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391865,398,600 - 65,526,959 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1865,398,600 - 65,527,137 (-)EnsemblGRCm39 Ensembl
GRCm381865,265,529 - 65,393,888 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1865,265,529 - 65,394,066 (-)EnsemblGRCm38mm10GRCm38
MGSCv371865,425,183 - 65,553,542 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361865,391,194 - 65,474,903 (-)NCBIMGSCv36mm8
Celera1866,541,032 - 66,666,987 (-)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1838.41NCBI
Alpk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81861,045,717 - 61,161,703 (-)NCBIGRCr8
mRatBN7.21858,775,603 - 58,906,150 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1858,775,605 - 58,906,258 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01860,960,009 - 61,072,116 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1860,960,662 - 61,057,365 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01860,158,973 - 60,268,224 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41861,562,696 - 61,587,804 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1856,922,773 - 57,035,140 (-)NCBICelera
Cytogenetic Map18q12.1NCBI
Alpk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540242,749,534 - 42,871,772 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540242,749,005 - 42,871,756 (-)NCBIChiLan1.0ChiLan1.0
ALPK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21776,022,313 - 76,153,298 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11861,714,926 - 61,846,177 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01851,872,394 - 52,020,137 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11855,205,337 - 55,352,100 (-)NCBIpanpan1.1PanPan1.1panPan2
ALPK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1117,421,673 - 17,563,732 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl117,445,543 - 17,583,600 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha118,428,963 - 18,547,640 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0117,301,628 - 17,443,969 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl117,326,519 - 17,446,007 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1117,360,210 - 17,502,294 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0117,258,137 - 17,400,351 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0117,526,061 - 17,668,450 (+)NCBIUU_Cfam_GSD_1.0
Alpk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494430,710,592 - 30,810,043 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364975,949,640 - 6,048,425 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364975,934,857 - 6,049,090 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALPK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1162,175,573 - 162,305,305 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11162,175,241 - 162,308,074 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21179,761,531 - 179,891,873 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ALPK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11821,123,913 - 21,252,228 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1821,107,369 - 21,252,693 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660604,318,054 - 4,446,186 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Alpk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247923,966,683 - 4,111,504 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247923,967,876 - 4,148,169 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in ALPK2
3164 total Variants

1 to 10 of 3246 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
GRCh38/hg38 18q21.1-23(chr18:50068129-80252149)x3 copy number gain See cases [RCV000050989] Chr18:50068129..80252149 [GRCh38]
Chr18:47594499..78010032 [GRCh37]
Chr18:45848497..76111023 [NCBI36]
Chr18:18q21.1-23		 pathogenic
GRCh38/hg38 18q21.31-23(chr18:56618038-80252149)x1 copy number loss See cases [RCV000051032] Chr18:56618038..80252149 [GRCh38]
Chr18:54285269..78010032 [GRCh37]
Chr18:52436267..76111023 [NCBI36]
Chr18:18q21.31-23		 pathogenic
GRCh38/hg38 18p11.32-q23(chr18:148963-80252149)x3 copy number gain See cases [RCV000051048] Chr18:148963..80252149 [GRCh38]
Chr18:148963..78010032 [GRCh37]
Chr18:138963..76111023 [NCBI36]
Chr18:18p11.32-q23		 pathogenic
GRCh38/hg38 18q11.1-23(chr18:20960320-80234429)x3 copy number gain See cases [RCV000052543] Chr18:20960320..80234429 [GRCh38]
Chr18:18540281..77992312 [GRCh37]
Chr18:16794279..76093303 [NCBI36]
Chr18:18q11.1-23		 pathogenic
GRCh38/hg38 18q11.1-23(chr18:20989762-80209986)x3 copy number gain See cases [RCV000052549] Chr18:20989762..80209986 [GRCh38]
Chr18:18569723..77967869 [GRCh37]
Chr18:16823721..76068860 [NCBI36]
Chr18:18q11.1-23		 pathogenic
GRCh38/hg38 18p11.32-q23(chr18:53345-80209986)x3 copy number gain See cases [RCV000052501] Chr18:53345..80209986 [GRCh38]
Chr18:53345..77967869 [GRCh37]
Chr18:43345..76068860 [NCBI36]
Chr18:18p11.32-q23		 pathogenic
GRCh38/hg38 18p11.32-q23(chr18:148763-80252290)x3 copy number gain See cases [RCV000052507] Chr18:148763..80252290 [GRCh38]
Chr18:148763..78010173 [GRCh37]
Chr18:138763..76111164 [NCBI36]
Chr18:18p11.32-q23		 pathogenic
GRCh38/hg38 18q12.1-22.1(chr18:29249202-65448117)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052563]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052563]|See cases [RCV000052563] Chr18:29249202..65448117 [GRCh38]
Chr18:26829167..63115353 [GRCh37]
Chr18:25083165..61266333 [NCBI36]
Chr18:18q12.1-22.1		 pathogenic
GRCh38/hg38 18p11.32-q23(chr18:148963-80244381)x3 copy number gain See cases [RCV000052514] Chr18:148963..80244381 [GRCh38]
Chr18:148963..78002264 [GRCh37]
Chr18:138963..76103255 [NCBI36]
Chr18:18p11.32-q23		 pathogenic
GRCh38/hg38 18q21.31-21.32(chr18:58251999-58789954)x3 copy number gain See cases [RCV000054085] Chr18:58251999..58789954 [GRCh38]
Chr18:55919231..56457186 [GRCh37]
Chr18:54070211..54608166 [NCBI36]
Chr18:18q21.31-21.32		 uncertain significance
1 to 10 of 3246 rows

Predicted Target Of
Summary Value
Count of predictions:662
Count of miRNA genes:525
Interacting mature miRNAs:564
Transcripts:ENST00000361673, ENST00000587399, ENST00000587842, ENST00000589204, ENST00000590642, ENST00000590662
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 21 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
597017653GWAS1113727_Heosinophil count QTL GWAS1113727 (human)5e-16eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)185854460858544609Human
597392187GWAS1488261_Heosinophil count QTL GWAS1488261 (human)8e-10eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)185854460858544609Human
597030997GWAS1127071_Hsystolic blood pressure, multiple sclerosis QTL GWAS1127071 (human)0.000008systolic blood pressure, multiple sclerosissystolic blood pressure (CMO:0000004)185854615858546159Human
407102082GWAS751058_Heosinophil count QTL GWAS751058 (human)3e-15eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)185862077758620778Human
597367097GWAS1463171_Heosinophil percentage of leukocytes QTL GWAS1463171 (human)2e-11eosinophil quantity (VT:0002602)blood eosinophil count to total leukocyte count ratio (CMO:0000369)185854460858544609Human
597337176GWAS1433250_Hosteoarthritis QTL GWAS1433250 (human)0.0000005osteoarthritis185856206558562066Human
597164539GWAS1260613_Hlipid measurement QTL GWAS1260613 (human)0.000008lipid measurementblood lipid measurement (CMO:0000050)185859449158594492Human
597223792GWAS1319866_Hserum gamma-glutamyl transferase measurement QTL GWAS1319866 (human)8e-11serum gamma-glutamyl transferase measurementserum gamma-glutamyltransferase activity level (CMO:0002241)185853751558537516Human
406938600GWAS587576_Heosinophil percentage of leukocytes QTL GWAS587576 (human)9e-12eosinophil quantity (VT:0002602)blood eosinophil count to total leukocyte count ratio (CMO:0000369)185862077758620778Human
597055324GWAS1151398_Heosinophil count QTL GWAS1151398 (human)1e-10eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)185862077758620778Human

1 to 10 of 21 rows
D18S881  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371856,232,781 - 56,233,063UniSTSGRCh37
Build 361854,383,761 - 54,384,043RGDNCBI36
Celera1852,948,549 - 52,948,823RGD
Cytogenetic Map18q21.31UniSTS
HuRef1852,940,639 - 52,940,917UniSTS
G18021  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371856,223,413 - 56,223,618UniSTSGRCh37
Build 361854,374,393 - 54,374,598RGDNCBI36
Celera1852,939,172 - 52,939,377RGD
Cytogenetic Map18q21.31UniSTS
HuRef1852,931,299 - 52,931,504UniSTS
RH99213  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371856,148,600 - 56,148,728UniSTSGRCh37
Build 361854,299,580 - 54,299,708RGDNCBI36
Celera1852,864,911 - 52,865,039RGD
Cytogenetic Map18q21.31UniSTS
HuRef1852,856,740 - 52,856,868UniSTS
GeneMap99-GB4 RH Map18396.5UniSTS
SHGC-145775  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371856,168,115 - 56,168,394UniSTSGRCh37
Build 361854,319,095 - 54,319,374RGDNCBI36
Celera1852,884,437 - 52,884,716RGD
Cytogenetic Map18q21.31UniSTS
HuRef1852,876,227 - 52,876,506UniSTS
TNG Radiation Hybrid Map1822660.0UniSTS
STS-R27572  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371856,201,631 - 56,201,779UniSTSGRCh37
Build 361854,352,611 - 54,352,759RGDNCBI36
Celera1852,918,128 - 52,918,276RGD
Cytogenetic Map18q21.31UniSTS
HuRef1852,909,492 - 52,909,640UniSTS
GeneMap99-GB4 RH Map18396.41UniSTS
NCBI RH Map18756.0UniSTS




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
1191 2205 2577 2034 4197 1518 2072 4 599 1697 450 2214 6657 5872 45 3000 789 1626 1355 158



Ensembl Acc Id: ENST00000361673   ⟹   ENSP00000354991
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1858,481,247 - 58,629,091 (-)Ensembl
Ensembl Acc Id: ENST00000587399
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1858,544,228 - 58,579,212 (-)Ensembl
Ensembl Acc Id: ENST00000587842
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1858,538,140 - 58,579,024 (-)Ensembl
Ensembl Acc Id: ENST00000589204
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1858,528,752 - 58,537,119 (-)Ensembl
Ensembl Acc Id: ENST00000590642
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1858,580,260 - 58,580,973 (-)Ensembl
Ensembl Acc Id: ENST00000590662
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1858,577,944 - 58,580,169 (-)Ensembl
RefSeq Acc Id: NM_052947   ⟹   NP_443179
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381858,481,247 - 58,629,091 (-)NCBI
GRCh371856,148,479 - 56,296,189 (-)RGD
Build 361854,299,459 - 54,447,169 (-)NCBI Archive
Celera1852,864,790 - 53,011,746 (-)RGD
HuRef1852,856,619 - 53,004,353 (-)RGD
CHM1_11856,143,681 - 56,291,408 (-)NCBI
T2T-CHM13v2.01858,681,900 - 58,830,246 (-)NCBI
Sequence:
Protein RefSeqs NP_443179 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAK95952 (Get FASTA)   NCBI Sequence Viewer  
  BAC03812 (Get FASTA)   NCBI Sequence Viewer  
  CAD89922 (Get FASTA)   NCBI Sequence Viewer  
  EAW63077 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000354991
  ENSP00000354991.3
GenBank Protein Q86TB3 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_443179   ⟸   NM_052947
- UniProtKB: Q8NAT5 (UniProtKB/Swiss-Prot),   Q6ZUX0 (UniProtKB/Swiss-Prot),   Q96L95 (UniProtKB/Swiss-Prot),   Q86TB3 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000354991   ⟸   ENST00000361673
Alpha-type protein kinase   Ig-like

Name Modeler Protein Id AA Range Protein Structure
AF-Q86TB3-F1-model_v2 AlphaFold Q86TB3 1-2170 view protein structure

RGD ID:6794768
Promoter ID:HG_KWN:28098
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   K562,   Lymphoblastoid
Transcripts:UC002LHK.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361854,353,366 - 54,357,422 (-)MPROMDB
RGD ID:7237431
Promoter ID:EPDNEW_H24462
Type:initiation region
Name:ALPK2_1
Description:alpha kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H24463  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381858,628,957 - 58,629,017EPDNEW
RGD ID:7237435
Promoter ID:EPDNEW_H24463
Type:initiation region
Name:ALPK2_2
Description:alpha kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H24462  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381858,629,091 - 58,629,151EPDNEW


1 to 40 of 40 rows
Database
Acc Id
Source(s)
COSMIC ALPK2 COSMIC
Ensembl Genes ENSG00000198796 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000361673 ENTREZGENE
  ENST00000361673.4 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
  MHCK/EF2 kinase UniProtKB/Swiss-Prot
GTEx ENSG00000198796 GTEx
HGNC ID HGNC:20565 ENTREZGENE
Human Proteome Map ALPK2 Human Proteome Map
InterPro Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_I-set UniProtKB/Swiss-Prot
  Ig_sub UniProtKB/Swiss-Prot
  Ig_sub2 UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  MHCK_EF2_kinase UniProtKB/Swiss-Prot
KEGG Report hsa:115701 UniProtKB/Swiss-Prot
NCBI Gene 115701 ENTREZGENE
OMIM 619965 OMIM
PANTHER ALPHA-PROTEIN KINASE 2 UniProtKB/Swiss-Prot
  ALPHA-PROTEIN KINASE 2-RELATED UniProtKB/Swiss-Prot
Pfam Alpha_kinase UniProtKB/Swiss-Prot
  I-set UniProtKB/Swiss-Prot
PharmGKB PA134916108 PharmGKB
PROSITE ALPHA_KINASE UniProtKB/Swiss-Prot
  IG_LIKE UniProtKB/Swiss-Prot
SMART Alpha_kinase UniProtKB/Swiss-Prot
  IGc2 UniProtKB/Swiss-Prot
  SM00409 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
UniProt ALPK2_HUMAN UniProtKB/Swiss-Prot
  Q6ZUX0 ENTREZGENE
  Q86TB3 ENTREZGENE
  Q8NAT5 ENTREZGENE
  Q96L95 ENTREZGENE
UniProt Secondary Q6ZUX0 UniProtKB/Swiss-Prot
  Q8NAT5 UniProtKB/Swiss-Prot
  Q96L95 UniProtKB/Swiss-Prot
1 to 40 of 40 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-17 ALPK2  alpha kinase 2    alpha-kinase 2  Symbol and/or name change 5135510 APPROVED