ALPK2 (alpha kinase 2) - Rat Genome Database

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Gene: ALPK2 (alpha kinase 2) Sus scrofa
Analyze
Symbol: ALPK2
Name: alpha kinase 2
RGD ID: 13992727
Description: ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); protein serine/threonine kinase activity (inferred); INVOLVED IN regulation of gene expression (ortholog); ASSOCIATED WITH genetic disease (ortholog); immunodeficiency 12 (ortholog); isolated microphthalmia 3 (ortholog); FOUND IN basolateral plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: alpha-protein kinase 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1162,175,573 - 162,305,305 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11162,175,241 - 162,308,074 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21179,761,531 - 179,891,873 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
ALPK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1162,175,573 - 162,305,305 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11162,175,241 - 162,308,074 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21179,761,531 - 179,891,873 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ALPK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381858,481,247 - 58,629,091 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1858,481,247 - 58,629,091 (-)EnsemblGRCh38hg38GRCh38
GRCh371856,148,479 - 56,296,323 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361854,299,459 - 54,447,169 (-)NCBINCBI36Build 36hg18NCBI36
Build 341854,299,463 - 54,398,381NCBI
Celera1852,864,790 - 53,011,746 (-)NCBICelera
Cytogenetic Map18q21.31-q21.32NCBI
HuRef1852,856,619 - 53,004,353 (-)NCBIHuRef
CHM1_11856,143,681 - 56,291,408 (-)NCBICHM1_1
T2T-CHM13v2.01858,681,900 - 58,830,246 (-)NCBIT2T-CHM13v2.0
Alpk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391865,398,600 - 65,526,959 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1865,398,600 - 65,527,137 (-)EnsemblGRCm39 Ensembl
GRCm381865,265,529 - 65,393,888 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1865,265,529 - 65,394,066 (-)EnsemblGRCm38mm10GRCm38
MGSCv371865,425,183 - 65,553,542 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361865,391,194 - 65,474,903 (-)NCBIMGSCv36mm8
Celera1866,541,032 - 66,666,987 (-)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1838.41NCBI
Alpk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81861,045,717 - 61,161,703 (-)NCBIGRCr8
mRatBN7.21858,775,603 - 58,906,150 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1858,775,605 - 58,906,258 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01860,960,009 - 61,072,116 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1860,960,662 - 61,057,365 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01860,158,973 - 60,268,224 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41861,562,696 - 61,587,804 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1856,922,773 - 57,035,140 (-)NCBICelera
Cytogenetic Map18q12.1NCBI
Alpk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540242,749,534 - 42,871,772 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540242,749,005 - 42,871,756 (-)NCBIChiLan1.0ChiLan1.0
ALPK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21776,022,313 - 76,153,298 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11861,714,926 - 61,846,177 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01851,872,394 - 52,020,137 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11855,205,337 - 55,352,100 (-)NCBIpanpan1.1PanPan1.1panPan2
ALPK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1117,421,673 - 17,563,732 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl117,445,543 - 17,583,600 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha118,428,963 - 18,547,640 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0117,301,628 - 17,443,969 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl117,326,519 - 17,446,007 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1117,360,210 - 17,502,294 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0117,258,137 - 17,400,351 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0117,526,061 - 17,668,450 (+)NCBIUU_Cfam_GSD_1.0
Alpk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494430,710,592 - 30,810,043 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364975,949,640 - 6,048,425 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364975,934,857 - 6,049,090 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALPK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11821,123,913 - 21,252,228 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1821,107,369 - 21,252,693 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660604,318,054 - 4,446,186 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Alpk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247923,966,683 - 4,111,504 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247923,967,876 - 4,148,169 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ALPK2
4402 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2 2
Low 4 2 3 5 6 1 2 1
Below cutoff 6 16 1 1 2

Sequence


RefSeq Acc Id: ENSSSCT00000005427   ⟹   ENSSSCP00000005292
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1162,144,471 - 162,367,879 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000041269   ⟹   ENSSSCP00000037672
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1162,175,573 - 162,305,305 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000062871   ⟹   ENSSSCP00000035605
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1162,175,446 - 162,305,310 (+)Ensembl
RefSeq Acc Id: XM_001925970   ⟹   XP_001926005
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11162,175,243 - 162,308,074 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013993295   ⟹   XP_013848749
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11162,175,681 - 162,308,074 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021073807   ⟹   XP_020929466
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11162,178,978 - 162,308,074 (+)NCBI
Sequence:
RefSeq Acc Id: XR_002338854
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11162,175,241 - 162,305,310 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_001926005 (Get FASTA)   NCBI Sequence Viewer  
  XP_013848749 (Get FASTA)   NCBI Sequence Viewer  
  XP_020929466 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000037672
  ENSSSCP00000037672.1
  ENSSSCP00050017619.1
RefSeq Acc Id: XP_001926005   ⟸   XM_001925970
- Peptide Label: isoform X1
- UniProtKB: A0A8D1M476 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013848749   ⟸   XM_013993295
- Peptide Label: isoform X3
- UniProtKB: A0A287A1R9 (UniProtKB/TrEMBL),   A0A8D1M476 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020929466   ⟸   XM_021073807
- Peptide Label: isoform X2
- UniProtKB: A0A8D1M476 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000005292   ⟸   ENSSSCT00000005427
RefSeq Acc Id: ENSSSCP00000037672   ⟸   ENSSSCT00000041269
RefSeq Acc Id: ENSSSCP00000035605   ⟸   ENSSSCT00000062871
Protein Domains
Alpha-type protein kinase   Ig-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000004918 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00050031668 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000041269 ENTREZGENE
  ENSSSCT00000041269.3 UniProtKB/TrEMBL
  ENSSSCT00050042571.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  MHCK/EF2 kinase UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_I-set UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  MHCK_EF2_kinase UniProtKB/TrEMBL
NCBI Gene ALPK2 ENTREZGENE
PANTHER ALPHA-PROTEIN KINASE 2 UniProtKB/TrEMBL
  ALPHA-PROTEIN KINASE 2-RELATED UniProtKB/TrEMBL
Pfam Alpha_kinase UniProtKB/TrEMBL
  I-set UniProtKB/TrEMBL
PROSITE ALPHA_KINASE UniProtKB/TrEMBL
  IG_LIKE UniProtKB/TrEMBL
SMART Alpha_kinase UniProtKB/TrEMBL
  IGc2 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A287A1R9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1M476 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:85268 ENTREZGENE