URI1 (URI1 prefoldin like chaperone) - Rat Genome Database

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Gene: URI1 (URI1 prefoldin like chaperone) Homo sapiens
Analyze
Symbol: URI1
Name: URI1 prefoldin like chaperone
RGD ID: 1321217
HGNC Page HGNC
Description: Enables several functions, including RNA polymerase II complex binding activity; phosphoprotein binding activity; and transcription corepressor activity. Involved in several processes, including cellular response to steroid hormone stimulus; negative regulation of cellular metabolic process; and negative regulation of intrinsic apoptotic signaling pathway. Located in cytosol and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C19orf2; FLJ10575; NNX3; PPP1R19; protein phosphatase 1 regulatory subunit 19; protein phosphatase 1, regulatory subunit 19; RMP; RNA polymerase II subunit 5-mediating protein; RNA polymerase II, subunit 5-mediating protein; RPB5-mediating protein; unconventional prefoldin RPB5 interactor; unconventional prefoldin RPB5 interactor 1; URI; URI1 prefoldin-like chaperone; URI1, prefoldin like chaperone; URI1, prefoldin-like chaperone
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: AC245060.3  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1929,923,644 - 30,016,612 (+)EnsemblGRCh38hg38GRCh38
GRCh381929,923,650 - 30,016,612 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371930,414,564 - 30,507,519 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361935,125,265 - 35,198,456 (+)NCBINCBI36hg18NCBI36
Build 341935,125,264 - 35,198,451NCBI
Celera1927,127,113 - 27,200,278 (+)NCBI
Cytogenetic Map19q12NCBI
HuRef1926,921,938 - 27,014,764 (+)NCBIHuRef
CHM1_11930,414,913 - 30,507,875 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

Additional References at PubMed
PMID:9819440   PMID:9878255   PMID:11827465   PMID:12477932   PMID:12737519   PMID:14615539   PMID:14702039   PMID:15367675   PMID:15923622   PMID:16055720   PMID:17081983   PMID:17643375  
PMID:17936702   PMID:19450687   PMID:19490893   PMID:19875381   PMID:20195357   PMID:20371770   PMID:20379614   PMID:20864032   PMID:21310960   PMID:21397856   PMID:21730289   PMID:21832049  
PMID:21873635   PMID:21948523   PMID:23667685   PMID:24104479   PMID:24228101   PMID:24366813   PMID:24625985   PMID:24981860   PMID:25036637   PMID:25453901   PMID:25476789   PMID:25527175  
PMID:25544563   PMID:25605019   PMID:26186194   PMID:26344197   PMID:26496610   PMID:26638075   PMID:26673895   PMID:26972000   PMID:27105489   PMID:27173435   PMID:27505673   PMID:27582547  
PMID:27780869   PMID:27880917   PMID:28330616   PMID:28423737   PMID:28514442   PMID:28515276   PMID:28561026   PMID:28611215   PMID:28675297   PMID:28977470   PMID:29229926   PMID:29507755  
PMID:30344098   PMID:30745168   PMID:31048545   PMID:31541481   PMID:31617661   PMID:31738558   PMID:31739577   PMID:32296183   PMID:32513696   PMID:33001583   PMID:34079125  


Genomics

Comparative Map Data
URI1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1929,923,644 - 30,016,612 (+)EnsemblGRCh38hg38GRCh38
GRCh381929,923,650 - 30,016,612 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371930,414,564 - 30,507,519 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361935,125,265 - 35,198,456 (+)NCBINCBI36hg18NCBI36
Build 341935,125,264 - 35,198,451NCBI
Celera1927,127,113 - 27,200,278 (+)NCBI
Cytogenetic Map19q12NCBI
HuRef1926,921,938 - 27,014,764 (+)NCBIHuRef
CHM1_11930,414,913 - 30,507,875 (+)NCBICHM1_1
Uri1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39737,659,417 - 37,722,989 (-)NCBIGRCm39mm39
GRCm39 Ensembl737,659,417 - 37,722,976 (-)Ensembl
GRCm38737,959,992 - 38,023,564 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl737,959,992 - 38,023,551 (-)EnsemblGRCm38mm10GRCm38
MGSCv37738,745,011 - 38,804,571 (-)NCBIGRCm37mm9NCBIm37
MGSCv36737,668,762 - 37,728,302 (-)NCBImm8
Celera733,115,193 - 33,174,905 (-)NCBICelera
Cytogenetic Map7B3NCBI
Uri1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2190,646,392 - 90,704,811 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl190,646,393 - 90,709,026 (-)Ensembl
Rnor_6.0194,346,513 - 94,404,362 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl194,346,514 - 94,404,211 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0195,435,846 - 95,493,474 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4190,430,169 - 90,490,153 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1190,508,282 - 90,568,264 (-)NCBI
Celera184,979,704 - 85,037,972 (-)NCBICelera
Cytogenetic Map1q21NCBI
Uri1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554687,648,456 - 7,718,074 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554687,651,061 - 7,718,968 (-)NCBIChiLan1.0ChiLan1.0
URI1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11935,621,130 - 35,694,390 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1935,601,872 - 35,694,273 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01926,865,190 - 26,939,510 (+)NCBIMhudiblu_PPA_v0panPan3
URI1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11121,528,706 - 121,612,200 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1121,530,203 - 121,614,909 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1120,897,395 - 120,980,814 (-)NCBI
ROS_Cfam_1.01122,157,827 - 122,241,288 (-)NCBI
UMICH_Zoey_3.11121,737,554 - 121,820,951 (-)NCBI
UNSW_CanFamBas_1.01121,344,096 - 121,427,703 (-)NCBI
UU_Cfam_GSD_1.01122,409,100 - 122,492,731 (-)NCBI
Uri1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244093496,238,300 - 6,266,629 (+)NCBI
SpeTri2.0NW_0049365705,379,253 - 5,419,595 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
URI1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl640,023,595 - 40,109,816 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1640,043,320 - 40,110,540 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2635,409,250 - 35,476,422 (+)NCBISscrofa10.2Sscrofa10.2susScr3
URI1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1625,005,512 - 25,078,054 (+)NCBI
ChlSab1.1 Ensembl625,005,316 - 25,078,541 (+)Ensembl
Vero_WHO_p1.0NW_0236660732,546,698 - 2,620,295 (+)NCBI
Uri1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247945,059,961 - 5,126,771 (+)NCBI

Position Markers
RH12894  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371930,506,297 - 30,506,464UniSTSGRCh37
Build 361935,198,137 - 35,198,304RGDNCBI36
Celera1927,199,959 - 27,200,126RGD
Cytogenetic Map19q12UniSTS
HuRef1927,013,542 - 27,013,709UniSTS
GeneMap99-GB4 RH Map19157.32UniSTS
NCBI RH Map19287.4UniSTS
STS-R63092  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371930,507,373 - 30,507,496UniSTSGRCh37
Build 361935,199,213 - 35,199,336RGDNCBI36
Celera1927,201,035 - 27,201,158RGD
Cytogenetic Map19q12UniSTS
HuRef1927,014,618 - 27,014,741UniSTS
GeneMap99-GB4 RH Map19180.67UniSTS
NCBI RH Map19291.4UniSTS
RH45535  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371930,467,256 - 30,467,391UniSTSGRCh37
Build 361935,159,096 - 35,159,231RGDNCBI36
Celera1927,160,942 - 27,161,077RGD
Cytogenetic Map19q12UniSTS
HuRef1926,974,520 - 26,974,655UniSTS
STS-Z41049  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371930,506,377 - 30,506,456UniSTSGRCh37
Build 361935,198,217 - 35,198,296RGDNCBI36
Celera1927,200,039 - 27,200,118RGD
Cytogenetic Map19q12UniSTS
HuRef1927,013,622 - 27,013,701UniSTS
GeneMap99-GB4 RH Map19181.52UniSTS
NCBI RH Map19287.4UniSTS
px-16e8  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371930,487,734 - 30,487,834UniSTSGRCh37
GRCh37491,332,612 - 91,333,851UniSTSGRCh37
Build 361935,179,574 - 35,179,674RGDNCBI36
Celera488,629,768 - 88,631,007UniSTS
Celera1927,181,395 - 27,181,495RGD
HuRef1926,994,972 - 26,995,072UniSTS
HuRef487,083,500 - 87,084,739UniSTS
SGC30870  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371930,472,634 - 30,472,759UniSTSGRCh37
Build 361935,164,474 - 35,164,599RGDNCBI36
Celera1927,166,324 - 27,166,449RGD
Cytogenetic Map19q12UniSTS
HuRef1926,979,898 - 26,980,023UniSTS
Whitehead-RH Map19216.1UniSTS
SHGC-30736  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371930,505,599 - 30,505,748UniSTSGRCh37
Build 361935,197,439 - 35,197,588RGDNCBI36
Celera1927,199,261 - 27,199,410RGD
Cytogenetic Map19q12UniSTS
HuRef1927,012,844 - 27,012,993UniSTS
Stanford-G3 RH Map191173.0UniSTS
GeneMap99-GB4 RH Map19158.8UniSTS
Whitehead-RH Map19214.8UniSTS
NCBI RH Map19289.6UniSTS
GeneMap99-G3 RH Map191184.0UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2818
Count of miRNA genes:899
Interacting mature miRNAs:1051
Transcripts:ENST00000312051, ENST00000360605, ENST00000392271, ENST00000542441, ENST00000570564, ENST00000570704, ENST00000573052, ENST00000574110, ENST00000574176, ENST00000574233, ENST00000574666, ENST00000574766, ENST00000575242, ENST00000576442, ENST00000585655
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 4
Medium 2344 1747 1503 414 1214 255 4350 1841 3305 371 1453 1609 175 1 1200 2782 6 2
Low 95 1234 223 210 727 210 7 356 429 48 3 4 4 6
Below cutoff 10 10

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_047095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001252641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_003796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_045557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005259362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005259363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011527435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024451751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA678820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC008507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF091095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK001437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK226173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK292170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK314313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW003989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW954529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC014933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC026184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC067259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG742069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB461036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ234306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000360605   ⟹   ENSP00000353817
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1929,923,644 - 30,015,695 (+)Ensembl
RefSeq Acc Id: ENST00000392271   ⟹   ENSP00000376097
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1929,942,239 - 30,016,612 (+)Ensembl
RefSeq Acc Id: ENST00000570564   ⟹   ENSP00000459966
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1929,923,657 - 29,986,377 (+)Ensembl
RefSeq Acc Id: ENST00000570704
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1929,983,233 - 30,007,579 (+)Ensembl
RefSeq Acc Id: ENST00000573052   ⟹   ENSP00000458161
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1930,012,423 - 30,015,026 (+)Ensembl
RefSeq Acc Id: ENST00000574110   ⟹   ENSP00000461003
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1929,942,261 - 30,015,704 (+)Ensembl
RefSeq Acc Id: ENST00000574176
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1930,004,295 - 30,009,019 (+)Ensembl
RefSeq Acc Id: ENST00000574233   ⟹   ENSP00000458480
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1929,923,691 - 30,005,436 (+)Ensembl
RefSeq Acc Id: ENST00000574666   ⟹   ENSP00000458533
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1929,942,311 - 30,005,706 (+)Ensembl
RefSeq Acc Id: ENST00000574766
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1929,923,712 - 29,937,997 (+)Ensembl
RefSeq Acc Id: ENST00000575242   ⟹   ENSP00000459450
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1930,009,080 - 30,012,899 (+)Ensembl
RefSeq Acc Id: ENST00000576442   ⟹   ENSP00000461895
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1929,971,093 - 30,007,547 (+)Ensembl
RefSeq Acc Id: ENST00000585655   ⟹   ENSP00000468048
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1929,923,734 - 29,925,897 (+)Ensembl
RefSeq Acc Id: NM_001252641   ⟹   NP_001239570
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381929,923,657 - 30,016,612 (+)NCBI
GRCh371930,414,551 - 30,507,519 (+)NCBI
HuRef1926,921,938 - 27,014,764 (+)NCBI
CHM1_11930,414,913 - 30,507,875 (+)NCBI
Sequence:
RefSeq Acc Id: NM_003796   ⟹   NP_003787
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381929,942,239 - 30,016,612 (+)NCBI
GRCh371930,414,551 - 30,507,519 (+)NCBI
Build 361935,125,265 - 35,198,456 (+)NCBI Archive
Celera1927,127,113 - 27,200,278 (+)RGD
HuRef1926,921,938 - 27,014,764 (+)NCBI
CHM1_11930,433,508 - 30,507,875 (+)NCBI
Sequence:
RefSeq Acc Id: NR_045557
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381929,942,239 - 30,016,612 (+)NCBI
GRCh371930,414,551 - 30,507,519 (+)NCBI
HuRef1926,921,938 - 27,014,764 (+)NCBI
CHM1_11930,433,508 - 30,507,875 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005259362   ⟹   XP_005259419
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381929,923,650 - 30,016,608 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005259363   ⟹   XP_005259420
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381929,942,503 - 30,016,610 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011527435   ⟹   XP_011525737
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381929,923,667 - 30,016,608 (+)NCBI
Sequence:
RefSeq Acc Id: XM_024451751   ⟹   XP_024307519
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381929,978,136 - 30,016,608 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_003787   ⟸   NM_003796
- Peptide Label: isoform a
- UniProtKB: O94763 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001239570   ⟸   NM_001252641
- Peptide Label: isoform c
- UniProtKB: O94763 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_005259419   ⟸   XM_005259362
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005259420   ⟸   XM_005259363
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_011525737   ⟸   XM_011527435
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_024307519   ⟸   XM_024451751
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSP00000459966   ⟸   ENST00000570564
RefSeq Acc Id: ENSP00000468048   ⟸   ENST00000585655
RefSeq Acc Id: ENSP00000353817   ⟸   ENST00000360605
RefSeq Acc Id: ENSP00000458161   ⟸   ENST00000573052
RefSeq Acc Id: ENSP00000458480   ⟸   ENST00000574233
RefSeq Acc Id: ENSP00000461003   ⟸   ENST00000574110
RefSeq Acc Id: ENSP00000458533   ⟸   ENST00000574666
RefSeq Acc Id: ENSP00000459450   ⟸   ENST00000575242
RefSeq Acc Id: ENSP00000461895   ⟸   ENST00000576442
RefSeq Acc Id: ENSP00000376097   ⟸   ENST00000392271

Promoters
RGD ID:7239371
Promoter ID:EPDNEW_H25430
Type:initiation region
Name:URI1_2
Description:URI1, prefoldin like chaperone
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H25431  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381929,923,657 - 29,923,717EPDNEW
RGD ID:7239369
Promoter ID:EPDNEW_H25431
Type:initiation region
Name:URI1_1
Description:URI1, prefoldin like chaperone
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H25430  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381929,942,260 - 29,942,320EPDNEW
RGD ID:6795437
Promoter ID:HG_KWN:29505
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000312051,   ENST00000392271
Position:
Human AssemblyChrPosition (strand)Source
Build 361935,124,871 - 35,125,497 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19p13.11-q13.11(chr19:17176767-34924150)x3 copy number gain See cases [RCV000050635] Chr19:17176767..34924150 [GRCh38]
Chr19:17287576..35415054 [GRCh37]
Chr19:17148576..40106894 [NCBI36]
Chr19:19p13.11-q13.11
pathogenic
NM_001252641.1(URI1):c.98+117T>G single nucleotide variant Lung cancer [RCV000101185] Chr19:29971344 [GRCh38]
Chr19:30462251 [GRCh37]
Chr19:19q12
uncertain significance
GRCh38/hg38 19p13.2-q13.31(chr19:11227942-44626354)x3 copy number gain See cases [RCV000133888] Chr19:11227942..44626354 [GRCh38]
Chr19:11338618..45129651 [GRCh37]
Chr19:11199618..49821491 [NCBI36]
Chr19:19p13.2-q13.31
pathogenic
GRCh38/hg38 19q12-13.13(chr19:29661858-38114723)x1 copy number loss See cases [RCV000135879] Chr19:29661858..38114723 [GRCh38]
Chr19:30152765..38605363 [GRCh37]
Chr19:34844605..43297203 [NCBI36]
Chr19:19q12-13.13
pathogenic
GRCh38/hg38 19q12-13.13(chr19:29671324-37902990)x1 copy number loss See cases [RCV000136794] Chr19:29671324..37902990 [GRCh38]
Chr19:30162231..38393630 [GRCh37]
Chr19:34854071..43085470 [NCBI36]
Chr19:19q12-13.13
pathogenic
GRCh38/hg38 19q12-13.11(chr19:29051888-31967596)x1 copy number loss See cases [RCV000141953] Chr19:29051888..31967596 [GRCh38]
Chr19:29542795..32458502 [GRCh37]
Chr19:34234635..37150342 [NCBI36]
Chr19:19q12-13.11
likely pathogenic|uncertain significance
GRCh38/hg38 19q11-13.11(chr19:27780238-34783942)x3 copy number gain See cases [RCV000143705] Chr19:27780238..34783942 [GRCh38]
Chr19:28271146..35274846 [GRCh37]
Chr19:32962986..39966686 [NCBI36]
Chr19:19q11-13.11
uncertain significance
NM_001252641.2(URI1):c.33C>A (p.His11Gln) single nucleotide variant Abnormality of neuronal migration [RCV000201340] Chr19:29923724 [GRCh38]
Chr19:30414631 [GRCh37]
Chr19:19q12
benign|uncertain significance
NM_003796.3(URI1):c.698C>T (p.Thr233Ile) single nucleotide variant Abnormality of neuronal migration [RCV000201379] Chr19:30009016 [GRCh38]
Chr19:30499923 [GRCh37]
Chr19:19q12
benign
GRCh37/hg19 19q12(chr19:29830628-31395657)x3 copy number gain See cases [RCV000447509] Chr19:29830628..31395657 [GRCh37]
Chr19:19q12
uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 copy number gain See cases [RCV000511289] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic|uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) copy number gain See cases [RCV000512296] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19q12(chr19:30112378-31939682)x3 copy number gain See cases [RCV000512411] Chr19:30112378..31939682 [GRCh37]
Chr19:19q12
likely pathogenic
GRCh37/hg19 19q11-12(chr19:28271107-31110233)x1 copy number loss See cases [RCV000512455] Chr19:28271107..31110233 [GRCh37]
Chr19:19q11-12
likely pathogenic
GRCh37/hg19 19q12(chr19:29083484-31804809)x3 copy number gain not provided [RCV000684093] Chr19:29083484..31804809 [GRCh37]
Chr19:19q12
uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 copy number gain not provided [RCV000752439] Chr19:68029..59110290 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 copy number gain not provided [RCV000752444] Chr19:260912..59097160 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19q12(chr19:30328828-30593549)x3 copy number gain not provided [RCV000740124] Chr19:30328828..30593549 [GRCh37]
Chr19:19q12
benign
NM_003796.3(URI1):c.303G>C (p.Gly101=) single nucleotide variant not provided [RCV000923448] Chr19:29986353 [GRCh38]
Chr19:30477260 [GRCh37]
Chr19:19q12
likely benign
NM_003796.3(URI1):c.333G>A (p.Lys111=) single nucleotide variant not provided [RCV000925222] Chr19:29986383 [GRCh38]
Chr19:30477290 [GRCh37]
Chr19:19q12
likely benign
GRCh37/hg19 19q12(chr19:30422224-30902373)x1 copy number loss not provided [RCV000847702] Chr19:30422224..30902373 [GRCh37]
Chr19:19q12
uncertain significance
GRCh37/hg19 19q11-13.33(chr19:28271106-49213832)x3 copy number gain not provided [RCV000845733] Chr19:28271106..49213832 [GRCh37]
Chr19:19q11-13.33
pathogenic
NM_003796.3(URI1):c.1461A>G (p.Val487=) single nucleotide variant not provided [RCV000964438] Chr19:30014922 [GRCh38]
Chr19:30505829 [GRCh37]
Chr19:19q12
benign
GRCh37/hg19 19q12(chr19:29739728-31053524)x3 copy number gain not provided [RCV001259935] Chr19:29739728..31053524 [GRCh37]
Chr19:19q12
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:13236 AgrOrtholog
COSMIC URI1 COSMIC
Ensembl Genes ENSG00000105176 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000353817 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000376097 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000458161 UniProtKB/TrEMBL
  ENSP00000458480 UniProtKB/TrEMBL
  ENSP00000458533 UniProtKB/TrEMBL
  ENSP00000459450 UniProtKB/TrEMBL
  ENSP00000459966 UniProtKB/TrEMBL
  ENSP00000461003 UniProtKB/TrEMBL
  ENSP00000461895 UniProtKB/TrEMBL
  ENSP00000468048 UniProtKB/TrEMBL
Ensembl Transcript ENST00000360605 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000392271 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000570564 UniProtKB/TrEMBL
  ENST00000573052 UniProtKB/TrEMBL
  ENST00000574110 UniProtKB/TrEMBL
  ENST00000574233 UniProtKB/TrEMBL
  ENST00000574666 UniProtKB/TrEMBL
  ENST00000575242 UniProtKB/TrEMBL
  ENST00000576442 UniProtKB/TrEMBL
  ENST00000585655 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.370 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000105176 GTEx
HGNC ID HGNC:13236 ENTREZGENE
Human Proteome Map URI1 Human Proteome Map
InterPro Prefoldin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prefoldin_subunit_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:8725 UniProtKB/Swiss-Prot
NCBI Gene 8725 ENTREZGENE
OMIM 603494 OMIM
Pfam Prefoldin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA134962614 PharmGKB
UniProt I3L0K5_HUMAN UniProtKB/TrEMBL
  I3L104_HUMAN UniProtKB/TrEMBL
  I3L130_HUMAN UniProtKB/TrEMBL
  I3L280_HUMAN UniProtKB/TrEMBL
  I3L2V7_HUMAN UniProtKB/TrEMBL
  I3L467_HUMAN UniProtKB/TrEMBL
  I3NI51_HUMAN UniProtKB/TrEMBL
  K7EQZ9_HUMAN UniProtKB/TrEMBL
  O94763 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A8K805 UniProtKB/Swiss-Prot
  H7BY42 UniProtKB/Swiss-Prot
  Q8TC23 UniProtKB/Swiss-Prot
  Q9UNU3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-29 URI1  URI1 prefoldin like chaperone    URI1, prefoldin like chaperone  Symbol and/or name change 5135510 APPROVED
2016-06-14 URI1  URI1, prefoldin like chaperone    URI1 prefoldin-like chaperone  Symbol and/or name change 5135510 APPROVED
2015-11-24 URI1  URI1 prefoldin-like chaperone    URI1, prefoldin-like chaperone  Symbol and/or name change 5135510 APPROVED
2011-11-29 URI1  URI1, prefoldin-like chaperone  C19orf2  chromosome 19 open reading frame 2  Symbol and/or name change 5135510 APPROVED
2011-09-01 C19orf2  chromosome 19 open reading frame 2  C19orf2  chromosome 19 open reading frame 2  Symbol and/or name change 5135510 APPROVED