Tlx2 (T cell leukemia, homeobox 2) - Rat Genome Database

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Gene: Tlx2 (T cell leukemia, homeobox 2) Mus musculus
Analyze
Symbol: Tlx2
Name: T cell leukemia, homeobox 2
RGD ID: 1320083
MGI Page MGI
Description: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within enteric nervous system development; mesoderm formation; and negative regulation of dendrite morphogenesis. Located in cytoplasm and nucleus. Is expressed in several structures, including adrenal gland; alimentary system; nervous system; primitive streak; and urinary system. Used to study intestinal pseudo-obstruction. Orthologous to human TLX2 (T cell leukemia homeobox 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: En; enteric neuron homeobox; Enx; homeo box 11-like 1; homeobox protein Hox-11L1; homeobox TLX-2; Hox11; Hox11L; Hox11L.1; Hox11l1; NC; NCX; Ncx1; PMUR10F; T-cell leukemia homeobox protein 2; T-cell leukemia, homeobox 2; Tlx1; Tlx1l1; Tlx1l2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39683,045,306 - 83,047,206 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl683,045,305 - 83,047,274 (-)EnsemblGRCm39 Ensembl
GRCm38683,068,325 - 83,070,225 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl683,068,324 - 83,070,293 (-)EnsemblGRCm38mm10GRCm38
MGSCv37683,018,319 - 83,020,219 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36683,033,983 - 83,035,883 (-)NCBIMGSCv36mm8
Celera685,050,935 - 85,052,835 (-)NCBICelera
Cytogenetic Map6C3NCBI
cM Map635.94NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
2. New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo. Heyer BS, etal., Mol Reprod Dev 1997 Jun;47(2):148-56.
3. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. MGD IEA MGD IEA
6. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7. Mouse MP Annotation Import Pipeline RGD automated import pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1681546   PMID:7698766   PMID:7747804   PMID:7908826   PMID:8099440   PMID:9021157   PMID:9176491   PMID:9259577   PMID:9550720   PMID:9738002   PMID:10198162   PMID:10343123  
PMID:10349636   PMID:10446220   PMID:11042159   PMID:11076861   PMID:11287196   PMID:11353393   PMID:11581159   PMID:11587205   PMID:12477932   PMID:12502601   PMID:14598259   PMID:14633973  
PMID:14681479   PMID:15803212   PMID:16141072   PMID:16141073   PMID:16291166   PMID:16329126   PMID:16602821   PMID:17035299   PMID:17560225   PMID:18287559   PMID:20682252   PMID:21267068  
PMID:21873635   PMID:24952961   PMID:29031500   PMID:30917309   PMID:37196079  


Genomics

Comparative Map Data
Tlx2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39683,045,306 - 83,047,206 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl683,045,305 - 83,047,274 (-)EnsemblGRCm39 Ensembl
GRCm38683,068,325 - 83,070,225 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl683,068,324 - 83,070,293 (-)EnsemblGRCm38mm10GRCm38
MGSCv37683,018,319 - 83,020,219 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36683,033,983 - 83,035,883 (-)NCBIMGSCv36mm8
Celera685,050,935 - 85,052,835 (-)NCBICelera
Cytogenetic Map6C3NCBI
cM Map635.94NCBI
TLX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38274,514,450 - 74,517,148 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl274,513,463 - 74,517,148 (+)EnsemblGRCh38hg38GRCh38
GRCh37274,741,577 - 74,744,275 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36274,595,119 - 74,597,398 (+)NCBINCBI36Build 36hg18NCBI36
Build 34274,653,265 - 74,655,545NCBI
Celera274,572,760 - 74,575,439 (+)NCBICelera
Cytogenetic Map2p13.1NCBI
HuRef274,477,857 - 74,480,536 (+)NCBIHuRef
CHM1_1274,670,993 - 74,673,672 (+)NCBICHM1_1
T2T-CHM13v2.0274,523,015 - 74,525,713 (+)NCBIT2T-CHM13v2.0
Tlx2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84117,131,516 - 117,133,359 (-)NCBIGRCr8
mRatBN7.24115,573,736 - 115,576,097 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4115,573,799 - 115,575,642 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4121,050,396 - 121,052,239 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04116,825,589 - 116,827,432 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04115,440,152 - 115,441,995 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04114,766,401 - 114,768,243 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4114,766,714 - 114,768,029 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl4113,900,556 - 113,902,399 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04178,585,662 - 178,587,437 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44117,279,091 - 117,281,693 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4104,568,477 - 104,570,295 (-)NCBICelera
Cytogenetic Map4q34NCBI
Tlx2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542411,269,426 - 11,275,200 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542411,269,426 - 11,275,200 (-)NCBIChiLan1.0ChiLan1.0
TLX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21251,872,437 - 51,874,750 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A51,868,245 - 51,877,504 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A74,581,111 - 74,583,425 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A76,087,700 - 76,089,082 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A76,087,113 - 76,089,324 (+)Ensemblpanpan1.1panPan2
TLX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11748,625,008 - 48,627,085 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1748,625,632 - 48,627,052 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1748,266,914 - 48,269,141 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01749,484,463 - 49,486,700 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1749,485,087 - 49,486,515 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11748,501,609 - 48,503,834 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01748,568,353 - 48,570,574 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01749,126,036 - 49,128,273 (-)NCBIUU_Cfam_GSD_1.0
Tlx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629210,007,670 - 10,010,330 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936556727,637 - 729,361 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936556727,637 - 729,391 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TLX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl368,531,962 - 68,534,543 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1368,532,111 - 68,537,385 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2371,857,416 - 71,876,586 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TLX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11432,761,338 - 32,764,030 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1432,762,310 - 32,763,692 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604579,407,184 - 79,409,954 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tlx2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474928,997,326 - 28,999,546 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474928,996,912 - 28,998,900 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:417
Count of miRNA genes:229
Interacting mature miRNAs:245
Transcripts:ENSMUST00000089641, ENSMUST00000174674
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396633110Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671958006105958152Mouse
14697704Stsl4_mSalmonella typhimurium susceptibility locus 4 (mouse)67707698389976982Mouse
10412119Stv_mstriatal volumne (mouse)Not determined660026991100026967Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671958006105958152Mouse
13824985Alh1_mamplitude of lateral head displacement 1 (mouse)67797698396976961Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46912919136400690Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648696934125336963Mouse
12792979Fbmd2_mfemoral bone mineral density 2, females only (mouse)675026989115026943Mouse
1301571Arrd1_mage-related retinal degeneration 1 (mouse)Not determined67552133992584431Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396633110Mouse
1300674Nidd3n_mnon-insulin-dependent diabetes mellitus 3 in NSY (mouse)Not determined67552133994202936Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648696934148351498Mouse
1301254Skts11_mskin tumor susceptibility 11 (mouse)Not determined65115613485156284Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65842456692424693Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671552042105552160Mouse
1302020Bbaa20_mB.burgdorferi-associated arthritis 20 (mouse)Not determined67129960593441074Mouse
1300618Pgia19_mproteoglycan induced arthritis 19 (mouse)Not determined64529099387403016Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648703490125333748Mouse
4141990Etax6_methanol induced ataxia 6 (mouse)Not determined7129960586252701Mouse
4141028Mclr_mmethylcholanthrene lymphoma resistance (mouse)Not determined5435041188356155Mouse
1301320Ots1_movarian teratoma susceptibility 1 (mouse)Not determined675424566104480516Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65851741692517416Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487403016Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63864656092584431Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645290993128811995Mouse
25440480Moaq2_mmodifier of alien QTL 2 (mouse)63050001117476961Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675584287109584431Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396633110Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670402880104403016Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396633110Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652138693116132228Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670402880104403016Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676440930110441074Mouse
15039373Adip28_madiposity 28 (mouse)65628519490285194Mouse
15039375Bw41_mbody weight QTL 41 (mouse)65628519490285194Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66346172197461888Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675693484109693678Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666690851100691013Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670402880104403016Mouse
14696731Pairq1_mP. aeruginosa infection resistance QTL 1 (mouse)681476981102176961Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673476983134676963Mouse
10412195Efw_mepididymal fat weight (mouse)Not determined67552133994202936Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66003466394034782Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678606487121092347Mouse

Markers in Region
UniSTS:492892  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38683,068,603 - 83,070,099UniSTSGRCm38
MGSCv37683,018,597 - 83,020,093UniSTSGRCm37
Celera685,051,213 - 85,052,709UniSTS
Cytogenetic Map6C3-D1UniSTS
Tlx2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6C3-D1UniSTS
cM Map635.94UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000089641   ⟹   ENSMUSP00000087069
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl683,045,572 - 83,047,274 (-)Ensembl
GRCm38.p6 Ensembl683,068,591 - 83,070,293 (-)Ensembl
Ensembl Acc Id: ENSMUST00000174674   ⟹   ENSMUSP00000133420
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl683,045,305 - 83,047,206 (-)Ensembl
GRCm38.p6 Ensembl683,068,324 - 83,070,225 (-)Ensembl
RefSeq Acc Id: NM_009392   ⟹   NP_033418
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39683,045,306 - 83,047,206 (-)NCBI
GRCm38683,068,325 - 83,070,225 (-)ENTREZGENE
MGSCv37683,018,319 - 83,020,219 (-)RGD
Celera685,050,935 - 85,052,835 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_033418   ⟸   NM_009392
- UniProtKB: B2RR62 (UniProtKB/Swiss-Prot),   Q61663 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000133420   ⟸   ENSMUST00000174674
Ensembl Acc Id: ENSMUSP00000087069   ⟸   ENSMUST00000089641
Protein Domains
Homeobox

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q61663-F1-model_v2 AlphaFold Q61663 1-284 view protein structure

Promoters
RGD ID:6839789
Promoter ID:MM_KWN:46567
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Lung
Transcripts:NM_009392,   UC009CMF.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36683,020,471 - 83,020,971 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1350935 AgrOrtholog
Ensembl Genes ENSMUSG00000068327 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000089641 ENTREZGENE
  ENSMUST00000089641.6 UniProtKB/Swiss-Prot
  ENSMUST00000174674.3 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_metazoa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TLX1/2/3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:21909 UniProtKB/Swiss-Prot
MGD MGI:1350935 ENTREZGENE
NCBI Gene 21909 ENTREZGENE
PANTHER PTHR45921 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T-CELL LEUKEMIA HOMEOBOX PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tlx2 PhenoGen
PRINTS HOMEOBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B2RR62 ENTREZGENE
  G3UWU0_MOUSE UniProtKB/TrEMBL
  Q61663 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary B2RR62 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-02-07 Tlx2  T cell leukemia, homeobox 2  Tlx2  T-cell leukemia, homeobox 2  Symbol and/or name change 5135510 APPROVED