Tlx2 (T cell leukemia, homeobox 2) - Rat Genome Database
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Gene: Tlx2 (T cell leukemia, homeobox 2) Mus musculus
Analyze
Symbol: Tlx2
Name: T cell leukemia, homeobox 2
RGD ID: 1320083
MGI Page MGI
Description: Is expressed in several structures, including adrenal gland; alimentary system; nervous system; primitive streak; and urethra. Used to study intestinal pseudo-obstruction. Orthologous to human TLX2 (T cell leukemia homeobox 2); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxyphenyl retinamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: En; enteric neuron homeobox; Enx; homeo box 11-like 1; homeobox protein Hox-11L1; homeobox TLX-2; Hox11; Hox11L; Hox11L.1; Hox11l1; NC; NCX; Ncx1; PMUR10F; T-cell leukemia homeobox protein 2; T-cell leukemia, homeobox 2; Tlx1; Tlx1l1; Tlx1l2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39683,045,306 - 83,047,206 (-)NCBIGRCm39mm39
GRCm39 Ensembl683,045,305 - 83,047,274 (-)Ensembl
GRCm38683,068,325 - 83,070,225 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl683,068,324 - 83,070,293 (-)EnsemblGRCm38mm10GRCm38
MGSCv37683,018,319 - 83,020,219 (-)NCBIGRCm37mm9NCBIm37
MGSCv36683,033,983 - 83,035,883 (-)NCBImm8
Celera685,050,935 - 85,052,835 (-)NCBICelera
Cytogenetic Map6C3NCBI
cM Map635.94NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

Additional References at PubMed
PMID:1681546   PMID:7698766   PMID:7747804   PMID:7908826   PMID:8099440   PMID:9021157   PMID:9176491   PMID:9259577   PMID:9550720   PMID:9738002   PMID:10198162   PMID:10343123  
PMID:10349636   PMID:10446220   PMID:11042159   PMID:11076861   PMID:11287196   PMID:11353393   PMID:11581159   PMID:11587205   PMID:12477932   PMID:12502601   PMID:14598259   PMID:14633973  
PMID:14681479   PMID:15803212   PMID:16141072   PMID:16141073   PMID:16291166   PMID:16329126   PMID:16602821   PMID:17035299   PMID:17560225   PMID:18287559   PMID:20682252   PMID:21267068  
PMID:21873635   PMID:24952961   PMID:29031500   PMID:30917309  


Genomics

Comparative Map Data
Tlx2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39683,045,306 - 83,047,206 (-)NCBIGRCm39mm39
GRCm39 Ensembl683,045,305 - 83,047,274 (-)Ensembl
GRCm38683,068,325 - 83,070,225 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl683,068,324 - 83,070,293 (-)EnsemblGRCm38mm10GRCm38
MGSCv37683,018,319 - 83,020,219 (-)NCBIGRCm37mm9NCBIm37
MGSCv36683,033,983 - 83,035,883 (-)NCBImm8
Celera685,050,935 - 85,052,835 (-)NCBICelera
Cytogenetic Map6C3NCBI
cM Map635.94NCBI
TLX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl274,513,463 - 74,517,148 (+)EnsemblGRCh38hg38GRCh38
GRCh38274,514,450 - 74,517,148 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37274,741,577 - 74,744,275 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36274,595,119 - 74,597,398 (+)NCBINCBI36hg18NCBI36
Build 34274,653,265 - 74,655,545NCBI
Celera274,572,760 - 74,575,439 (+)NCBI
Cytogenetic Map2p13.1NCBI
HuRef274,477,857 - 74,480,536 (+)NCBIHuRef
CHM1_1274,670,993 - 74,673,672 (+)NCBICHM1_1
Tlx2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24115,573,736 - 115,576,097 (-)NCBI
Rnor_6.0 Ensembl4113,900,556 - 113,902,399 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl4114,766,714 - 114,768,029 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04114,766,401 - 114,768,243 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04178,585,662 - 178,587,437 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44117,279,091 - 117,281,693 (-)NCBIRGSC3.4rn4RGSC3.4
Celera4104,568,477 - 104,570,295 (-)NCBICelera
Cytogenetic Map4q34NCBI
Tlx2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542411,269,426 - 11,275,200 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542411,269,426 - 11,275,200 (-)NCBIChiLan1.0ChiLan1.0
TLX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A76,087,700 - 76,089,082 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A76,087,113 - 76,089,324 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A74,581,111 - 74,583,425 (+)NCBIMhudiblu_PPA_v0panPan3
TLX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1748,625,632 - 48,627,052 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11748,625,008 - 48,627,085 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Tlx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936556727,637 - 729,391 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TLX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl368,532,963 - 68,534,344 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1368,532,111 - 68,537,385 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2371,857,416 - 71,876,586 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TLX2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11432,761,338 - 32,764,030 (-)NCBI
ChlSab1.1 Ensembl1432,762,310 - 32,763,692 (-)Ensembl
Tlx2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474928,996,912 - 28,998,900 (-)NCBI

Position Markers
UniSTS:492892  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38683,068,603 - 83,070,099UniSTSGRCm38
MGSCv37683,018,597 - 83,020,093UniSTSGRCm37
Celera685,051,213 - 85,052,709UniSTS
Cytogenetic Map6C3-D1UniSTS
Tlx2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6C3-D1UniSTS
cM Map635.94UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487426034Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396656149Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396656149Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396656149Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396656149Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63866962592607450Mouse
1300618Pgia19_mproteoglycan induced arthritis 19 (mouse)Not determined64531405987426034Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
1301254Skts11_mskin tumor susceptibility 11 (mouse)Not determined65117915085179300Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652161713116155267Mouse
4141028Mclr_mmethylcholanthrene lymphoma resistance (mouse)Not determined5437342788379171Mouse
15039373Adip28_madiposity 28 (mouse)65630821190308211Mouse
15039375Bw41_mbody weight QTL 41 (mouse)65630821190308211Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65844758392447710Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65854043392540433Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66005768094057799Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66348473897484905Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666713869100714031Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670425898104426034Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670425898104426034Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670425898104426034Mouse
4141990Etax6_methanol induced ataxia 6 (mouse)Not determined7132262186275719Mouse
1302020Bbaa20_mB.burgdorferi-associated arthritis 20 (mouse)Not determined67132262193464093Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671575060105575178Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671981024105981170Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671981024105981170Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673500000134700000Mouse
1301320Ots1_movarian teratoma susceptibility 1 (mouse)Not determined675447583104503555Mouse
1301571Arrd1_mage-related retinal degeneration 1 (mouse)Not determined67554435692607450Mouse
1300674Nidd3n_mnon-insulin-dependent diabetes mellitus 3 in NSY (mouse)Not determined67554435694225955Mouse
10412195Efw_mepididymal fat weight (mouse)Not determined67554435694225955Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675607306109607450Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675716503109716697Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676463949110464093Mouse
14697704Stsl4_mSalmonella typhimurium susceptibility locus 4 (mouse)67710000090000000Mouse
13824985Alh1_mamplitude of lateral head displacement 1 (mouse)67800000097000000Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678629504121115387Mouse
14696731Pairq1_mP. aeruginosa infection resistance QTL 1 (mouse)681500000102200000Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir1a-1mmu-miR-1a-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23436819
Mir1a-2mmu-miR-1a-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23436819

Predicted Target Of
Summary Value
Count of predictions:417
Count of miRNA genes:229
Interacting mature miRNAs:245
Transcripts:ENSMUST00000089641, ENSMUST00000174674
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000089641   ⟹   ENSMUSP00000087069
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl683,068,591 - 83,070,293 (-)Ensembl
RefSeq Acc Id: ENSMUST00000174674   ⟹   ENSMUSP00000133420
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl683,068,324 - 83,070,225 (-)Ensembl
RefSeq Acc Id: NM_009392   ⟹   NP_033418
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39683,045,306 - 83,047,206 (-)NCBI
GRCm38683,068,325 - 83,070,225 (-)ENTREZGENE
MGSCv37683,018,319 - 83,020,219 (-)RGD
Celera685,050,935 - 85,052,835 (-)RGD
cM Map6 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_033418   ⟸   NM_009392
- UniProtKB: Q61663 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000133420   ⟸   ENSMUST00000174674
RefSeq Acc Id: ENSMUSP00000087069   ⟸   ENSMUST00000089641

Promoters
RGD ID:6839789
Promoter ID:MM_KWN:46567
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Lung
Transcripts:NM_009392,   UC009CMF.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36683,020,471 - 83,020,971 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1350935 AgrOrtholog
Ensembl Genes ENSMUSG00000068327 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000087069 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000133420 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000089641 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000174674 UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_metazoa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TLX1/2/3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:21909 UniProtKB/Swiss-Prot
MGD MGI:1350935 ENTREZGENE
NCBI Gene 21909 ENTREZGENE
PANTHER PTHR45921 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tlx2 PhenoGen
PRINTS HOMEOBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt G3UWU0_MOUSE UniProtKB/TrEMBL
  Q61663 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary B2RR62 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-02-07 Tlx2  T cell leukemia, homeobox 2  Tlx2  T-cell leukemia, homeobox 2  Symbol and/or name change 5135510 APPROVED