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Gene: TLX2 (T cell leukemia homeobox 2) Chlorocebus sabaeus

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Symbol:

TLX2

Name:

T cell leukemia homeobox 2

RGD ID:

18539792

Description:

ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN enteric nervous system development (ortholog); mesoderm formation (ortholog); negative regulation of dendrite morphogenesis (ortholog); ASSOCIATED WITH congenital disorder of glycosylation type IIb (ortholog); dystonia (ortholog); intestinal pseudo-obstruction (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

T-cell leukemia homeobox protein 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	32,761,338 - 32,764,030 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	32,762,310 - 32,763,692 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	79,407,184 - 79,409,954 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

congenital disorder of glycosylation type IIb (ISO)

dystonia (ISO)

intestinal pseudo-obstruction (ISO)

Methylmalonyl-CoA Epimerase Deficiency (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

animal organ development (IEA)

enteric nervous system development (IEA,ISO)

mesoderm formation (IEA,ISO)

negative regulation of dendrite morphogenesis (IEA,ISO)

positive regulation of transcription by RNA polymerase II (IEA)

regulation of DNA-templated transcription (IEA)

regulation of transcription by RNA polymerase II (IEA)

Cellular Component

cytoplasm (IEA)

nucleus (IEA)

Molecular Function

DNA binding (IEA)

DNA-binding transcription activator activity, RNA polymerase II-specific (IEA)

DNA-binding transcription factor activity, RNA polymerase II-specific (IEA)

protein binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IEA)

sequence-specific DNA binding (IEA)

sequence-specific double-stranded DNA binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

TLX2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	32,761,338 - 32,764,030 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	32,762,310 - 32,763,692 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	79,407,184 - 79,409,954 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

TLX2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	74,514,450 - 74,517,148 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	74,513,463 - 74,517,148 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	74,741,577 - 74,744,275 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	74,595,119 - 74,597,398 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	74,653,265 - 74,655,545	NCBI
Celera	2	74,572,760 - 74,575,439 (+)	NCBI		Celera
Cytogenetic Map	2	p13.1	NCBI
HuRef	2	74,477,857 - 74,480,536 (+)	NCBI		HuRef
CHM1_1	2	74,670,993 - 74,673,672 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	74,523,015 - 74,525,713 (+)	NCBI		T2T-CHM13v2.0

Tlx2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	83,045,306 - 83,047,206 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	83,045,305 - 83,047,274 (-)	Ensembl		GRCm39 Ensembl
GRCm38	6	83,068,325 - 83,070,225 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	83,068,324 - 83,070,293 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	83,018,319 - 83,020,219 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	83,033,983 - 83,035,883 (-)	NCBI		MGSCv36	mm8
Celera	6	85,050,935 - 85,052,835 (-)	NCBI		Celera
Cytogenetic Map	6	C3	NCBI
cM Map	6	35.94	NCBI

Tlx2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	117,131,516 - 117,133,359 (-)	NCBI		GRCr8
mRatBN7.2	4	115,573,736 - 115,576,097 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	115,573,799 - 115,575,642 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	121,050,396 - 121,052,239 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	116,825,589 - 116,827,432 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	115,440,152 - 115,441,995 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	114,766,401 - 114,768,243 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	114,766,714 - 114,768,029 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0 Ensembl	4	113,900,556 - 113,902,399 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	178,585,662 - 178,587,437 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	117,279,091 - 117,281,693 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	4	104,568,477 - 104,570,295 (-)	NCBI		Celera
Cytogenetic Map	4	q34	NCBI

Tlx2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955424	11,269,426 - 11,275,200 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955424	11,269,426 - 11,275,200 (-)	NCBI	ChiLan1.0	ChiLan1.0

TLX2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	51,872,437 - 51,874,750 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	51,868,245 - 51,877,504 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	74,581,111 - 74,583,425 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	76,087,700 - 76,089,082 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	76,087,113 - 76,089,324 (+)	Ensembl	panpan1.1		panPan2

TLX2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	48,625,008 - 48,627,085 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	48,625,632 - 48,627,052 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	48,266,914 - 48,269,141 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	49,484,463 - 49,486,700 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	49,485,087 - 49,486,515 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	48,501,609 - 48,503,834 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	48,568,353 - 48,570,574 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	49,126,036 - 49,128,273 (-)	NCBI		UU_Cfam_GSD_1.0

Tlx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	10,007,670 - 10,010,330 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936556	727,637 - 729,361 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936556	727,637 - 729,391 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TLX2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	68,531,962 - 68,534,543 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	68,532,111 - 68,537,385 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	71,857,416 - 71,876,586 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Tlx2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624749	28,997,326 - 28,999,546 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624749	28,996,912 - 28,998,900 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in TLX2
31 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
50	25	19	35	35	34	9

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007970105	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000013752 ⟹ ENSCSAP00000011742

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	14	32,762,310 - 32,763,692 (-)	Ensembl

RefSeq Acc Id:

XM_007970105 ⟹ XP_007968296

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	14	32,761,338 - 32,764,030 (-)	NCBI
Vero_WHO_p1.0	NW_023666045	79,407,184 - 79,409,954 (+)	NCBI

Sequence:

show sequence

GCTGGCCAACCCTCTCCACCCGGGACTTGGGCAGCGGCCCCGGCAGCCCAGCGTCTATTTGCGC
TTGAGAGCCAGCAAGAAAGCTCCAGGGGCCCCAGCCGGCCGTGCTCCCCCGGGATGCAAGTCCC
TGCGCGGACGCCCAGCAGCTGCTGGCAGGGGCGCGGCTGCTCCGGGTGCACAGGGATGCTGCTG
TTCTGGGGACCCCGGCGCCCTGCCTTGGCCAGCCCCGCGGGCCCCTGAGGCCACTGTCCGGAGC
GCACCGCCGCCGGGCTTCTGGAGCTGCCTGAGGCATCCTCCCCAACCACCGAACCTCCGGCGGT
TCTTCTCGGCCCGGGCCGATGGAGCCGGGGATGCTGGGTCCACACAACCTCCCACACCACGAGC
CAATCAGCTTCGGCATCGATCAGATCCTGAGCGGCCCCGAAACCCCTGGGGGCGGCCTAGGTCC
GGGTCGCGGGGGCCAGGGTCATGGGGAGAGTGGGGCGTTCTCGGGTGGATACCACGGAGCCTCG
GGCTACGGTCCCGCTGGCTCACTGGCCCCGCTCCCCGGCAGCTCCGGAGTGGGCCCGGGCGGCG
TGATCCGCGTCCCTGCGCACCGCCCGCTGCCTGTGCCGCCGCCCGCGGCGGGGGCGCCTGCAGT
GCCTGGGCCCTCGGGTTTGGGCGGCGCCGGAGGCCTAGCGGGACTCACCTTCCCCTGGATGGAC
AGCGGCCGCCGCTTTGCCAAGGACCGGCTCACGGCTGCGCTCTCGCCCTTCTCTGGGACGCGCC
GCATAGGCCACCCCTACCAAAACCGGACCCCTCCGAAAAGGAAGAAGCCGCGCACGTCCTTCTC
CCGCTCACAGGTGCTGGAGCTGGAGCGGCGCTTCCTGCGCCAGAAGTACCTGGCCTCGGCGGAG
AGGGCGGCATTGGCCAAGGCCTTGCGCATGACCGACGCACAGGTCAAAACGTGGTTCCAGAACC
GACGCACCAAGTGGCGGCGCCAGACGGCGGAGGAGCGCGAGGCCGAGCGGCACCGCGCGGGCCG
GCTGCTCCTGCACCTGCAGCAGGACGCGTTGCCACGGCCGCTGCGGCCGCCGCTGCCTCCGGAC
CCTCTCTGCCTGCACAACTCGTCGCTCTTCGCGCTGCAGAACCTGCAGCCCTGGGCCGAGGACA
ACAAAGTGGCTTCCGTGTCCGGGCTCGCCTCGGTGGTGTGAGCGACGCCCGTCCGATCGGCGTG
GAGCGCCGGGCCCGGAGCGGTGGAGCGCGCGGCTGCCTGAGCACATGGTCTGGTGGCAGCCGGG
CGCGTGAGGAGCGGCAGGCCTTGAGGCTGTCGTCGAGGGCTCCCCCACCACCGGCCGACTCCCA
AGCCAGCGTTGCGCAGATGCACGGTCCGCTCAGAGGCGGCCCTTCCCGCCATTTTTCACTTCAC
TGCAGTTAAGCCGCCGCTGGAACCTGAGGCGCCGAGAGGGCGGGACCTGCAGGACAGTAGCCAA
TGAGGTGCGGGGAGGGGGCCGGGCTGGCCAATGGGAGCTGCTTTCCTGAGGGACTCGGAATTCT
CCGGCGGGTGGTCGGGAGCTGGGGCTCTGCGGGGCGCTAGCGGCATTGCGCGCGGTGCAGGCTG
GGTCCGTACCAAAGGTGTGAAGGAAGGAAGACATCTACCACTGCGAAGTCATGGAGGGGGTGCC
GGAGCGCGAGAGGCTGGCTGATTGTGACCGGAACCAGAGGGTTGTCCACCCCGGGCATCTCATC
CCTCAACTGTAAAATAATCGCTAAGGATTCCTTCCTGACTTTGAGCCTCACGTTGTCATGTGTG
TTCAGCCTGCTGGCAACATCCTCTGGCAACACGCCTGGGCAGGAGGCGAGTAGGATACTTACAC
ACCCAACGAAAGAGAAAATCTAGAAAGAAAATCTGGCTCTGGTGTCACATAGGGACAGAGAAGG
GAGAGGAGGAAACAGTGGACAAAGTTAATGGGCCCAGTGGAGTTAGGGTGAAGAGAATTTTGAA
AATAATTTGGAAGTGACAAGCTTAAGAAGAATCAAAGGTAATTCCAAGACTGGAAATGTGCAGC
ATCAGGAAATCAGTGGTGCTGTGGATGATGAAAGGGAAATTGGGAAGATTGGAGCAAGATTAAC
TATACAGGCAAAACTAAATGTTATACCTAGAGAAAATAAATCCTGGAGAAGTG

hide sequence

Protein Sequences


Protein RefSeqs	XP_007968296	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000011742
	ENSCSAP00000011742.1

RefSeq Acc Id:	XP_007968296 ⟸ XM_007970105
- UniProtKB:	A0A0D9RT03 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000011742 ⟸ ENSCSAT00000013752

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000015661	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000013752.1	UniProtKB/TrEMBL
Gene3D-CATH	Homeodomain-like	UniProtKB/TrEMBL
InterPro	Homeobox-like_sf	UniProtKB/TrEMBL
	Homeobox_CS	UniProtKB/TrEMBL
	Homeobox_dom	UniProtKB/TrEMBL
	Homeobox_metazoa	UniProtKB/TrEMBL
	TLX1/2/3	UniProtKB/TrEMBL
KEGG Report	csab:103220016	UniProtKB/TrEMBL
NCBI Gene	TLX2	ENTREZGENE
PANTHER	PTHR45921	UniProtKB/TrEMBL
	T-CELL LEUKEMIA HOMEOBOX PROTEIN 2	UniProtKB/TrEMBL
Pfam	Homeodomain	UniProtKB/TrEMBL
PRINTS	HOMEOBOX	UniProtKB/TrEMBL
PROSITE	HOMEOBOX_1	UniProtKB/TrEMBL
	HOMEOBOX_2	UniProtKB/TrEMBL
SMART	HOX	UniProtKB/TrEMBL
Superfamily-SCOP	SSF46689	UniProtKB/TrEMBL
UniProt	A0A0D9RT03	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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