Dhtkd1 (dehydrogenase E1 and transketolase domain containing 1) - Rat Genome Database

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Gene: Dhtkd1 (dehydrogenase E1 and transketolase domain containing 1) Mus musculus
Analyze
Symbol: Dhtkd1
Name: dehydrogenase E1 and transketolase domain containing 1
RGD ID: 1317664
MGI Page MGI
Description: Predicted to enable 2-oxoadipate dehydrogenase activity; oxoglutarate dehydrogenase (succinyl-transferring) activity; and thiamine pyrophosphate binding activity. Acts upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in mitochondrion. Predicted to be part of oxoadipate dehydrogenase complex. Used to study 2-aminoadipic 2-oxoadipic aciduria and Charcot-Marie-Tooth disease axonal type 2Q. Human ortholog(s) of this gene implicated in 2-aminoadipic 2-oxoadipic aciduria and Charcot-Marie-Tooth disease axonal type 2Q. Orthologous to human DHTKD1 (dehydrogenase E1 and transketolase domain containing 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2-oxoadipate dehydrogenase complex component E1; 2-oxoadipate dehydrogenase, mitochondrial; alpha-KADH-E1; alpha-ketoadipate dehydrogenase; C330018I04Rik; dehydrogenase E1 and transketolase domain-containing protein 1; E1a; OADC-E1; OADH-E1; probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3925,901,030 - 5,947,648 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl25,900,926 - 5,947,603 (-)EnsemblGRCm39 Ensembl
GRCm3825,896,219 - 5,942,829 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl25,896,115 - 5,942,792 (-)EnsemblGRCm38mm10GRCm38
MGSCv3725,819,106 - 5,863,838 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3625,813,366 - 5,860,064 (-)NCBIMGSCv36mm8
Celera25,851,991 - 5,882,783 (-)NCBICelera
Cytogenetic Map2A1NCBI
cM Map23.62NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Object Symbol
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Original Reference(s)
Dhtkd1Mouse2-aminoadipic 2-oxoadipic aciduria  ISORGD:13176638554872ClinVar Annotator: match by term: 2-aminoadipic 2-oxoadipic aciduria | ClinVar Annotator: match by term: ALPHA-AMINOADIPIC more ...ClinVarPMID:16199547|PMID:17576681|PMID:23141293|PMID:23141294|PMID:25326637|PMID:25640679|PMID:25741868|PMID:25860818|PMID:26141459|PMID:28454995|PMID:28492532|PMID:28902413|PMID:29127259|PMID:29653220|PMID:29669943|PMID:29752936|PMID:29858556|PMID:30842647|PMID:30896807|PMID:32005694|PMID:32303640|PMID:32633484|PMID:32695416|PMID:32768327|PMID:32860008|PMID:33369814|PMID:34169998|PMID:34946966|PMID:35052424|PMID:35897808|PMID:37091313|PMID:8069629|PMID:9536098
Dhtkd1MouseCharcot-Marie-Tooth disease axonal type 2Q  ISORGD:13176638554872ClinVar Annotator: match by term: CHARCOT-MARIE-TOOTH NEUROPATHY, TYPE 2Q | ClinVar Annotator: match by term: more ...ClinVarPMID:16199547|PMID:23141293|PMID:23141294|PMID:25326637|PMID:25741868|PMID:25860818|PMID:28492532|PMID:29669943
Dhtkd1MouseCharcot-Marie-Tooth Disease Type 2A2  ISORGD:13176638554872ClinVar Annotator: match by term: Charcot-Marie-Tooth Neuropathy Type 2A2 | ClinVar Annotator: match by term: more ...ClinVarPMID:23141293|PMID:23141294|PMID:25326637|PMID:25741868|PMID:25860818|PMID:26141459|PMID:28492532|PMID:29752936|PMID:29858556|PMID:30842647|PMID:32303640|PMID:32695416|PMID:32768327|PMID:37091313
Dhtkd1MouseCharcot-Marie-Tooth disease type 2A2A  ISORGD:13176638554872ClinVar Annotator: match by term: CHARCOT-MARIE-TOOTH DISEASE, AXONAL, AUTOSOMAL DOMINANT, TYPE 2A2AClinVarPMID:23141293|PMID:25326637|PMID:25741868|PMID:25860818|PMID:26141459|PMID:28492532|PMID:29752936|PMID:29858556|PMID:30842647|PMID:32303640|PMID:32695416|PMID:32768327|PMID:37091313
Dhtkd1Mousegenetic disease  ISORGD:13176638554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:17576681|PMID:23141293|PMID:23141294|PMID:25326637|PMID:25741868|PMID:25860818|PMID:26141459|PMID:28454995|PMID:28492532|PMID:28902413|PMID:29752936|PMID:29858556|PMID:30842647|PMID:32303640|PMID:32695416|PMID:32768327|PMID:32860008|PMID:33369814|PMID:34946966|PMID:35052424|PMID:35897808|PMID:37091313|PMID:8069629|PMID:9536098
Dhtkd1Mousehypoparathyroidism-deafness-renal disease syndrome  ISORGD:13176638554872ClinVar Annotator: match by term: Hypoparathyroidism, deafness, renal disease syndromeClinVarPMID:25741868
Dhtkd1Mousenephrotic syndrome  ISORGD:13176638554872ClinVar Annotator: match by term: Nephrotic syndromeClinVarPMID:28492532|PMID:29127259
Dhtkd1Mouseneuropathy  ISORGD:13176638554872ClinVar Annotator: match by term: Peripheral neuropathyClinVar 
Dhtkd1Mouseperipheral nervous system disease  ISORGD:13176638554872ClinVar Annotator: match by term: Peripheral neuropathyClinVar 
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Original Reference(s)
Dhtkd1MouseExperimental Liver Cirrhosis  ISORGD:131766311554173CTD Direct Evidence: marker/mechanismCTDPMID:25380136
Object Symbol
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Original Reference(s)
Dhtkd1Mouse2-aminoadipic 2-oxoadipic aciduria  IAGP 13592920OMIM:204750MouseDO 
Dhtkd1MouseCharcot-Marie-Tooth disease axonal type 2Q  IAGP 13592920OMIM:615025MouseDO 
Object Symbol
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Original Reference(s)
Dhtkd1Mouse2-aminoadipic 2-oxoadipic aciduria  ISORGD:13176637240710 OMIM 
Dhtkd1MouseCharcot-Marie-Tooth disease axonal type 2Q  ISORGD:13176637240710 OMIM 

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Original Reference(s)
Dhtkd1Mouse(+)-schisandrin B multiple interactionsISORGD:13080926480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of DHTKD1 mRNA]CTDPMID:31150632
Dhtkd1Mouse1,1-dichloroethene decreases expressionEXP 6480464vinylidene chloride results in decreased expression of DHTKD1 mRNACTDPMID:26682919
Dhtkd1Mouse1,2-dichloroethane increases expressionEXP 6480464ethylene dichloride results in increased expression of DHTKD1 mRNACTDPMID:28960355
Dhtkd1Mouse1,2-dimethylhydrazine decreases expressionEXP 64804641,2-Dimethylhydrazine results in decreased expression of DHTKD1 mRNACTDPMID:22206623
Dhtkd1Mouse1-naphthyl isothiocyanate decreases expressionISORGD:130809264804641-Naphthylisothiocyanate results in decreased expression of DHTKD1 mRNACTDPMID:25380136
Dhtkd1Mouse17beta-estradiol multiple interactionsISORGD:13176636480464[Estradiol co-treated with TGFB1 protein] results in decreased expression of DHTKD1 mRNACTDPMID:30165855
Dhtkd1Mouse17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of DHTKD1 mRNACTDPMID:39298647
Dhtkd1Mouse17beta-estradiol decreases expressionISORGD:13080926480464Estradiol results in decreased expression of DHTKD1 mRNACTDPMID:32145629
Dhtkd1Mouse2,3,7,8-tetrachlorodibenzodioxine affects expressionISORGD:13080926480464Tetrachlorodibenzodioxin affects the expression of DHTKD1 mRNACTDPMID:22298810
Dhtkd1Mouse2,3,7,8-tetrachlorodibenzodioxine increases expressionISORGD:13080926480464Tetrachlorodibenzodioxin results in increased expression of DHTKD1 mRNACTDPMID:33387578
Dhtkd1Mouse2,3,7,8-tetrachlorodibenzodioxine multiple interactionsEXP 6480464[TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression more ...CTDPMID:25975270
Dhtkd1Mouse2,3,7,8-tetrachlorodibenzodioxine decreases expressionISORGD:13080926480464Tetrachlorodibenzodioxin results in decreased expression of DHTKD1 mRNACTDPMID:21215274
Dhtkd1Mouse2,4-dinitrotoluene affects expressionISORGD:130809264804642,4-dinitrotoluene affects the expression of DHTKD1 mRNACTDPMID:21346803
Dhtkd1Mouse2,6-dinitrotoluene affects expressionISORGD:130809264804642,6-dinitrotoluene affects the expression of DHTKD1 mRNACTDPMID:21346803
Dhtkd1Mouse3-chloropropane-1,2-diol decreases expressionISORGD:13080926480464alpha-Chlorohydrin results in decreased expression of DHTKD1 proteinCTDPMID:34915118
Dhtkd1Mouse4,4'-sulfonyldiphenol decreases expressionEXP 6480464bisphenol S results in decreased expression of DHTKD1 mRNACTDPMID:33297965|PMID:39298647
Dhtkd1Mouse4-hydroxyphenyl retinamide decreases expressionEXP 6480464Fenretinide results in decreased expression of DHTKD1 mRNACTDPMID:28973697
Dhtkd1Mouseacetamide decreases expressionISORGD:13080926480464acetamide results in decreased expression of DHTKD1 mRNACTDPMID:31881176
Dhtkd1Mouseaflatoxin B1 affects expressionISORGD:13176636480464Aflatoxin B1 affects the expression of DHTKD1 proteinCTDPMID:20106945
Dhtkd1Mouseaflatoxin B1 decreases expressionISORGD:13176636480464Aflatoxin B1 results in decreased expression of DHTKD1 mRNACTDPMID:22100608|PMID:27153756

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Biological Process

  
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Original Reference(s)
Dhtkd1Mousegeneration of precursor metabolites and energy involved_inISSUniProtKB:Q96HY72290270 UniProtGO_REF:0000024
Dhtkd1Mousegeneration of precursor metabolites and energy involved_inISOUniProtKB:Q96HY72290270 GO_CentralGO_REF:0000119
Dhtkd1Mouseglycolytic process involved_inIEAUniProtKB-KW:KW-03242290270 UniProtGO_REF:0000043
Dhtkd1Mousehematopoietic progenitor cell differentiation acts_upstream_of_or_withinIGIMGI:13431842290270 PMID:24029230MGIPMID:24029230

Cellular Component

  
Object Symbol
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Original Reference(s)
Dhtkd1Mousemitochondrion located_inISOUniProtKB:Q96HY72290270 GO_CentralGO_REF:0000119
Dhtkd1Mousemitochondrion located_inISSUniProtKB:Q96HY72290270 UniProtGO_REF:0000024
Dhtkd1Mouseoxoadipate dehydrogenase complex part_ofIEAUniProtKB:Q96HY7|ensembl:ENSP000002630352290270 EnsemblGO_REF:0000107

Molecular Function

  
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Original Reference(s)
Dhtkd1Mouse2-oxoadipate dehydrogenase activity enablesIEARHEA:695762290270 RHEAGO_REF:0000116
Dhtkd1Mouseoxoglutarate dehydrogenase (succinyl-transferring) activity enablesIEAEC:1.2.4.22290270 UniProtGO_REF:0000003
Dhtkd1Mouseprotein binding enablesISOUniProtKB:Q96LB99068941 PMID:28514442, PMID:33961781IntActPMID:28514442|PMID:33961781
Dhtkd1Mouseprotein binding enablesISOUniProtKB:O00327-89068941 PMID:32296183IntActPMID:32296183
Dhtkd1Mousethiamine pyrophosphate binding enablesIEAInterPro:IPR0116032290270 InterProGO_REF:0000002

Imported Annotations - SMPDB

Object Symbol
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Original Reference(s)
Dhtkd1Mouse2-aminoadipic 2-oxoadipic aciduria pathway  ISORGD:131766310402751 SMPDBSMP:00719
Dhtkd1Mouseglutaric aciduria type I pathway  ISORGD:131766310402751 SMPDBSMP:00186
Dhtkd1Mousehyperlysinemia pathway  ISORGD:131766310402751 SMPDBSMP:00527
Dhtkd1Mouselysine degradation pathway  ISORGD:131766310402751 SMPDBSMP:00037
Dhtkd1Mousesaccharopinuria pathway  ISORGD:131766310402751 SMPDBSMP:00239
Dhtkd1Mousesaccharopinuria pathway  ISORGD:131766310402751 SMPDBSMP:00528
1 to 20 of 46 rows
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Original Reference(s)
Dhtkd1Mouseabnormal amino acid metabolism  IAGP 5509061 MGIPMID:28545977
Dhtkd1Mouseabnormal axon morphology  IAGP 5509061 MGIPMID:32169121
Dhtkd1Mouseabnormal gastrocnemius morphology  IAGP 5509061 MGIPMID:32169121
Dhtkd1Mouseabnormal motor capabilities/coordination/movement  IAGP 5509061 MGIPMID:29661920
Dhtkd1Mouseabnormal myelin sheath morphology  IAGP 5509061 MGIPMID:29661920
Dhtkd1Mouseabnormal myelination  IAGP 5509061 MGIPMID:32169121
Dhtkd1Mouseabnormal nervous system morphology  IAGP 5509061 MGIPMID:29661920
Dhtkd1Mouseabnormal neuromuscular synapse morphology  IAGP 5509061 MGIPMID:29661920
Dhtkd1Mouseabnormal pancreatic islet morphology  IAGP 5509061 MGIPMID:29661920
Dhtkd1Mouseabnormal sarcomere morphology  IAGP 5509061 MGIPMID:29661920
Dhtkd1Mouseabnormal Schwann cell physiology  IAGP 5509061 MGIPMID:29661920
Dhtkd1Mouseabnormal sciatic nerve morphology  IAGP 5509061 MGIPMID:29661920
Dhtkd1Mouseaciduria  IAGP 5509061 MGIPMID:29661920
Dhtkd1Mouseaxon degeneration  IAGP 5509061 MGIPMID:29661920
Dhtkd1Mouseaxon degeneration  IAGP 5509061 MGIPMID:32169121
Dhtkd1Mousedecreased circulating cholesterol level  IAGP 5509061 MGIPMID:32169121
Dhtkd1Mousedecreased circulating glucose level  IAGP 5509061 MGIPMID:29661920
Dhtkd1Mousedecreased circulating glycerol level  IAGP 5509061 MGIPMID:32169121
Dhtkd1Mousedecreased circulating triglyceride level  IAGP 5509061 MGIPMID:32169121
Dhtkd1Mousedecreased locomotor activity  IAGP 5509061 MGIPMID:28545977
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#
Reference Title
Reference Citation
1. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:12520002   PMID:14610273   PMID:15368895   PMID:16141072   PMID:16141073   PMID:18799693  
PMID:21267068   PMID:21873635   PMID:22496890   PMID:24029230   PMID:25215496   PMID:28130547   PMID:28545977   PMID:29661920   PMID:30709776   PMID:32160276   PMID:32169121   PMID:38355793  



Dhtkd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3925,901,030 - 5,947,648 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl25,900,926 - 5,947,603 (-)EnsemblGRCm39 Ensembl
GRCm3825,896,219 - 5,942,829 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl25,896,115 - 5,942,792 (-)EnsemblGRCm38mm10GRCm38
MGSCv3725,819,106 - 5,863,838 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3625,813,366 - 5,860,064 (-)NCBIMGSCv36mm8
Celera25,851,991 - 5,882,783 (-)NCBICelera
Cytogenetic Map2A1NCBI
cM Map23.62NCBI
DHTKD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381012,068,954 - 12,123,221 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1012,068,954 - 12,123,221 (+)EnsemblGRCh38hg38GRCh38
GRCh371012,110,953 - 12,165,220 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361012,150,940 - 12,205,230 (+)NCBINCBI36Build 36hg18NCBI36
Build 341012,150,976 - 12,205,229NCBI
Celera1012,040,496 - 12,094,736 (+)NCBICelera
Cytogenetic Map10p14NCBI
HuRef1012,028,394 - 12,082,077 (+)NCBIHuRef
CHM1_11012,110,884 - 12,165,186 (+)NCBICHM1_1
T2T-CHM13v2.01012,080,265 - 12,134,492 (+)NCBIT2T-CHM13v2.0
Dhtkd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81777,242,512 - 77,316,074 (+)NCBIGRCr8
mRatBN7.21772,355,201 - 72,406,725 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1772,355,201 - 72,406,723 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1775,862,147 - 75,912,680 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01779,683,597 - 79,734,126 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01773,733,852 - 73,784,395 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01776,306,585 - 76,358,058 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1776,306,585 - 76,358,058 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01777,943,860 - 78,003,052 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01778,007,307 - 78,014,756 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41783,461,479 - 83,463,086 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11783,407,566 - 83,477,143 (+)NCBI
Celera1771,810,969 - 71,857,821 (+)NCBICelera
Cytogenetic Map17q12.3NCBI
Dhtkd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955462103,598 - 162,344 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955462103,501 - 163,472 (+)NCBIChiLan1.0ChiLan1.0
DHTKD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2824,592,829 - 24,658,832 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11024,599,491 - 24,659,548 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01012,073,324 - 12,130,589 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11012,053,943 - 12,110,691 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1012,054,060 - 12,108,387 (+)Ensemblpanpan1.1panPan2
DHTKD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1224,298,323 - 24,349,848 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl224,299,789 - 24,349,899 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha221,322,088 - 21,373,860 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0224,668,644 - 24,720,216 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl224,668,726 - 24,720,383 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1221,795,337 - 21,846,631 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0222,638,206 - 22,689,654 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0223,353,134 - 23,404,876 (-)NCBIUU_Cfam_GSD_1.0
Dhtkd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934427,043,369 - 27,100,551 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364843,208,198 - 3,251,896 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364843,207,650 - 3,251,661 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DHTKD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1059,820,423 - 59,875,290 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11059,820,418 - 59,875,322 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21065,608,721 - 65,613,359 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DHTKD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1912,117,927 - 12,169,217 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605117,620,513 - 17,674,270 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dhtkd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248054,814,546 - 4,869,359 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248054,814,444 - 4,871,097 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Dhtkd1
3308 total Variants

Predicted Target Of
Summary Value
Count of predictions:1603
Count of miRNA genes:600
Interacting mature miRNAs:724
Transcripts:ENSMUST00000026924, ENSMUST00000095147, ENSMUST00000127609, ENSMUST00000151649, ENSMUST00000155977, ENSMUST00000169865
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
4142333Tgq10_mtriglyceride QTL 10 (mouse)Not determined125324559Mouse
4141836Tgq11_mtriglyceride QTL 11 (mouse)Not determined125324559Mouse
12904743Carcdq3_mcardiac collagen deposition QTL 3 (mouse)2323494028179150Mouse
10045633Heal15_mwound healing/regeneration 15 (mouse)Not determined2121989642Mouse
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388712693421651Mouse
1301838Sluc16_msusceptibility to lung cancer 16 (mouse)Not determined2126529589Mouse







Ensembl Acc Id: ENSMUST00000026924   ⟹   ENSMUSP00000026924
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl25,901,989 - 5,947,554 (-)Ensembl
GRCm38.p6 Ensembl25,897,178 - 5,942,743 (-)Ensembl
Ensembl Acc Id: ENSMUST00000095147   ⟹   ENSMUSP00000092769
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl25,900,926 - 5,947,603 (-)Ensembl
GRCm38.p6 Ensembl25,896,115 - 5,942,792 (-)Ensembl
Ensembl Acc Id: ENSMUST00000127609
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl25,928,686 - 5,929,587 (-)Ensembl
GRCm38.p6 Ensembl25,923,875 - 5,924,776 (-)Ensembl
Ensembl Acc Id: ENSMUST00000151649
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl25,929,693 - 5,935,667 (-)Ensembl
GRCm38.p6 Ensembl25,924,882 - 5,930,856 (-)Ensembl
Ensembl Acc Id: ENSMUST00000155977
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl25,908,403 - 5,916,647 (-)Ensembl
GRCm38.p6 Ensembl25,903,592 - 5,911,836 (-)Ensembl
RefSeq Acc Id: NM_001081131   ⟹   NP_001074600
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3925,902,871 - 5,947,603 (-)NCBI
GRCm3825,898,060 - 5,942,792 (-)NCBI
MGSCv3725,819,106 - 5,863,838 (-)RGD
Celera25,851,991 - 5,882,783 (-)ENTREZGENE
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_017316877   ⟹   XP_017172366
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3925,901,030 - 5,929,992 (-)NCBI
GRCm3825,896,219 - 5,925,181 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017316878   ⟹   XP_017172367
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3925,901,030 - 5,929,992 (-)NCBI
GRCm3825,896,219 - 5,925,181 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017316879   ⟹   XP_017172368
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3925,901,030 - 5,929,992 (-)NCBI
GRCm3825,896,219 - 5,925,181 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036160213   ⟹   XP_036016106
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3925,901,030 - 5,947,638 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036160214   ⟹   XP_036016107
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3925,907,787 - 5,947,639 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036160216   ⟹   XP_036016109
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3925,918,356 - 5,947,648 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036160217   ⟹   XP_036016110
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3925,901,030 - 5,929,992 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004939306
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3925,901,030 - 5,947,642 (-)NCBI
Sequence:
1 to 5 of 10 rows
1 to 5 of 10 rows
RefSeq Acc Id: NP_001074600   ⟸   NM_001081131
- UniProtKB: Q69ZE3 (UniProtKB/Swiss-Prot),   Q0VFY3 (UniProtKB/Swiss-Prot),   Q8BWT3 (UniProtKB/Swiss-Prot),   A2ATU0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017172367   ⟸   XM_017316878
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017172366   ⟸   XM_017316877
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017172368   ⟸   XM_017316879
- Peptide Label: isoform X4
- Sequence:
Ensembl Acc Id: ENSMUSP00000026924   ⟸   ENSMUST00000026924

Name Modeler Protein Id AA Range Protein Structure
AF-A2ATU0-F1-model_v2 AlphaFold A2ATU0 1-921 view protein structure

RGD ID:6831160
Promoter ID:MM_KWN:27608
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell,   Liver,   Lung
Transcripts:ENSMUST00000026924,   ENSMUST00000095147,   NM_001081131
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3625,863,551 - 5,864,051 (-)MPROMDB
RGD ID:6876278
Promoter ID:EPDNEW_M1590
Type:initiation region
Name:Dhtkd1_1
Description:Mus musculus dehydrogenase E1 and transketolase domain containing1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3825,942,768 - 5,942,828EPDNEW


1 to 32 of 32 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000025815 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000095147 ENTREZGENE
  ENSMUST00000095147.9 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.11610 UniProtKB/Swiss-Prot
  3.40.50.12470 UniProtKB/Swiss-Prot
  3.40.50.970 UniProtKB/Swiss-Prot
  TPP helical domain UniProtKB/Swiss-Prot
InterPro 2oxoglutarate_DH_E1 UniProtKB/Swiss-Prot
  DH_E1 UniProtKB/Swiss-Prot
  KGD_C UniProtKB/Swiss-Prot
  KGD_C_sf UniProtKB/Swiss-Prot
  THDP-binding UniProtKB/Swiss-Prot
  Transketolase-like_Pyr-bd UniProtKB/Swiss-Prot
KEGG Report mmu:209692 UniProtKB/Swiss-Prot
MGD MGI:2445096 ENTREZGENE
NCBI Gene 209692 ENTREZGENE
PANTHER 2-OXOGLUTARATE DEHYDROGENASE E1 COMPONENT DHKTD1, MITOCHONDRIAL-RELATED UniProtKB/Swiss-Prot
  PTHR23152 UniProtKB/Swiss-Prot
Pfam E1_dh UniProtKB/Swiss-Prot
  OxoGdeHyase_C UniProtKB/Swiss-Prot
  Transket_pyr UniProtKB/Swiss-Prot
PhenoGen Dhtkd1 PhenoGen
PIRSF Oxoglu_dh_E1 UniProtKB/Swiss-Prot
SMART Transket_pyr UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52518 UniProtKB/Swiss-Prot
UniProt A2ATU0 ENTREZGENE, UniProtKB/Swiss-Prot
  Q0VFY3 ENTREZGENE
  Q69ZE3 ENTREZGENE
  Q8BWT3 ENTREZGENE
UniProt Secondary Q0VFY3 UniProtKB/Swiss-Prot
  Q69ZE3 UniProtKB/Swiss-Prot
  Q8BWT3 UniProtKB/Swiss-Prot
1 to 32 of 32 rows