Abhd8 (abhydrolase domain containing 8) - Rat Genome Database
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Gene: Abhd8 (abhydrolase domain containing 8) Mus musculus
Analyze
Symbol: Abhd8
Name: abhydrolase domain containing 8
RGD ID: 1313871
MGI Page MGI
Description: Predicted to have carboxylic ester hydrolase activity and lysophosphatidic acid acyltransferase activity. Predicted to be involved in lipid homeostasis and phosphatidic acid biosynthetic process. Predicted to localize to mitochondrion. Is expressed in several structures, including adrenal gland; gallbladder; genitourinary system; gut; and nervous system. Orthologous to human ABHD8 (abhydrolase domain containing 8); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 0910001L24Rik; AB030191; abhydrolase domain-containing protein 8; alpha/beta hydrolase domain-containing protein 8
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39871,909,344 - 71,917,351 (-)NCBIGRCm39mm39
GRCm38871,456,700 - 71,464,707 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl871,456,705 - 71,463,655 (-)EnsemblGRCm38mm10GRCm38
MGSCv37873,980,599 - 73,987,556 (-)NCBIGRCm37mm9NCBIm37
MGSCv36874,385,694 - 74,392,635 (-)NCBImm8
Celera873,975,916 - 73,982,874 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10679242   PMID:11042159   PMID:11076861   PMID:12477932   PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073   PMID:21267068   PMID:21677750  
PMID:21873635   PMID:24194600   PMID:27626380   PMID:30157441  


Genomics

Comparative Map Data
Abhd8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39871,909,344 - 71,917,351 (-)NCBIGRCm39mm39
GRCm38871,456,700 - 71,464,707 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl871,456,705 - 71,463,655 (-)EnsemblGRCm38mm10GRCm38
MGSCv37873,980,599 - 73,987,556 (-)NCBIGRCm37mm9NCBIm37
MGSCv36874,385,694 - 74,392,635 (-)NCBImm8
Celera873,975,916 - 73,982,874 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
ABHD8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1917,292,131 - 17,310,236 (-)EnsemblGRCh38hg38GRCh38
GRCh381917,292,131 - 17,303,425 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371917,402,940 - 17,414,282 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361917,263,940 - 17,275,282 (-)NCBINCBI36hg18NCBI36
Build 341917,263,940 - 17,275,234NCBI
Celera1917,304,682 - 17,316,010 (-)NCBI
Cytogenetic Map19p13.11NCBI
HuRef1916,969,585 - 16,980,841 (-)NCBIHuRef
CHM1_11917,402,410 - 17,413,755 (-)NCBICHM1_1
Abhd8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01619,866,028 - 19,872,765 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1619,866,022 - 19,872,774 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01619,727,394 - 19,734,131 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41618,628,138 - 18,634,875 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11618,628,150 - 18,634,815 (-)NCBI
Celera1618,349,543 - 18,356,280 (-)NCBICelera
Cytogenetic Map16p14NCBI
Abhd8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955524925,102 - 930,270 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955524924,128 - 932,046 (+)NCBIChiLan1.0ChiLan1.0
ABHD8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11917,755,973 - 17,765,502 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1917,755,973 - 17,765,502 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01916,780,132 - 16,791,233 (-)NCBIMhudiblu_PPA_v0panPan3
ABHD8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2045,449,871 - 45,459,506 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12045,448,457 - 45,459,507 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Abhd8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365963,559,139 - 3,567,626 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABHD8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl260,380,705 - 60,388,986 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1260,380,691 - 60,388,986 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ABHD8
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1615,798,462 - 15,810,012 (-)NCBI
ChlSab1.1 Ensembl615,798,256 - 15,810,036 (-)Ensembl
Abhd8
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624908641,181 - 648,366 (+)NCBI

Position Markers
RH125067  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38871,465,498 - 71,465,620UniSTSGRCm38
MGSCv37873,989,397 - 73,989,519UniSTSGRCm37
Celera873,984,715 - 73,984,837UniSTS
Cytogenetic Map8C1UniSTS
Cytogenetic Map8B3.3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86826982782600347Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined871396181105396393Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84429488078295025Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7113678390202598Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871102903105103009Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:243
Count of miRNA genes:183
Interacting mature miRNAs:215
Transcripts:ENSMUST00000008094
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_022419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030243705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036154226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB030191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC127416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK003090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK037669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK080618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK177261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK178673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK178904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK178916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK181179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK181236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK181691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK184390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK187254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK189463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK207815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK207833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK209444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC026540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000008094   ⟹   ENSMUSP00000008094
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl871,456,705 - 71,463,655 (-)Ensembl
RefSeq Acc Id: ENSMUST00000212321
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl871,457,325 - 71,458,907 (-)Ensembl
RefSeq Acc Id: ENSMUST00000212503
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl871,459,504 - 71,463,622 (-)Ensembl
RefSeq Acc Id: NM_022419   ⟹   NP_071864
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39871,909,344 - 71,916,301 (-)NCBI
GRCm38871,456,700 - 71,463,657 (-)ENTREZGENE
MGSCv37873,980,599 - 73,987,556 (-)RGD
Celera873,975,916 - 73,982,874 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030243705   ⟹   XP_030099565
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39871,909,349 - 71,917,351 (-)NCBI
GRCm38871,456,705 - 71,464,707 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036154226   ⟹   XP_036010119
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39871,909,349 - 71,917,264 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_071864   ⟸   NM_022419
- UniProtKB: Q8R0P8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030099565   ⟸   XM_030243705
- Peptide Label: isoform X1
RefSeq Acc Id: ENSMUSP00000008094   ⟸   ENSMUST00000008094
RefSeq Acc Id: XP_036010119   ⟸   XM_036154226
- Peptide Label: isoform X1
Protein Domains
AB hydrolase-1

Promoters
RGD ID:8667393
Promoter ID:EPDNEW_M11728
Type:initiation region
Name:Abhd8_1
Description:Mus musculus abhydrolase domain containing 8 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38871,463,648 - 71,463,708EPDNEW
RGD ID:6848243
Promoter ID:MM_ACW:47892
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:ABHD8.DSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36873,980,611 - 73,981,111 (-)MPROMDB
RGD ID:6842599
Promoter ID:MM_KWN:54782
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_022419,   UC009MDG.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36873,987,456 - 73,988,552 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1918946 AgrOrtholog
Ensembl Genes ENSMUSG00000007950 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000008094 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000008094 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot
InterPro AB_hydrolase UniProtKB/Swiss-Prot
  AB_hydrolase_1 UniProtKB/Swiss-Prot
  Epox_hydrolase-like UniProtKB/Swiss-Prot
KEGG Report mmu:64296 UniProtKB/Swiss-Prot
MGD MGI:1918946 ENTREZGENE
NCBI Gene 64296 ENTREZGENE
Pfam Abhydrolase_1 UniProtKB/Swiss-Prot
PhenoGen Abhd8 PhenoGen
PRINTS ABHYDROLASE UniProtKB/Swiss-Prot
  EPOXHYDRLASE UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot
UniGene Mm.276383 ENTREZGENE
UniProt ABHD8_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q9DC79 UniProtKB/Swiss-Prot
  Q9JMF5 UniProtKB/Swiss-Prot