Kdelr2 (KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2) - Rat Genome Database

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Gene: Kdelr2 (KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2) Mus musculus
Analyze
Symbol: Kdelr2
Name: KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
RGD ID: 1312162
MGI Page MGI
Description: Predicted to enable KDEL sequence binding activity. Predicted to be involved in protein retention in ER lumen and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to be located in Golgi membrane and endoplasmic reticulum membrane. Predicted to be active in cis-Golgi network and endoplasmic reticulum. Predicted to colocalize with COPI-coated vesicle membrane. Is expressed in limb; otic capsule; palatal shelf; and skeleton. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 21. Orthologous to human KDELR2 (KDEL endoplasmic reticulum protein retention receptor 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1110007A14Rik; ER lumen protein retaining receptor 2; ER lumen protein-retaining receptor 2; KDEL endoplasmic reticulum protein retention receptor 2; KDEL receptor 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395143,389,575 - 143,407,659 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5143,389,593 - 143,407,656 (+)EnsemblGRCm39 Ensembl
GRCm385143,403,820 - 143,421,904 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5143,403,838 - 143,421,901 (+)EnsemblGRCm38mm10GRCm38
MGSCv375144,165,499 - 144,182,955 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365144,165,505 - 144,182,947 (+)NCBIMGSCv36mm8
Celera5140,450,973 - 140,468,362 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map582.12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2-methylcholine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
amiodarone  (ISO)
amitrole  (ISO)
atrazine  (ISO)
benzbromarone  (ISO)
benzo[a]pyrene  (ISO)
beta-hexachlorocyclohexane  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
cadmium sulfate  (EXP)
carbamazepine  (ISO)
carbon nanotube  (EXP)
chlorpyrifos  (EXP)
clobetasol  (EXP)
clofibrate  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
Dibutyl phosphate  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
endosulfan  (ISO)
flutamide  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
ivermectin  (ISO)
L-ethionine  (ISO)
mercury atom  (EXP)
mercury(0)  (EXP)
methidathion  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
mifepristone  (ISO)
nickel atom  (ISO)
Nivalenol  (EXP)
omeprazole  (ISO)
paracetamol  (EXP)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
propiconazole  (EXP)
pyrimidifen  (ISO)
rotenone  (ISO)
Salinomycin  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
T-2 toxin  (ISO)
tamoxifen  (EXP)
temozolomide  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
thifluzamide  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12520002   PMID:12904583   PMID:14610273   PMID:15489334   PMID:16141072   PMID:16141073  
PMID:19474315   PMID:21267068   PMID:21873635   PMID:38355793  


Genomics

Comparative Map Data
Kdelr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395143,389,575 - 143,407,659 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5143,389,593 - 143,407,656 (+)EnsemblGRCm39 Ensembl
GRCm385143,403,820 - 143,421,904 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5143,403,838 - 143,421,901 (+)EnsemblGRCm38mm10GRCm38
MGSCv375144,165,499 - 144,182,955 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365144,165,505 - 144,182,947 (+)NCBIMGSCv36mm8
Celera5140,450,973 - 140,468,362 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map582.12NCBI
KDELR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3876,461,089 - 6,484,152 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl76,445,953 - 6,484,190 (-)EnsemblGRCh38hg38GRCh38
GRCh3776,500,720 - 6,523,783 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3676,467,237 - 6,490,374 (-)NCBINCBI36Build 36hg18NCBI36
Build 3476,275,509 - 6,296,940NCBI
Celera76,211,338 - 6,234,431 (+)NCBICelera
Cytogenetic Map7p22.1NCBI
HuRef76,373,518 - 6,395,670 (-)NCBIHuRef
CHM1_176,500,302 - 6,523,431 (-)NCBICHM1_1
T2T-CHM13v2.076,580,398 - 6,603,413 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v276,547,172 - 6,570,287 (-)NCBI
Kdelr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81216,252,424 - 16,270,737 (-)NCBIGRCr8
mRatBN7.21211,138,820 - 11,157,117 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1211,138,820 - 11,157,153 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1211,946,125 - 11,964,325 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01212,569,412 - 12,587,613 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01211,595,547 - 11,613,739 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01213,192,452 - 13,210,758 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1213,192,453 - 13,210,758 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01215,232,465 - 15,250,771 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41211,498,420 - 11,513,595 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11211,524,186 - 11,543,482 (-)NCBI
Celera1212,932,160 - 12,950,458 (-)NCBICelera
Cytogenetic Map12p11NCBI
Kdelr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546013,202,401 - 13,221,319 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546013,202,400 - 13,221,319 (+)NCBIChiLan1.0ChiLan1.0
KDELR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2611,188,025 - 11,211,263 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1759,512,862 - 59,535,981 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v076,960,456 - 6,983,515 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.176,654,430 - 6,667,794 (-)NCBIpanpan1.1PanPan1.1panPan2
KDELR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1611,796,586 - 11,815,765 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl611,798,377 - 11,815,760 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha613,421,923 - 13,441,095 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0611,798,777 - 11,817,951 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl611,799,791 - 11,817,956 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1611,674,580 - 11,693,744 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0611,654,175 - 11,673,193 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0611,880,887 - 11,900,112 (-)NCBIUU_Cfam_GSD_1.0
Kdelr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344140,024,950 - 140,042,738 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493676515,820 - 33,932 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493676516,017 - 33,812 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KDELR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl34,716,646 - 4,735,300 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.134,716,651 - 4,735,303 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
KDELR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12815,671,314 - 15,694,192 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2815,672,442 - 15,694,148 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666102377,263 - 401,933 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kdelr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474030,853,425 - 30,873,754 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474030,853,252 - 30,875,730 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:287
Count of miRNA genes:245
Interacting mature miRNAs:262
Transcripts:ENSMUST00000110731
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301363Pbwg13_mpostnatal body weight growth 13 (mouse)Not determined5125133457151758149Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589418876146787935Mouse
1300913Bwefm_mbody weight females and males day 10 (mouse)Not determined5109439348143439459Mouse
4141081Nidd7k_mNidd7 on KK-A (mouse)Not determined119945037149347326Mouse
11528552Scram1_mspinal cord resistance to astrocytoma modifier 1 (mouse)5121455402151758149Mouse
1300827Cora1_mcorrelation in cytokine production 1 (mouse)Not determined5115156883149157015Mouse
1302079Lbw3_mlupus NZB x NZW 3 (mouse)Not determined5124700335151758149Mouse
13504737Ifvrq5_minfluenza virus resistance QTL 5 (mouse)5139509801151658149Mouse
13504734Ifvrq4_minfluenza virus resistance QTL 4 (mouse)5139985755151658149Mouse
1301986Bpq4_mblood pressure QTL 4 (mouse)Not determined5121555236151758149Mouse
13504735Ifvrq7_minfluenza virus resistance QTL 7 (mouse)5139509801151658149Mouse
1301857Bglq14_mbody growth late QTL 14 (mouse)Not determined5118948964151758149Mouse
12880406Jcdq2_mjoint cartilage degeneration QTL 2 (mouse)5129787831151758149Mouse
1301226Bbaa2_mB.burgdorferi-associated arthritis 2 (mouse)Not determined5115156883149157015Mouse
4141218Ath24_matherosclerosis 24 (mouse)Not determined129520084151758149Mouse
11049557Lmr26_mleishmaniasis resistance 26 (mouse)5133925558151758149Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000110731   ⟹   ENSMUSP00000106359
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5143,389,593 - 143,407,656 (+)Ensembl
GRCm38.p6 Ensembl5143,403,838 - 143,421,901 (+)Ensembl
RefSeq Acc Id: NM_025841   ⟹   NP_080117
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395143,389,575 - 143,407,659 (+)NCBI
GRCm385143,403,820 - 143,421,904 (+)ENTREZGENE
MGSCv375144,165,499 - 144,182,955 (+)RGD
Celera5140,450,973 - 140,468,362 (+)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_080117   ⟸   NM_025841
- UniProtKB: Q4FK20 (UniProtKB/Swiss-Prot),   Q9CQM2 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000106359   ⟸   ENSMUST00000110731

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9CQM2-F1-model_v2 AlphaFold Q9CQM2 1-212 view protein structure

Promoters
RGD ID:6888678
Promoter ID:EPDNEW_M7790
Type:initiation region
Name:Kdelr2_1
Description:Mus musculus KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum proteinretention receptor 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385143,403,826 - 143,403,886EPDNEW
RGD ID:6837027
Promoter ID:MM_KWN:44750
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_025841,   UC009AKG.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365144,165,276 - 144,166,152 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1914163 AgrOrtholog
Ensembl Genes ENSMUSG00000001852
  ENSMUSG00000079111 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000110731 ENTREZGENE
  ENSMUST00000110731.4 UniProtKB/Swiss-Prot
InterPro ER_ret_rcpt UniProtKB/Swiss-Prot
KEGG Report mmu:66913 UniProtKB/Swiss-Prot
MGD MGI:1914163 ENTREZGENE
NCBI Gene 66913 ENTREZGENE
PANTHER ER LUMEN PROTEIN-RETAINING RECEPTOR 2 UniProtKB/Swiss-Prot
  PTHR10585 UniProtKB/Swiss-Prot
Pfam ER_lumen_recept UniProtKB/Swiss-Prot
PhenoGen Kdelr2 PhenoGen
PRINTS ERLUMENR UniProtKB/Swiss-Prot
PROSITE ER_LUMEN_RECEPTOR_1 UniProtKB/Swiss-Prot
  ER_LUMEN_RECEPTOR_2 UniProtKB/Swiss-Prot
UniProt ERD22_MOUSE UniProtKB/Swiss-Prot
  Q4FK20 ENTREZGENE
  Q9CQM2 ENTREZGENE
UniProt Secondary Q4FK20 UniProtKB/Swiss-Prot