Arv1 (ARV1 homolog, fatty acid homeostasis modulator) - Rat Genome Database

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Gene: Arv1 (ARV1 homolog, fatty acid homeostasis modulator) Rattus norvegicus
Analyze
Symbol: Arv1
Name: ARV1 homolog, fatty acid homeostasis modulator
RGD ID: 1310264
Description: Predicted to be involved in several processes, including intracellular sterol transport; regulation of intracellular cholesterol transport; and regulation of plasma membrane sterol distribution. Predicted to act upstream of or within bile acid metabolic process; cholesterol transport; and regulation of cholesterol metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in Golgi apparatus and cortical endoplasmic reticulum. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 38. Orthologous to human ARV1 (ARV1 homolog, fatty acid homeostasis modulator); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ARV1 fatty acid homeostatsis modulator; ARV1 homolog; ARV1 homolog (S. cerevisiae); ARV1 homolog (yeast); LOC292097; RGD1310264; similar to ARV1 homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81969,589,728 - 69,601,547 (+)NCBIGRCr8
mRatBN7.21952,692,337 - 52,704,156 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1952,692,337 - 52,704,156 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1959,477,003 - 59,489,034 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01960,327,753 - 60,339,568 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01962,403,453 - 62,415,484 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01957,484,720 - 57,496,539 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1957,484,634 - 57,496,695 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01968,189,521 - 68,201,340 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41954,904,721 - 54,916,541 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11954,909,646 - 54,921,403 (+)NCBI
Celera1952,060,698 - 52,072,513 (+)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:20663892  


Genomics

Comparative Map Data
Arv1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81969,589,728 - 69,601,547 (+)NCBIGRCr8
mRatBN7.21952,692,337 - 52,704,156 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1952,692,337 - 52,704,156 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1959,477,003 - 59,489,034 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01960,327,753 - 60,339,568 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01962,403,453 - 62,415,484 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01957,484,720 - 57,496,539 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1957,484,634 - 57,496,695 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01968,189,521 - 68,201,340 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41954,904,721 - 54,916,541 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11954,909,646 - 54,921,403 (+)NCBI
Celera1952,060,698 - 52,072,513 (+)NCBICelera
Cytogenetic Map19q12NCBI
ARV1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381230,979,094 - 231,000,733 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1230,978,981 - 231,000,733 (+)EnsemblGRCh38hg38GRCh38
GRCh371231,114,840 - 231,136,479 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361229,181,446 - 229,203,102 (+)NCBINCBI36Build 36hg18NCBI36
Build 341227,421,557 - 227,443,212NCBI
Celera1204,380,771 - 204,402,432 (+)NCBICelera
Cytogenetic Map1q42.2NCBI
HuRef1201,599,541 - 201,621,202 (+)NCBIHuRef
CHM1_11232,388,113 - 232,409,767 (+)NCBICHM1_1
T2T-CHM13v2.01230,359,572 - 230,381,205 (+)NCBIT2T-CHM13v2.0
Arv1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398125,448,765 - 125,469,533 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8125,448,878 - 125,460,862 (+)EnsemblGRCm39 Ensembl
GRCm388124,722,026 - 124,742,794 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8124,722,139 - 124,734,123 (+)EnsemblGRCm38mm10GRCm38
MGSCv378127,246,039 - 127,258,023 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368127,608,229 - 127,620,213 (+)NCBIMGSCv36mm8
Celera8129,027,282 - 129,042,285 (+)NCBICelera
Cytogenetic Map8E2NCBI
cM Map872.81NCBI
Arv1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554927,672,746 - 7,683,728 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554927,669,956 - 7,683,293 (-)NCBIChiLan1.0ChiLan1.0
ARV1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2118,206,337 - 18,228,141 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1118,402,184 - 18,420,649 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01206,527,777 - 206,549,606 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11211,554,553 - 211,576,484 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1211,554,553 - 211,576,484 (+)Ensemblpanpan1.1panPan2
ARV1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.148,409,039 - 8,424,776 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl48,409,484 - 8,424,644 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha48,400,805 - 8,416,587 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.048,433,785 - 8,449,987 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl48,433,790 - 8,449,888 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.148,437,946 - 8,453,484 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.048,559,958 - 8,575,500 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.048,790,025 - 8,805,558 (-)NCBIUU_Cfam_GSD_1.0
Arv1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934443,386,058 - 43,396,908 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648419,551,293 - 19,562,138 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648419,551,293 - 19,562,132 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARV1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1459,396,962 - 59,408,958 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11459,396,958 - 59,409,008 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21464,061,498 - 64,073,531 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ARV1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12568,251,110 - 68,271,530 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2568,251,130 - 68,271,607 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605570,157,256 - 70,177,626 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arv1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477518,638,010 - 18,652,985 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477518,634,671 - 18,652,476 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Arv1
29 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:146
Count of miRNA genes:112
Interacting mature miRNAs:123
Transcripts:ENSRNOT00000025695
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194997648153225766Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)194434021455283277Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat

Markers in Region
RH128017  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21952,703,838 - 52,704,034 (+)MAPPERmRatBN7.2
Rnor_6.01957,496,222 - 57,496,417NCBIRnor6.0
Rnor_5.01968,201,023 - 68,201,218UniSTSRnor5.0
RGSC_v3.41954,916,224 - 54,916,419UniSTSRGSC3.4
Celera1952,072,196 - 52,072,391UniSTS
RH 3.4 Map19723.1UniSTS
Cytogenetic Map19q12UniSTS
RH142390  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81969,592,551 - 69,592,726 (+)Marker Load Pipeline
mRatBN7.21952,695,160 - 52,695,335 (+)MAPPERmRatBN7.2
Rnor_6.01957,487,544 - 57,487,718NCBIRnor6.0
Rnor_5.01968,192,345 - 68,192,519UniSTSRnor5.0
RGSC_v3.41954,907,545 - 54,907,720UniSTSRGSC3.4
Celera1952,063,522 - 52,063,692UniSTS
RH 3.4 Map19716.1UniSTS
Cytogenetic Map19q12UniSTS
RH136659  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21952,697,540 - 52,697,752 (+)MAPPERmRatBN7.2
Rnor_6.01957,489,924 - 57,490,135NCBIRnor6.0
Rnor_5.01968,194,725 - 68,194,936UniSTSRnor5.0
RGSC_v3.41954,909,926 - 54,910,137UniSTSRGSC3.4
Celera1952,065,898 - 52,066,109UniSTS
RH 3.4 Map19718.4UniSTS
Cytogenetic Map19q12UniSTS
BF390154  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21952,704,297 - 52,704,447 (+)MAPPERmRatBN7.2
Rnor_6.01957,496,681 - 57,496,830NCBIRnor6.0
Rnor_5.01968,201,482 - 68,201,631UniSTSRnor5.0
RGSC_v3.41954,916,683 - 54,916,832UniSTSRGSC3.4
Celera1952,072,655 - 52,072,804UniSTS
RH 3.4 Map19716.0UniSTS
Cytogenetic Map19q12UniSTS
AI231345  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21952,694,207 - 52,694,420 (+)MAPPERmRatBN7.2
Rnor_6.01957,486,591 - 57,486,803NCBIRnor6.0
Rnor_5.01968,191,392 - 68,191,604UniSTSRnor5.0
RGSC_v3.41954,906,592 - 54,906,804UniSTSRGSC3.4
Celera1952,062,569 - 52,062,781UniSTS
RH 3.4 Map19723.0UniSTS
Cytogenetic Map19q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000025695   ⟹   ENSRNOP00000025695
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1952,692,337 - 52,704,156 (+)Ensembl
Rnor_6.0 Ensembl1957,484,634 - 57,496,695 (+)Ensembl
RefSeq Acc Id: NM_001106197   ⟹   NP_001099667
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81969,589,728 - 69,601,547 (+)NCBI
mRatBN7.21952,692,337 - 52,704,156 (+)NCBI
Rnor_6.01957,484,720 - 57,496,539 (+)NCBI
Rnor_5.01968,189,521 - 68,201,340 (+)NCBI
RGSC_v3.41954,904,721 - 54,916,541 (+)RGD
Celera1952,060,698 - 52,072,513 (+)RGD
Sequence:
RefSeq Acc Id: XM_008772606   ⟹   XP_008770828
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81969,589,730 - 69,601,528 (+)NCBI
mRatBN7.21952,692,356 - 52,704,139 (+)NCBI
Rnor_6.01957,484,741 - 57,496,522 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039097667   ⟹   XP_038953595
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81969,589,802 - 69,601,528 (+)NCBI
mRatBN7.21952,692,410 - 52,704,139 (+)NCBI
RefSeq Acc Id: XM_039097668   ⟹   XP_038953596
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81969,589,757 - 69,601,528 (+)NCBI
mRatBN7.21952,692,562 - 52,704,139 (+)NCBI
RefSeq Acc Id: XM_063277956   ⟹   XP_063134026
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81969,589,733 - 69,601,528 (+)NCBI
RefSeq Acc Id: XM_063277957   ⟹   XP_063134027
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81969,589,757 - 69,601,528 (+)NCBI
RefSeq Acc Id: NP_001099667   ⟸   NM_001106197
- UniProtKB: D3ZTJ1 (UniProtKB/TrEMBL),   A6KJ16 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008770828   ⟸   XM_008772606
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000025695   ⟸   ENSRNOT00000025695
RefSeq Acc Id: XP_038953595   ⟸   XM_039097667
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038953596   ⟸   XM_039097668
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063134026   ⟸   XM_063277956
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063134027   ⟸   XM_063277957
- Peptide Label: isoform X4

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZTJ1-F1-model_v2 AlphaFold D3ZTJ1 1-267 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701239
Promoter ID:EPDNEW_R11762
Type:multiple initiation site
Name:Arv1_1
Description:ARV1 homolog, fatty acid homeostasis modulator
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01957,484,749 - 57,484,809EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310264 AgrOrtholog
BioCyc Gene G2FUF-5238 BioCyc
Ensembl Genes ENSRNOG00000018909 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025695.7 UniProtKB/TrEMBL
InterPro Arv1 UniProtKB/TrEMBL
KEGG Report rno:292097 UniProtKB/TrEMBL
NCBI Gene 292097 ENTREZGENE
PANTHER Arv1 UniProtKB/TrEMBL
  PROTEIN ARV1 UniProtKB/TrEMBL
Pfam Arv1 UniProtKB/TrEMBL
PhenoGen Arv1 PhenoGen
RatGTEx ENSRNOG00000018909 RatGTEx
UniProt A6KJ16 ENTREZGENE, UniProtKB/TrEMBL
  D3ZTJ1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-11 Arv1  ARV1 homolog, fatty acid homeostasis modulator  Arv1  ARV1 fatty acid homeostatsis modulator  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-06-24 Arv1  ARV1 fatty acid homeostatsis modulator  Arv1  ARV1 homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Arv1  ARV1 homolog (S. cerevisiae)  Arv1  ARV1 homolog (yeast)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Arv1  ARV1 homolog (yeast)   Arv1_predicted  ARV1 homolog (yeast) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Arv1_predicted  ARV1 homolog (yeast) (predicted)  RGD1310264_predicted  similar to ARV1 homolog (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1310264_predicted  similar to ARV1 homolog (predicted)  LOC292097_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC292097_predicted  similar to ARV1 homolog (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL