Enoph1 (enolase-phosphatase 1) - Rat Genome Database

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Gene: Enoph1 (enolase-phosphatase 1) Rattus norvegicus
Analyze
Symbol: Enoph1
Name: enolase-phosphatase 1
RGD ID: 1309016
Description: Predicted to enable acireductone synthase activity. Predicted to be involved in L-methionine salvage from methylthioadenosine. Predicted to be located in cytoplasm and nucleus. Orthologous to human ENOPH1 (enolase-phosphatase 1); PARTICIPATES IN cysteine and methionine metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bis(2-ethylhexyl) phthalate; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; E-1 enzyme; enolase-phosphatase E1; LOC305177; MASA homolog; MGC105720; RGD1309016; similar to RIKEN cDNA 2310057D15
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8149,835,626 - 9,862,051 (-)NCBIGRCr8
mRatBN7.2149,531,336 - 9,557,797 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl149,531,339 - 9,569,273 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx149,503,609 - 9,529,449 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01410,803,450 - 10,829,288 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0149,500,061 - 9,525,899 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01411,172,359 - 11,198,799 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1411,172,362 - 11,198,194 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01411,116,182 - 11,142,029 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41410,833,647 - 10,859,844 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11410,833,647 - 10,859,844 (-)NCBI
Celera149,632,567 - 9,658,325 (-)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
nucleus  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:15843022   PMID:23376485  


Genomics

Comparative Map Data
Enoph1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8149,835,626 - 9,862,051 (-)NCBIGRCr8
mRatBN7.2149,531,336 - 9,557,797 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl149,531,339 - 9,569,273 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx149,503,609 - 9,529,449 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01410,803,450 - 10,829,288 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0149,500,061 - 9,525,899 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01411,172,359 - 11,198,799 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1411,172,362 - 11,198,194 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01411,116,182 - 11,142,029 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41410,833,647 - 10,859,844 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11410,833,647 - 10,859,844 (-)NCBI
Celera149,632,567 - 9,658,325 (-)NCBICelera
Cytogenetic Map14p22NCBI
ENOPH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38482,430,590 - 82,461,177 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl482,430,590 - 82,461,177 (+)EnsemblGRCh38hg38GRCh38
GRCh37483,351,743 - 83,382,330 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36483,570,787 - 83,601,264 (+)NCBINCBI36Build 36hg18NCBI36
Celera480,643,013 - 80,673,557 (+)NCBICelera
Cytogenetic Map4q21.22NCBI
HuRef479,093,083 - 79,123,323 (+)NCBIHuRef
CHM1_1483,328,211 - 83,358,759 (+)NCBICHM1_1
T2T-CHM13v2.0485,760,198 - 85,790,791 (+)NCBIT2T-CHM13v2.0
Enoph1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395100,186,887 - 100,216,784 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5100,187,844 - 100,216,619 (+)EnsemblGRCm39 Ensembl
GRCm385100,039,028 - 100,068,925 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5100,039,985 - 100,068,760 (+)EnsemblGRCm38mm10GRCm38
MGSCv375100,469,013 - 100,497,784 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365100,280,316 - 100,309,064 (+)NCBIMGSCv36mm8
Celera597,353,498 - 97,383,582 (+)NCBICelera
Cytogenetic Map5E4NCBI
cM Map548.46NCBI
Enoph1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554336,522,663 - 6,549,352 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554336,522,663 - 6,549,352 (+)NCBIChiLan1.0ChiLan1.0
ENOPH1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2347,608,889 - 47,639,002 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1447,798,093 - 47,828,255 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0441,741,072 - 41,771,150 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1447,591,329 - 47,621,558 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl447,591,329 - 47,621,357 (-)Ensemblpanpan1.1panPan2
ENOPH1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1326,408,778 - 6,451,606 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl326,407,460 - 6,450,790 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3235,430,030 - 35,472,419 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0326,432,233 - 6,474,655 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl326,432,156 - 6,474,731 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1326,504,574 - 6,546,514 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0326,369,084 - 6,411,365 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03233,551,815 - 33,593,875 (-)NCBIUU_Cfam_GSD_1.0
Enoph1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244052855,864,719 - 5,900,494 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049367382,034,169 - 2,062,271 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ENOPH1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8135,775,745 - 135,802,388 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18135,775,743 - 135,802,404 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28145,145,807 - 145,172,579 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ENOPH1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1730,810,727 - 30,843,252 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl730,810,816 - 30,844,852 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660379,372,057 - 9,406,234 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Enoph1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247578,456,966 - 8,488,229 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247578,456,021 - 8,488,262 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Enoph1
157 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:259
Count of miRNA genes:155
Interacting mature miRNAs:179
Transcripts:ENSRNOT00000003083
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
71115Niddm15Non-insulin dependent diabetes mellitus QTL 154.8blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14121760611030812Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14121760616960180Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)14381307418274691Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14381307418274691Rat
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 28 40 24 19 24 74 30 39 11
Low 15 17 17 17 8 11 5 2 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000003083   ⟹   ENSRNOP00000003083
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl149,531,339 - 9,557,292 (-)Ensembl
Rnor_6.0 Ensembl1411,172,362 - 11,198,194 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000103292   ⟹   ENSRNOP00000091321
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl149,531,339 - 9,569,273 (-)Ensembl
RefSeq Acc Id: NM_001009391   ⟹   NP_001009391
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8149,835,626 - 9,861,459 (-)NCBI
mRatBN7.2149,531,338 - 9,557,173 (-)NCBI
Rnor_6.01411,172,361 - 11,198,194 (-)NCBI
Rnor_5.01411,116,182 - 11,142,029 (-)NCBI
RGSC_v3.41410,833,647 - 10,859,844 (-)RGD
Celera149,632,567 - 9,658,325 (-)RGD
Sequence:
RefSeq Acc Id: XM_017599169   ⟹   XP_017454658
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8149,845,563 - 9,862,051 (-)NCBI
mRatBN7.2149,541,277 - 9,557,797 (-)NCBI
Rnor_6.01411,182,314 - 11,198,799 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001009391   ⟸   NM_001009391
- UniProtKB: Q5PPH0 (UniProtKB/Swiss-Prot),   A6K613 (UniProtKB/TrEMBL),   A0A8I6ADH3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454658   ⟸   XM_017599169
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000003083   ⟸   ENSRNOT00000003083
RefSeq Acc Id: ENSRNOP00000091321   ⟸   ENSRNOT00000103292

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5PPH0-F1-model_v2 AlphaFold Q5PPH0 1-261 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699197
Promoter ID:EPDNEW_R9721
Type:initiation region
Name:Enoph1_1
Description:enolase-phosphatase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01411,198,291 - 11,198,351EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309016 AgrOrtholog
BioCyc Gene G2FUF-16390 BioCyc
Ensembl Genes ENSRNOG00000002262 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055006203 UniProtKB/Swiss-Prot
  ENSRNOG00060011035 UniProtKB/Swiss-Prot
  ENSRNOG00065012987 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000003083 ENTREZGENE
  ENSRNOT00000003083.4 UniProtKB/Swiss-Prot
  ENSRNOT00000103292.1 UniProtKB/TrEMBL
  ENSRNOT00055010068 UniProtKB/Swiss-Prot
  ENSRNOT00060018666 UniProtKB/Swiss-Prot
  ENSRNOT00065021267 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.720.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.1000 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7312419 IMAGE-MGC_LOAD
InterPro Enolase-ppase_E1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENOPH1_eukaryotes UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HAD-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HAD-SF_hydro_IA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HAD_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:305177 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105720 IMAGE-MGC_LOAD
NCBI Gene 305177 ENTREZGENE
PANTHER ENOLASE-PHOSPHATASE E1 UniProtKB/Swiss-Prot
  ENOLASE-PHOSPHATASE E1 UniProtKB/Swiss-Prot
  ENOLASE-PHOSPHATASE E1 UniProtKB/TrEMBL
  ENOLASE-PHOSPHATASE E1 UniProtKB/TrEMBL
Pfam Hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Enoph1 PhenoGen
RatGTEx ENSRNOG00000002262 RatGTEx
  ENSRNOG00055006203 RatGTEx
  ENSRNOG00060011035 RatGTEx
  ENSRNOG00065012987 RatGTEx
Superfamily-SCOP SSF56784 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6ADH3 ENTREZGENE, UniProtKB/TrEMBL
  A6K613 ENTREZGENE, UniProtKB/TrEMBL
  A6K614_RAT UniProtKB/TrEMBL
  ENOPH_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-26 Enoph1  enolase-phosphatase 1  RGD1309016  similar to RIKEN cDNA 2310057D15  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1309016  similar to RIKEN cDNA 2310057D15  RGD1309016_predicted  similar to RIKEN cDNA 2310057D15 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1309016_predicted  similar to RIKEN cDNA 2310057D15 (predicted)  LOC305177_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC305177_predicted  similar to RIKEN cDNA 2310057D15 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL