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Gene: Trmt6 (tRNA methyltransferase 6 non-catalytic subunit) Rattus norvegicus

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Symbol:

Trmt6

Name:

tRNA methyltransferase 6 non-catalytic subunit

RGD ID:

1308877

Description:

Predicted to be involved in mRNA processing. Predicted to be part of tRNA (m1A) methyltransferase complex. Predicted to be active in nucleus. Orthologous to human TRMT6 (tRNA methyltransferase 6 non-catalytic subunit); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC311441; RGD1308877; similar to CGI-09 protein; tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; tRNA (adenine-N(1)-)-methyltransferase non-catalytic subunit TRM6; tRNA methyltransferase 6; tRNA methyltransferase 6 homolog; tRNA methyltransferase 6 homolog (S. cerevisiae)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TRMT6 (tRNA methyltransferase 6 non-catalytic subunit)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Trmt6 (tRNA methyltransferase 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Trmt6 (tRNA methyltransferase 6 non-catalytic subunit)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TRMT6 (tRNA methyltransferase 6 non-catalytic subunit)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TRMT6 (tRNA methyltransferase 6 non-catalytic subunit)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Trmt6 (tRNA methyltransferase 6 non-catalytic subunit)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TRMT6 (tRNA methyltransferase 6 non-catalytic subunit)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TRMT6 (tRNA methyltransferase 6 non-catalytic subunit)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Trmt6 (tRNA methyltransferase 6 non-catalytic subunit)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Trmt6 (tRNA methyltransferase 6)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	TRMT6 (tRNA methyltransferase 6 non-catalytic subunit)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	trmt6 (tRNA methyltransferase 6)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	GCD10	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG9596	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ZK858.7	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	trmt6	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	140,527,785 - 140,539,520 (-)	NCBI		GRCr8
mRatBN7.2	3	120,074,899 - 120,086,639 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	120,074,911 - 120,086,559 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	123,969,956 - 123,981,674 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	132,573,585 - 132,585,306 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	130,226,090 - 130,237,808 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	125,458,692 - 125,470,413 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	125,458,692 - 125,470,413 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	131,942,467 - 131,954,194 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	120,602,570 - 120,614,291 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	120,509,438 - 120,519,743 (-)	NCBI
Celera	3	118,860,870 - 118,872,591 (-)	NCBI		Celera
Cytogenetic Map	3	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Huntington's disease-like 1 (ISO)

Inosine Triphosphatase Deficiency (ISO)

pantothenate kinase-associated neurodegeneration (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dichloroethane (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-hydroxypropanoic acid (ISO)

3-chloropropane-1,2-diol (EXP)

acrolein (ISO)

acrylamide (EXP)

aflatoxin B1 (ISO)

alpha-pinene (ISO)

antirheumatic drug (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

carbon nanotube (ISO)

chromium(6+) (ISO)

cocaine (EXP)

copper(II) sulfate (ISO)

coumestrol (ISO)

cyclosporin A (ISO)

dibutyl phthalate (ISO)

dioxygen (ISO)

diuron (EXP)

flutamide (EXP)

folic acid (ISO)

furan (EXP)

gentamycin (EXP)

hydrogen peroxide (ISO)

indole-3-methanol (EXP)

methylmercury chloride (ISO)

mono(2-ethylhexyl) phthalate (ISO)

nickel atom (ISO)

nickel sulfate (ISO)

ozone (ISO)

paracetamol (ISO)

paraquat (EXP)

pentachlorophenol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP)

rac-lactic acid (ISO)

resveratrol (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

succimer (ISO)

sunitinib (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

toluene (EXP)

triphenyl phosphate (ISO)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

mRNA processing (ISO)

tRNA methylation (IEA)

Cellular Component

nucleus (IBA)

tRNA (m1A) methyltransferase complex (IBA,ISO)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:22658674	PMID:29072297	PMID:29107537

Genomics

Comparative Map Data

Trmt6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	140,527,785 - 140,539,520 (-)	NCBI		GRCr8
mRatBN7.2	3	120,074,899 - 120,086,639 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	120,074,911 - 120,086,559 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	123,969,956 - 123,981,674 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	132,573,585 - 132,585,306 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	130,226,090 - 130,237,808 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	125,458,692 - 125,470,413 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	125,458,692 - 125,470,413 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	131,942,467 - 131,954,194 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	120,602,570 - 120,614,291 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	120,509,438 - 120,519,743 (-)	NCBI
Celera	3	118,860,870 - 118,872,591 (-)	NCBI		Celera
Cytogenetic Map	3	q36	NCBI

TRMT6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	5,937,228 - 5,950,533 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	5,937,228 - 5,950,558 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	5,917,874 - 5,931,179 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	5,866,486 - 5,879,173 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	20	5,990,095 - 6,002,785 (-)	NCBI		Celera
Cytogenetic Map	20	p12.3	NCBI
HuRef	20	5,875,029 - 5,887,738 (-)	NCBI		HuRef
CHM1_1	20	5,918,869 - 5,931,593 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	20	5,977,563 - 5,990,868 (-)	NCBI		T2T-CHM13v2.0

Trmt6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	132,646,127 - 132,658,127 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	132,646,127 - 132,657,975 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	132,804,207 - 132,816,054 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	132,804,207 - 132,816,055 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	132,629,951 - 132,641,790 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	132,495,656 - 132,507,496 (-)	NCBI		MGSCv36	mm8
Celera	2	134,031,674 - 134,043,498 (-)	NCBI		Celera
Cytogenetic Map	2	F2	NCBI
cM Map	2	64.74	NCBI

Trmt6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955415	16,330,482 - 16,344,973 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955415	16,333,766 - 16,390,112 (-)	NCBI	ChiLan1.0	ChiLan1.0

TRMT6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	6,859,872 - 6,872,629 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	6,856,698 - 6,869,445 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	5,932,217 - 5,944,930 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	5,715,016 - 5,727,726 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	5,715,015 - 5,727,726 (-)	Ensembl	panpan1.1		panPan2

TRMT6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	15,836,359 - 15,905,147 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	15,893,335 - 15,903,889 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	15,658,478 - 15,728,233 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	16,238,910 - 16,308,685 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	16,296,017 - 16,315,027 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	15,845,681 - 15,915,204 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	15,953,824 - 16,023,561 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	16,285,565 - 16,355,086 (+)	NCBI		UU_Cfam_GSD_1.0

Trmt6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	164,677,074 - 164,689,921 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936485	13,108,588 - 13,119,939 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936485	13,108,450 - 13,121,276 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TRMT6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	14,777,683 - 14,965,130 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	14,777,683 - 14,790,318 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	15,885,122 - 15,896,868 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TRMT6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	32,181,276 - 32,195,024 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	32,181,279 - 32,195,019 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666071	12,346,452 - 12,360,021 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Trmt6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624741	6,775,944 - 6,788,161 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624741	6,774,767 - 6,787,461 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	434
Count of miRNA genes:	232
Interacting mature miRNAs:	284
Transcripts:	ENSRNOT00000028893
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1582233	Insul10	Insulin level QTL 10	5.4	0.0015	blood insulin amount (VT:0001560)	serum insulin level times blood glucose level (CMO:0002040)	3	133259579	178259579	Rat
2301414	Kidm37	Kidney mass QTL 37		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	96509147	141509147	Rat
2302373	Gluco39	Glucose level QTL 39	5.01		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	3	129154923	182114333	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	51581665	184004958	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	67641776	167835660	Rat
1358362	Srcrt2	Stress Responsive Cort QTL 2	2.78		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	58601291	153936591	Rat
1578754	Stresp16	Stress response QTL 16	4	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	3	133134628	178134628	Rat
1300111	Rf12	Renal function QTL 12	3.78		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	81425008	141509147	Rat
8694437	Bw167	Body weight QTL 167	22.46	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	3	112250810	157250810	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	79649560	177741895	Rat
1581503	Cm58	Cardiac mass QTL 58	2.7	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	96509147	141509147	Rat
1354611	Despr2	Despair related QTL 2	3.03	0.0028	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	3	117537367	162537367	Rat
2303620	Vencon4	Ventilatory control QTL 4	3.9		respiration trait (VT:0001943)	tidal volume (CMO:0000222)	3	125116475	170116475	Rat
631649	Bp123	Blood pressure QTL 123	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	110225882	155225882	Rat
1358204	Insglur1	Insulin/glucose ratio QTL 1	3.8		blood glucose amount (VT:0000188)	serum glucose level (CMO:0000543)	3	136091420	155634702	Rat
1576306	Schws3	Schwannoma susceptibility QTL 3		0.001	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	3	139299381	184299381	Rat
12879848	Bw181	Body weght QTL 181		0.015	body mass (VT:0001259)	body weight (CMO:0000012)	3	90755164	141509147	Rat
5686842	Rf59	Renal function QTL 59			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	3	122395989	167395989	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	131036586	176036586	Rat
631673	Iddm13	Insulin dependent diabetes mellitus QTL 13	1.3	0.663	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	3	137114333	182114333	Rat
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	1	141509147	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	131036586	176036586	Rat
1581546	Pur13	Proteinuria QTL 13	2.93	0.0335	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	3	98651826	167012663	Rat
1331758	Bp207	Blood pressure QTL 207	2.848		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	110634702	155634702	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	5675975	141509147	Rat
724532	Cm17	Cardiac mass QTL 17	2		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	3	116188400	161188400	Rat

Markers in Region

AW531077

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	120,074,979 - 120,075,130 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	125,458,770 - 125,458,920	NCBI	Rnor6.0
Rnor_5.0	3	131,942,548 - 131,942,698	UniSTS	Rnor5.0
RGSC_v3.4	3	120,602,648 - 120,602,798	UniSTS	RGSC3.4
Celera	3	118,860,948 - 118,861,098	UniSTS
Cytogenetic Map	3	q36	UniSTS

BE097836

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	120,076,175 - 120,076,356 (+)	MAPPER	mRatBN7.2
mRatBN7.2	1	227,637,259 - 227,637,440 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	248,046,107 - 248,046,287	NCBI	Rnor6.0
Rnor_6.0	3	125,459,966 - 125,460,146	NCBI	Rnor6.0
Rnor_5.0	3	131,943,744 - 131,943,924	UniSTS	Rnor5.0
Rnor_5.0	1	255,297,358 - 255,297,538	UniSTS	Rnor5.0
RGSC_v3.4	1	233,583,990 - 233,584,170	UniSTS	RGSC3.4
RGSC_v3.4	3	120,603,844 - 120,604,024	UniSTS	RGSC3.4
Celera	3	118,862,144 - 118,862,324	UniSTS
Celera	1	224,787,644 - 224,787,824	UniSTS
Cytogenetic Map	1	q52	UniSTS
Cytogenetic Map	3	q36	UniSTS

BF389667

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	120,087,684 - 120,087,896 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	125,471,473 - 125,471,684	NCBI	Rnor6.0
Rnor_5.0	3	131,955,251 - 131,955,462	UniSTS	Rnor5.0
RGSC_v3.4	3	120,615,351 - 120,615,562	UniSTS	RGSC3.4
Celera	3	118,873,651 - 118,873,862	UniSTS
RH 3.4 Map	3	1030.61	UniSTS
Cytogenetic Map	3	q36	UniSTS

RH138707

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	120,081,779 - 120,082,907 (+)	MAPPER	mRatBN7.2
mRatBN7.2	1	227,638,457 - 227,638,622 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	248,047,305 - 248,047,469	NCBI	Rnor6.0
Rnor_6.0	3	125,465,570 - 125,466,697	NCBI	Rnor6.0
Rnor_5.0	3	131,949,348 - 131,950,475	UniSTS	Rnor5.0
Rnor_5.0	1	255,298,556 - 255,298,720	UniSTS	Rnor5.0
RGSC_v3.4	3	120,609,448 - 120,610,575	UniSTS	RGSC3.4
RGSC_v3.4	1	233,585,188 - 233,585,352	UniSTS	RGSC3.4
Celera	1	224,788,842 - 224,789,006	UniSTS
Celera	3	118,867,748 - 118,868,875	UniSTS
RH 3.4 Map	1	1616.6	UniSTS
Cytogenetic Map	3	q36	UniSTS
Cytogenetic Map	1	q52	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107779	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039105013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063283784	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005501885	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ209408	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000028893 ⟹ ENSRNOP00000028893

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	120,074,911 - 120,086,559 (-)	Ensembl
Rnor_6.0 Ensembl	3	125,458,692 - 125,470,413 (-)	Ensembl

RefSeq Acc Id:

NM_001107779 ⟹ NP_001101249

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	140,527,788 - 140,539,509 (-)	NCBI
mRatBN7.2	3	120,074,902 - 120,086,625 (-)	NCBI
Rnor_6.0	3	125,458,692 - 125,470,413 (-)	NCBI
Rnor_5.0	3	131,942,467 - 131,954,194 (-)	NCBI
RGSC_v3.4	3	120,602,570 - 120,614,291 (-)	RGD
Celera	3	118,860,870 - 118,872,591 (-)	RGD

Sequence:

show sequence

GGAAAGCGGAAGCGGCGTGCAGCACGTGGAGGCGGTTCCCGAGGAGACGCAGGTCCCTCCTGGT
TGTGCTGGGCTCCTAGCGGCTGTAGCAAGAACGGAGGTTGAAGACTGCCTGGCGTCCATGGAGT
TGTCAGCAGCGGAGCAGCCGAGCCCACAGCCCCCGCATCTCGGGGACCACTGCATCCATGACGG
CGACTTCGTGGTACTGAAACGAGAAGATGTGTTCAAAGCAGTGCAAGTCCAGCGGAGAAAAAAA
GTAACTTTTGAAAAACAGTGGTTCTACCTGGATAACGCCATTGGCCATAGTTACGGGTCAACGT
TTGAAGTGAGCAGTGGAGGAAGCCTTCAGCTCAGGAAGAAGCTGGAAGAGCCCACATCAGAGAC
CAAAGAAGCAGGCACTGATAATCGAAATATAGTTGATGATGGAAAGTCCCAGAAACTTACTCAA
GATGATATAAAGGCTCTGAAAGACAAGGGCATTAAAGGAGAGGAAATAGTTCAGCAGCTAATTG
AAAATAGTACAACATTTCGAGACAAGACAGAATTTGCTCAAGATAAATATATTAAAAAGAAGAA
GAAAAAATATGAAGCCATCATTACTATTTTGAAGCCATCTACCCGTATTCTTTCAATTATGTAT
TATGCAAGAGAACCTGGAAAAATTAACCACATGAGATATGATACACTAGCCCAGATGTTGACCT
TGGGAAATATCCGTGCTGGCAATAAAATGATTGTCATGGAAACGTGTTCAGGCTTGGTGCTAGG
TGCCATGATGGAACGAATGGGAGGCTTTGGCTCCATTATTCAGCTGTACCCTGGAGATGGACCT
GTTCGGGCAGCAACAGCTTGTTTTGGATTTCCCAAATCTTTCCTCAGTGGTCTTCATGAATTTC
CCCTCAACAAAGTAAAAAGTCTCCTCAATGGAACATTTTCTGCTGAAATGCTATCCTCAGAGCC
TAAAGACAGCACTCCAGTTAAAGAAAGTAATGGTGAGCTTGAGAAAGAGATTGCTGAGCAAGCG
GATAAGGACAGCATTGCAGACGGCCCAGAGAGCAACGCAGAACAGAATCCAGTGGACATTGTTC
CTGGGGACCCAGAGAGTAAGGAGCCTAAAGAAAAAGGAAGCAAAAGAGATTATATTCAGGAAAA
ACAGAGGAGACAAGAAGAGCAGAGGAAAAGACATATGGAGGCTGCTGCTCTGCTGGGAGAAAGA
AATGCAGATGGTTTGATTGTGGCCAGTCGTTTCCACCCCACACCCCTGCTGCTGTCTTTGCTGG
ACTTTGTAGCCCCATCAAGGCCGTTTGTGGTCTATTGTCAGTATAAAGAGCCTTTGTTGGAATG
CTACACAAAACTGCGGGAGAGAGGAGGAGTCATTAACTTGAGACTGTCTGAAACCTGGCTCAGA
AATTACCAGGTTCTGCCAGATCGGAGTCATCCCAAATTGTTGATGAGTGGAGGTGGAGGGTACC
TTCTGTCAGGCTTCACTGTTGTCTCGGACAGCCATCGAGTAGACCCCAGTCTCAAGTCCTGTGC
GAGTGCTTTAGACTCACCCAAGACTGAGGAGCCAGCAGCCAAGAAACAGAAATGCATGGAATCT
GCCTCTTAACTCTTAGGAGATCAATGTTTGTTCCAAGGCCTTCTGCTGCTGGTAATTAAACTTT
AAGTGTCACCACTAAAATTTTTTCCCTGTCCTAAGAGTATGTGTGCACCTGTTCCTGGGAAGAC
GTAAGCCTTTTGTTTGCCTCTGATGCAGGAGGATTAGTCAGGGCTGCAACTCTGATGGGCAGTA
ATGGATTGATACAGCAGTTGTGTATCACAGAAGACTCAGTACTTAAAGTATCTGCAAATACCTT
GGAAATGTCAACACCTTGAAAATGTGGATGTGTAAGTCTTTGTTTATATTGTAAGCAAAGATGA
ATACTGTGGACTAGCTAAAACATGGTGAACAACGAAAGGGAATTTCCTCTCATCCCTTTTCTTC
CACCTGACCAGTATGGATGTGTGAGCCTATGAGATTTACAGTACCAAAAATGTCTACCCTGTGC
CCTGCAATGGAATAAGCTTTTATAGACACTAGATTTTGTTATTTTAATAGTTGAGGCCTGAGGA
AGATCCAGGTATTTCTTTTCCTGCCTCTCCCCTTTTCGGTGCACAGAAAGGTTTGGTGGATGCT
CCTTTGCTGTGAAAGCTTCTCCTTTGTTCTGGAGGAAGTGATTAAAATGTCTGTGCTCTATTAA
ACAATTGATTGTCCCTCTCCAGACACAGACACAGAAACGTGTGTCAGTATTGGTATATATACAT
ATACACAGATGTATCTATGTGTCAGCATGGCTGGAATGTGCTGTCTGTGGTGGACAGGGAGAAT
GCATACACCTTTATTCGAGCTGTGGTAAAGACTTGTGCAGGACAGAGCAGATATCGGTGTGTTG
CTGTCATTCCTTGTCAAGTGTGTTTCAAGTGCCTTCTGGGGTTTCTCGCCCTGGTCTGTAAACA
TCTGCTGGTGTGAGGTGGGTGTCTGGGGATGAGGTGGGTGTCTGGGGATGAGGTGGGTGTCCGG
GGATTTCACGCCCTGCTCTGTAAAGGTCTGCTGGCATAAGGTAGGTGTCCTTTATCTCCTCTGA
GGGAAGTATGGTCGGATGCCTTTACCATCTCCATTGTAAGAAATAGGAAATGTGTAGAGTTATG
AAGACTTGTCTCCTTGAGAGTCTCAAGTCTTGTTCACTAGGACATGCACAGTGTTTCTGTCACC
ATAGAATCCTGGCCAGCGTGAAGCATCTTGAAAGGAAAAAAAATTGCTCTCCTAATAGCTTGTG
CTGTTTGGATAAGGCTGCAGTAAAAACTTTGGTTTTTAATTCCTTTTTCTCTAAACAATTGCTT
TTAAAGAATAAAATTTTCCTCCTCTGAGCCATAAG

hide sequence

RefSeq Acc Id:

XM_039105013 ⟹ XP_038960941

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	140,527,785 - 140,539,519 (-)	NCBI
mRatBN7.2	3	120,074,899 - 120,086,638 (-)	NCBI

RefSeq Acc Id:

XM_063283784 ⟹ XP_063139854

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	140,527,785 - 140,533,860 (-)	NCBI

RefSeq Acc Id:

XR_005501885

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	140,529,234 - 140,539,520 (-)	NCBI
mRatBN7.2	3	120,074,899 - 120,086,639 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001101249	(Get FASTA)	NCBI Sequence Viewer
	XP_038960941	(Get FASTA)	NCBI Sequence Viewer
	XP_063139854	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL80274	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000028893.5

RefSeq Acc Id:

NP_001101249 ⟸ NM_001107779

- UniProtKB:

D3ZVK3 (UniProtKB/TrEMBL), A6HQH3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MELSAAEQPSPQPPHLGDHCIHDGDFVVLKREDVFKAVQVQRRKKVTFEKQWFYLDNAIGHSYG
STFEVSSGGSLQLRKKLEEPTSETKEAGTDNRNIVDDGKSQKLTQDDIKALKDKGIKGEEIVQQ
LIENSTTFRDKTEFAQDKYIKKKKKKYEAIITILKPSTRILSIMYYAREPGKINHMRYDTLAQM
LTLGNIRAGNKMIVMETCSGLVLGAMMERMGGFGSIIQLYPGDGPVRAATACFGFPKSFLSGLH
EFPLNKVKSLLNGTFSAEMLSSEPKDSTPVKESNGELEKEIAEQADKDSIADGPESNAEQNPVD
IVPGDPESKEPKEKGSKRDYIQEKQRRQEEQRKRHMEAAALLGERNADGLIVASRFHPTPLLLS
LLDFVAPSRPFVVYCQYKEPLLECYTKLRERGGVINLRLSETWLRNYQVLPDRSHPKLLMSGGG
GYLLSGFTVVSDSHRVDPSLKSCASALDSPKTEEPAAKKQKCMESAS

hide sequence

Ensembl Acc Id:

ENSRNOP00000028893 ⟸ ENSRNOT00000028893

RefSeq Acc Id:	XP_038960941 ⟸ XM_039105013
- Peptide Label:	isoform X1
- UniProtKB:	D3ZVK3 (UniProtKB/TrEMBL), A6HQH3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063139854 ⟸ XM_063283784
- Peptide Label:	isoform X2

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZVK3-F1-model_v2	AlphaFold	D3ZVK3	1-495	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692459

Promoter ID:

EPDNEW_R2982

Type:

multiple initiation site

Name:

Trmt6_1

Description:

tRNA methyltransferase 6

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	125,470,395 - 125,470,455	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308877	AgrOrtholog
BioCyc Gene	G2FUF-47764	BioCyc
BioCyc Pathway	PWY-6829 [tRNA methylation (yeast)]	BioCyc
BioCyc Pathway Image	PWY-6829	BioCyc
Ensembl Genes	ENSRNOG00000021270	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000028893.6	UniProtKB/TrEMBL
InterPro	tRNA_m1A_mtfrase	UniProtKB/TrEMBL
KEGG Report	rno:311441	UniProtKB/TrEMBL
NCBI Gene	311441	ENTREZGENE
PANTHER	EIF3_gamma	UniProtKB/TrEMBL
	TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT TRM6	UniProtKB/TrEMBL
Pfam	Gcd10p	UniProtKB/TrEMBL
PhenoGen	Trmt6	PhenoGen
PIRSF	tRNA_m1A_mtfrase	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000021270	RatGTEx
UniProt	A6HQH3	ENTREZGENE, UniProtKB/TrEMBL
	D3ZVK3	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2022-06-17	Trmt6	tRNA methyltransferase 6 non-catalytic subunit	Trmt6	tRNA methyltransferase 6	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2014-12-01	Trmt6	tRNA methyltransferase 6	Trmt6	tRNA methyltransferase 6 homolog (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-02-26	Trmt6	tRNA methyltransferase 6 homolog (S. cerevisiae)	RGD1308877_predicted	similar to CGI-09 protein (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	RGD1308877_predicted	similar to CGI-09 protein (predicted)	LOC311441_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC311441_predicted	similar to CGI-09 protein (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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