Trp53rkb (transformation related protein 53 regulating kinase B) - Rat Genome Database

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Gene: Trp53rkb (transformation related protein 53 regulating kinase B) Rattus norvegicus
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Symbol: Trp53rkb (Ensembl: Tp53rk)
Name: transformation related protein 53 regulating kinase B (Ensembl:TP53 regulating kinase)
RGD ID: 1304911
Description: Predicted to enable p53 binding activity and protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation and tRNA threonylcarbamoyladenosine metabolic process. Predicted to be located in cytoplasm. Predicted to be part of EKC/KEOPS complex. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome 4. Orthologous to human TP53RK (TP53 regulating kinase); INTERACTS WITH 1,2-dimethylhydrazine (ortholog); 4,4'-sulfonyldiphenol (ortholog); bisphenol A (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC362272; TP53 regulating kinase; TP53 regulating kinase B; TP53-regulating kinase; Tp53rk; Tp53rkb; Trp53rk
RGD Orthologs
Mouse
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23155,529,298 - 155,532,662 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3155,529,298 - 155,532,728 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3159,330,153 - 159,333,722 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03167,829,113 - 167,832,682 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03165,570,818 - 165,574,387 (+)NCBIRnor_WKY
Rnor_6.03163,552,166 - 163,555,925 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3163,552,166 - 163,555,596 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03169,715,189 - 169,718,948 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43157,949,564 - 157,953,323 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13157,856,207 - 157,858,815 (+)NCBI
Celera3154,111,274 - 154,115,346 (+)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (ISO)
cytosol  (IBA)
EKC/KEOPS complex  (IBA,ISO)
nucleus  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11546806   PMID:27903914   PMID:28805828  


Genomics

Comparative Map Data
Trp53rkb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23155,529,298 - 155,532,662 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3155,529,298 - 155,532,728 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3159,330,153 - 159,333,722 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03167,829,113 - 167,832,682 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03165,570,818 - 165,574,387 (+)NCBIRnor_WKY
Rnor_6.03163,552,166 - 163,555,925 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3163,552,166 - 163,555,596 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03169,715,189 - 169,718,948 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43157,949,564 - 157,953,323 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13157,856,207 - 157,858,815 (+)NCBI
Celera3154,111,274 - 154,115,346 (+)NCBICelera
Cytogenetic Map3q42NCBI
Trp53rkb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392166,634,379 - 166,641,412 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2166,634,451 - 166,641,425 (+)EnsemblGRCm39 Ensembl
GRCm382166,792,459 - 166,799,492 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2166,792,531 - 166,799,505 (+)EnsemblGRCm38mm10GRCm38
MGSCv372166,619,267 - 166,624,992 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362166,484,972 - 166,490,697 (+)NCBIMGSCv36mm8
Celera2172,733,223 - 172,738,948 (+)NCBICelera
Cytogenetic Map2H3NCBI

Variants

.
Variants in Trp53rkb
12 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:119
Count of miRNA genes:94
Interacting mature miRNAs:106
Transcripts:ENSRNOT00000049082
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141339013162184794Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141339236155617360Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3145526770169034231Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3145925360166177555Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3145925360166177555Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3145925360166177555Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3145925360166177555Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3145925360166177555Rat
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3145925360166177555Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145925360166177555Rat
1300113Bp176Blood pressure QTL 1763.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145956084157309487Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3145956084161299569Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3145956084169034231Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3149040888168026850Rat

Markers in Region
RH131345  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23155,532,236 - 155,532,456 (+)MAPPERmRatBN7.2
Rnor_6.03163,555,105 - 163,555,324NCBIRnor6.0
Rnor_5.03169,718,128 - 169,718,347UniSTSRnor5.0
RGSC_v3.43157,952,503 - 157,952,722UniSTSRGSC3.4
Celera3154,114,415 - 154,114,634UniSTS
RH 3.4 Map31441.6UniSTS
Cytogenetic Map3q42UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 7
Low 3 43 57 41 19 41 8 11 74 35 34 11 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000049082   ⟹   ENSRNOP00000050360
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3155,529,298 - 155,532,728 (+)Ensembl
Rnor_6.0 Ensembl3163,552,166 - 163,555,596 (+)Ensembl
RefSeq Acc Id: NM_001108606   ⟹   NP_001102076
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23155,529,298 - 155,532,662 (+)NCBI
Rnor_6.03163,552,166 - 163,555,925 (+)NCBI
Rnor_5.03169,715,189 - 169,718,948 (+)NCBI
RGSC_v3.43157,949,564 - 157,953,323 (+)RGD
Celera3154,111,274 - 154,115,346 (+)RGD
Sequence:
RefSeq Acc Id: XM_039105544   ⟹   XP_038961472
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23155,530,050 - 155,532,662 (+)NCBI
RefSeq Acc Id: XM_039105545   ⟹   XP_038961473
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23155,529,330 - 155,532,662 (+)NCBI
RefSeq Acc Id: XM_039105546   ⟹   XP_038961474
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23155,529,323 - 155,532,662 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001102076 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961472 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961473 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961474 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL96432 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001102076   ⟸   NM_001108606
- UniProtKB: D3ZCD7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000050360   ⟸   ENSRNOT00000049082
RefSeq Acc Id: XP_038961474   ⟸   XM_039105546
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038961473   ⟸   XM_039105545
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038961472   ⟸   XM_039105544
- Peptide Label: isoform X1
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZCD7-F1-model_v2 AlphaFold D3ZCD7 1-244 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304911 AgrOrtholog
BioCyc Gene G2FUF-46763 BioCyc
Ensembl Genes ENSRNOG00000007285 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000050360 ENTREZGENE
  ENSRNOP00000050360.3 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000049082 ENTREZGENE
  ENSRNOT00000049082.4 UniProtKB/TrEMBL
InterPro Kae1-assoc_kinase_Bud32 UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:362272 UniProtKB/TrEMBL
NCBI Gene 362272 ENTREZGENE
PANTHER PTHR12209 UniProtKB/TrEMBL
PhenoGen Trp53rkb PhenoGen
PROSITE PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
TIGRFAMs arch_bud32 UniProtKB/TrEMBL
UniProt D3ZCD7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-03-03 Trp53rkb  transformation related protein 53 regulating kinase B  Tp53rkb  transformation related protein 53 regulating kinase B  Symbol changed 629549 APPROVED
2022-03-03 Tp53rkb  transformation related protein 53 regulating kinase B  Tp53rkb  TP53 regulating kinase B  Name changed 629549 APPROVED
2022-03-03 Tp53rkb  TP53 regulating kinase B  Tp53rk  TP53 regulating kinase  Name and Symbol changed 629549 APPROVED
2010-05-25 Tp53rk  TP53 regulating kinase  Trp53rk  TP53 regulating kinase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Trp53rk  TP53 regulating kinase   Trp53rk_predicted  TP53 regulating kinase (predicted)  'predicted' is removed 2292626 APPROVED
2008-01-09 Trp53rk_predicted  TP53 regulating kinase (predicted)  LOC686212  similar to TP53-regulating kinase (p53-related protein kinase) (Nori-2)  Data Merged 1643240 APPROVED
2006-11-19 LOC686212  similar to TP53-regulating kinase (p53-related protein kinase) (Nori-2)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Trp53rk_predicted  TP53 regulating kinase (predicted)      Symbol and Name status set to approved 70820 APPROVED