Gk2 (glycerol kinase 2) - Rat Genome Database

Name: Gk2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Gk2 (glycerol kinase 2) Rattus norvegicus

Analyze

Symbol:

Gk2

Name:

glycerol kinase 2

RGD ID:

1303263

Description:

Predicted to enable glycerol kinase activity. Predicted to be involved in several processes, including glycerol-3-phosphate biosynthetic process; sperm mitochondrial sheath assembly; and triglyceride metabolic process. Predicted to be located in mitochondrial outer membrane and sperm mitochondrial sheath. Predicted to be active in mitochondrion. Orthologous to human GK2 (glycerol kinase 2); PARTICIPATES IN eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; glycerolipid metabolic pathway; INTERACTS WITH bisphenol A; malathion; 17alpha-ethynylestradiol (ortholog).

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

Gk-rs2; glucokinase activity, related sequence 2; MGC94998

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GK2 (glycerol kinase 2)	HGNC	Ensembl, HomoloGene, NCBI, OrthoDB, OrthoMCL, PhylomeDB, Treefam
Mus musculus (house mouse):	Gk2 (glycerol kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Gk2 (glycerol kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GK2 (glycerol kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GK2 (glycerol kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gk2 (glycerol kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GK2 (glycerol kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GK2 (glycerol kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gk2 (glycerol kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	GK3 (glycerol kinase 3)	HGNC	OrthoDB, Panther
Homo sapiens (human):	GK (glycerol kinase)	HGNC	OrthoDB, Panther
Homo sapiens (human):	MROH9 (maestro heat like repeat family member 9)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	GK2 (glycerol kinase 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Mus musculus (house mouse):	Gk2 (glycerol kinase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	zgc:172295	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	GUT1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG8298	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Gk1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Gk2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	R11F4.1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	gk	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	14	12,107,071 - 12,108,923 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	12,107,020 - 12,128,473 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	12,074,029 - 12,075,881 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	14	13,373,870 - 13,375,722 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	14	12,090,253 - 12,092,105 (+)	NCBI	Rnor_WKY
Rnor_6.0	14	13,751,284 - 13,753,136 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	13,751,231 - 13,753,160 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	13,695,244 - 13,697,096 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	13,547,917 - 13,549,769 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	13,547,916 - 13,549,767 (+)	NCBI
Celera	14	12,168,374 - 12,170,226 (+)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Kabuki Syndrome 1 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17alpha-ethynylestradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

all-trans-retinoic acid (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

CGP 52608 (ISO)

copper(II) sulfate (ISO)

malathion (EXP)

pirinixic acid (ISO)

sodium fluoride (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

flagellated sperm motility (ISO)

glycerol catabolic process (IEA)

glycerol metabolic process (IBA)

glycerol-3-phosphate biosynthetic process (IBA)

phosphorylation (IBA)

sperm mitochondrial sheath assembly (ISO)

spermatogenesis (ISO)

triglyceride metabolic process (IBA)

Cellular Component

mitochondrial outer membrane (ISO)

mitochondrion (IBA)

sperm midpiece (ISO)

sperm mitochondrial sheath (ISO)

Molecular Function

ATP binding (IEA)

glycerol kinase activity (IBA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma (IEA)

glycerolipid metabolic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:18614015	PMID:19056867

Genomics

Comparative Map Data

Gk2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	14	12,107,071 - 12,108,923 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	12,107,020 - 12,128,473 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	12,074,029 - 12,075,881 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	14	13,373,870 - 13,375,722 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	14	12,090,253 - 12,092,105 (+)	NCBI	Rnor_WKY
Rnor_6.0	14	13,751,284 - 13,753,136 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	13,751,231 - 13,753,160 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	13,695,244 - 13,697,096 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	13,547,917 - 13,549,769 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	13,547,916 - 13,549,767 (+)	NCBI
Celera	14	12,168,374 - 12,170,226 (+)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI

GK2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	79,406,361 - 79,408,228 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	4	79,406,361 - 79,408,228 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	80,327,515 - 80,329,382 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	80,546,531 - 80,548,396 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	80,684,686 - 80,686,551	NCBI
Celera	4	77,623,185 - 77,625,050 (-)	NCBI		Celera
Cytogenetic Map	4	q21.21	NCBI
HuRef	4	76,074,667 - 76,076,532 (-)	NCBI		HuRef
CHM1_1	4	80,304,001 - 80,305,866 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	82,742,131 - 82,743,998 (-)	NCBI		T2T-CHM13v2.0

Gk2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	97,602,989 - 97,604,882 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	97,603,001 - 97,604,880 (-)	Ensembl		GRCm39 Ensembl
GRCm38	5	97,455,130 - 97,457,023 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	97,455,142 - 97,457,021 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	97,884,180 - 97,886,027 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	97,695,463 - 97,697,310 (-)	NCBI		MGSCv36	mm8
Celera	5	94,794,682 - 94,796,529 (-)	NCBI		Celera
Cytogenetic Map	5	E3	NCBI
cM Map	5	47.71	NCBI

Gk2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955433	3,736,428 - 3,738,360 (-)	NCBI	ChiLan1.0	ChiLan1.0

GK2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	4	50,837,576 - 50,841,516 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	44,780,488 - 44,784,433 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	50,628,852 - 50,630,785 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	50,628,938 - 50,630,599 (+)	Ensembl	panpan1.1		panPan2

GK2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	32	3,731,108 - 3,732,973 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	32	3,731,281 - 3,732,942 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	32	38,148,744 - 38,150,635 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	32	3,752,871 - 3,754,760 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	32	3,753,051 - 3,754,712 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	32	3,794,192 - 3,796,080 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	32	3,691,343 - 3,693,232 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	32	36,370,963 - 36,372,854 (+)	NCBI		UU_Cfam_GSD_1.0

Gk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	8,587,789 - 8,589,716 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936676	2,917,525 - 2,919,435 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GK2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	138,265,030 - 138,267,394 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	138,264,916 - 138,266,872 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	147,410,403 - 147,412,360 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GK2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	27,854,064 - 27,856,126 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	27,854,245 - 27,855,906 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	6,260,848 - 6,262,925 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gk2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624757	11,726,648 - 11,728,674 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Gk2
2 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	23
Count of miRNA genes:	20
Interacting mature miRNAs:	23
Transcripts:	ENSRNOT00000044244
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2300159	Bmd61	Bone mineral density QTL 61	5.3	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	14	1	26541967	Rat
2300183	Bmd60	Bone mineral density QTL 60	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	14	1	26541967	Rat
619619	Rf4	Renal disease susceptibility QTL 4	4.1	0.002	urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	14	1	32754612	Rat
634352	Apr6	Acute phase response QTL 6	3.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	14	1	41131407	Rat
70204	Niddm20	Non-insulin dependent diabetes mellitus QTL 20	5.1	0.000008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	1217606	16960180	Rat
2293089	Iddm31	Insulin dependent diabetes mellitus QTL 31	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	3813074	18274691	Rat
2293089	Iddm31	Insulin dependent diabetes mellitus QTL 31	4.7		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	14	3813074	18274691	Rat
1300114	Srn2	Serum renin concentration QTL 2	3.27		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	14	3813074	21217635	Rat
70195	Mcs8	Mammary carcinoma susceptibility QTL 8	4.28		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	14	3813074	24531477	Rat
1331740	Bw26	Body weight QTL 26	3.028		body mass (VT:0001259)	body weight (CMO:0000012)	14	3813074	30767156	Rat
1581500	Renag1	Renal agenesis QTL 1			kidney development trait (VT:0000527)	percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)	14	8170668	68298175	Rat
1358296	Ael3	Aortic elastin QTL 3	3.7	0.00051	aorta elastin amount (VT:0003905)	aortic elastin	14	8267090	53267090	Rat
2302045	Pia39	Pristane induced arthritis QTL 39	4.9	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G2a level (CMO:0002116)	14	8267090	53267090	Rat
731183	Pia20	Pristane induced arthritis QTL 20	3.55		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	14	9088978	39057237	Rat
2302277	Gluco38	Glucose level QTL 38	5.8		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	11030622	28035204	Rat
631839	Niddm37	Non-insulin dependent diabetes mellitus QTL 37	3.37		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	11030622	95876975	Rat
631212	Bw5	Body weight QTL5	5.43		retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	14	11030812	30320092	Rat

Markers in Region

mGk2

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	12,107,947 - 12,108,431 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	13,752,161 - 13,752,644	NCBI	Rnor6.0
Rnor_5.0	14	13,696,121 - 13,696,604	UniSTS	Rnor5.0
RGSC_v3.4	14	13,548,794 - 13,549,277	UniSTS	RGSC3.4
Celera	14	12,169,251 - 12,169,734	UniSTS
Cytogenetic Map	14	p22	UniSTS

UniSTS:546792

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	12,107,755 - 12,108,637 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	13,751,969 - 13,752,850	NCBI	Rnor6.0
Rnor_5.0	14	13,695,929 - 13,696,810	UniSTS	Rnor5.0
Celera	14	12,169,059 - 12,169,940	UniSTS
Cytogenetic Map	14	p22	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium											7
Low							2	2	1		3		2
Below cutoff	2	2	10	5	9	5	3	4	13	1	9	4	3

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001004077	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC133442	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC079449	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474022	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000248	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000044244 ⟹ ENSRNOP00000045775

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	12,107,020 - 12,110,598 (+)	Ensembl
Rnor_6.0 Ensembl	14	13,751,231 - 13,753,160 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000101217 ⟹ ENSRNOP00000096054

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	12,107,020 - 12,128,473 (+)	Ensembl

RefSeq Acc Id:

NM_001004077 ⟹ NP_001004077

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	14	12,107,071 - 12,108,923 (+)	NCBI
Rnor_6.0	14	13,751,284 - 13,753,136 (+)	NCBI
Rnor_5.0	14	13,695,244 - 13,697,096 (+)	NCBI
RGSC_v3.4	14	13,547,917 - 13,549,769 (+)	RGD
Celera	14	12,168,374 - 12,170,226 (+)	RGD

Sequence:

show sequence

CACTGACCAGTTTCATGGCAGACTCCAAGGAAACCCCTGAGGAGCCGTTGGTGGGAGCGGTGGT
CCAGGGAACCAACTCCACTCGCTTTCTGGTTTTCAATCCCAAAACAGCAGAACTAGTCGGCAGT
CATCAGGTGGAACTGACACAAGAGTATCCGAAAGAAGGATGGGTGGAGGAAGATCCCAAGGAAA
TCCTTCAGTCTGTCTATGAATGCATAGCGAAAACTTGCGAGAAACTTACTGAGGCGAACATTGA
TACTTCCAAGATTAAAGCTATCGGCGTGAGTAACCAGCGGGAAACCACTGTGGTCTGGGACAAG
TTCACGGGAGAGCCCCTATACAATGCCGTGGTGTGGCTTGATCTCAGAACCCAGTCTACTGTGG
AGAGTCTCAATAAGAAAATCCCAGGGAATAGCAACTTTGTCAAGTCTAAGACAGGCCTTCCACT
TAGCACTTACTTCAGTGCTGTGAAACTGCGGTGGATGCTGGACAACCTAAGACCCATTCAAAAG
GCTGTTGAGGAAGACAGAGCCCTATTTGGAACCATCGACTCGTGGCTCATCTGGTGTATGACCG
GAGGAGTCAACGGAGGCATCCACTGTACCGATGTAACAAATGCGAGCAGAACGATGCTTTTCAA
CATCCACTCTTTGGAATGGGATAAAGAACTCTGTAAATTTTTTGAAATTCCAATGAGCATCCTC
CCAAATGTACGCAGTTCTTCCGAGATCTACGGCCAGATGACATCCGGGGCTTTGGAAGGCGTGC
CAATATCCGGATGTTTGGGGGATCAGTCTGCTGCTTTAGTGGGACAAATGTGCTTCCAGGAAGG
TCAAGCCAAAAACACGTACGGAACCGGATGTTTTTTACTATGCAATACAGGCCAGAAATGTGTA
TTTTCTGAACATGGCCTTCTGACTACAGTGGCTTACAAACTAGGCAAAAATAAGCCAGCTTTTT
ATGCCTTAGAAGGCTCTGTTGCTATAGCTGGTGCTGTTATTCGCTGGCTAAGAGACAATTTCGA
ACTTATAACGTCCTCGGGGGAAGTTGAAGATCTTGCAAGAGAGGTAGGCACGGCCTACGGCTGC
TACTTTGTCCCAGCCTTTTCTGGGTTGTATGCACCTTACTGGGAACCCAGTGCAAGAGGGATAA
TCTGTGGTCTCACTCAGTTCACCAACAAATGCCATATTGCCTTTGCTGCATTAGAAGCCGTTTG
TTTCCAAACCCGAGAGATTGTGGATGCCATGAACCGCGACTGTGGGATTCCACTCAGTCATTTG
CGGGTAGATGGAAGAATGACCAACAACAAGATTCTCATGCAGCTCCAGGCAGATATTCTGCACA
TTCCGGTAGTTAAATCTGTTATGCCCGAAACCACAGCCCTGGGAGCAGCCATGGCAGCCGGAGC
TGCAGAAGGGATAGATGTTTGGAGTATTGAACCCGAAGACTTGTCTTCAATGTTAATGGAACGA
TATGAACCACAAATCCAAGCCACAGAGAGTGAAATTCGTTTTTCAACATGGAAGAGAGCAGTGA
TGAAGTCAATGGGTTGGGTTACAGCCAAGGATCCTGAAAGTAACGCTAACCCTGTCTTCGCTTG
CCTGCCCTTGGGGTTTTTTATAGTGAGTAGCATGACGTTATTAATTGGAGCAAGGTGTATCTCA
TACGCTGAAGAATAATTCCAACCACAGACTTGCAATGTGAGAGTTTATACAGAATGAATTCCAT
CTTTTAGTGTGAGACTAATATTATAGGTTTATTTTTACCTATAAACTACTTGCTACAGGATCCC
AATGATGCTCCTACACATACTCCTTAAAGGTTTTGAATAAAGAGAGTACATTAGAAAACAAAAA
AAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001004077	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH79449	(Get FASTA)	NCBI Sequence Viewer
	EDL99625	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001004077 ⟸ NM_001004077

- UniProtKB:

Q68FP7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MADSKETPEEPLVGAVVQGTNSTRFLVFNPKTAELVGSHQVELTQEYPKEGWVEEDPKEILQSV
YECIAKTCEKLTEANIDTSKIKAIGVSNQRETTVVWDKFTGEPLYNAVVWLDLRTQSTVESLNK
KIPGNSNFVKSKTGLPLSTYFSAVKLRWMLDNLRPIQKAVEEDRALFGTIDSWLIWCMTGGVNG
GIHCTDVTNASRTMLFNIHSLEWDKELCKFFEIPMSILPNVRSSSEIYGQMTSGALEGVPISGC
LGDQSAALVGQMCFQEGQAKNTYGTGCFLLCNTGQKCVFSEHGLLTTVAYKLGKNKPAFYALEG
SVAIAGAVIRWLRDNFELITSSGEVEDLAREVGTAYGCYFVPAFSGLYAPYWEPSARGIICGLT
QFTNKCHIAFAALEAVCFQTREIVDAMNRDCGIPLSHLRVDGRMTNNKILMQLQADILHIPVVK
SVMPETTALGAAMAAGAAEGIDVWSIEPEDLSSMLMERYEPQIQATESEIRFSTWKRAVMKSMG
WVTAKDPESNANPVFACLPLGFFIVSSMTLLIGARCISYAEE

hide sequence

RefSeq Acc Id:

ENSRNOP00000045775 ⟸ ENSRNOT00000044244

RefSeq Acc Id:

ENSRNOP00000096054 ⟸ ENSRNOT00000101217

Protein Domains

Carbohydrate kinase FGGY C-terminal Carbohydrate kinase FGGY N-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q68FP7-F1-model_v2	AlphaFold	Q68FP7	1-554	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699200

Promoter ID:

EPDNEW_R9725

Type:

initiation region

Name:

Gk2_1

Description:

glycerol kinase 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	14	13,751,280 - 13,751,340	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1303263	AgrOrtholog
BioCyc Gene	G2FUF-16353	BioCyc
Ensembl Genes	ENSRNOG00000029397	Ensembl, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000045775.3	UniProtKB/TrEMBL
	ENSRNOP00000096054.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000044244.5	UniProtKB/TrEMBL
	ENSRNOT00000101217.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.420.40	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7115796	IMAGE-MGC_LOAD
InterPro	ATPase_NBD	UniProtKB/TrEMBL
	Carb_kinase_FGGY	UniProtKB/TrEMBL
	Carb_kinase_FGGY_C	UniProtKB/TrEMBL
	Carb_kinase_FGGY_CS	UniProtKB/TrEMBL
	Carb_kinase_FGGY_N	UniProtKB/TrEMBL
	GK1-3_metazoa	UniProtKB/TrEMBL
	Glycerol_kin	UniProtKB/TrEMBL
KEGG Report	rno:289481	UniProtKB/TrEMBL
MGC_CLONE	MGC:94998	IMAGE-MGC_LOAD
NCBI Gene	289481	ENTREZGENE
PANTHER	GLYCEROL KINASE 2	UniProtKB/TrEMBL
	SUGAR KINASE	UniProtKB/TrEMBL
Pfam	FGGY_C	UniProtKB/TrEMBL
	FGGY_N	UniProtKB/TrEMBL
PhenoGen	Gk2	PhenoGen
PIRSF	GlpK	UniProtKB/TrEMBL
PROSITE	FGGY_KINASES_1	UniProtKB/TrEMBL
	FGGY_KINASES_2	UniProtKB/TrEMBL
Superfamily-SCOP	SSF53067	UniProtKB/TrEMBL
TIGRFAMs	glycerol_kin	UniProtKB/TrEMBL
UniProt	A0A8I6AQ25_RAT	UniProtKB/TrEMBL
	F7FNM6_RAT	UniProtKB/TrEMBL
	Q68FP7	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-04	Gk2	glycerol kinase 2	Gk-rs2	glucokinase activity, related sequence 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-09-30	Gk-rs2				Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)