Gk2 (glycerol kinase 2) - Rat Genome Database

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Gene: Gk2 (glycerol kinase 2) Rattus norvegicus
Analyze
Symbol: Gk2
Name: glycerol kinase 2
RGD ID: 1303263
Description: Predicted to enable glycerol kinase activity. Predicted to be involved in several processes, including glycerol-3-phosphate biosynthetic process; sperm mitochondrial sheath assembly; and triglyceride metabolic process. Predicted to be located in mitochondrial outer membrane and sperm mitochondrial sheath. Predicted to be active in mitochondrion. Orthologous to human GK2 (glycerol kinase 2); PARTICIPATES IN eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; glycerolipid metabolic pathway; INTERACTS WITH bisphenol A; malathion; 17alpha-ethynylestradiol (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Gk-rs2; glucokinase activity, related sequence 2; MGC94998
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81412,411,077 - 12,412,929 (+)NCBIGRCr8
mRatBN7.21412,107,071 - 12,108,923 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1412,107,020 - 12,128,473 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1412,074,029 - 12,075,881 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01413,373,870 - 13,375,722 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01412,090,253 - 12,092,105 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01413,751,284 - 13,753,136 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1413,751,231 - 13,753,160 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01413,695,244 - 13,697,096 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41413,547,917 - 13,549,769 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11413,547,916 - 13,549,767 (+)NCBI
Celera1412,168,374 - 12,170,226 (+)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:18614015   PMID:19056867  


Genomics

Comparative Map Data
Gk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81412,411,077 - 12,412,929 (+)NCBIGRCr8
mRatBN7.21412,107,071 - 12,108,923 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1412,107,020 - 12,128,473 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1412,074,029 - 12,075,881 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01413,373,870 - 13,375,722 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01412,090,253 - 12,092,105 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01413,751,284 - 13,753,136 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1413,751,231 - 13,753,160 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01413,695,244 - 13,697,096 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41413,547,917 - 13,549,769 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11413,547,916 - 13,549,767 (+)NCBI
Celera1412,168,374 - 12,170,226 (+)NCBICelera
Cytogenetic Map14p22NCBI
GK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38479,406,361 - 79,408,228 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl479,406,361 - 79,408,228 (-)EnsemblGRCh38hg38GRCh38
GRCh37480,327,515 - 80,329,382 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36480,546,531 - 80,548,396 (-)NCBINCBI36Build 36hg18NCBI36
Build 34480,684,686 - 80,686,551NCBI
Celera477,623,185 - 77,625,050 (-)NCBICelera
Cytogenetic Map4q21.21NCBI
HuRef476,074,667 - 76,076,532 (-)NCBIHuRef
CHM1_1480,304,001 - 80,305,866 (-)NCBICHM1_1
T2T-CHM13v2.0482,742,131 - 82,743,998 (-)NCBIT2T-CHM13v2.0
Gk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39597,602,989 - 97,604,882 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl597,603,001 - 97,604,880 (-)EnsemblGRCm39 Ensembl
GRCm38597,455,130 - 97,457,023 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl597,455,142 - 97,457,021 (-)EnsemblGRCm38mm10GRCm38
MGSCv37597,884,180 - 97,886,027 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36597,695,463 - 97,697,310 (-)NCBIMGSCv36mm8
Celera594,794,682 - 94,796,529 (-)NCBICelera
Cytogenetic Map5E3NCBI
cM Map547.71NCBI
Gk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554333,736,428 - 3,738,360 (-)NCBIChiLan1.0ChiLan1.0
GK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2350,648,438 - 50,654,381 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1450,837,576 - 50,841,516 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0444,780,488 - 44,784,433 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1450,628,852 - 50,630,785 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl450,628,938 - 50,630,599 (+)Ensemblpanpan1.1panPan2
GK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1323,731,108 - 3,732,973 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl323,731,281 - 3,732,942 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3238,148,744 - 38,150,635 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0323,752,871 - 3,754,760 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl323,753,051 - 3,754,712 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1323,794,192 - 3,796,080 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0323,691,343 - 3,693,232 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03236,370,963 - 36,372,854 (+)NCBIUU_Cfam_GSD_1.0
Gk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244052858,587,789 - 8,589,716 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366762,917,525 - 2,919,435 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8138,265,030 - 138,267,394 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18138,264,916 - 138,266,872 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28147,410,403 - 147,412,360 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1727,854,064 - 27,856,126 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl727,854,245 - 27,855,906 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660376,260,848 - 6,262,925 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475711,726,648 - 11,728,674 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gk2
2 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:23
Count of miRNA genes:20
Interacting mature miRNAs:23
Transcripts:ENSRNOT00000044244
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14121760616960180Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)14381307418274691Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14381307418274691Rat
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062228035204Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141103081230320092Rat

Markers in Region
mGk2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21412,107,947 - 12,108,431 (+)MAPPERmRatBN7.2
Rnor_6.01413,752,161 - 13,752,644NCBIRnor6.0
Rnor_5.01413,696,121 - 13,696,604UniSTSRnor5.0
RGSC_v3.41413,548,794 - 13,549,277UniSTSRGSC3.4
Celera1412,169,251 - 12,169,734UniSTS
Cytogenetic Map14p22UniSTS
UniSTS:546792  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21412,107,755 - 12,108,637 (+)MAPPERmRatBN7.2
Rnor_6.01413,751,969 - 13,752,850NCBIRnor6.0
Rnor_5.01413,695,929 - 13,696,810UniSTSRnor5.0
Celera1412,169,059 - 12,169,940UniSTS
Cytogenetic Map14p22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 7
Low 2 2 1 3 2
Below cutoff 2 2 10 5 9 5 3 4 13 1 9 4 3

Sequence


RefSeq Acc Id: ENSRNOT00000044244   ⟹   ENSRNOP00000045775
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1412,107,020 - 12,110,598 (+)Ensembl
Rnor_6.0 Ensembl1413,751,231 - 13,753,160 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000101217   ⟹   ENSRNOP00000096054
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1412,107,020 - 12,128,473 (+)Ensembl
RefSeq Acc Id: NM_001004077   ⟹   NP_001004077
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81412,411,077 - 12,412,929 (+)NCBI
mRatBN7.21412,107,071 - 12,108,923 (+)NCBI
Rnor_6.01413,751,284 - 13,753,136 (+)NCBI
Rnor_5.01413,695,244 - 13,697,096 (+)NCBI
RGSC_v3.41413,547,917 - 13,549,769 (+)RGD
Celera1412,168,374 - 12,170,226 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001004077 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH79449 (Get FASTA)   NCBI Sequence Viewer  
  EDL99625 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000045775.3
  ENSRNOP00000096054.1
RefSeq Acc Id: NP_001004077   ⟸   NM_001004077
- UniProtKB: Q68FP7 (UniProtKB/TrEMBL),   F7FNM6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000045775   ⟸   ENSRNOT00000044244
RefSeq Acc Id: ENSRNOP00000096054   ⟸   ENSRNOT00000101217
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q68FP7-F1-model_v2 AlphaFold Q68FP7 1-554 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699200
Promoter ID:EPDNEW_R9725
Type:initiation region
Name:Gk2_1
Description:glycerol kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01413,751,280 - 13,751,340EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303263 AgrOrtholog
BioCyc Gene G2FUF-16353 BioCyc
Ensembl Genes ENSRNOG00000029397 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000044244.5 UniProtKB/TrEMBL
  ENSRNOT00000101217.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.420.40 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7115796 IMAGE-MGC_LOAD
InterPro ATPase_NBD UniProtKB/TrEMBL
  Carb_kinase_FGGY UniProtKB/TrEMBL
  Carb_kinase_FGGY_C UniProtKB/TrEMBL
  Carb_kinase_FGGY_CS UniProtKB/TrEMBL
  Carb_kinase_FGGY_N UniProtKB/TrEMBL
  GK1-3_metazoa UniProtKB/TrEMBL
  Glycerol_kin UniProtKB/TrEMBL
KEGG Report rno:289481 UniProtKB/TrEMBL
MGC_CLONE MGC:94998 IMAGE-MGC_LOAD
NCBI Gene 289481 ENTREZGENE
PANTHER GLYCEROL KINASE 2 UniProtKB/TrEMBL
  SUGAR KINASE UniProtKB/TrEMBL
Pfam FGGY_C UniProtKB/TrEMBL
  FGGY_N UniProtKB/TrEMBL
PhenoGen Gk2 PhenoGen
PIRSF GlpK UniProtKB/TrEMBL
PROSITE FGGY_KINASES_1 UniProtKB/TrEMBL
  FGGY_KINASES_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000029397 RatGTEx
Superfamily-SCOP SSF53067 UniProtKB/TrEMBL
UniProt A0A8I6AQ25_RAT UniProtKB/TrEMBL
  F7FNM6 ENTREZGENE, UniProtKB/TrEMBL
  Q68FP7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-04 Gk2  glycerol kinase 2  Gk-rs2  glucokinase activity, related sequence 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-09-30 Gk-rs2        Symbol and Name status set to provisional 70820 PROVISIONAL