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Gene: Dock8 (dedicator of cytokinesis 8) Ictidomys tridecemlineatus

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Symbol:

Dock8

Name:

dedicator of cytokinesis 8

RGD ID:

12735486

Description:

ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (inferred); INVOLVED IN dendritic cell migration (ortholog); positive regulation of GTPase activity (ortholog); ASSOCIATED WITH atopic dermatitis (ortholog); autosomal dominant intellectual developmental disorder 2 (ortholog); bacterial infectious disease (ortholog); FOUND IN cell leading edge (inferred); cytoplasm (inferred); cytosol (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

dedicator of cytokinesis protein 8

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	136,597,710 - 136,810,653 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936503	4,363,926 - 4,574,932 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936503	4,362,573 - 4,575,307 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Dock8	Squirrel	atopic dermatitis		ISO	RGD:1603953	9068941	DNA:mutations:cds:	RGD	PMID:22476911\|REF_RGD_ID:40903056
Dock8	Squirrel	bacterial infectious disease	susceptibility	ISO	RGD:1603953	9068941	DNA:mutations: :	RGD	PMID:25724123\|REF_RGD_ID:40886274
Dock8	Squirrel	Eczema		ISO	RGD:1603953	9068941	DNA:mutations: :	RGD	PMID:22534316\|REF_RGD_ID:40902960
Dock8	Squirrel	hepatitis B	disease_progression	ISO	RGD:1603953	9068941	DNA:SNP::rs506121(human)	RGD	PMID:32297155\|REF_RGD_ID:40903057
Dock8	Squirrel	herpes simplex	severity	ISO	RGD:1317066	9068941		RGD	PMID:25776845\|REF_RGD_ID:11055046
Dock8	Squirrel	immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome		ISO	RGD:1603953	9068941	DNA:mutations:cds:c.2402 ��1G>A,c.1498 C>T (p.R500X)(human)	RGD	PMID:29058101\|REF_RGD_ID:40886273
Dock8	Squirrel	type 1 diabetes mellitus		ISO	RGD:1561588	9068941		RGD	PMID:26363782\|REF_RGD_ID:11532657
Dock8	Squirrel	viral infectious disease	susceptibility	ISO	RGD:1603953	9068941	DNA:mutations: :	RGD	PMID:25724123\|REF_RGD_ID:40886274

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Dock8	Squirrel	autosomal dominant intellectual developmental disorder 2		ISO	RGD:1603953	8554872	ClinVar Annotator: match by term: Intellectual disability, autosomal dominant 2	ClinVar	PMID:28492532
Dock8	Squirrel	chromosome 9p deletion syndrome		ISO	RGD:1603953	8554872	ClinVar Annotator: match by term: Chromosome 9p deletion syndrome	ClinVar	PMID:25741868
Dock8	Squirrel	genetic disease		ISO	RGD:1603953	8554872	ClinVar Annotator: match by term: Inborn genetic diseases	ClinVar	PMID:24033266\|PMID:25741868\|PMID:28492532\|PMID:35753512
Dock8	Squirrel	hepatoblastoma		ISO	RGD:1603953	8554872	ClinVar Annotator: match by term: Hepatoblastoma	ClinVar	PMID:28492532
Dock8	Squirrel	hyper IgE recurrent infection syndrome 2		ISO	RGD:1603953	8554872	ClinVar Annotator: match by term: DOCK8-related condition \| ClinVar Annotator: match by term: HYPER-IgE RECURRENT more ...	ClinVar	PMID:14722525\|PMID:16199547\|PMID:16391785\|PMID:17576681\|PMID:18060736\|PMID:19776401\|PMID:20004785\|PMID:20226292\|PMID:20622910\|PMID:22476911\|PMID:23380217\|PMID:23859592\|PMID:24033266\|PMID:24797421\|PMID:25167861\|PMID:25640679\|PMID:25724123\|PMID:25741868\|PMID:26046366\|PMID:26659092\|PMID:26680607\|PMID:26689913\|PMID:26744459\|PMID:27379089\|PMID:27872624\|PMID:27890707\|PMID:27980540\|PMID:28070732\|PMID:28191889\|PMID:28492532\|PMID:28750028\|PMID:29058101\|PMID:29590070\|PMID:29867916\|PMID:30564305\|PMID:31589614\|PMID:31596517\|PMID:31911633\|PMID:31980526\|PMID:32135276\|PMID:32191290\|PMID:32888943\|PMID:33188554\|PMID:33206719\|PMID:33290277\|PMID:33332384\|PMID:33854233\|PMID:34308104\|PMID:34662886\|PMID:35753512\|PMID:35874679\|PMID:36451132\|PMID:36790564\|PMID:37592284\|PMID:38274105\|PMID:39098944\|PMID:9536098
Dock8	Squirrel	hyper IgE recurrent infection syndrome 2		ISO	RGD:1603953	8554872	ClinVar Annotator: match by term: DOCK8-related condition \| ClinVar Annotator: match by term: HYPER-IgE RECURRENT more ...	ClinVar	PMID:14722525\|PMID:16199547\|PMID:16391785\|PMID:17576681\|PMID:18060736\|PMID:19776401\|PMID:20004785\|PMID:20226292\|PMID:20622910\|PMID:21324546\|PMID:22006977\|PMID:22476911\|PMID:22534316\|PMID:23380217\|PMID:23859592\|PMID:24033266\|PMID:24418481\|PMID:24673638\|PMID:24797421\|PMID:25167861\|PMID:25640679\|PMID:25724123\|PMID:25741868\|PMID:26046366\|PMID:26467025\|PMID:26573532\|PMID:26659092\|PMID:26680607\|PMID:26744459\|PMID:27379089\|PMID:27398204\|PMID:27457812\|PMID:27872624\|PMID:27890707\|PMID:27980540\|PMID:28070732\|PMID:28191889\|PMID:28492532\|PMID:28750028\|PMID:29058101\|PMID:29483666\|PMID:29867916\|PMID:30425284\|PMID:30564305\|PMID:30697212\|PMID:31242861\|PMID:31596517\|PMID:31980526\|PMID:32108967\|PMID:32135276\|PMID:32531373\|PMID:32888943\|PMID:33251169\|PMID:33290277\|PMID:33587123\|PMID:33809641\|PMID:34093558\|PMID:34662886\|PMID:35753512\|PMID:9536098
Dock8	Squirrel	hyper IgE syndrome		ISO	RGD:1603953	8554872	ClinVar Annotator: match by term: Autosomal recessive hyper-IgE syndrome \| ClinVar Annotator: match by term: more ...	ClinVar	PMID:14722525\|PMID:16199547\|PMID:16391785\|PMID:17576681\|PMID:18060736\|PMID:19776401\|PMID:20004785\|PMID:20226292\|PMID:20622910\|PMID:22006977\|PMID:22476911\|PMID:23380217\|PMID:23859592\|PMID:24033266\|PMID:24673638\|PMID:24797421\|PMID:25167861\|PMID:25640679\|PMID:25724123\|PMID:25741868\|PMID:26046366\|PMID:26659092\|PMID:26680607\|PMID:26689913\|PMID:26744459\|PMID:27379089\|PMID:27872624\|PMID:27890707\|PMID:27980540\|PMID:28070732\|PMID:28191889\|PMID:28492532\|PMID:28750028\|PMID:29058101\|PMID:29590070\|PMID:29867916\|PMID:30564305\|PMID:31589614\|PMID:31596517\|PMID:31911633\|PMID:31980526\|PMID:32108967\|PMID:32135276\|PMID:32191290\|PMID:32888943\|PMID:33188554\|PMID:33206719\|PMID:33251169\|PMID:33290277\|PMID:33332384\|PMID:33854233\|PMID:34308104\|PMID:34662886\|PMID:35753512\|PMID:35874679\|PMID:36451132\|PMID:36790564\|PMID:37533579\|PMID:37592284\|PMID:38274105\|PMID:39098944\|PMID:9536098
Dock8	Squirrel	intellectual disability		ISO	RGD:1603953	8554872	ClinVar Annotator: match by term: Intellectual disability	ClinVar	PMID:14722525\|PMID:16199547\|PMID:18060736\|PMID:19776401\|PMID:24033266\|PMID:25724123\|PMID:25741868\|PMID:26046366\|PMID:26744459\|PMID:28492532\|PMID:29867916\|PMID:31596517\|PMID:31980526\|PMID:37592284
Dock8	Squirrel	intellectual disability		ISO	RGD:1603953	8554872	ClinVar Annotator: match by term: Intellectual disability	ClinVar	PMID:14722525\|PMID:16199547\|PMID:18060736\|PMID:19776401\|PMID:24033266\|PMID:25724123\|PMID:25741868\|PMID:26046366\|PMID:26689913\|PMID:26744459\|PMID:28492532\|PMID:29867916\|PMID:31589614\|PMID:31596517\|PMID:31980526\|PMID:32191290\|PMID:33188554\|PMID:34308104\|PMID:34662886\|PMID:36451132\|PMID:37592284\|PMID:38274105
Dock8	Squirrel	primary immunodeficiency disease		ISO	RGD:1603953	8554872	ClinVar Annotator: match by term: Inherited Immunodeficiency Diseases	ClinVar	PMID:25741868
Dock8	Squirrel	schizophrenia		ISO	RGD:1603953	8554872	ClinVar Annotator: match by term: Schizophrenia	ClinVar	PMID:21681106\|PMID:30208311
Dock8	Squirrel	severe combined immunodeficiency		ISO	RGD:1603953	8554872	ClinVar Annotator: match by term: Severe combined immunodeficiency disease	ClinVar	PMID:14722525\|PMID:19776401\|PMID:25724123\|PMID:27891178\|PMID:28492532\|PMID:29930340\|PMID:30697212\|PMID:32888943

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Dock8	Squirrel	Developmental Disabilities		ISO	RGD:1603953	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:18060736
Dock8	Squirrel	neuroblastoma		ISO	RGD:1603953	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:26121086
Dock8	Squirrel	Neurodevelopmental Disorders		ISO	RGD:1603953	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:28191889
Dock8	Squirrel	Recurrence		ISO	RGD:1603953	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:26121086

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Dock8	Squirrel	hyper IgE recurrent infection syndrome 2		ISO	RGD:1603953	7240710		OMIM

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Dock8	Squirrel	cellular response to chemokine	involved_in	IEA	UniProtKB:Q8NF50\|ensembl:ENSP00000394888	150520179		Ensembl	GO_REF:0000107
Dock8	Squirrel	dendritic cell migration	involved_in	ISO	RGD:1317066	9068941	PMID:25713392	UniProt	PMID:25713392
Dock8	Squirrel	dendritic cell migration	acts_upstream_of_or_within	IEA	UniProtKB:Q8C147\|ensembl:ENSMUSP00000025831	150520179		Ensembl	GO_REF:0000107
Dock8	Squirrel	immunological synapse formation	acts_upstream_of_or_within	IEA	UniProtKB:Q8C147\|ensembl:ENSMUSP00000025831	150520179		Ensembl	GO_REF:0000107
Dock8	Squirrel	memory T cell proliferation	acts_upstream_of_or_within	IEA	UniProtKB:Q8NF50\|ensembl:ENSP00000394888	150520179		Ensembl	GO_REF:0000107
Dock8	Squirrel	negative regulation of T cell apoptotic process	acts_upstream_of_or_within	IEA	UniProtKB:Q8C147\|ensembl:ENSMUSP00000025831	150520179		Ensembl	GO_REF:0000107
Dock8	Squirrel	positive regulation of establishment of T cell polarity	involved_in	IEA	PANTHER:PTN001153467	150520179		TreeGrafter	GO_REF:0000118
Dock8	Squirrel	positive regulation of establishment of T cell polarity	involved_in	IEA	UniProtKB:Q8C147\|UniProtKB:Q8NF50\|ensembl:ENSMUSP00000025831\|ensembl:ENSP00000394888	150520179		Ensembl	GO_REF:0000107
Dock8	Squirrel	positive regulation of GTPase activity	involved_in	ISO	RGD:1603953	9068941	PMID:28028151	UniProt	PMID:28028151
Dock8	Squirrel	positive regulation of T cell migration	involved_in	IEA	PANTHER:PTN001153467	150520179		TreeGrafter	GO_REF:0000118
Dock8	Squirrel	positive regulation of T cell migration	involved_in	IEA	UniProtKB:Q8C147\|UniProtKB:Q8NF50\|ensembl:ENSMUSP00000025831\|ensembl:ENSP00000394888	150520179		Ensembl	GO_REF:0000107
Dock8	Squirrel	small GTPase-mediated signal transduction	involved_in	IEA	InterPro:IPR026791	150520179		InterPro	GO_REF:0000002

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Dock8	Squirrel	cell leading edge	located_in	IEA	PANTHER:PTN001153467	150520179		TreeGrafter	GO_REF:0000118
Dock8	Squirrel	cell leading edge	located_in	IEA	UniProtKB:Q8C147\|ensembl:ENSMUSP00000025831	150520179		Ensembl	GO_REF:0000107
Dock8	Squirrel	cytoplasm	located_in	IEA	UniProtKB:Q8NF50\|ensembl:ENSP00000394888	150520179		Ensembl	GO_REF:0000107
Dock8	Squirrel	cytosol	located_in	IEA	UniProtKB:Q8NF50\|ensembl:ENSP00000394888	150520179		Ensembl	GO_REF:0000107
Dock8	Squirrel	leading edge membrane	located_in	IEA	UniProtKB:Q8NF50\|ensembl:ENSP00000394888	150520179		Ensembl	GO_REF:0000107
Dock8	Squirrel	plasma membrane	located_in	IEA	UniProtKB:Q8NF50\|ensembl:ENSP00000394888	150520179		Ensembl	GO_REF:0000107

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Dock8	Squirrel	guanyl-nucleotide exchange factor activity	enables	IEA	PANTHER:PTN001153467	150520179		TreeGrafter	GO_REF:0000118
Dock8	Squirrel	guanyl-nucleotide exchange factor activity	enables	IEA	UniProtKB:Q8C147\|UniProtKB:Q8NF50\|ensembl:ENSMUSP00000025831\|ensembl:ENSP00000394888	150520179		Ensembl	GO_REF:0000107
Dock8	Squirrel	guanyl-nucleotide exchange factor activity	enables	IEA	UniProtKB-KW:KW-0344	150520179		UniProt	GO_REF:0000043
Dock8	Squirrel	guanyl-nucleotide exchange factor activity	enables	IEA	InterPro:IPR026791	150520179		InterPro	GO_REF:0000002
Dock8	Squirrel	protein binding	enables	ISO	UniProtKB:Q99836	9068941	PMID:22581261	IntAct	PMID:22581261
Dock8	Squirrel	protein binding	enables	ISO	UniProtKB:P62046	9068941	PMID:28028151	UniProt	PMID:28028151
Dock8	Squirrel	protein binding	enables	ISO	UniProtKB:O75427\|UniProtKB:Q5VUJ6	9068941	PMID:32203420	IntAct	PMID:32203420
Dock8	Squirrel	protein binding	enables	ISO	UniProtKB:Q5VUJ6	9068941	PMID:28514442	IntAct	PMID:28514442
Dock8	Squirrel	protein binding	enables	ISO	UniProtKB:A8K900\|UniProtKB:B2R894\|UniProtKB:G3V1X1\|UniProtKB:O43633\|UniProtKB:P02008\|UniProtKB:P50222\|UniProtKB:Q13895\|UniProtKB:Q14D33\|UniProtKB:Q3B820\|UniProtKB:Q6A162\|UniProtKB:Q86V42\|UniProtKB:Q96HR3\|UniProtKB:Q96II8\|UniProtKB:Q9NQT4\|UniProtKB:Q9NW38\|UniProtKB:Q9NXK8\|UniProtKB:Q9P0T4\|UniProtKB:Q9Y2L9\|UniProtKB:Q9Y2V2	9068941	PMID:25416956	IntAct	PMID:25416956
Dock8	Squirrel	protein binding	enables	ISO	UniProtKB:Q9Y2L9	9068941	PMID:31515488	IntAct	PMID:31515488
Dock8	Squirrel	protein binding	enables	ISO	UniProtKB:O75031\|UniProtKB:Q6FHY5\|UniProtKB:Q9Y2V7	9068941	PMID:32296183	IntAct	PMID:32296183
Dock8	Squirrel	protein binding	enables	ISO	UniProtKB:P60953\|UniProtKB:Q9Y2L9	9068941	PMID:28028151	UniProt	PMID:28028151
Dock8	Squirrel	protein binding	enables	ISO	UniProtKB:Q9BSJ6	9068941	PMID:26871637	IntAct	PMID:26871637
Dock8	Squirrel	protein binding	enables	ISO	UniProtKB:Q5VUJ6\|UniProtKB:Q9Y2L9	9068941	PMID:24255178, PMID:33961781	IntAct	PMID:24255178\|PMID:33961781

PMID:30032202

Dock8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	136,597,710 - 136,810,653 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936503	4,363,926 - 4,574,932 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936503	4,362,573 - 4,575,307 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DOCK8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	211,257 - 465,255 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	214,854 - 465,259 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	214,865 - 465,255 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	263,048 - 455,255 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	9	129,697 - 382,253 (+)	NCBI		Celera
Cytogenetic Map	9	p24.3	NCBI
HuRef	9	168,609 - 417,080 (+)	NCBI		HuRef
CHM1_1	9	215,319 - 464,907 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	9	208,892 - 464,924 (+)	NCBI		T2T-CHM13v2.0

Dock8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	24,976,753 - 25,179,796 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	24,976,898 - 25,179,796 (+)	Ensembl		GRCm39 Ensembl
GRCm38	19	24,999,321 - 25,202,432 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	24,999,534 - 25,202,432 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	25,074,019 - 25,276,922 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	19	25,066,626 - 25,269,529 (+)	NCBI		MGSCv36	mm8
Celera	19	25,771,990 - 25,988,915 (+)	NCBI		Celera
Cytogenetic Map	19	B	NCBI
cM Map	19	19.91	NCBI

Dock8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	232,075,468 - 232,268,830 (+)	NCBI		GRCr8
mRatBN7.2	1	222,649,309 - 222,842,474 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	222,649,309 - 222,842,474 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	231,101,903 - 231,293,334 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	238,031,979 - 238,223,404 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	230,850,102 - 231,043,264 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	242,934,685 - 243,153,472 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	242,959,488 - 243,153,465 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	250,200,507 - 250,417,771 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	228,441,384 - 228,634,717 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	1	219,852,410 - 220,042,463 (+)	NCBI		Celera
Cytogenetic Map	1	q51	NCBI

Dock8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955434	4,867,016 - 5,049,118 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955434	4,849,147 - 5,050,545 (+)	NCBI	ChiLan1.0	ChiLan1.0

DOCK8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	124,121,179 - 124,370,714 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	124,127,121 - 124,376,660 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	6,791 - 256,837 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	201,156 - 446,910 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	201,156 - 446,910 (+)	Ensembl	panpan1.1		panPan2

DOCK8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	89,152,456 - 89,379,203 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	89,150,856 - 89,378,013 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	89,621,978 - 89,850,471 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	89,701,521 - 89,930,127 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	89,700,853 - 89,928,963 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	89,347,665 - 89,576,215 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	89,059,801 - 89,288,656 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	89,820,804 - 90,055,669 (+)	NCBI		UU_Cfam_GSD_1.0

DOCK8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	221,256,009 - 221,491,953 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	221,257,771 - 221,491,889 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	247,516,602 - 247,752,057 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DOCK8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	79,060,579 - 79,298,145 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	79,060,425 - 79,298,164 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	67,459,893 - 67,698,795 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dock8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624736	4,959,634 - 5,193,928 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624736	4,959,482 - 5,195,182 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.


RefSeq Transcripts	XM_021725637	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040283801	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000016417 ⟹ ENSSTOP00000014693

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936503	4,363,926 - 4,574,932 (-)	Ensembl

RefSeq Acc Id:

XM_040283801 ⟹ XP_040139735

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404947	136,597,710 - 136,810,653 (+)	NCBI


Protein RefSeqs	XP_040139735	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000014693.3
GenBank Protein	KAG3287138	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_040139735 ⟸ XM_040283801
- UniProtKB:	I3MRH5 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSSTOP00000014693 ⟸ ENSSTOT00000016417

Protein Domains

C2 DOCK-type DOCKER

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000016411	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000016417.3	UniProtKB/TrEMBL
Gene3D-CATH	1.20.58.740	UniProtKB/TrEMBL
	1.25.40.410	UniProtKB/TrEMBL
	2.60.40.150	UniProtKB/TrEMBL
InterPro	ARM-type_fold	UniProtKB/TrEMBL
	C2_Dock-C	UniProtKB/TrEMBL
	C2_DOCK-type_domain	UniProtKB/TrEMBL
	C2_DOCKER_dom	UniProtKB/TrEMBL
	C2_domain_sf	UniProtKB/TrEMBL
	DOCK	UniProtKB/TrEMBL
	DOCK_C/D_N	UniProtKB/TrEMBL
	DOCK_C_lobe_A	UniProtKB/TrEMBL
	DOCK_C_lobe_C	UniProtKB/TrEMBL
	DOCKER_Lobe_A	UniProtKB/TrEMBL
	DOCKER_Lobe_B	UniProtKB/TrEMBL
	DOCKER_Lobe_C	UniProtKB/TrEMBL
NCBI Gene	Dock8	ENTREZGENE
PANTHER	DEDICATOR OF CYTOKINESIS PROTEIN 8	UniProtKB/TrEMBL
	PTHR23317	UniProtKB/TrEMBL
Pfam	DHR-2	UniProtKB/TrEMBL
	DHR-2_Lobe_B	UniProtKB/TrEMBL
	DHR-2_Lobe_C	UniProtKB/TrEMBL
	DOCK-C2	UniProtKB/TrEMBL
	DUF3398	UniProtKB/TrEMBL
PROSITE	C2_DOCK	UniProtKB/TrEMBL
	DOCKER	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48371	UniProtKB/TrEMBL
UniProt	I3MRH5	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

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