Dock8 (dedicator of cytokinesis 8) - Rat Genome Database

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Gene: Dock8 (dedicator of cytokinesis 8) Ictidomys tridecemlineatus
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Symbol: Dock8
Name: dedicator of cytokinesis 8
RGD ID: 12735486
Description: ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (inferred); INVOLVED IN dendritic cell migration (ortholog); immunological synapse formation (ortholog); memory T cell proliferation (ortholog); ASSOCIATED WITH atopic dermatitis (ortholog); autosomal dominant intellectual developmental disorder 2 (ortholog); bacterial infectious disease (ortholog); FOUND IN cell leading edge (inferred); cytoplasm (inferred); cytosol (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: dedicator of cytokinesis protein 8
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947136,597,710 - 136,810,653 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365034,363,926 - 4,574,932 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365034,362,573 - 4,575,307 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Dock8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947136,597,710 - 136,810,653 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365034,363,926 - 4,574,932 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365034,362,573 - 4,575,307 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DOCK8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389211,257 - 465,255 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9214,854 - 465,259 (+)EnsemblGRCh38hg38GRCh38
GRCh379214,865 - 465,255 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369263,048 - 455,255 (+)NCBINCBI36Build 36hg18NCBI36
Celera9129,697 - 382,253 (+)NCBICelera
Cytogenetic Map9p24.3NCBI
HuRef9168,609 - 417,080 (+)NCBIHuRef
CHM1_19215,319 - 464,907 (+)NCBICHM1_1
T2T-CHM13v2.09208,892 - 464,924 (+)NCBIT2T-CHM13v2.0
Dock8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391924,976,753 - 25,179,796 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1924,976,898 - 25,179,796 (+)EnsemblGRCm39 Ensembl
GRCm381924,999,321 - 25,202,432 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1924,999,534 - 25,202,432 (+)EnsemblGRCm38mm10GRCm38
MGSCv371925,074,019 - 25,276,922 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361925,066,626 - 25,269,529 (+)NCBIMGSCv36mm8
Celera1925,771,990 - 25,988,915 (+)NCBICelera
Cytogenetic Map19BNCBI
cM Map1919.91NCBI
Dock8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81232,075,468 - 232,268,830 (+)NCBIGRCr8
mRatBN7.21222,649,309 - 222,842,474 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1222,649,309 - 222,842,474 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1231,101,903 - 231,293,334 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01238,031,979 - 238,223,404 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01230,850,102 - 231,043,264 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01242,934,685 - 243,153,472 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1242,959,488 - 243,153,465 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01250,200,507 - 250,417,771 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41228,441,384 - 228,634,717 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1219,852,410 - 220,042,463 (+)NCBICelera
Cytogenetic Map1q51NCBI
Dock8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554344,867,016 - 5,049,118 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554344,849,147 - 5,050,545 (+)NCBIChiLan1.0ChiLan1.0
DOCK8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v211124,121,179 - 124,370,714 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan19124,127,121 - 124,376,660 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v096,791 - 256,837 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19201,156 - 446,910 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9201,156 - 446,910 (+)Ensemblpanpan1.1panPan2
DOCK8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1189,152,456 - 89,379,203 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl189,150,856 - 89,378,013 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha189,621,978 - 89,850,471 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0189,701,521 - 89,930,127 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl189,700,853 - 89,928,963 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1189,347,665 - 89,576,215 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0189,059,801 - 89,288,656 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0189,820,804 - 90,055,669 (+)NCBIUU_Cfam_GSD_1.0
DOCK8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1221,256,009 - 221,491,953 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11221,257,771 - 221,491,889 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21247,516,602 - 247,752,057 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DOCK8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11279,060,579 - 79,298,145 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1279,060,425 - 79,298,164 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603867,459,893 - 67,698,795 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dock8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247364,959,634 - 5,193,928 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247364,959,482 - 5,195,182 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000016417   ⟹   ENSSTOP00000014693
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365034,363,926 - 4,574,932 (-)Ensembl
RefSeq Acc Id: XM_040283801   ⟹   XP_040139735
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947136,597,710 - 136,810,653 (+)NCBI
Protein Sequences
Protein RefSeqs XP_040139735 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000014693.3
GenBank Protein KAG3287138 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_040139735   ⟸   XM_040283801
- UniProtKB: I3MRH5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSSTOP00000014693   ⟸   ENSSTOT00000016417
Protein Domains
C2 DOCK-type   DOCKER


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000016411 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000016417.3 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.740 UniProtKB/TrEMBL
  1.25.40.410 UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/TrEMBL
  C2_Dock-C UniProtKB/TrEMBL
  C2_DOCK-type_domain UniProtKB/TrEMBL
  C2_DOCKER_dom UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  DOCK UniProtKB/TrEMBL
  DOCK_C/D_N UniProtKB/TrEMBL
  DOCK_C_lobe_A UniProtKB/TrEMBL
  DOCK_C_lobe_C UniProtKB/TrEMBL
  DOCKER_Lobe_A UniProtKB/TrEMBL
  DOCKER_Lobe_B UniProtKB/TrEMBL
  DOCKER_Lobe_C UniProtKB/TrEMBL
NCBI Gene Dock8 ENTREZGENE
PANTHER DEDICATOR OF CYTOKINESIS PROTEIN 8 UniProtKB/TrEMBL
  PTHR23317 UniProtKB/TrEMBL
Pfam DHR-2 UniProtKB/TrEMBL
  DHR-2_Lobe_B UniProtKB/TrEMBL
  DHR-2_Lobe_C UniProtKB/TrEMBL
  DOCK-C2 UniProtKB/TrEMBL
  DUF3398 UniProtKB/TrEMBL
PROSITE C2_DOCK UniProtKB/TrEMBL
  DOCKER UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/TrEMBL
UniProt I3MRH5 ENTREZGENE, UniProtKB/TrEMBL