Cmpk2 (cytidine/uridine monophosphate kinase 2)

Gene: Cmpk2 (cytidine/uridine monophosphate kinase 2) Ictidomys tridecemlineatus

Analyze

Symbol:

Cmpk2

Name:

cytidine/uridine monophosphate kinase 2

RGD ID:

12731233

Description:

ENCODES a protein that exhibits thymidylate kinase activity (ortholog); UMP/dUMP kinase activity (ortholog); INVOLVED IN cellular response to lipopolysaccharide (ortholog); dTDP biosynthetic process (ortholog); dUDP biosynthetic process (ortholog); PARTICIPATES IN beta-ureidopropionase deficiency pathway; de novo pyrimidine biosynthetic pathway; dihydropyrimidinase deficiency pathway; ASSOCIATED WITH multiple sclerosis (ortholog); FOUND IN cytoplasm (inferred); mitochondrion (inferred); nucleoplasm (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

UMP-CMP kinase 2, mitochondrial

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	49,140,895 - 49,153,365 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936532	3,895,755 - 3,908,367 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936532	3,896,654 - 3,908,184 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

multiple sclerosis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to lipopolysaccharide (IEA,ISO)

dTDP biosynthetic process (IEA,ISO)

dTTP biosynthetic process (IEA)

dUDP biosynthetic process (IEA,ISO)

nucleoside monophosphate phosphorylation (IEA)

Cellular Component

cytoplasm (IEA)

mitochondrion (IEA)

nucleoplasm (IEA)

Molecular Function

(d)CMP kinase activity (IEA)

nucleoside diphosphate kinase activity (IEA)

nucleoside monophosphate kinase activity (IEA)

thymidylate kinase activity (IEA,ISO)

UMP kinase activity (IEA)

UMP/dUMP kinase activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

beta-ureidopropionase deficiency pathway (ISO)

de novo pyrimidine biosynthetic pathway (ISO)

dihydropyrimidinase deficiency pathway (ISO)

mitochondrial neurogastrointestinal encephalopathy syndrome pathway (ISO)

orotic aciduria 1 pathway (ISO)

pyrimidine metabolic pathway (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Cmpk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	49,140,895 - 49,153,365 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936532	3,895,755 - 3,908,367 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936532	3,896,654 - 3,908,184 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CMPK2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	6,840,553 - 6,866,635 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	6,840,570 - 6,866,635 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	6,980,684 - 7,006,766 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	6,905,902 - 6,923,387 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	2	6,901,418 - 6,918,887 (-)	NCBI		Celera
Cytogenetic Map	2	p25.2	NCBI
HuRef	2	6,827,170 - 6,854,378 (-)	NCBI		HuRef
CHM1_1	2	6,910,237 - 6,936,319 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	6,862,071 - 6,888,137 (-)	NCBI		T2T-CHM13v2.0

Cmpk2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	26,519,121 - 26,529,836 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	26,519,203 - 26,529,836 (+)	Ensembl		GRCm39 Ensembl
GRCm38	12	26,469,117 - 26,479,837 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	26,469,204 - 26,479,837 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	27,154,080 - 27,164,702 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	12	27,055,650 - 27,066,102 (+)	NCBI		MGSCv36	mm8
Celera	12	27,927,424 - 27,938,075 (+)	NCBI		Celera
Cytogenetic Map	12	A2	NCBI
cM Map	12	9.69	NCBI

Cmpk2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	48,802,150 - 48,813,652 (+)	NCBI		GRCr8
mRatBN7.2	6	43,073,706 - 43,085,183 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	43,073,796 - 43,085,183 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	43,386,944 - 43,397,752 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	43,701,813 - 43,712,621 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	43,134,950 - 43,145,758 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	45,683,242 - 45,694,824 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	45,683,234 - 45,694,822 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	54,403,014 - 54,414,586 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	44,128,544 - 44,139,346 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	44,131,662 - 44,142,474 (+)	NCBI
Celera	6	42,340,630 - 42,351,433 (+)	NCBI		Celera
Cytogenetic Map	6	q16	NCBI

Cmpk2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955487	2,010,228 - 2,029,175 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955487	2,010,126 - 2,024,804 (+)	NCBI	ChiLan1.0	ChiLan1.0

CMPK2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	119,646,173 - 119,663,765 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	119,650,157 - 119,667,740 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	6,856,242 - 6,874,567 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	6,985,922 - 7,013,703 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

CMPK2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	4,466,615 - 4,478,546 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	4,392,411 - 4,405,578 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	4,569,103 - 4,582,289 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	4,569,983 - 4,582,289 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	4,456,522 - 4,469,702 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	4,465,166 - 4,478,340 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	4,478,967 - 4,492,134 (-)	NCBI		UU_Cfam_GSD_1.0

CMPK2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	128,903,616 - 128,917,871 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	128,903,395 - 128,917,873 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	137,688,692 - 137,704,129 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CMPK2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	100,804,295 - 100,820,565 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	100,804,400 - 100,819,027 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	11,521,315 - 11,537,626 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cmpk2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624846	3,417,626 - 3,430,516 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624846	3,417,672 - 3,432,207 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005327342	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010001352	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000028426 ⟹ ENSSTOP00000015012

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936532	3,895,755 - 3,908,367 (-)	Ensembl

RefSeq Acc Id:

XM_005327342 ⟹ XP_005327399

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024406292	49,140,895 - 49,153,365 (-)	NCBI
SpeTri2.0	NW_004936532	3,896,654 - 3,908,184 (-)	NCBI

Sequence:

show sequence

TGGCCTTTGCCGGGCGCCCGCGCGCCGCACTGCTGCTCTGGCGGCTCTCAGGGCGGCTGCGCGC
CTGGCGCGGGCTCTGCGCTCTGGCCATGGCTCGGCCGCGCTGCTTCGCTCTGGAGCTGAGGGAC
TGCACTTTAGCTCACTTCGCTCTGGGCGCGGAGGGCTCCCATGCACGCCCTGACCCCCGCCTGG
CTGAGCTGCTGGGGCCTCCAGGGCGCAGCTACTCGCTGTGCGTGCCGGCGGCCGCGGATGGCGA
CTGCGGGGCCCGAGTCCAAGCGGCTCGGGTGCATCAGAACCTGCAGCGCCAGCTGCGCAGTGAC
CCCTTCCAGCGGTGCCAGCTGCACAGGCTGCTCTGCTACTGCCCAGGCAGCCAGGCCCAAGGCA
TGCAGCACGGCTTCCTGCTGCGCGACCCCTGTGACTGCCTGGACACCCGGCGCGCTCTGCTAGA
ACTGCTGGGCAGATTCCAGGAGGCTGAGCGTCCGCACCTGGGGGAGTTTGAGGCCGACTCACAA
GGTGTACTGTGGCAGCGAGTCTGGGTACTGCAGGAGAGTGGGCAGCTGCAGGTGGGCTGCGCAC
GTGTCCTACCCACCTTGGAGCCCCCGCTGCATCCAGTGGTGCCCCACCTCCTCAGCTCGGTGGT
CTTCCGGGACCTGGACACTGCCAGAGCTATTTTAGAGACGTGTATGTCCTCTATTCCGGAAGCC
CGGGCAGTTCTTGACGTGGTTGACAAGTGCCCAAGGCAGGTCCAAAGAGGAAAGTTCCCAGTCA
TTGCCATCGAAGGACTGGATGCCACTGGTAAGACCACGGTGACCCAGGCAGTCTCCAAGTCTCT
CAAGGCTGCCCTCTTATACTCACCACCCTCTTGCATTGGCCAATGGAGGAAAACCTTTGATGAT
GAACCAACTATTATTAAAAGAGCATTTTACTCTTTGGGCAATTACATTGTGGCTTCTGAAATAG
CTAAGGCATCTGCCGAGTCTCCTGTGATTGTAGACAGGTTCTGGCACAGCACAGCCACCTATGG
CATAGCCACTGAGTTGAGTGGGGGTCTGCAGCACCTGCCTCCTGCCCACCACCCCGTATACCAG
TGGCCAGGGGACCTGCTCAAGCCTGACCTCGTCCTGCTGCTCACCATGAGTCCTGAGGAGAGGG
CACAGAGGCTGCGGGACCGGGGCCTGGAGCAGACCAGAGAAGAGGCTGAACTTGAGGCCAACAG
CGTATTTCGTCAGAAGGTGGAGCTGTCCTACCGACGGATGGAGAATCCCGGCTGCCTCGAGGTT
GACGCCAGCCCCTCGAGAGAGAAGGTCCTGCAGACCGTTTTGGGCCTGATCCGAAACACTTTTC
AGGACTTGTAGGTCTCTGGCCAGGTGCCCCGTCTCAGCAGAGTGGGTGTCGGCTTGGTAGATCC
ACGTTGCCCAGGTGTATTGTGTGACAGAAAACGGGAGACTGGGCATTTTATTTGACTCCAGCCA
TTTATTTGCCTGAAGGCCCTGGCAAGCTTGTGCCTGGTGGGGCTCCACAGGGACTGGCGATTTC
CTTCTGCCCAGTATGTGGACAATCTCCTCAGAACATGTTTTCAGCTCTGTCACTGTCAGACTTC
TCCAAGAAGGATCTCATCCAGAACTTATCAGGTGTACAGAAGCCACCAGGAAGCTCTCCGCAGC
AGCAGACAGCCCAGCAGCCCCTTCCGATGAACACCTGCATCCCTACAACATCGCCCGTCAGGAC
TTCCAGACCTGGAGGCACCACATCTGCGTCAGCCATGCATTTCCACACAACACACCTGTTCACG
GCCACCTCTACAGAGCTGTTTGTGCTGGGGGACATTCGCAGAGCAGGCAGCAACCTTGTGCCTG
AGGCTCCGAGCCCCTTGGATAGAACCCTGGGTTCCTCGCGCTCAGAGTTGAACAGGAAGATGAT
CAGCCAAGCTGCTCTCGCTGCAGACACTCCAGCCTTCTGTGCGTTCCTTGTTTCCATCCCCTTC
CCTTCCTTTGAAATATGGCTCTGAATGTAATGAGCAGTCTGCAAGGAGCTGGTTGCCTTTCACT
TAGCCAATCCAGCAATTTATTTATATTGATGTTTACATTATGTGTTTCCTCAGTGTAGGAGCTA
TGAGTCACTAATTAAAATTGAAGTCAAGAAG

hide sequence

Protein Sequences


Protein RefSeqs	XP_005327399	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000015012.1
GenBank Protein	KAG3267533	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005327399 ⟸ XM_005327342

- UniProtKB:

I3MSB7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MARPRCFALELRDCTLAHFALGAEGSHARPDPRLAELLGPPGRSYSLCVPAAADGDCGARVQAA
RVHQNLQRQLRSDPFQRCQLHRLLCYCPGSQAQGMQHGFLLRDPCDCLDTRRALLELLGRFQEA
ERPHLGEFEADSQGVLWQRVWVLQESGQLQVGCARVLPTLEPPLHPVVPHLLSSVVFRDLDTAR
AILETCMSSIPEARAVLDVVDKCPRQVQRGKFPVIAIEGLDATGKTTVTQAVSKSLKAALLYSP
PSCIGQWRKTFDDEPTIIKRAFYSLGNYIVASEIAKASAESPVIVDRFWHSTATYGIATELSGG
LQHLPPAHHPVYQWPGDLLKPDLVLLLTMSPEERAQRLRDRGLEQTREEAELEANSVFRQKVEL
SYRRMENPGCLEVDASPSREKVLQTVLGLIRNTFQDL

hide sequence

Ensembl Acc Id:

ENSSTOP00000015012 ⟸ ENSSTOT00000028426

Protein Domains

Thymidylate kinase-like

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000019402	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000028426.2	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.300	UniProtKB/TrEMBL
InterPro	P-loop_NTPase	UniProtKB/TrEMBL
	Thymidylate_kin-like_dom	UniProtKB/TrEMBL
	UMP-CMP_kinase_2	UniProtKB/TrEMBL
NCBI Gene	Cmpk2	ENTREZGENE
PANTHER	THYMIDYLATE KINASE	UniProtKB/TrEMBL
	UMP-CMP KINASE 2, MITOCHONDRIAL	UniProtKB/TrEMBL
Pfam	Thymidylate_kin	UniProtKB/TrEMBL
PIRSF	dTMP_TKRP1	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52540	UniProtKB/TrEMBL
UniProt	I3MSB7	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

RGD Manual Annotations

Imported Annotations - SMPDB

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RGD Manual Annotations

Imported Annotations - SMPDB