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Gene: Brf2 (BRF2 general transcription factor IIIB subunit) Ictidomys tridecemlineatus

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Symbol:

Brf2

Name:

BRF2 general transcription factor IIIB subunit (Ensembl:BRF2 RNA polymerase III transcription initiation factor subunit)

RGD ID:

12727687

Description:

ENCODES a protein that exhibits RNA polymerase III type 3 promoter sequence-specific DNA binding (inferred); TBP-class protein binding (inferred); zinc ion binding (inferred); INVOLVED IN cellular response to oxidative stress (inferred); DNA-templated transcription initiation (inferred); regulation of transcription by RNA polymerase III (inferred); PARTICIPATES IN RNA polymerase III transcription pathway; ASSOCIATED WITH hereditary spastic paraplegia 54 (ortholog); hypogonadotropic hypogonadism 2 with or without anosmia (ortholog); paraplegia (ortholog); FOUND IN nucleus (inferred); transcription factor TFIIIB complex (inferred); transcription preinitiation complex (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

BRF2 RNA polymerase III transcription initiation factor subunit; BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit; BRF2, RNA polymerase III transcription initiation factor subunit; transcription factor IIIB 50 kDa subunit

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404943	50,160,010 - 50,164,914 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936710	1,293,129 - 1,301,048 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936710	1,296,475 - 1,301,752 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

hereditary spastic paraplegia 54 (ISO)

hypogonadotropic hypogonadism 2 with or without anosmia (ISO)

paraplegia (ISO)

prostate cancer (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to oxidative stress (IEA)

DNA-templated transcription initiation (IEA)

regulation of transcription by RNA polymerase III (IEA)

transcription preinitiation complex assembly (IEA)

Cellular Component

nucleus (IEA)

transcription factor TFIIIB complex (IEA)

transcription preinitiation complex (IEA)

Molecular Function

protein binding (ISO)

RNA polymerase III type 3 promoter sequence-specific DNA binding (IEA)

TBP-class protein binding (IEA)

zinc ion binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

RNA polymerase III transcription pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Brf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404943	50,160,010 - 50,164,914 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936710	1,293,129 - 1,301,048 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936710	1,296,475 - 1,301,752 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

BRF2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	37,843,268 - 37,849,861 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	37,843,268 - 37,849,861 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	37,700,786 - 37,707,379 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	37,820,558 - 37,826,569 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	37,820,562 - 37,826,569	NCBI
Celera	8	36,652,978 - 36,659,011 (-)	NCBI		Celera
Cytogenetic Map	8	p11.23	NCBI
HuRef	8	36,235,927 - 36,241,960 (-)	NCBI		HuRef
CHM1_1	8	37,902,845 - 37,908,878 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	8	38,119,669 - 38,126,265 (-)	NCBI		T2T-CHM13v2.0

Brf2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	27,613,367 - 27,618,743 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	27,613,392 - 27,618,708 (-)	Ensembl		GRCm39 Ensembl
GRCm38	8	27,123,339 - 27,128,715 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	27,123,364 - 27,128,680 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	28,234,304 - 28,239,104 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	28,589,768 - 28,594,568 (-)	NCBI		MGSCv36	mm8
Celera	8	28,613,490 - 28,618,293 (-)	NCBI		Celera
Cytogenetic Map	8	A2	NCBI
cM Map	8	15.91	NCBI

Brf2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	71,626,146 - 71,635,909 (+)	NCBI		GRCr8
mRatBN7.2	16	64,928,334 - 64,933,057 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	64,928,300 - 64,933,059 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	70,211,909 - 70,216,635 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	73,618,242 - 73,622,968 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	68,863,717 - 68,868,440 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	69,089,955 - 69,094,678 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	69,089,955 - 69,094,680 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	68,763,911 - 68,768,633 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	69,250,416 - 69,255,138 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	69,250,621 - 69,255,340 (+)	NCBI
Celera	16	62,847,875 - 62,852,598 (+)	NCBI		Celera
Cytogenetic Map	16	q12.3	NCBI

Brf2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955463	13,547,071 - 13,554,277 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955463	13,549,571 - 13,553,946 (-)	NCBI	ChiLan1.0	ChiLan1.0

BRF2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	56,404,884 - 56,410,953 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	32,122,595 - 32,128,045 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	37,144,341 - 37,150,371 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	34,321,741 - 34,327,625 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	34,321,746 - 34,327,622 (-)	Ensembl	panpan1.1		panPan2

BRF2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	16	27,543,588 - 27,547,712 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	16	27,543,858 - 27,547,106 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	16	28,060,505 - 28,064,459 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	16	29,442,854 - 29,446,808 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	16	29,442,903 - 29,446,805 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	16	27,664,474 - 27,668,427 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	16	28,242,034 - 28,245,988 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	16	28,281,218 - 28,285,171 (+)	NCBI		UU_Cfam_GSD_1.0

BRF2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	48,568,202 - 48,573,029 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	48,568,207 - 48,573,036 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	55,684,661 - 55,689,474 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

BRF2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	35,879,762 - 35,885,572 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	35,880,373 - 35,885,485 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666052	6,118,831 - 6,124,752 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Brf2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624780	5,751,435 - 5,757,447 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624780	5,752,018 - 5,757,323 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005338378	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000029611 ⟹ ENSSTOP00000021628

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936710	1,293,129 - 1,301,048 (-)	Ensembl

RefSeq Acc Id:

XM_005338378 ⟹ XP_005338435

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404943	50,160,010 - 50,164,914 (+)	NCBI
SpeTri2.0	NW_004936710	1,296,475 - 1,301,752 (-)	NCBI

Sequence:

show sequence

CCCCAGCCCCCATTAATCCATTTTTTTAATACTACTTTTTAATGTGAAAAGTAAGAACAAAAGG
AATAGAAGATAAACCAGAAACTAATGAAAAGTATTACCTCTGGAGGTTAATCCATTCTTAAGGG
CAGAGCTCTCATGATCTAAACAACTTCCCAAGACCCCACCTTATAACATGTTACATTGGGGATT
AACACATGAATTTTAGGGGACACATTCAGATCATTGCACATTTCTACGTGTTGGTTTGAGATGG
GCCTTCTTGCACCTTCCAATTTGCCAAAAGCCTCACTACTGCCTATTATTTCACTCCAAAGTCC
GTTAGACATTCTTTGCAATTTGCCTGGGGAAGCAGCTCTGAAAAAGAGAATAAAATTTCCTGCT
CTCTCACTACATTACTCTTGTAGCAACATACTTTGCACTCGGGCCAAAATTAACATTCGAAGAG
AAATGAAGAACCTGCGATTCCCAGTGCTTTAAAAACAGGGTGGTTCAGGAGTGGCAACAATTTC
TAGTCTGTTATACGTGTCCATGTACGTAGAAAGTTTCCCCAATTCAAACCCCACATGGCCCATC
TCAAACCAACTACAGAGAGCAGAGAATGTGAGTCGCAGTTCAGACCGGGAACCTCTTCTCTGAA
CTCATGTTTCTAACGGAGCCTGAAGAGGAGAAGACCGGAAGTGGCGCGCCGCCGTGGGGAGGAG
CCAACCATTTATGCCGCCGTCGCTCTGGACGGAAAAGAAAAGTGCAGCCCTTATAAGGGTCCCC
TCCTACTCTGATAACACAGTTGCTGTTGCGGACGGGGAAGGGAGTATCCAAGGCTTCAGCGACG
TTGCGCAGGTGGTGAGATGCCGGGCGGAGGCCGATGCCCCGACTGTGGTTCTACTGAACTCGTG
GAAGACTCTCACTATTCGCAGAGCCAGTTGGTTTGCTCTGATTGCGGCTGCGTGGTCACCGAGG
GGGTACTTACCACCACCTTCACCGATGAGGGCAACCTCCGAGAAGTAACATATTCTCGAAGCAC
AGGGGAAAGTGAACAAGTTAGTCGCAGCCAGCAAAGAGGTCTCCGCCGGGTGAGAGACCTTTGT
CGAGTTCTGCAGTTGCCACCAACGTTTGAGGATACAGCAATTGCTTACTACCAACAGGCATATC
GGCACTCTGGCATCCGAGCTGCTAGGCTGCAGAAGAAGGAGGTGTTGGTTGGATGCTGTGTTTT
AATCACCTGCCGGCAGCATAATTGGCCCCTAACCATGGGAACCATCTGTGCCCTATTGTATGCA
GATCTGGATGTGTTTTCTGGCACTTACATGCAGATAGTGAAGCTCCTGGGGCTGGACGTGCCAT
CCTTGTGCCTGGCAGATTTGGTGAAGACTTATTGTAGCAGCTTCAAACTCTTTCAAGTCTCCGC
ATCAGTGCCAGCCAAATACGTGGAAGACAAAGATAAGATGCTGTCTCGAACCTTGCAACTGGTA
GAACTGGCAAATGAGACGTGGCTGGTGACTGGGCGGCATCCCTTGCCTGTCATCACTGCAGCTA
CTTTCCTGGCGTGGCAGTCTCTGCAGCCTTCAGATCGTCTGACATGTTCCCTTGCCCGATTTTG
TAAATTGGCAAACGTGGACCTCCCGTACCCTGCTGCATCTCGCTTGCAGGAGCTGCTGGCTGTG
TTGCTGCGGATGGCTGACCAACTGGCATGGTTGCAGGTTCTGAAACTTGACAAGCGGTCTGTAG
TGAAGTACATTGGTGACCTTCTTCAGCACCGTCACATGCTGATCCGCATGGCCTTTCGGGATGG
AACAGCAGAAACGGAGGAGGAGAAGGAGCAGCAGGGGCAAGGGCAGGAGCAAAACCATGGAGAA
GAGGAGGTGGGGGATAGCTCCTTAGATCTGCGCAAGGGGAAAAGGCCAGCTAGTCCTGCCCTTC
TTCTCCCACCCTGCATGTTAAAGCCTCCAAAGCGGATCTGTCCGGTACTCCCTGTATCCACAGT
TACTGGAGATGAGAACATCTCTGATAGTGAAATAGAGCAGTATTTGCGTACCCCTCAGGAGGTT
AGGGACTTTGAGAGAGCCCAAGCTGCTAGCCAAGCTTCCACAAGTGTCCCTAATCCTCCTTGAT
GCACAGCCACTGGAGGTACCTTACTTCCTGACAGCAACTGGATAATAGGCCTGTCAAATTCAAG
GAAATGGGTATATACAAGCCCTTGGATATTGTCTTGTGTAAAGGGATCAAGAGTGGTACTACAG
TTAGTTGGACTGGAAGTCCTGGAGTAGAAGCTGGGAGGAGTGACTACAAGTGGAAAAGAGTCTC
CCTTGGTGCAGATCAAGTTGCATGTGTTCACATTCTGTGGGATGTGAACTGGCTTCCTCCTGAT
GTGGAAATGCCAGCCTCTTTTGCATTAAACACATCGATAGTTTTGCAGGCCTAGTATGGCTGCC
TTAGTGGCACTTCTGTGGGGTGGCTGGTACTGTCAGTACTATCCAGCCTCAAGAGCAATAACTG
GAGAATTCTTTGCCCCATATCCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005338435	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000021628.1
GenBank Protein	KAG3294828	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005338435 ⟸ XM_005338378

- UniProtKB:

I3NB81 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPGGGRCPDCGSTELVEDSHYSQSQLVCSDCGCVVTEGVLTTTFTDEGNLREVTYSRSTGESEQ
VSRSQQRGLRRVRDLCRVLQLPPTFEDTAIAYYQQAYRHSGIRAARLQKKEVLVGCCVLITCRQ
HNWPLTMGTICALLYADLDVFSGTYMQIVKLLGLDVPSLCLADLVKTYCSSFKLFQVSASVPAK
YVEDKDKMLSRTLQLVELANETWLVTGRHPLPVITAATFLAWQSLQPSDRLTCSLARFCKLANV
DLPYPAASRLQELLAVLLRMADQLAWLQVLKLDKRSVVKYIGDLLQHRHMLIRMAFRDGTAETE
EEKEQQGQGQEQNHGEEEVGDSSLDLRKGKRPASPALLLPPCMLKPPKRICPVLPVSTVTGDEN
ISDSEIEQYLRTPQEVRDFERAQAASQASTSVPNPP

hide sequence

Ensembl Acc Id:

ENSSTOP00000021628 ⟸ ENSSTOT00000029611

Protein Domains

TFIIB-type

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000027742	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000029611.2	UniProtKB/TrEMBL
Gene3D-CATH	2.20.25.10	UniProtKB/TrEMBL
	Cyclin-like	UniProtKB/TrEMBL
InterPro	BRF2-like_C	UniProtKB/TrEMBL
	Cyclin-like_sf	UniProtKB/TrEMBL
	TFIIB	UniProtKB/TrEMBL
	TFIIB_cyclin	UniProtKB/TrEMBL
	Znf_TFIIB	UniProtKB/TrEMBL
NCBI Gene	Brf2	ENTREZGENE
PANTHER	PTHR11618	UniProtKB/TrEMBL
	TRANSCRIPTION FACTOR IIIB 50 KDA SUBUNIT	UniProtKB/TrEMBL
Pfam	BRF2-like_C_cyclin_rpt	UniProtKB/TrEMBL
	TF_Zn_Ribbon	UniProtKB/TrEMBL
	TFIIB	UniProtKB/TrEMBL
PROSITE	ZF_TFIIB	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47954	UniProtKB/TrEMBL
	Zinc beta-ribbon	UniProtKB/TrEMBL
UniProt	I3NB81	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2024-10-01	Brf2	BRF2 general transcription factor IIIB subunit	Brf2	BRF2 RNA polymerase III transcription initiation factor subunit	Symbol and/or name change	5135510	APPROVED
2019-01-29	Brf2	BRF2 RNA polymerase III transcription initiation factor subunit		BRF2, RNA polymerase III transcription initiation factor subunit	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

RGD Manual Annotations