Gpx4 (glutathione peroxidase 4) - Rat Genome Database

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Gene: Gpx4 (glutathione peroxidase 4) Ictidomys tridecemlineatus
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Symbol: Gpx4
Name: glutathione peroxidase 4
RGD ID: 12724977
Description: ENCODES a protein that exhibits phospholipid-hydroperoxide glutathione peroxidase activity (ortholog); selenium binding (ortholog); INVOLVED IN apoptotic process (ortholog); cerebellum development (ortholog); chromatin organization (ortholog); ASSOCIATED WITH Acute Coronary Syndrome (ortholog); acute kidney failure (ortholog); Binge Drinking (ortholog); FOUND IN cytosol (ortholog); mitochondrion (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: phospholipid hydroperoxide glutathione peroxidase; phospholipid hydroperoxide glutathione peroxidase, mitochondrial; uncharacterized protein Gpx4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118217,324,770 - 217,328,696 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936588506,147 - 508,101 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936588506,101 - 508,469 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Gpx4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118217,324,770 - 217,328,696 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936588506,147 - 508,101 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936588506,101 - 508,469 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPX4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38191,103,994 - 1,106,779 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl191,103,982 - 1,106,791 (+)EnsemblGRCh38hg38GRCh38
GRCh37191,103,993 - 1,106,778 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36191,054,936 - 1,057,787 (+)NCBINCBI36Build 36hg18NCBI36
Build 34191,054,965 - 1,057,778NCBI
Celera191,036,910 - 1,039,761 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef19877,428 - 880,271 (+)NCBIHuRef
CHM1_1191,103,529 - 1,106,380 (+)NCBICHM1_1
T2T-CHM13v2.0191,068,660 - 1,071,445 (+)NCBIT2T-CHM13v2.0
Gpx4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,883,000 - 79,892,273 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1079,883,000 - 79,892,273 (+)EnsemblGRCm39 Ensembl
GRCm381080,047,166 - 80,056,439 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1080,047,166 - 80,056,439 (+)EnsemblGRCm38mm10GRCm38
MGSCv371079,516,255 - 79,519,184 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361079,456,617 - 79,459,567 (+)NCBIMGSCv36mm8
Celera1081,068,319 - 81,071,248 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Gpx4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,300,833 - 10,303,629 (-)NCBIGRCr8
mRatBN7.279,650,186 - 9,652,982 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,650,185 - 9,652,982 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,533,042 - 12,535,860 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,408,380 - 14,411,198 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,269,509 - 12,272,287 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,516,357 - 12,519,154 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,516,352 - 12,519,154 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,686,460 - 12,689,257 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,162,521 - 11,165,318 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1711,162,520 - 11,165,318 (-)NCBI
Celera77,826,041 - 7,828,838 (-)NCBICelera
Cytogenetic Map7q11NCBI
Gpx4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554956,767,975 - 6,772,178 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554956,767,969 - 6,772,256 (-)NCBIChiLan1.0ChiLan1.0
GPX4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2205,439,232 - 5,443,396 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,675,807 - 4,679,965 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01920,904 - 23,828 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1191,082,917 - 1,085,538 (+)NCBIpanpan1.1PanPan1.1panPan2
GPX4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha2057,443,525 - 57,445,796 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02058,383,449 - 58,385,704 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2058,383,450 - 58,385,689 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12057,438,781 - 57,441,040 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02057,918,275 - 57,920,554 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02058,121,304 - 58,123,564 (-)NCBIUU_Cfam_GSD_1.0
GPX4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,320,464 - 77,323,931 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1277,321,568 - 77,323,931 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2277,673,720 - 77,676,083 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GPX4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.16873,867 - 876,225 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660817,991,488 - 7,994,293 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpx4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248287,534,449 - 7,536,586 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248287,534,251 - 7,536,675 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000033817   ⟹   ENSSTOP00000029357
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936588506,147 - 508,101 (+)Ensembl
RefSeq Acc Id: XM_005331957   ⟹   XP_005332014
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118217,326,473 - 217,328,693 (-)NCBI
SpeTri2.0NW_004936588506,102 - 508,310 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021730818   ⟹   XP_021586493
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118217,324,770 - 217,328,696 (-)NCBI
SpeTri2.0NW_004936588506,101 - 508,469 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005332014 (Get FASTA)   NCBI Sequence Viewer  
  XP_021586493 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000029357.1
RefSeq Acc Id: XP_005332014   ⟸   XM_005331957
- Peptide Label: isoform X1
- UniProtKB: A0A287D705 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021586493   ⟸   XM_021730818
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSSTOP00000029357   ⟸   ENSSTOT00000033817


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000032740 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000033817.1 UniProtKB/TrEMBL
Gene3D-CATH Glutaredoxin UniProtKB/TrEMBL
InterPro Glutathione_peroxidase UniProtKB/TrEMBL
  GPX_CS UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/TrEMBL
NCBI Gene Gpx4 ENTREZGENE
PANTHER PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE UniProtKB/TrEMBL
  PTHR11592 UniProtKB/TrEMBL
Pfam GSHPx UniProtKB/TrEMBL
PIRSF Glutathion_perox UniProtKB/TrEMBL
PRINTS GLUTPROXDASE UniProtKB/TrEMBL
PROSITE GLUTATHIONE_PEROXID_2 UniProtKB/TrEMBL
  GLUTATHIONE_PEROXID_3 UniProtKB/TrEMBL
Superfamily-SCOP SSF52833 UniProtKB/TrEMBL
UniProt A0A287D705 ENTREZGENE, UniProtKB/TrEMBL