GPX4 (glutathione peroxidase 4) - Rat Genome Database
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Gene: GPX4 (glutathione peroxidase 4) Sus scrofa
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Symbol: GPX4
Name: glutathione peroxidase 4
RGD ID: 13921981
Description: ENCODES a protein that exhibits phospholipid-hydroperoxide glutathione peroxidase activity; identical protein binding (ortholog); selenium binding (ortholog); INVOLVED IN response to oxidative stress; aging (ortholog); arachidonic acid metabolic process (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); Cadmium Poisoning (ortholog); cerebral creatine deficiency syndrome (ortholog); FOUND IN cytosol (ortholog); protein-containing complex (ortholog); INTERACTS WITH deoxynivalenol; disodium selenite; malathion
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: glutathione peroxidase 4 (phospholipid hydroperoxidase); GPx-4; GSHPx-4; PHGPx; phospholipid hydroperoxide glutathione peroxidase; Phospholipid hydroperoxide glutathione peroxidase, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,320,464 - 77,323,886 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1277,321,568 - 77,323,931 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2277,673,720 - 77,676,083 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:1778506   PMID:2386798   PMID:8125951   PMID:8135530   PMID:8323565   PMID:14681463   PMID:17145712  


Genomics

Comparative Map Data
GPX4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,320,464 - 77,323,886 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1277,321,568 - 77,323,931 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2277,673,720 - 77,676,083 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GPX4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl191,103,926 - 1,106,791 (+)EnsemblGRCh38hg38GRCh38
GRCh38191,103,994 - 1,106,779 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37191,103,936 - 1,106,787 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36191,054,936 - 1,057,787 (+)NCBINCBI36hg18NCBI36
Build 34191,054,965 - 1,057,778NCBI
Celera191,036,910 - 1,039,761 (+)NCBI
Cytogenetic Map19p13.3NCBI
HuRef19877,428 - 880,271 (+)NCBIHuRef
CHM1_1191,103,518 - 1,106,381 (+)NCBICHM1_1
Gpx4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,883,000 - 79,892,273 (+)NCBIGRCm39mm39
GRCm381080,047,166 - 80,056,439 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1080,047,166 - 80,056,439 (+)EnsemblGRCm38mm10GRCm38
MGSCv371079,516,255 - 79,519,184 (+)NCBIGRCm37mm9NCBIm37
MGSCv361079,456,617 - 79,459,567 (+)NCBImm8
Celera1081,068,319 - 81,071,248 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Gpx4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0712,516,357 - 12,519,154 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,516,352 - 12,519,154 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,686,460 - 12,689,257 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,162,521 - 11,165,318 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1711,162,520 - 11,165,318 (-)NCBI
Celera77,826,041 - 7,828,838 (-)NCBICelera
Cytogenetic Map7q11NCBI
Gpx4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554956,767,975 - 6,772,178 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554956,767,969 - 6,772,256 (-)NCBIChiLan1.0ChiLan1.0
GPX4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1191,082,917 - 1,085,538 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01920,904 - 23,828 (-)NCBIMhudiblu_PPA_v0panPan3
GPX4
(Canis lupus familiaris - dog)
No map positions available.
Gpx4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936588506,101 - 508,469 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPX4
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.16873,867 - 876,225 (+)NCBI
Gpx4
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248287,534,251 - 7,536,675 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000051893   ⟹   ENSSSCP00000046912
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl277,320,464 - 77,323,886 (-)Ensembl
RefSeq Acc Id: NM_214407   ⟹   NP_999572
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1277,321,568 - 77,323,931 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_999572   ⟸   NM_214407
- Peptide Label: precursor
- UniProtKB: P36968 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSSSCP00000046912   ⟸   ENSSSCT00000051893


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000024052 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCG00030015859 UniProtKB/Swiss-Prot
  ENSSSCG00040056197 UniProtKB/Swiss-Prot
  ENSSSCG00045035370 UniProtKB/Swiss-Prot
  ENSSSCG00050062797 UniProtKB/Swiss-Prot
  ENSSSCG00060017858 UniProtKB/Swiss-Prot
  ENSSSCG00070026740 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000046912 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCP00030009935 UniProtKB/Swiss-Prot
  ENSSSCP00040032715 UniProtKB/Swiss-Prot
  ENSSSCP00045042685 UniProtKB/Swiss-Prot
  ENSSSCP00050036727 UniProtKB/Swiss-Prot
  ENSSSCP00060010026 UniProtKB/Swiss-Prot
  ENSSSCP00070045473 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000051893 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCT00030021984 UniProtKB/Swiss-Prot
  ENSSSCT00040076156 UniProtKB/Swiss-Prot
  ENSSSCT00045060762 UniProtKB/Swiss-Prot
  ENSSSCT00050085532 UniProtKB/Swiss-Prot
  ENSSSCT00060023935 UniProtKB/Swiss-Prot
  ENSSSCT00070053641 UniProtKB/TrEMBL
Gene3D-CATH 3.40.30.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Glutathione_peroxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPX_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPX_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:399537 UniProtKB/Swiss-Prot
NCBI Gene GPX4 ENTREZGENE
PANTHER PTHR11592 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GSHPx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF Glutathion_perox UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS GLUTPROXDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GLUTATHIONE_PEROXID_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLUTATHIONE_PEROXID_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLUTATHIONE_PEROXID_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Ssc.93915 ENTREZGENE
UniProt A0A4X1VUZ7_PIG UniProtKB/TrEMBL
  GPX4_PIG UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:99753 ENTREZGENE