GPX4 (glutathione peroxidase 4) - Rat Genome Database

Name: GPX4
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: GPX4 (glutathione peroxidase 4) Sus scrofa

Analyze

Symbol:

GPX4

Name:

glutathione peroxidase 4

RGD ID:

13921981

Description:

ENCODES a protein that exhibits phospholipid-hydroperoxide glutathione peroxidase activity; identical protein binding (ortholog); selenium binding (ortholog); INVOLVED IN response to oxidative stress; aging (ortholog); arachidonic acid metabolic process (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); Cadmium Poisoning (ortholog); cerebral creatine deficiency syndrome (ortholog); FOUND IN cytosol (ortholog); protein-containing complex (ortholog); INTERACTS WITH deoxynivalenol; disodium selenite; malathion

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

glutathione peroxidase 4 (phospholipid hydroperoxidase); GPx-4; GSHPx-4; PHGPx; phospholipid hydroperoxide glutathione peroxidase; Phospholipid hydroperoxide glutathione peroxidase, mitochondrial

RGD Orthologs

Human

Mouse

Rat

Chinchilla

Bonobo

Dog

Squirrel

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GPX4 (glutathione peroxidase 4)	HGNC	Ensembl, Inparanoid, NCBI, OrthoDB
Mus musculus (house mouse):	Gpx4 (glutathione peroxidase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Gpx4 (glutathione peroxidase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Gpx4 (glutathione peroxidase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GPX4 (glutathione peroxidase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GPX4 (glutathione peroxidase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gpx4 (glutathione peroxidase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	GPX4 (glutathione peroxidase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gpx4 (glutathione peroxidase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	77,320,464 - 77,323,886 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	77,321,568 - 77,323,931 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	77,673,720 - 77,676,083 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Breast Neoplasms (ISO)

Cadmium Poisoning (ISO)

cerebral creatine deficiency syndrome (ISO)

Colorectal Neoplasms (ISO)

congestive heart failure (ISO)

cryptorchidism (ISO)

Embryo Loss (ISO)

fatty liver disease (ISO)

Fibrosis (ISO)

glucose intolerance (ISO)

male infertility (ISO)

Peutz-Jeghers syndrome (ISO)

Spondylometaphyseal Dysplasia, Sedaghatian Type (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

deoxynivalenol (EXP)

disodium selenite (EXP)

malathion (EXP)

melatonin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

aging (ISO)

arachidonic acid metabolic process (ISS)

cellular oxidant detoxification (IEA)

chromatin organization (IEA)

glutathione metabolic process (ISO)

lipoxygenase pathway (ISS)

multicellular organism development (IEA)

negative regulation of ferroptosis (ISS)

obsolete oxidation-reduction process (IEA)

protein polymerization (ISO)

regulation of inflammatory response (ISO)

response to estradiol (ISO)

response to oxidative stress (IDA)

spermatogenesis (ISS)

Cellular Component

cytosol (ISS)

mitochondrion (IBA)

nuclear envelope (IEA)

nucleus (IBA)

protein-containing complex (ISO)

Molecular Function

glutathione peroxidase activity (IBA)

identical protein binding (ISO)

peroxidase activity (IBA)

phospholipid-hydroperoxide glutathione peroxidase activity (IBA,IDA)

protein binding (ISO)

selenium binding (ISO)

References

Additional References at PubMed

PMID:1778506	PMID:2386798	PMID:8125951	PMID:8135530	PMID:8323565	PMID:14681463	PMID:17145712

Genomics

Comparative Map Data

GPX4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	77,320,464 - 77,323,886 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	77,321,568 - 77,323,931 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	77,673,720 - 77,676,083 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GPX4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	19	1,103,926 - 1,106,791 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	19	1,103,994 - 1,106,779 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	19	1,103,936 - 1,106,787 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	1,054,936 - 1,057,787 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	19	1,054,965 - 1,057,778	NCBI
Celera	19	1,036,910 - 1,039,761 (+)	NCBI
Cytogenetic Map	19	p13.3	NCBI
HuRef	19	877,428 - 880,271 (+)	NCBI		HuRef
CHM1_1	19	1,103,518 - 1,106,381 (+)	NCBI		CHM1_1

Gpx4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	79,883,000 - 79,892,273 (+)	NCBI	GRCm39		mm39
GRCm38	10	80,047,166 - 80,056,439 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	80,047,166 - 80,056,439 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	79,516,255 - 79,519,184 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	10	79,456,617 - 79,459,567 (+)	NCBI			mm8
Celera	10	81,068,319 - 81,071,248 (+)	NCBI		Celera
Cytogenetic Map	10	C1	NCBI
cM Map	10	39.72	NCBI

Gpx4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	7	12,516,357 - 12,519,154 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	12,516,352 - 12,519,154 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	12,686,460 - 12,689,257 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	11,162,521 - 11,165,318 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	7	11,162,520 - 11,165,318 (-)	NCBI
Celera	7	7,826,041 - 7,828,838 (-)	NCBI		Celera
Cytogenetic Map	7	q11	NCBI

Gpx4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955495	6,767,975 - 6,772,178 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955495	6,767,969 - 6,772,256 (-)	NCBI	ChiLan1.0	ChiLan1.0

GPX4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	19	1,082,917 - 1,085,538 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
Mhudiblu_PPA_v0	19	20,904 - 23,828 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

GPX4
(Canis lupus familiaris - dog)

No map positions available.

Gpx4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936588	506,101 - 508,469 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GPX4
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	873,867 - 876,225 (+)	NCBI

Gpx4
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624828	7,534,251 - 7,536,675 (-)	NCBI

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_214407	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK232479	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK346713	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK392406	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FP475994	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GFLN01064857	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L12743	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	S80257	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X76008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X76009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSSSCT00000051893 ⟹ ENSSSCP00000046912

RefSeq Status:

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	2	77,320,464 - 77,323,886 (-)	Ensembl

RefSeq Acc Id:

NM_214407 ⟹ NP_999572

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	2	77,321,568 - 77,323,931 (-)	NCBI

Sequence:

show sequence

GAATTCGGCACGAGAGGAGCGCTGCCTCCCCGGAGCCCCCGCCGCCGCGATGAGCTTTAGCCGC
CTGTTCCGCCTGCTGAAGCCAACGCTTCTCTGCGGGACCCTGGCGGTGCCCGGCCTGGCCGGCA
CCATGTGCGCGTCCCGCGACGACTGGCGATGTGCTCGCTCCATGCACGAATTCTCAGCCAAGGA
CATCGACGGGCACATGGTGAACCTGGACAAGTACCGGGGCTACGTGTGCATCGTCACCAATGTG
GCCTCTCAATGAGGCAAGACGGAGGTAAACTACACTCAGCTGGTCGACCTGCACGCCCGATATG
CTGAGTGTGGTTTACGGATTCTGGCCTTCCCTTGCAACCAGTTTGGGAGGCAGGAGCCAGGGAG
TGATGCTGAGATCAAAGAATTTGCTGCTGGCTACAACGTCAAATTTGATATGTTCAGCAAGATC
TGTGTGAATGGGGACGATGCCCACCCTCTGTGGAAGTGGATGAAAGTCCAGCCCAAGGGGAGGG
GCATGCTGGGAAATGCTATCAAATGGAACTTTACCAAGTTCCTCATTGATAAGAACGGCTGTGT
GGTGAAGCGGTACGGTCCCATGGAAGAGCCCCAGGTCATAGAGAAGGACCTGCCGTGCTACCTC
TAGCTCAACAAGTGTGTGCTGAGCCTGCTGCCTGTGCCCTCAGAGCCTTCCACCTGGCACCCAT
GACAGTCTGCCTAAAAACCAGCCCCTGGTGGGGCAGACTCGAGAACCTGGCGTGCAACCCCGCC
AGAGGAAGGTCCCTTGGCCCAGCTTGCAGCTCGCACCCCACCCCAGGCTGCCTTGTGGGAATAA
ACCAAACAAATTGGCTAGTTCAGTGTTCCTGCTTATGGGAATAAACCATACAAATTGGCTAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAACTCGAG

hide sequence

Protein Sequences


Protein RefSeqs	NP_999572	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA31098	(Get FASTA)	NCBI Sequence Viewer
	AAA31099	(Get FASTA)	NCBI Sequence Viewer
	AAB21327	(Get FASTA)	NCBI Sequence Viewer
	CAA53595	(Get FASTA)	NCBI Sequence Viewer
	CAA53596	(Get FASTA)	NCBI Sequence Viewer
	P36968	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_999572 ⟸ NM_214407
- Peptide Label:	precursor
- UniProtKB:	P36968 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MSFSRLFRLLKPTLLCGTLAVPGLAGTMCASRDDWRCARSMHEFSAKDIDGHMVNLDKYRGYVC IVTNVASQUGKTEVNYTQLVDLHARYAECGLRILAFPCNQFGRQEPGSDAEIKEFAAGYNVKFD MFSKICVNGDDAHPLWKWMKVQPKGRGMLGNAIKWNFTKFLIDKNGCVVKRYGPMEEPQVIEKD LPCYL hide sequence

RefSeq Acc Id:

ENSSSCP00000046912 ⟸ ENSSSCT00000051893

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000024052	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
	ENSSSCG00030015859	UniProtKB/Swiss-Prot
	ENSSSCG00040056197	UniProtKB/Swiss-Prot
	ENSSSCG00045035370	UniProtKB/Swiss-Prot
	ENSSSCG00050062797	UniProtKB/Swiss-Prot
	ENSSSCG00060017858	UniProtKB/Swiss-Prot
	ENSSSCG00070026740	UniProtKB/TrEMBL
Ensembl Protein	ENSSSCP00000046912	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSSSCP00030009935	UniProtKB/Swiss-Prot
	ENSSSCP00040032715	UniProtKB/Swiss-Prot
	ENSSSCP00045042685	UniProtKB/Swiss-Prot
	ENSSSCP00050036727	UniProtKB/Swiss-Prot
	ENSSSCP00060010026	UniProtKB/Swiss-Prot
	ENSSSCP00070045473	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000051893	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSSSCT00030021984	UniProtKB/Swiss-Prot
	ENSSSCT00040076156	UniProtKB/Swiss-Prot
	ENSSSCT00045060762	UniProtKB/Swiss-Prot
	ENSSSCT00050085532	UniProtKB/Swiss-Prot
	ENSSSCT00060023935	UniProtKB/Swiss-Prot
	ENSSSCT00070053641	UniProtKB/TrEMBL
Gene3D-CATH	3.40.30.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Glutathione_peroxidase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPX_AS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPX_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Thioredoxin-like_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	ssc:399537	UniProtKB/Swiss-Prot
NCBI Gene	GPX4	ENTREZGENE
PANTHER	PTHR11592	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	GSHPx	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF	Glutathion_perox	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS	GLUTPROXDASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	GLUTATHIONE_PEROXID_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GLUTATHIONE_PEROXID_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GLUTATHIONE_PEROXID_3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF52833	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene	Ssc.93915	ENTREZGENE
UniProt	A0A4X1VUZ7_PIG	UniProtKB/TrEMBL
	GPX4_PIG	UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID	VGNC:99753	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM