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Gene: GPX4 (glutathione peroxidase 4) Sus scrofa
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Symbol: GPX4
Name: glutathione peroxidase 4
Description: ENCODES a protein that exhibits phospholipid-hydroperoxide glutathione peroxidase activity; INVOLVED IN response to oxidative stress; negative regulation of ferroptosis (ortholog); spermatogenesis (ortholog); PARTICIPATES IN glutathione metabolic pathway; ASSOCIATED WITH Breast Neoplasms (ortholog); Cadmium Poisoning (ortholog); Colorectal Neoplasms (ortholog); FOUND IN cytosol (inferred); nuclear envelope (inferred); nucleoplasm (inferred); INTERACTS WITH deoxynivalenol; disodium selenite
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: glutathione peroxidase 4 (phospholipid hydroperoxidase); GPx-4; GSHPx-4; PHGPx; phospholipid hydroperoxide glutathione peroxidase; Phospholipid hydroperoxide glutathione peroxidase, mitochondrial
Orthologs:
Homo sapiens (human) : GPX4 (glutathione peroxidase 4)  HGNC  Alliance
Mus musculus (house mouse) : Gpx4 (glutathione peroxidase 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gpx4 (glutathione peroxidase 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gpx4 (glutathione peroxidase 4)
Pan paniscus (bonobo/pygmy chimpanzee) : GPX4 (glutathione peroxidase 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gpx4 (glutathione peroxidase 4)
more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1277,321,568 - 77,323,931 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2277,673,720 - 77,676,083 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap2 NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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Molecular Pathway Annotations
References - uncurated

Genomics

Comparative Map Data

Expression


Sequence

Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
 
More on GPX4
NCBI Gene
Ensembl Gene
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 13921981
Created: 2019-01-29
Species: Sus scrofa
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.