Hadhb (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta) - Rat Genome Database

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Gene: Hadhb (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta) Ictidomys tridecemlineatus
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Symbol: Hadhb
Name: hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
RGD ID: 12707497
Description: ENCODES a protein that exhibits acetyl-CoA C-acyltransferase activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN fatty acid beta-oxidation (ortholog); PARTICIPATES IN carnitine palmitoyltransferase I deficiency pathway; ethylmalonic encephalopathy pathway; fatty acid beta degradation pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Breast Neoplasms (ortholog); Charcot-Marie-Tooth disease (ortholog); FOUND IN endoplasmic reticulum (ortholog); mitochondrial fatty acid beta-oxidation multienzyme complex (ortholog); mitochondrial inner membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit; trifunctional enzyme subunit beta, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629264,656,832 - 64,699,845 (+)NCBI
SpeTri2.0NW_0049364936,139,717 - 6,182,792 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

Genomics

Comparative Map Data
Hadhb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629264,656,832 - 64,699,845 (+)NCBI
SpeTri2.0NW_0049364936,139,717 - 6,182,792 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HADHB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl226,243,170 - 26,290,465 (+)EnsemblGRCh38hg38GRCh38
GRCh38226,244,917 - 26,290,465 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37226,467,807 - 26,513,333 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36226,321,120 - 26,366,837 (+)NCBINCBI36hg18NCBI36
Build 34226,379,471 - 26,424,983NCBI
Celera226,307,847 - 26,353,565 (+)NCBI
Cytogenetic Map2p23.3NCBI
HuRef226,213,206 - 26,249,388 (+)NCBIHuRef
CHM1_1226,397,520 - 26,443,240 (+)NCBICHM1_1
Hadhb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39530,360,251 - 30,389,591 (+)NCBIGRCm39mm39
GRCm39 Ensembl530,360,246 - 30,389,591 (+)Ensembl
GRCm38530,155,253 - 30,184,593 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl530,155,248 - 30,184,593 (+)EnsemblGRCm38mm10GRCm38
MGSCv37530,481,862 - 30,511,123 (+)NCBIGRCm37mm9NCBIm37
MGSCv36530,486,109 - 30,515,370 (+)NCBImm8
Celera527,672,860 - 27,702,121 (+)NCBICelera
Cytogenetic Map5B1NCBI
Hadhb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2626,153,572 - 26,187,668 (-)NCBI
Rnor_6.0 Ensembl627,555,412 - 27,582,995 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0627,555,408 - 27,589,539 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0637,366,082 - 37,400,364 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4626,139,397 - 26,173,428 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1626,142,349 - 26,169,900 (-)NCBI
Celera625,630,447 - 25,664,546 (-)NCBICelera
Cytogenetic Map6q14NCBI
Hadhb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554698,233,980 - 8,274,450 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554698,233,980 - 8,272,149 (+)NCBIChiLan1.0ChiLan1.0
HADHB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A26,334,043 - 26,379,059 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A26,334,043 - 26,379,059 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A26,240,365 - 26,285,982 (+)NCBIMhudiblu_PPA_v0panPan3
HADHB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11720,355,778 - 20,399,869 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1720,251,473 - 20,294,727 (+)NCBI
ROS_Cfam_1.01720,678,487 - 20,721,816 (+)NCBI
UMICH_Zoey_3.11720,365,181 - 20,408,616 (+)NCBI
UNSW_CanFamBas_1.01720,376,149 - 20,419,589 (+)NCBI
UU_Cfam_GSD_1.01720,422,834 - 20,465,929 (+)NCBI
HADHB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3112,704,023 - 112,753,086 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13112,712,894 - 112,753,121 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23119,651,210 - 119,676,200 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HADHB
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11481,361,735 - 81,411,588 (-)NCBI
ChlSab1.1 Ensembl1481,361,612 - 81,411,432 (-)Ensembl
Vero_WHO_p1.0NW_02366604530,746,759 - 30,796,507 (+)NCBI
Hadhb
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247388,384,789 - 8,420,994 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005322567   ⟹   XP_005322624
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440629264,656,832 - 64,699,845 (+)NCBI
SpeTri2.0NW_0049364936,139,717 - 6,182,792 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013357360   ⟹   XP_013212814
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_0049364936,139,717 - 6,182,792 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040271459   ⟹   XP_040127393
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440629264,657,043 - 64,699,845 (+)NCBI
Protein Sequences
Protein RefSeqs XP_005322624 (Get FASTA)   NCBI Sequence Viewer  
  XP_040127393 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_013212814   ⟸   XM_013357360
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005322624   ⟸   XM_005322567
- UniProtKB: I3LYW1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040127393   ⟸   XM_040271459
Protein Domains
Thiolase_C   Thiolase_N


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000001601 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000001433 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000001602 UniProtKB/TrEMBL
Gene3D-CATH 3.40.47.10 UniProtKB/TrEMBL
InterPro Thiolase UniProtKB/TrEMBL
  Thiolase-like UniProtKB/TrEMBL
  Thiolase_acyl_enz_int_AS UniProtKB/TrEMBL
  Thiolase_AS UniProtKB/TrEMBL
  Thiolase_C UniProtKB/TrEMBL
  Thiolase_CS UniProtKB/TrEMBL
  Thiolase_N UniProtKB/TrEMBL
NCBI Gene Hadhb ENTREZGENE
Pfam Thiolase_C UniProtKB/TrEMBL
  Thiolase_N UniProtKB/TrEMBL
PROSITE THIOLASE_1 UniProtKB/TrEMBL
  THIOLASE_2 UniProtKB/TrEMBL
  THIOLASE_3 UniProtKB/TrEMBL
Superfamily-SCOP SSF53901 UniProtKB/TrEMBL
TIGRFAMs AcCoA-C-Actrans UniProtKB/TrEMBL
UniProt I3LYW1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-09-26 Hadhb  hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta    hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit  Symbol and/or name change 5135510 APPROVED