Ttf1 (transcription termination factor 1) - Rat Genome Database

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Gene: Ttf1 (transcription termination factor 1) Ictidomys tridecemlineatus
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Symbol: Ttf1
Name: transcription termination factor 1
RGD ID: 12638546
Description: ENCODES a protein that exhibits chromatin binding (inferred); DNA binding (inferred); INVOLVED IN chromatin remodeling (inferred); termination of RNA polymerase I transcription (inferred); transcription by RNA polymerase I (inferred); PARTICIPATES IN RNA polymerase I transcription pathway; ASSOCIATED WITH congenital nongoitrous hypothyroidism 2 (ortholog); developmental and epileptic encephalopathy (ortholog); developmental and epileptic encephalopathy 14 (ortholog); FOUND IN fibrillar center (inferred); nucleolus (inferred); nucleoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: transcription termination factor 1, transcript variant X1; transcription termination factor 1, transcript variant X2; transcription termination factor 1, transcript variant X3; transcription termination factor 1, transcript variant X4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947199,188,472 - 199,215,336 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648718,956,899 - 18,983,888 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648718,956,364 - 18,983,850 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 9 of 9 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ttf1Squirrelcongenital nongoitrous hypothyroidism 2  ISOTTF1 (Homo sapiens)8554872ClinVar Annotator: match by term: Hypothyroidism more ...ClinVarPMID:25741868
Ttf1Squirreldevelopmental and epileptic encephalopathy  ISOTTF1 (Homo sapiens)8554872ClinVar Annotator: match by term: Developmental and epileptic encephalopathyClinVarPMID:28492532
Ttf1Squirreldevelopmental and epileptic encephalopathy 14  ISOTTF1 (Homo sapiens)8554872ClinVar Annotator: match by term: Developmental and epileptic encephalopathy and 14ClinVarPMID:28492532
Ttf1Squirrelearly infantile epileptic encephalopathy  ISOTTF1 (Homo sapiens)8554872ClinVar Annotator: match by term: Early infantile epileptic encephalopathyClinVarPMID:28492532
Ttf1SquirrelEhlers-Danlos syndrome classic type 1  ISOTTF1 (Homo sapiens)8554872ClinVar Annotator: match by term: Ehlers-Danlos syndrome and classic typeClinVarPMID:28492532
Ttf1SquirrelLeigh disease  ISOTTF1 (Homo sapiens)8554872ClinVar Annotator: match by term: Leigh syndromeClinVarPMID:28492532
Ttf1Squirrelprimary coenzyme Q10 deficiency 7  ISOTTF1 (Homo sapiens)8554872ClinVar Annotator: match by term: Neonatal encephalomyopathy-cardiomyopathy-respiratory distress syndromeClinVarPMID:28492532
Ttf1SquirrelRafiq syndrome  ISOTTF1 (Homo sapiens)8554872ClinVar Annotator: match by term: Rafiq syndromeClinVarPMID:28492532
Ttf1Squirreltuberous sclerosis 1  ISOTTF1 (Homo sapiens)8554872ClinVar Annotator: match by term: Tuberous sclerosis 1ClinVarPMID:28492532
1 to 9 of 9 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ttf1Squirrellung adenocarcinoma  ISOTTF1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:25851810


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ttf1Squirrelchromatin remodeling acts_upstream_of_or_withinIEAUniProtKB:Q62187 and ensembl:ENSMUSP00000097809150520179 EnsemblGO_REF:0000107
Ttf1Squirreltermination of RNA polymerase I transcription involved_inIEAPANTHER:PTN000067850150520179 TreeGrafterGO_REF:0000118
Ttf1Squirreltermination of RNA polymerase I transcription acts_upstream_of_or_withinIEAUniProtKB:Q62187 and ensembl:ENSMUSP00000097809150520179 EnsemblGO_REF:0000107
Ttf1Squirreltranscription by RNA polymerase I involved_inIEAUniProtKB:Q62187 and ensembl:ENSMUSP00000097809150520179 EnsemblGO_REF:0000107
Ttf1Squirreltranscription initiation at RNA polymerase I promoter acts_upstream_of_or_withinIEAUniProtKB:Q62187 and ensembl:ENSMUSP00000097809150520179 EnsemblGO_REF:0000107

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ttf1Squirrelfibrillar center located_inIEAUniProtKB:Q15361 and ensembl:ENSP00000333920150520179 EnsemblGO_REF:0000107
Ttf1Squirrelnucleolus located_inIEAPANTHER:PTN000067850150520179 TreeGrafterGO_REF:0000118
Ttf1Squirrelnucleolus located_inIEAUniProtKB:Q62187 and ensembl:ENSMUSP00000097809150520179 EnsemblGO_REF:0000107
Ttf1Squirrelnucleoplasm located_inIEAUniProtKB:Q62187 and ensembl:ENSMUSP00000097809150520179 EnsemblGO_REF:0000107
Ttf1Squirrelnucleus located_inIEAUniProtKB:Q62187 and ensembl:ENSMUSP00000097809150520179 EnsemblGO_REF:0000107

Molecular Function
1 to 9 of 9 rows

  
1 to 9 of 9 rows

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ttf1SquirrelRNA polymerase I transcription pathway   ISOTtf1 (Mus musculus)9068941 RGDPMID:23092677 and REF_RGD_ID:9588249


Ttf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947199,188,472 - 199,215,336 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648718,956,899 - 18,983,888 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648718,956,364 - 18,983,850 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TTF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389132,375,548 - 132,406,840 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9132,375,548 - 132,406,851 (-)EnsemblGRCh38hg38GRCh38
GRCh379135,250,935 - 135,282,227 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369134,240,756 - 134,272,042 (-)NCBINCBI36Build 36hg18NCBI36
Build 349132,280,492 - 132,311,775NCBI
Celera9105,792,754 - 105,824,048 (-)NCBICelera
Cytogenetic Map9q34.13NCBI
HuRef9104,744,257 - 104,775,555 (-)NCBIHuRef
CHM1_19135,400,954 - 135,432,252 (-)NCBICHM1_1
T2T-CHM13v2.09144,590,014 - 144,621,286 (-)NCBIT2T-CHM13v2.0
Ttf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39228,950,211 - 28,977,668 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl228,950,274 - 28,977,668 (+)EnsemblGRCm39 Ensembl
GRCm38229,060,199 - 29,087,656 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl229,060,262 - 29,087,656 (+)EnsemblGRCm38mm10GRCm38
MGSCv37228,915,783 - 28,943,170 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36228,882,286 - 28,909,115 (+)NCBIMGSCv36mm8
Celera228,766,271 - 28,793,645 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map219.38NCBI
Ttf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8332,782,544 - 32,807,202 (+)NCBIGRCr8
mRatBN7.2312,384,626 - 12,409,257 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl312,384,655 - 12,409,257 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.037,635,630 - 7,660,153 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl37,635,933 - 7,660,673 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0312,984,215 - 13,008,867 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.438,067,017 - 8,086,185 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera37,163,853 - 7,188,383 (+)NCBICelera
Cytogenetic Map3p12NCBI
Ttf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555131,804,690 - 1,829,705 (-)NCBIChiLan1.0ChiLan1.0
TTF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2116,950,839 - 6,980,899 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan196,953,176 - 6,983,236 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09103,495,737 - 103,525,775 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19132,129,318 - 132,158,660 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9132,129,318 - 132,158,660 (-)Ensemblpanpan1.1panPan2
TTF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1951,855,565 - 51,881,000 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl951,855,559 - 51,878,459 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha951,120,246 - 51,145,642 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0952,748,649 - 52,774,067 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl952,746,666 - 52,772,199 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1951,528,526 - 51,553,908 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0951,852,982 - 51,876,680 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0951,939,290 - 51,964,688 (+)NCBIUU_Cfam_GSD_1.0
TTF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1272,180,498 - 272,212,478 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11272,180,488 - 272,212,504 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21306,231,749 - 306,244,296 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TTF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1125,734,136 - 5,763,768 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl125,738,166 - 5,764,533 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660799,856,700 - 9,886,986 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ttf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247603,893,665 - 3,918,237 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.






Ensembl Acc Id: ENSSTOT00000007956   ⟹   ENSSTOP00000007120
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493648718,956,899 - 18,983,888 (-)Ensembl
Ensembl Acc Id: ENSSTOT00000030379   ⟹   ENSSTOP00000025560
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493648718,956,899 - 18,983,888 (-)Ensembl
RefSeq Acc Id: XM_005321104   ⟹   XP_005321161
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947199,188,472 - 199,215,336 (-)NCBI
SpeTri2.0NW_00493648718,956,364 - 18,983,850 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021723667   ⟹   XP_021579342
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947199,188,472 - 199,215,264 (-)NCBI
SpeTri2.0NW_00493648718,956,364 - 18,983,796 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021723668   ⟹   XP_021579343
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947199,188,472 - 199,215,264 (-)NCBI
SpeTri2.0NW_00493648718,956,364 - 18,983,796 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040286532   ⟹   XP_040142466
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947199,188,472 - 199,215,264 (-)NCBI
RefSeq Acc Id: XR_005734178
Type: NON-CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947199,197,851 - 199,215,265 (-)NCBI
RefSeq Acc Id: XP_005321161   ⟸   XM_005321104
- Peptide Label: isoform X1
- UniProtKB: I3MAQ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021579343   ⟸   XM_021723668
- Peptide Label: isoform X1
- UniProtKB: I3MAQ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021579342   ⟸   XM_021723667
- Peptide Label: isoform X1
- UniProtKB: I3MAQ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040142466   ⟸   XM_040286532
- Peptide Label: isoform X2
Ensembl Acc Id: ENSSTOP00000007120   ⟸   ENSSTOT00000007956
Myb-like



1 to 13 of 13 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSSTOG00000007957 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000007956.3 UniProtKB/TrEMBL
  ENSSTOT00000030379.1 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro SANT/Myb UniProtKB/TrEMBL
  TTF1-like UniProtKB/TrEMBL
NCBI Gene Ttf1 ENTREZGENE
PANTHER TRANSCRIPTION TERMINATION FACTOR 1 UniProtKB/TrEMBL
  TRANSCRIPTION TERMINATION FACTOR 1 UniProtKB/TrEMBL
Pfam Myb_DNA-bind_6 UniProtKB/TrEMBL
PROSITE MYB_LIKE UniProtKB/TrEMBL
SMART SANT UniProtKB/TrEMBL
UniProt I3MAQ9 ENTREZGENE, UniProtKB/TrEMBL
1 to 13 of 13 rows